正交试验法优选复方清肺泡腾片成型工艺
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摘要
研究复方清肺泡腾片的最佳成型工艺,开发具有清肺止咳、清咽利喉、清热解毒功效的保健食品。在单因素试验结果基础上,以崩解时限、CO_2释放量为指标,采用L_9(3~4)正交试验法,考察泡腾片中干浸膏粉的用量、泡腾剂中酸碱源的用量及其比例,确定复方清肺泡腾片的最佳成型工艺。试验确定复方清肺泡腾片的最佳成型工艺为取组份比例为19.78%柠檬酸,与17.5%干浸膏粉、15%乳糖混合混匀,加入适量1%PEG6000无水乙醇混匀,制得酸源颗粒;取组份比例为15.22%的碳酸氢钠,与17.5%干浸膏粉、15%乳糖混匀,加入适量1%PEG6000无水乙醇溶液混匀,制得碱源颗粒;再将酸源颗粒与碱源颗粒混匀,整粒,进行压片。
To optimize molding technology of Fufangqingfei effervescent tablets,and develop as a health-care food with the efficacy of purifing the lung,relieving a cough,clearing throat and clearing hot detoxify. The molding technology of Fufangqingfei effervescent tablets was optimized by L_9(3~4)orthogonal test with effervescent acid-base ratio,the amount of dry extraction powder and effervescent as factors using disintegration time and CO_2 release amount as indexes based on the results of single factor experiment. The optimal molding technology of Fufangqingfei effervescent tablets was as follows:mixed up 19.78 % citric acid,17.5 % dry extraction powder and 15 % lactose,then added in proper 1 % PEG6000 ethyl absolute solution to get acid source granule.And used the same method to prepare alkali source granule. At last,combined acid source granule with alkali source granule to stove and pellet.
To optimize molding technology of Fufangqingfei effervescent tablets,and develop as a health-care food with the efficacy of purifing the lung,relieving a cough,clearing throat and clearing hot detoxify. The molding technology of Fufangqingfei effervescent tablets was optimized by L_9(3~4)orthogonal test with effervescent acid-base ratio,the amount of dry extraction powder and effervescent as factors using disintegration time and CO_2 release amount as indexes based on the results of single factor experiment. The optimal molding technology of Fufangqingfei effervescent tablets was as follows:mixed up 19.78 % citric acid,17.5 % dry extraction powder and 15 % lactose,then added in proper 1 % PEG6000 ethyl absolute solution to get acid source granule.And used the same method to prepare alkali source granule. At last,combined acid source granule with alkali source granule to stove and pellet.
引文
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[2]陈凌,王海坤,张晨,等.中药泡腾片的制备技术及研究进展[J].山东化工,2017,46(6):57-60,62
[3]王牛民,贾富平,李莎,等.健胃消食泡腾片的成型工艺研究[J].西北药学杂志,2014,29(5):502-505
[4]滕再进,马荔,王志强.聚乙二醇前药设计原理与应用研究进展[J].中国药业,2014,23(15):1-4
[5]马燕,张华.聚乙二醇在药剂学中的应用[J].辽宁中医药大学学报,2013,85(10):144-145
[6]李宏梁.食品添加剂安全与应用.2版[M].北京:化学工业出版社,2012:218
[7]王双双,刘睿,何新.星点设计-效应面法优化桔梗泡腾片的处方[J].中国实验方剂学杂志,2016,22(12):23-27
[8]万华根.金鸡泡腾颗粒的研究[D].上海:华东理工大学,2009:21
[9]包强,刘效栓,李喜香,等.中药固体速释制剂及其工艺设计研究进展[J].中国药房,2013,24(43):4108-4111
[10]刘飞燕,张建方.多指标回归综合评分[J].数理统计与管理,2014,33(3):408-415
[11]魏筱华,赖伊姗,黄恺,等.双黄连泡腾片干法制粒工艺研究[J].中国实验方剂学杂志,2010,16(11):1-5