婴幼儿哮喘控制评估工具的临床应用进展
摘要
婴幼儿哮喘评估是哮喘规范化管理的重要一环,选择合适哮喘评估工具尤为重要。目前有多种控制及评估工具应用于哮喘规范化管理中,但由于婴幼儿群体的特殊性,常用的哮喘控制及评估工具在应用中存在一定的缺陷,不能够客观反映患儿病情评估中的气道可逆性及炎性相关性。此文就国内外现用于婴幼儿哮喘控制评估的工具进行综述,阐述在婴幼儿哮喘诊断、规范化管理及药物指导等方面的重要作用,并探讨有效、便捷、易于管理的哮喘控制与评估工具应用于科研及临床建立基础。
引文
[1]BATEMAN ED,HURD SS,BARNES PJ,et al.Global strategy for asthma management and prevention:GINA executive summary[J].European Respiratory Journal,2008,34(1):143-178.
[2]中华医学会儿科学分会呼吸学组,《中华儿科杂志》编辑委员会.儿童支气管哮喘诊断与防治指南(2016年版).中华儿科杂志.2016.54(3):167-181.
[3]全国儿科哮喘协作组,中国疾病预防控制中心环境与健康相关产品安全所.第三次中国城市儿童哮喘流行病调查[J].中华儿科杂志,2013,51(10):729-735.
[4]KIM HB,ECKEL SP,KIM JH,GILLILAND FD.Exhaled NO:Determinants and Clinical Application in Children With Allergic Airway Disease.Allergy Asthma Immunol Res.2016.8(1):12-21.
[5]VANDER HEIJDEN HH,BROUWER ML,HOEKSTRA F,et al.Reference values of exhaled nitric oxide in healthy children 1-5 years using off-line tidal breathing[J].Pediatr Pulmonol,2014,49(3):291-295.
[6]GABRIELE C,JADDOE VW,VAN MASTRIGT E,et al.Exhaled nitric oxide and the risk of wheezing in infancy:the Generation R Study.[J].European Respiratory Journal,2012,39(3):567.
[7]FANG LC,SHYUR SD,WANG JY,et al.Exhaled nitric oxide helps discriminating asthmatic children with and without positive specific IgE to aeroallergens.[J].Asian Pacific Journal of Allergy&Immunology,2017.
[8]DWEIK RA,BOGGS PB,ERZURUM SC,et al.An Official ATS Clinical Practice Guideline:Interpretation of Exhaled Nitric Oxide Levels(FeNO)for Clinical Applications[J].American Journal of Respiratory&Critical Care Medicine,2011,184(5):602.
[9]RD AW,APTER A,DUTMER CM,et al.Advances in Asthma 2016:Designing Individualized Approaches to Management.[J].Journal of Allergy&Clinical Immunology,2017,140(3).
[10]PEIRSMAN EJ,CARVELLI TJ,HAGE PY,et al.Exhaled nitric oxide in childhood allergic asthma management:Arandomised controlled trial[J].Pediatric Pulmonology,2014,49(7):624-631.
[11]张惠琴,张静静,刘雨东,等.肺功能检查及呼出气一氧化氮在儿童支气管哮喘规范化管理中的应用[J].中国当代儿科杂志,2017,19(4):419-424.
[12]向莉,付亚南,李珍,等.不同控制水平的哮喘患儿呼出气一氧化氮浓度水平及其临床意义[J].中国当代儿科杂志,2013,15(1):29-32.
[13]SPAHN JD,MALKA J,SZEFLER SJ.Current Application of Exhaled Nitric Oxide in Clinical Practice[J].Journal of Allergy&Clinical Immunology,2016,138(5):1296-1298.
[14]TENG Y,SUN P,ZHANG J,et al.Hydrogen Peroxide in Exhaled Breath Condensate in Patients with Asthma:APromising Biomarker?[J].Chest,2011,140(1):108-116.
[15]李莉,丁俊丽,荣杰鑫,等.呼出气冷凝液中LTB4和CCL11水平与儿童哮喘分期的研究[J].中国现代医学杂志,2017,27(9):133-136.
[16]WOJSYKBANASZAK I,MARCIN MIKOS',SZCZEPANK-IEWICZ A,et al.Evaluation of exhaled breath temperature(EBT)as a marker and predictor of asthma exacerbation in children and adolescents[J].Journal of Asthma Official Journal of the Association for the Care of Asthma,2017,54(55):1.
[17]中华医学会儿科学分会呼吸学组肺功能协作组《中华实用儿科临床杂志》编辑委员会.儿童肺功能系列指南(四):潮气呼吸肺功能[J].中华实用儿科临床杂志,2016,31(21):1617-1621.
[18]HEVRONI A,GOLDMAN A,BLANKBRACHFELD M,et al.Use of tidal breathing curves for evaluating expiratory airway obstruction in infants.[J].Journal of Asthma,2018.
[19]张皓,肖现民,郑珊,等.1002例4岁以下小儿潮气呼吸流速-容量环正常值的研究.临床儿科杂志.2006.24(6):486-488.
[20]张皓,邬宇芬,黄剑峰等.儿童肺功能检测及评估专家共识[J].临床儿科杂志,2014,32(2):104-114.
[21]张惠琴,张静静,陶小娟,等.潮气呼吸肺功能与呼出气一氧化氮检测对2~5岁哮喘患儿临床价值研究[J].中国实用儿科杂志,2018,33(3):229-232.
[22]BATMAZ SB,KUYUCU S,ARKOGLU T,et a1.Impulse oscil lometry in acute and stable asthmatic children:a comparison with spirometry[J].J Asthma,2015,53(2):1-8.
[23]中华医学会儿科学分会呼吸学组肺功能协作组《中华实用儿科临床杂志》编辑委员会.儿童肺功能系列指南(三):脉冲振荡[J].中华实用儿科临床志,2016,31(11):821-825.
[24]ROSENFELD M,ALLEN J,ARETS BH,et al.An official American Thoracic Society workshop report:optimal lung function tests for monitoring cystic fibrosis,bronchopulmonary dysplasia,and recurrent wheezing in children less than 6 years of age[J].Annals of the American Thoracic Society,2013,10(2):S1.
[25]LARSEN G L,MORGAN W,HELDT G P,et al.Impulse oscillometry versus spirometry in a long-term study of controller therapy for pediatric asthma[J].Journal of Allergy and Clinical Immunology,2009,123(4):861-867.e1.
[26]QI G S,ZHOU Z C,GU W C,et al.Detection of the airway obstruction stage in asthma using impulse oscillometry system[J].Journal of Asthma Official Journal of the Association for the Care of Asthma,2013,50(1):45-51.
[27]曾靖,胡琦,钟世民,等.学龄前儿童呼出一氧化氮及气道高反应性与哮喘控制的相关性研究[J].重庆医学,2017,46(25):3529-3531.
[28]张义,王菲,靳蓉,等.探讨对学龄前期儿童支气管哮喘进行肺功能脉冲振荡法测定的临床意义[J].世界最新医学信息文摘,2017(48):22-23.
[29]张义,靳蓉,苏守硕,等.肺功能脉冲振荡在学龄前期儿童哮喘支气管舒张试验中的临床价值[J].中国急救医学,2016,36(12 Suppl):83-83.
[30]CASTRO-RODRIGUEZ,JOSE A.The Asthma Predictive Index:A very useful tool for predicting asthma in young children[J].Journal of Allergy and Clinical Immunology,2010,126(2):212-216.
[31]滑超,侯沛君,郭春艳,等.哮喘预测指数在婴幼儿哮喘诊断中的意义[J].中国医药导报,2016,13(5):99-102.
[32]洪建国.儿童呼吸和哮喘控制测试(TRACK)改良中文版及其临床价值[J].中国实用儿科杂志,2018,33(3):192-195.
[33]CHIPPS B,ZEIGER RS,MURPHY K,et al.Longitudinal validation of the Test for Respiratory and Asthma Control in Kids in pediatric practices[J].Pediatrics,2011,127(3):737-47.
[34]KAYA A,ERKOCOGLU M,AKAN A,et al.TRACK as a complementary tool to GINA and NAEPP guidelines for assessing asthma control in pre-school children[J].Journal of Asthma,2014,51(5):530-535.
[35]BUYUKTIRYAKI B,SAHINER U M,YAVUZ S T,et al.Validation of the Turkish version of“Test for Respiratory and Asthma Control in Kids(TRACK)”questionnaire[J].Journal of Asthma Research,2013,50(10):6.
[36]Validation of the Spanish Version of the Test for Respiratory and Asthma Control in Kids(TRACK)in a Population of Hispanic Preschoolers[J].The Journal of Allergy and Clinical Immunology:In Practice,2014,2(3):326-331.e3.
[2]中华医学会儿科学分会呼吸学组,《中华儿科杂志》编辑委员会.儿童支气管哮喘诊断与防治指南(2016年版).中华儿科杂志.2016.54(3):167-181.
[3]全国儿科哮喘协作组,中国疾病预防控制中心环境与健康相关产品安全所.第三次中国城市儿童哮喘流行病调查[J].中华儿科杂志,2013,51(10):729-735.
[4]KIM HB,ECKEL SP,KIM JH,GILLILAND FD.Exhaled NO:Determinants and Clinical Application in Children With Allergic Airway Disease.Allergy Asthma Immunol Res.2016.8(1):12-21.
[5]VANDER HEIJDEN HH,BROUWER ML,HOEKSTRA F,et al.Reference values of exhaled nitric oxide in healthy children 1-5 years using off-line tidal breathing[J].Pediatr Pulmonol,2014,49(3):291-295.
[6]GABRIELE C,JADDOE VW,VAN MASTRIGT E,et al.Exhaled nitric oxide and the risk of wheezing in infancy:the Generation R Study.[J].European Respiratory Journal,2012,39(3):567.
[7]FANG LC,SHYUR SD,WANG JY,et al.Exhaled nitric oxide helps discriminating asthmatic children with and without positive specific IgE to aeroallergens.[J].Asian Pacific Journal of Allergy&Immunology,2017.
[8]DWEIK RA,BOGGS PB,ERZURUM SC,et al.An Official ATS Clinical Practice Guideline:Interpretation of Exhaled Nitric Oxide Levels(FeNO)for Clinical Applications[J].American Journal of Respiratory&Critical Care Medicine,2011,184(5):602.
[9]RD AW,APTER A,DUTMER CM,et al.Advances in Asthma 2016:Designing Individualized Approaches to Management.[J].Journal of Allergy&Clinical Immunology,2017,140(3).
[10]PEIRSMAN EJ,CARVELLI TJ,HAGE PY,et al.Exhaled nitric oxide in childhood allergic asthma management:Arandomised controlled trial[J].Pediatric Pulmonology,2014,49(7):624-631.
[11]张惠琴,张静静,刘雨东,等.肺功能检查及呼出气一氧化氮在儿童支气管哮喘规范化管理中的应用[J].中国当代儿科杂志,2017,19(4):419-424.
[12]向莉,付亚南,李珍,等.不同控制水平的哮喘患儿呼出气一氧化氮浓度水平及其临床意义[J].中国当代儿科杂志,2013,15(1):29-32.
[13]SPAHN JD,MALKA J,SZEFLER SJ.Current Application of Exhaled Nitric Oxide in Clinical Practice[J].Journal of Allergy&Clinical Immunology,2016,138(5):1296-1298.
[14]TENG Y,SUN P,ZHANG J,et al.Hydrogen Peroxide in Exhaled Breath Condensate in Patients with Asthma:APromising Biomarker?[J].Chest,2011,140(1):108-116.
[15]李莉,丁俊丽,荣杰鑫,等.呼出气冷凝液中LTB4和CCL11水平与儿童哮喘分期的研究[J].中国现代医学杂志,2017,27(9):133-136.
[16]WOJSYKBANASZAK I,MARCIN MIKOS',SZCZEPANK-IEWICZ A,et al.Evaluation of exhaled breath temperature(EBT)as a marker and predictor of asthma exacerbation in children and adolescents[J].Journal of Asthma Official Journal of the Association for the Care of Asthma,2017,54(55):1.
[17]中华医学会儿科学分会呼吸学组肺功能协作组《中华实用儿科临床杂志》编辑委员会.儿童肺功能系列指南(四):潮气呼吸肺功能[J].中华实用儿科临床杂志,2016,31(21):1617-1621.
[18]HEVRONI A,GOLDMAN A,BLANKBRACHFELD M,et al.Use of tidal breathing curves for evaluating expiratory airway obstruction in infants.[J].Journal of Asthma,2018.
[19]张皓,肖现民,郑珊,等.1002例4岁以下小儿潮气呼吸流速-容量环正常值的研究.临床儿科杂志.2006.24(6):486-488.
[20]张皓,邬宇芬,黄剑峰等.儿童肺功能检测及评估专家共识[J].临床儿科杂志,2014,32(2):104-114.
[21]张惠琴,张静静,陶小娟,等.潮气呼吸肺功能与呼出气一氧化氮检测对2~5岁哮喘患儿临床价值研究[J].中国实用儿科杂志,2018,33(3):229-232.
[22]BATMAZ SB,KUYUCU S,ARKOGLU T,et a1.Impulse oscil lometry in acute and stable asthmatic children:a comparison with spirometry[J].J Asthma,2015,53(2):1-8.
[23]中华医学会儿科学分会呼吸学组肺功能协作组《中华实用儿科临床杂志》编辑委员会.儿童肺功能系列指南(三):脉冲振荡[J].中华实用儿科临床志,2016,31(11):821-825.
[24]ROSENFELD M,ALLEN J,ARETS BH,et al.An official American Thoracic Society workshop report:optimal lung function tests for monitoring cystic fibrosis,bronchopulmonary dysplasia,and recurrent wheezing in children less than 6 years of age[J].Annals of the American Thoracic Society,2013,10(2):S1.
[25]LARSEN G L,MORGAN W,HELDT G P,et al.Impulse oscillometry versus spirometry in a long-term study of controller therapy for pediatric asthma[J].Journal of Allergy and Clinical Immunology,2009,123(4):861-867.e1.
[26]QI G S,ZHOU Z C,GU W C,et al.Detection of the airway obstruction stage in asthma using impulse oscillometry system[J].Journal of Asthma Official Journal of the Association for the Care of Asthma,2013,50(1):45-51.
[27]曾靖,胡琦,钟世民,等.学龄前儿童呼出一氧化氮及气道高反应性与哮喘控制的相关性研究[J].重庆医学,2017,46(25):3529-3531.
[28]张义,王菲,靳蓉,等.探讨对学龄前期儿童支气管哮喘进行肺功能脉冲振荡法测定的临床意义[J].世界最新医学信息文摘,2017(48):22-23.
[29]张义,靳蓉,苏守硕,等.肺功能脉冲振荡在学龄前期儿童哮喘支气管舒张试验中的临床价值[J].中国急救医学,2016,36(12 Suppl):83-83.
[30]CASTRO-RODRIGUEZ,JOSE A.The Asthma Predictive Index:A very useful tool for predicting asthma in young children[J].Journal of Allergy and Clinical Immunology,2010,126(2):212-216.
[31]滑超,侯沛君,郭春艳,等.哮喘预测指数在婴幼儿哮喘诊断中的意义[J].中国医药导报,2016,13(5):99-102.
[32]洪建国.儿童呼吸和哮喘控制测试(TRACK)改良中文版及其临床价值[J].中国实用儿科杂志,2018,33(3):192-195.
[33]CHIPPS B,ZEIGER RS,MURPHY K,et al.Longitudinal validation of the Test for Respiratory and Asthma Control in Kids in pediatric practices[J].Pediatrics,2011,127(3):737-47.
[34]KAYA A,ERKOCOGLU M,AKAN A,et al.TRACK as a complementary tool to GINA and NAEPP guidelines for assessing asthma control in pre-school children[J].Journal of Asthma,2014,51(5):530-535.
[35]BUYUKTIRYAKI B,SAHINER U M,YAVUZ S T,et al.Validation of the Turkish version of“Test for Respiratory and Asthma Control in Kids(TRACK)”questionnaire[J].Journal of Asthma Research,2013,50(10):6.
[36]Validation of the Spanish Version of the Test for Respiratory and Asthma Control in Kids(TRACK)in a Population of Hispanic Preschoolers[J].The Journal of Allergy and Clinical Immunology:In Practice,2014,2(3):326-331.e3.