针刺在促进神经再生中与Nogo-A蛋白关系初探
|
摘要
<正>成熟的中枢神经系统(central nervous system,CNS)损伤后几乎无再生能力,其再生修复问题一直是国内外医学界研究的难题。目前公认的是由于CNS神经元所生存的外部微环境中,存在各种外源性生长促进性和抑制性因子,这些因子均能诱导生长锥塌陷,导致轴突再生失败。神经再生抑制因子中Nogo蛋白作为抑制CNS再生的最重要的物质[1],在脑损伤中的作用越来越受到学者重视,被认为是造成CNS损伤后难以修复的重要
引文
[1]Wang T,Xiong JQ,Ren XB,et al.The role of Nogo-A in neuroregeneration:A review[J].Brain Res Bull.2012,5(3):229-235.
[2]Caroni P,Schwab ME.Two membrane protein factions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading.[J]Cell Biol,1988,106(4):1281-1288.
[3]Huber AB,Weinmann O,Brosamle C,et al.Patterns of Nogo m RNA and protein expression in the developing and adult rat and after CNS lesions[J].J Neurosci,2002,22(9):3553-3567.
[4]Gran-dpre T,Nakamura F,Vartanian T,et al.Identification of the Nogo inhibit or of axon regeneration as a reticulon protein[J].Nature,2000,403(6768):439-444.
[5]Chen MS,Huber AB,Schw ab ME,et al.Nogo-A is a myelin-associated neurite out growth inhibitor and an antigen for monoclonal antibody IN-1.[J].Nature,2000,403(6768):434-43.
[6]Hun Td,Coff in RS,Prin jha RK et al.Nogo-A expression in the intact andinjured nervous system.Mol Cel l N eurosc,i 2003;24:1083-1102.
[7]Josephon A,Widen falk J,Widmer HW et al.Nogo Mrna expression in adult and fetal human and rat nervous tissue and in weight drop injury.Exp Neurol,2001,169:319-328.
[8]程希平,刘惠玲,宋朝君,等.Nogo-A在成年大鼠脑内神经元的分布.解剖学报,2005,36:465-470.
[9]程希平,刘惠玲,宋朝君,等.Nogo-A在成年大鼠脊髓和背根节的分布.神经科学通报,2005,2:77-81.
[10]Shelley AC,Charmaine UP,Noboru M,et al.Nogo-Ainduction and localizati on during chickbrain development indicate a role disparate from neurite outgrowth inhibition[J].BMC Dev Biol,2007,7(1):32.
[11]宋红普,魏江磊,石敏.Nogo及其受体与中枢神经再生[J].中国中医药急症,2011,20(3):442-444.
[12]范有名.Ng R受体复合物介导中枢神经再生抑制机制研究[J].华南国防医学杂志,2010,24(1):72-74.
[13]Hunt D,Mason MR,Campbell G,et al.Nogo recept or m RNA expression in intact and regene-rating CNS neurons[J].Mol Cell Neurosci,2002,20(4):537-552.
[14]Wang X,Chun SJ,Treloar H,et al.Localization of Nogo-A and Nogo66 receptor proteins at sites of axon myelin and synaptic contact[J].J Neurosci,2002,22(13):5505-5515.
[15]熊南翔,赵洪洋,张方成.Nogo-66受体在神经元生长锥中的表达[J].神经解剖学杂志,2005,21(6):622-624.
[16]许丹阳,张励才.Nogo蛋白的研究进展[J].神经解志,2009,25(1):101-104.
[17]赵红洋,朱薇薇,王金丽Nogo-A及Nogo受体抑制剂/拮抗剂的神经防护作用[J].中国医药导报,2011,12(35):10-11.
[17]Hsieh SH,Ferraro GB,Foumier A,et 02.Myelin-associated inhibit-toys regulate cofilin hosphorylation and neuronal inhibition Through LIM kinase and Slingshot phos Phatase[J].J Neurosci,2006,26(3):1006-1015.
[18]曹健,周美启.近3年针刺防治脑血管疾病作用机制研究概况[J].安徽中医学院学报,2008,27(5):61-64.
[19]薛玉仙,高剑峰,刘轲.电针干预对老龄大鼠脑缺血再灌注海马齿状回内源性神经干细胞增殖分化的影响[J].北京中医药大学学报,2009,16(5):1-5.
[20]Pradhan AD,Case AM,Farrer RG,et al.Dendritic spine Alterations in neocortical pyramidal neurons following postnatal neuronal nogo-A knockdow[J].Dev Neurosci,2010,32(4):313-320.
[21]Cheatwood JL,Emerick AJ,Schwab ME,et al.Nogo-A expression after focal ischemic stroke in the adult rat[J].Stroke,2008,39(7):2091-2098.
[22]苏桂云,朱薇薇,王丽.Nogo-A及其受体拮抗剂在新生大鼠缺氧缺血性脑损伤修复中的作用机制[J].中国儿童保健杂志,2010,18(2):132-140.
[23]朱薇薇,赵红洋,温天莲,等.缺氧缺血性脑损伤新生儿大鼠脑Nogo受体水平及NEP1-40的神经保护作用[J].中华儿科杂志,2010,48(2):138-142.
[24]Seira O,Gavín R,Gil V,et al.Neurites regrowth of cortical neurons by GSK3-beta inhibition independently of Nogoreceptor[J].J Neurochem,2010,113(6):1644-58.
[25]Giger,Roman J,Venkatesh,et al.Mechanisms of CNS myelin inhibition:Evidence for distinct and neuronal cell type specific receptor systems[J].Restorative Neurology&Neuroscience,2008,26(2):97-115.
[26]钱宇斐,樊小农,李雅洁,等.针刺不同穴位对脑缺血模型大鼠脑血流量的影响[J].中国针灸,2009,29(3):312-215.
[27]宋金玲,张静思,黄长军,时素华,等.督脉电针对大鼠颅脑损伤后[Ca2+]i含量和Nogo-A表达的影响[J].中国学术期刊电子杂志出版社,305-313.
[28]杨冰,秀清,吉友,云钦建.刺激对脑梗死大鼠运动功能恢复及Nogo-A、Ng R表达的影响[J].山东大学学报,2008,10(46):931-935.
[29]王艳.针康法对局灶性脑缺血大鼠前肢运动功能的影响及相关机制的研究[J].黑龙江中医药大学学报,2012,41(2):161-168.
[2]Caroni P,Schwab ME.Two membrane protein factions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading.[J]Cell Biol,1988,106(4):1281-1288.
[3]Huber AB,Weinmann O,Brosamle C,et al.Patterns of Nogo m RNA and protein expression in the developing and adult rat and after CNS lesions[J].J Neurosci,2002,22(9):3553-3567.
[4]Gran-dpre T,Nakamura F,Vartanian T,et al.Identification of the Nogo inhibit or of axon regeneration as a reticulon protein[J].Nature,2000,403(6768):439-444.
[5]Chen MS,Huber AB,Schw ab ME,et al.Nogo-A is a myelin-associated neurite out growth inhibitor and an antigen for monoclonal antibody IN-1.[J].Nature,2000,403(6768):434-43.
[6]Hun Td,Coff in RS,Prin jha RK et al.Nogo-A expression in the intact andinjured nervous system.Mol Cel l N eurosc,i 2003;24:1083-1102.
[7]Josephon A,Widen falk J,Widmer HW et al.Nogo Mrna expression in adult and fetal human and rat nervous tissue and in weight drop injury.Exp Neurol,2001,169:319-328.
[8]程希平,刘惠玲,宋朝君,等.Nogo-A在成年大鼠脑内神经元的分布.解剖学报,2005,36:465-470.
[9]程希平,刘惠玲,宋朝君,等.Nogo-A在成年大鼠脊髓和背根节的分布.神经科学通报,2005,2:77-81.
[10]Shelley AC,Charmaine UP,Noboru M,et al.Nogo-Ainduction and localizati on during chickbrain development indicate a role disparate from neurite outgrowth inhibition[J].BMC Dev Biol,2007,7(1):32.
[11]宋红普,魏江磊,石敏.Nogo及其受体与中枢神经再生[J].中国中医药急症,2011,20(3):442-444.
[12]范有名.Ng R受体复合物介导中枢神经再生抑制机制研究[J].华南国防医学杂志,2010,24(1):72-74.
[13]Hunt D,Mason MR,Campbell G,et al.Nogo recept or m RNA expression in intact and regene-rating CNS neurons[J].Mol Cell Neurosci,2002,20(4):537-552.
[14]Wang X,Chun SJ,Treloar H,et al.Localization of Nogo-A and Nogo66 receptor proteins at sites of axon myelin and synaptic contact[J].J Neurosci,2002,22(13):5505-5515.
[15]熊南翔,赵洪洋,张方成.Nogo-66受体在神经元生长锥中的表达[J].神经解剖学杂志,2005,21(6):622-624.
[16]许丹阳,张励才.Nogo蛋白的研究进展[J].神经解志,2009,25(1):101-104.
[17]赵红洋,朱薇薇,王金丽Nogo-A及Nogo受体抑制剂/拮抗剂的神经防护作用[J].中国医药导报,2011,12(35):10-11.
[17]Hsieh SH,Ferraro GB,Foumier A,et 02.Myelin-associated inhibit-toys regulate cofilin hosphorylation and neuronal inhibition Through LIM kinase and Slingshot phos Phatase[J].J Neurosci,2006,26(3):1006-1015.
[18]曹健,周美启.近3年针刺防治脑血管疾病作用机制研究概况[J].安徽中医学院学报,2008,27(5):61-64.
[19]薛玉仙,高剑峰,刘轲.电针干预对老龄大鼠脑缺血再灌注海马齿状回内源性神经干细胞增殖分化的影响[J].北京中医药大学学报,2009,16(5):1-5.
[20]Pradhan AD,Case AM,Farrer RG,et al.Dendritic spine Alterations in neocortical pyramidal neurons following postnatal neuronal nogo-A knockdow[J].Dev Neurosci,2010,32(4):313-320.
[21]Cheatwood JL,Emerick AJ,Schwab ME,et al.Nogo-A expression after focal ischemic stroke in the adult rat[J].Stroke,2008,39(7):2091-2098.
[22]苏桂云,朱薇薇,王丽.Nogo-A及其受体拮抗剂在新生大鼠缺氧缺血性脑损伤修复中的作用机制[J].中国儿童保健杂志,2010,18(2):132-140.
[23]朱薇薇,赵红洋,温天莲,等.缺氧缺血性脑损伤新生儿大鼠脑Nogo受体水平及NEP1-40的神经保护作用[J].中华儿科杂志,2010,48(2):138-142.
[24]Seira O,Gavín R,Gil V,et al.Neurites regrowth of cortical neurons by GSK3-beta inhibition independently of Nogoreceptor[J].J Neurochem,2010,113(6):1644-58.
[25]Giger,Roman J,Venkatesh,et al.Mechanisms of CNS myelin inhibition:Evidence for distinct and neuronal cell type specific receptor systems[J].Restorative Neurology&Neuroscience,2008,26(2):97-115.
[26]钱宇斐,樊小农,李雅洁,等.针刺不同穴位对脑缺血模型大鼠脑血流量的影响[J].中国针灸,2009,29(3):312-215.
[27]宋金玲,张静思,黄长军,时素华,等.督脉电针对大鼠颅脑损伤后[Ca2+]i含量和Nogo-A表达的影响[J].中国学术期刊电子杂志出版社,305-313.
[28]杨冰,秀清,吉友,云钦建.刺激对脑梗死大鼠运动功能恢复及Nogo-A、Ng R表达的影响[J].山东大学学报,2008,10(46):931-935.
[29]王艳.针康法对局灶性脑缺血大鼠前肢运动功能的影响及相关机制的研究[J].黑龙江中医药大学学报,2012,41(2):161-168.