下肢动脉钙化研究进展及其对下肢动脉硬化闭塞症介入治疗的影响
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摘要
随着人口老龄化加快,外周动脉疾病发病率逐年升高,其中以下肢动脉硬化闭塞症(ASO)最为常见,对此血管腔内介入治疗是目前临床首选治疗方法。血管钙化作为ASO的特征表现,其严重程度对介入治疗的疗效及预后均具有重要影响,与截肢及全因死亡率密切相关。正确认识并积极干预血管钙化有利于提高疗效,改善患者预后。本文主要对下肢动脉钙化的研究进展及其对下肢ASO介入治疗的影响做一综述。
With the aging of population,the prevalence of peripheral arterial disease (PAD) shows a trend of rising.Lower limb arteriosclerosis occlusion disorder(ASO)is the most common disease of PAD.Endovascular therapy is the preferred treatment for ASO in lower extremity.As the characteristic of lower limb ASO,vascular calcification has an important impact on the efficacy and prognosis of interventional therapy,which is closely related to the rates of amputation and all-cause mortality.The correct understanding and active intervention of vascular calcification are helpful for the treatment and prognosis.The advancements of lower limb arterial calcification and vascular calcification affecting endovascular therapy of ASO in lower extremity were mainly reviewed in this article.
With the aging of population,the prevalence of peripheral arterial disease (PAD) shows a trend of rising.Lower limb arteriosclerosis occlusion disorder(ASO)is the most common disease of PAD.Endovascular therapy is the preferred treatment for ASO in lower extremity.As the characteristic of lower limb ASO,vascular calcification has an important impact on the efficacy and prognosis of interventional therapy,which is closely related to the rates of amputation and all-cause mortality.The correct understanding and active intervention of vascular calcification are helpful for the treatment and prognosis.The advancements of lower limb arterial calcification and vascular calcification affecting endovascular therapy of ASO in lower extremity were mainly reviewed in this article.
引文
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[3] 中华医学会外科学分会血管外科学组.下肢动脉硬化闭塞症诊治指南.中华医学杂志,2015,95(24):145-151.
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[10] Byon CH, Chen Y. Molecular mechanisms of vascular calcification in chronic kidney disease: The link between bone and the vasculature. Curr Osteoporos Rep, 2015,13(4):206-215.
[11] Lanzer P, Boehm M, Sorribas V, et al. Medial vascular calcification revisited: Review and perspectives. Eur Heart J, 2014,35(23):1515-1525.
[12] David Smith C, Gavin Bilmen J, Iqbal S, et al. Medial artery calcification as an indicator of diabetic peripheral vascular disease. Foot Ankle Int, 2008,29(2):185-190.
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[14] Vengrenyuk Y, Carlier S, Xanthos S, et al. A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps. Proc Natl Acad Sci U S A, 2006,103(40):14678-14683.
[15] Takeuchi K, Zhang B, Ideishi M. Influence of age and hypertension on the association between small artery compliance and coronary disease. Am J Hypertens, 2004,17(12):1188-1191.
[16] Chen NX, Moe SM. Vascular calcification: Pathophysiology and risk factors. Curr Hypertens Rep, 2012,14(3):228-237.
[17] Ohtake T, Ishioka K, Honda K, et al. Impact of coronary artery calcification in hemodialysis patients: Risk factors and associations with prognosis. Hemodialysis Intl, 2010,14(2):218-225.
[18] Ohtake T, Oka M, Ikee R, et al. Impact of lower limbs' arterial calcification on the prevalence and severity of PAD in patients on hemodialysis. Vasc Surg, 2011,53(3):676-683.
[19] Karwowski W, Naumnik B, Szczepański M, et al. The mechanism of vascular calcification—a systematic review. Med Sci Monit, 2012,18(1):RA1-RA11.
[20] Rocha-Singh KJ, Zeller T, Jaff MR. Peripheral arterial calcification: Prevalence, mechanism, detection, and clinical implications. Catheter Cardiovasc Interv, 2014,83(6):E212-E220.
[21] Leopold JA. Vascular calcification: Mechanisms of vascular smooth muscle cell calcification. Trends Cardiovasc Med, 2015,25(4):267-274.
[22] Bessueille L, Magne D. Inflammation: A culprit for vascular calcification in atherosclerosis and diabetes. Cell Mol Life Sci, 2015,72(13):2475-2489.
[23] Hutcheson JD, Maldonado N, Aikawa E. Small entities with large impact: Microcalcifications and atherosclerotic plaque vulnerability. Curr Opin Lipidol, 2014,25(5):327-332.
[24] Chen W, Dilsizian V. Targeted PET/CT imaging of vulnerable atherosclerotic plaques: Microcalcification with sodium fluoride and inflammation with fluorodeoxyglucose. Curr Cardiol Rep, 2013,15(6):364.
[25] Dweck MR, Chow MW, Joshi NV, et al. Coronary arterial 18F-sodium fluoride uptake: A novel marker of plaque biology. Am Coll Cardiol, 2012,59(17):1539-1548.
[26] Agatston AS, Janowitz WR, Hildner FJ, et al. Quantification of coronary artery calcium using ultrafast computed tomography. Am Coll Cardiol, 1990,15(4):827-832.
[27] Mary A, Hartemann A, Liabeuf S. et al. Association between metformin use and below-the-knee arterial calcification score in type 2 diabetic patients. Cardiovasc Diabetol, 2017,16(1):24.
[28] Banerjee S, Sarode K, Patel A, et al. Comparative assessment of guidewire and microcatheter vs a crossing device-based strategy to traverse infrainguinal peripheral artery chronic total occlusions. J Endovasc Ther, 2015,22(4):525-534.
[29] Banerjee S, Jeon-Slaughter H, Tsai S, et al. Comparative assessment of procedure cost and outcomes between guidewire and crossing device strategies to cross peripheral artery chronic total occlusions. JACC Cardiovasc Interv, 2016,9(21):2243-2252.
[30] Adlakha S, Sheikh M, Wu J, et al. Stent fracture in the coronary and peripheral arteries. J Interv Cardiol, 2010,23(4):411-419.
[31] Bausback Y, Botsios S, Flux J, et al. Outback catheter for femoropopliteal occlusions: Immediate and long-term results. J Endovasc Ther, 2011,18(1):13-21.
[32] Tzafriri AR, Garcia-Polite F, Zani B, et al. Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis. J Control Release, 2017,264:203-210.
[33] Cioppa A, Stabile E, Popusoi G, et al. Combined treatment of heavy calcified femoro-popliteal lesions using directional atherectomy and a paclitaxel coated balloon: One-year single centre clinical results. Cardiovasc Revasc Med, 2012,13(4):219-223.
[34] Finch JL, Lee DH, Liapis H, et al. Phosphate restriction significantly reduces mortality in uremic rats with established vascular calcification. Kidney Int, 2013,84(6):1145-1153.
[35] Lau WL, Leaf EM, Hu MC, et al. Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet. Kidney Int, 2012,82(12):1261-1270.
[36] Meiting W, Cameron R, Cecilia M. Vascular calcification: An update on mechanisms and challenges in treatment. Calcif Tissue Int, 2013,93(4):365-373.
[2] Olin JW, White CJ, Armstrong EJ, et al. Peripheralartery disease: Evolving role of exercise, medical therapy, and endovascular options. J Am Coll Cardiol, 2016,67(11):1338-1357.
[3] 中华医学会外科学分会血管外科学组.下肢动脉硬化闭塞症诊治指南.中华医学杂志,2015,95(24):145-151.
[4] May KK, Robless PA, Sidhu HR, et al. Limb salvage in patients with peripheral arterial disease managed by endovascular first approach. Vasc Endovascular Surg, 2014,48(2):129-133.
[5] Falk E. Pathogenesis of atherosclerosis. J Am Coll Cardiol, 2006,47(8 Suppl):C7-C12.
[6] Huang CL, Wu IH, Wu YW, et al. Association of lower extremity arterial calcification with amputation and mortality in patients with symptomatic peripheral artery disease. PLoS One, 2014, 9(2):e90201.
[7] Demer LL, Tintut Y. Inflammatory, metabolic, and genetic mechanisms of vascular calcification. Arterioscler Thromb Vasc Biol, 2014,34(4):715-723.
[8] Otsuka F, Sakakura K, Yahagi K, et al. Has our understanding of calcification in human coronary atherosclerosis progressed? Arterioscler Thromb Vasc Biol, 2014,34(4):724-736.
[9] Budoff MJ, Achenbach S, Blumenthal RS, et al. Assessment of coronary artery disease by cardiac computed tomography:A scientific statement from the American Heart Association Committee on Cardiovascular Imaging and Intervention, Council on Cardiovascular Radiology and Intervention, and Committee on Cardiac Imaging, Council on Clinical Cardiology. Circulation, 2006,114(16):1761-1791.
[10] Byon CH, Chen Y. Molecular mechanisms of vascular calcification in chronic kidney disease: The link between bone and the vasculature. Curr Osteoporos Rep, 2015,13(4):206-215.
[11] Lanzer P, Boehm M, Sorribas V, et al. Medial vascular calcification revisited: Review and perspectives. Eur Heart J, 2014,35(23):1515-1525.
[12] David Smith C, Gavin Bilmen J, Iqbal S, et al. Medial artery calcification as an indicator of diabetic peripheral vascular disease. Foot Ankle Int, 2008,29(2):185-190.
[13] 叶斐,严金川,徐绥宁,等.血管钙化研究的新进展.中华心血管病杂志,2017,45(2):170-173.
[14] Vengrenyuk Y, Carlier S, Xanthos S, et al. A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps. Proc Natl Acad Sci U S A, 2006,103(40):14678-14683.
[15] Takeuchi K, Zhang B, Ideishi M. Influence of age and hypertension on the association between small artery compliance and coronary disease. Am J Hypertens, 2004,17(12):1188-1191.
[16] Chen NX, Moe SM. Vascular calcification: Pathophysiology and risk factors. Curr Hypertens Rep, 2012,14(3):228-237.
[17] Ohtake T, Ishioka K, Honda K, et al. Impact of coronary artery calcification in hemodialysis patients: Risk factors and associations with prognosis. Hemodialysis Intl, 2010,14(2):218-225.
[18] Ohtake T, Oka M, Ikee R, et al. Impact of lower limbs' arterial calcification on the prevalence and severity of PAD in patients on hemodialysis. Vasc Surg, 2011,53(3):676-683.
[19] Karwowski W, Naumnik B, Szczepański M, et al. The mechanism of vascular calcification—a systematic review. Med Sci Monit, 2012,18(1):RA1-RA11.
[20] Rocha-Singh KJ, Zeller T, Jaff MR. Peripheral arterial calcification: Prevalence, mechanism, detection, and clinical implications. Catheter Cardiovasc Interv, 2014,83(6):E212-E220.
[21] Leopold JA. Vascular calcification: Mechanisms of vascular smooth muscle cell calcification. Trends Cardiovasc Med, 2015,25(4):267-274.
[22] Bessueille L, Magne D. Inflammation: A culprit for vascular calcification in atherosclerosis and diabetes. Cell Mol Life Sci, 2015,72(13):2475-2489.
[23] Hutcheson JD, Maldonado N, Aikawa E. Small entities with large impact: Microcalcifications and atherosclerotic plaque vulnerability. Curr Opin Lipidol, 2014,25(5):327-332.
[24] Chen W, Dilsizian V. Targeted PET/CT imaging of vulnerable atherosclerotic plaques: Microcalcification with sodium fluoride and inflammation with fluorodeoxyglucose. Curr Cardiol Rep, 2013,15(6):364.
[25] Dweck MR, Chow MW, Joshi NV, et al. Coronary arterial 18F-sodium fluoride uptake: A novel marker of plaque biology. Am Coll Cardiol, 2012,59(17):1539-1548.
[26] Agatston AS, Janowitz WR, Hildner FJ, et al. Quantification of coronary artery calcium using ultrafast computed tomography. Am Coll Cardiol, 1990,15(4):827-832.
[27] Mary A, Hartemann A, Liabeuf S. et al. Association between metformin use and below-the-knee arterial calcification score in type 2 diabetic patients. Cardiovasc Diabetol, 2017,16(1):24.
[28] Banerjee S, Sarode K, Patel A, et al. Comparative assessment of guidewire and microcatheter vs a crossing device-based strategy to traverse infrainguinal peripheral artery chronic total occlusions. J Endovasc Ther, 2015,22(4):525-534.
[29] Banerjee S, Jeon-Slaughter H, Tsai S, et al. Comparative assessment of procedure cost and outcomes between guidewire and crossing device strategies to cross peripheral artery chronic total occlusions. JACC Cardiovasc Interv, 2016,9(21):2243-2252.
[30] Adlakha S, Sheikh M, Wu J, et al. Stent fracture in the coronary and peripheral arteries. J Interv Cardiol, 2010,23(4):411-419.
[31] Bausback Y, Botsios S, Flux J, et al. Outback catheter for femoropopliteal occlusions: Immediate and long-term results. J Endovasc Ther, 2011,18(1):13-21.
[32] Tzafriri AR, Garcia-Polite F, Zani B, et al. Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis. J Control Release, 2017,264:203-210.
[33] Cioppa A, Stabile E, Popusoi G, et al. Combined treatment of heavy calcified femoro-popliteal lesions using directional atherectomy and a paclitaxel coated balloon: One-year single centre clinical results. Cardiovasc Revasc Med, 2012,13(4):219-223.
[34] Finch JL, Lee DH, Liapis H, et al. Phosphate restriction significantly reduces mortality in uremic rats with established vascular calcification. Kidney Int, 2013,84(6):1145-1153.
[35] Lau WL, Leaf EM, Hu MC, et al. Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet. Kidney Int, 2012,82(12):1261-1270.
[36] Meiting W, Cameron R, Cecilia M. Vascular calcification: An update on mechanisms and challenges in treatment. Calcif Tissue Int, 2013,93(4):365-373.