雨生红球藻中虾青素的研究与应用
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摘要
雨生红球藻是单细胞微藻,其中的虾青素具有抗氧化、抗肿瘤、预防心脑血管疾病等多种生物活性,在食品、医药、保健品、化妆品及养殖业有诸多用途。概述了雨生红球藻虾青素含量影响因素,雨生红球藻培养方法、虾青素的提取方法及其应用领域等最新研究成果,为虾青素的开发利用提供帮助。
Haematococcus pluvialis is a kind of microalga with single cell, capable to accumulate large quantities of astaxanthin,which possesses a variety of biological activities, such as antioxidant, anti-tumor and preventing cardiovascular and cerebrovascular diseases, etc, and finds many uses in foods, medicine, health products, cosmetics and aquaculture. This paper summarized the research findings about influencing factors of astaxanthin content in H. pluvialis, culture methods of H. pluvialis, extracting methods of astaxanthin and its application, to offer a reference for development of astaxanthin in H. pluvialis.
Haematococcus pluvialis is a kind of microalga with single cell, capable to accumulate large quantities of astaxanthin,which possesses a variety of biological activities, such as antioxidant, anti-tumor and preventing cardiovascular and cerebrovascular diseases, etc, and finds many uses in foods, medicine, health products, cosmetics and aquaculture. This paper summarized the research findings about influencing factors of astaxanthin content in H. pluvialis, culture methods of H. pluvialis, extracting methods of astaxanthin and its application, to offer a reference for development of astaxanthin in H. pluvialis.
引文
[1] 胡章立,吴玉荷,罗杏桃.雨生红球藻细胞类型转化影响因子的协同作用[J].深圳大学学报(理工版),2002,19(3):8-12.
[2] 李冬玲.极具经济价值的微藻——雨生红球藻[J].特种经济动植物,2014,17(3):42.
[3] GU W,XIE X,GAO S,ZHOU W,PAN G,et al.Comparison of different cells of Haematococcus pluvialis reveals an extensive acclimation mechanism during its aging process:from a perspective of photosynthesis[J].PLoS ONE,2013,8(7):e67028.doi:10.1371/journal.pone.0067028.
[4] 李浩明,高蓝.虾青素的结构、功能与应用[J].精细化工,2003,20(1):32-37.
[5] 张晓丽,刘建国.虾青素的抗氧化及其在营养和医药方面的研究[J].食品科学,2006,27(1):258-262.
[6] 吴忠兴,庄惠如.不同培养基对雨生红球藻生长和虾青素累积的影响[J].福建师范大学学报,2002,18(2):79-83.
[7] 邱保胜,刘其芳.雨生红球藻培养基的改良[J].水生生物学报,1999,23(4):391-394.
[8] 庄惠如,施巧琴,卢海声,等.营养胁迫对雨生红球藻虾青素累积的影响[J].水生生物学报,2000,24(3):208-212.
[9] 游泳,管斌,孔青,等.混合培养对雨生血球藻虾青素产量的影响[J].中国酿造,2011(6):43-46.
[10] 苗凤萍,李夜光,耿亚红,等.温度对雨生红球藻(Haematococcus pluvialis)生物量和虾青素产量的影响[J].武汉植物学研究,2005,23(1):74-77.
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[12] 庄惠如,卢海声,陈必链,等.雨生红球藻营养细胞的虾青素累积[J].水生生物学报,2001,25(4):73-77.
[13]TRIPATHI U,SARADA R,RAVISHANKAR G A.Effect of culture conditions on growth on growth of green alga-Haematococcus pluvialis and astaxanthin production[J].Acta Physiologiae Plantarum,2002,24(3):323-329.
[14]NORIHIKO HATA,JAMES C,OGBONNA,et al.Production of astaxanthin by Haematococcus pluvialis in a sequential heterotrophic-photoautotrophic culture[J].Journal of Applied Phycology,2001,13:395-402.
[15] 董庆霖,赵学明.雨生红球藻和红发夫酵母混合培养体系的氮代谢机理[J].天津大学学报,2006,39(S1):38-41.
[16] 沈源,蔡明刚,黄水英,等.利用光生物反应器培养雨生红球藻的研究初探[J].海洋科学,2010,34(10):85-91
[17] 刘娟妮,胡萍,姚领,等.微藻培养中光生物反应器的研究进展[J].食品科学,2006,27(12):772-777.
[18] 周湘池,刘必谦,曾庆国.雨生红球藻破壁方法对虾青素提取率的影响[J].海洋与湖沼,2006,37(5):42-47.
[19] 陈兴才,欧阳琴,黄亚治.雨生红球藻物理破壁法提取虾青素研究[J].中国食品学报,2007,7(2):53-57.
[20] 王灵昭,邓家权.微波法提取雨生红球藻中虾青素的工艺研究[J].食品研究与开发,2007,28(12):101-105.
[21] 赵立艳,陈芳,廖小军.影响雨生红球藻中虾青素的提取条件的研究[J].食品科学,2006,27(3):90-94.
[22] 邢淑婕,刘开华.虾青素联合茶多酚对南湾鳙鱼油抗氧化作用的研究[J].食品添加剂,2012(4):114-117.
[23] 石焕琦,张晓梅.虾青素在眼科疾病及全身疾病的应用进展[J].现代中西医结合杂志,2013,22(9):1017-1019.
[24] 宋光泉,阎杰,王荣辉,等.天然虾青素的提取纯化及其应用[J].广东化工,2007,34(11):63-66.
[25] JYONOUCHI H,SUN S,LIJIMA K,et al.Antitumor activity of astaxanthin and its mode of action[J].Nutr Cancer,2000,36(1):59-65.
[26] LENNIKOV A,KITAICHI N,FUKASE R,et al.Amelioration of ultraviolet induced photokeratitis in mice treated with astaxanthin eye drops[J].Mol Vis,2012,18:455-464.
[27] CORT A,OZTURK N,ALOPINAR D,et al.Suppressive effect of astaxanthin on retinal injury induced by elevate dintraocular pressure[J].Regul Toxicol Pharmacol,2010,58(1):121-130.
[28] BENNEDSEN M,WANG X,WILLEN R.Treatment of H.pylori infected mice with antioxidant astaxanthin reduces gastric inflammation bacterial load and modulates cytokine release by splenocytes[J].Immunol Lett,1999,70(3):185-189.
[29] 项荣,丁栋博,李杰.虾青素抑癌作用机制研究进展[J].天然产物研究与开发,2013,25(7):142-146.
[30] 荆州市天然虾青素有限公司.公司简介[EB/OL].[2018-01-18].http://www.asta.cn/news/2006-3/200632704826.htm
[31] A Technical Review of Haematococcus Algae[EB/OL].[2017-08-12].http://www.cyanotech.com/pdfs/bioastin/axbul60.pdf .
[32]TATYANA A K,MIN S K,JONG W H,et al.Cold-tolerant strain of Haematococcus pluvialis (Haematococcaceae,Chlorophyta) from Blomstrandhalv?ya (Svalbard)[J].Algae,2013,28(2):185-192.
[2] 李冬玲.极具经济价值的微藻——雨生红球藻[J].特种经济动植物,2014,17(3):42.
[3] GU W,XIE X,GAO S,ZHOU W,PAN G,et al.Comparison of different cells of Haematococcus pluvialis reveals an extensive acclimation mechanism during its aging process:from a perspective of photosynthesis[J].PLoS ONE,2013,8(7):e67028.doi:10.1371/journal.pone.0067028.
[4] 李浩明,高蓝.虾青素的结构、功能与应用[J].精细化工,2003,20(1):32-37.
[5] 张晓丽,刘建国.虾青素的抗氧化及其在营养和医药方面的研究[J].食品科学,2006,27(1):258-262.
[6] 吴忠兴,庄惠如.不同培养基对雨生红球藻生长和虾青素累积的影响[J].福建师范大学学报,2002,18(2):79-83.
[7] 邱保胜,刘其芳.雨生红球藻培养基的改良[J].水生生物学报,1999,23(4):391-394.
[8] 庄惠如,施巧琴,卢海声,等.营养胁迫对雨生红球藻虾青素累积的影响[J].水生生物学报,2000,24(3):208-212.
[9] 游泳,管斌,孔青,等.混合培养对雨生血球藻虾青素产量的影响[J].中国酿造,2011(6):43-46.
[10] 苗凤萍,李夜光,耿亚红,等.温度对雨生红球藻(Haematococcus pluvialis)生物量和虾青素产量的影响[J].武汉植物学研究,2005,23(1):74-77.
[11] 黄水英.雨生红球藻的培养及其虾青素的提取、稳定性和应用研究[D].厦门:厦门大学,2008.
[12] 庄惠如,卢海声,陈必链,等.雨生红球藻营养细胞的虾青素累积[J].水生生物学报,2001,25(4):73-77.
[13]TRIPATHI U,SARADA R,RAVISHANKAR G A.Effect of culture conditions on growth on growth of green alga-Haematococcus pluvialis and astaxanthin production[J].Acta Physiologiae Plantarum,2002,24(3):323-329.
[14]NORIHIKO HATA,JAMES C,OGBONNA,et al.Production of astaxanthin by Haematococcus pluvialis in a sequential heterotrophic-photoautotrophic culture[J].Journal of Applied Phycology,2001,13:395-402.
[15] 董庆霖,赵学明.雨生红球藻和红发夫酵母混合培养体系的氮代谢机理[J].天津大学学报,2006,39(S1):38-41.
[16] 沈源,蔡明刚,黄水英,等.利用光生物反应器培养雨生红球藻的研究初探[J].海洋科学,2010,34(10):85-91
[17] 刘娟妮,胡萍,姚领,等.微藻培养中光生物反应器的研究进展[J].食品科学,2006,27(12):772-777.
[18] 周湘池,刘必谦,曾庆国.雨生红球藻破壁方法对虾青素提取率的影响[J].海洋与湖沼,2006,37(5):42-47.
[19] 陈兴才,欧阳琴,黄亚治.雨生红球藻物理破壁法提取虾青素研究[J].中国食品学报,2007,7(2):53-57.
[20] 王灵昭,邓家权.微波法提取雨生红球藻中虾青素的工艺研究[J].食品研究与开发,2007,28(12):101-105.
[21] 赵立艳,陈芳,廖小军.影响雨生红球藻中虾青素的提取条件的研究[J].食品科学,2006,27(3):90-94.
[22] 邢淑婕,刘开华.虾青素联合茶多酚对南湾鳙鱼油抗氧化作用的研究[J].食品添加剂,2012(4):114-117.
[23] 石焕琦,张晓梅.虾青素在眼科疾病及全身疾病的应用进展[J].现代中西医结合杂志,2013,22(9):1017-1019.
[24] 宋光泉,阎杰,王荣辉,等.天然虾青素的提取纯化及其应用[J].广东化工,2007,34(11):63-66.
[25] JYONOUCHI H,SUN S,LIJIMA K,et al.Antitumor activity of astaxanthin and its mode of action[J].Nutr Cancer,2000,36(1):59-65.
[26] LENNIKOV A,KITAICHI N,FUKASE R,et al.Amelioration of ultraviolet induced photokeratitis in mice treated with astaxanthin eye drops[J].Mol Vis,2012,18:455-464.
[27] CORT A,OZTURK N,ALOPINAR D,et al.Suppressive effect of astaxanthin on retinal injury induced by elevate dintraocular pressure[J].Regul Toxicol Pharmacol,2010,58(1):121-130.
[28] BENNEDSEN M,WANG X,WILLEN R.Treatment of H.pylori infected mice with antioxidant astaxanthin reduces gastric inflammation bacterial load and modulates cytokine release by splenocytes[J].Immunol Lett,1999,70(3):185-189.
[29] 项荣,丁栋博,李杰.虾青素抑癌作用机制研究进展[J].天然产物研究与开发,2013,25(7):142-146.
[30] 荆州市天然虾青素有限公司.公司简介[EB/OL].[2018-01-18].http://www.asta.cn/news/2006-3/200632704826.htm
[31] A Technical Review of Haematococcus Algae[EB/OL].[2017-08-12].http://www.cyanotech.com/pdfs/bioastin/axbul60.pdf .
[32]TATYANA A K,MIN S K,JONG W H,et al.Cold-tolerant strain of Haematococcus pluvialis (Haematococcaceae,Chlorophyta) from Blomstrandhalv?ya (Svalbard)[J].Algae,2013,28(2):185-192.