植物多酚对机体肠道酶活性影响的研究进展
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摘要
植物多酚是一类广泛存在于植物体内含有多个羟基的酚类植物成分的总称,不仅对人体具有预防疾病、改善健康的作用,而且在动物养殖中对预防疾病的发生也具有重要作用。植物多酚对人体、动物肠道酶活性的影响是目前研究的一个热点,本文主要从植物多酚对机体肠道内源酶和外源酶活性的影响及其作用机制方面进行了综述,以期为植物多酚的开发利用提供科学依据。
Plant polyphenols,a class of natural compounds containing multiple hydroxide radicals,are widely present in plants. Polyphenols not only prevent disease and regulate human health,but also play an important role on animal breeding. The study on the effects of plant polyphenols on intestinal enzyme activities in man and animals is the current hotspot. In this paper,the impacts and mechanisms of several common plant polyphenols on endogenous enzyme and exogenous enzyme activities in organism were reviewed to provide scientific bases for the development and utilization of plant polyphenols.
Plant polyphenols,a class of natural compounds containing multiple hydroxide radicals,are widely present in plants. Polyphenols not only prevent disease and regulate human health,but also play an important role on animal breeding. The study on the effects of plant polyphenols on intestinal enzyme activities in man and animals is the current hotspot. In this paper,the impacts and mechanisms of several common plant polyphenols on endogenous enzyme and exogenous enzyme activities in organism were reviewed to provide scientific bases for the development and utilization of plant polyphenols.
引文
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[2]Sengottuvelan M,Nalini N.Dietary supplementation of resveratrol suppresses colonic tumour incidence in 1,2-dimethylhydrazine-treated rats by modulating biotransforming enzymes and aberrant crypt foci development[J].British Journal of Nutrition,2006,96(1):145-153.
[3]Tokunaga S,White I R,Frost C,et al.Green tea consumption and serum lipids and lipoproteins in a population of healthy workers in Japan[J].Annals of Epidemiology,2002,12(3):157-165.
[4]Ramos S.Cancer chemoprevention and chemotherapy:dietary polyphenols and signalling pathways[J].Molecular Nutrition&Food Research,2008,52(5):507-526.
[5]巩一丁,肖新云,唐标,等.长期食用黄豆对小鼠肠道酶活性的影响研究[J].湖南中医杂志,2016,32(11):173-175.
[6]胡忠泽,杨久峰,谭志静,等.姜黄素对草鱼生长和肠道酶活力的影响[J].粮食与饲料工业,2003(11):29-30.
[7]陈赛娟,谷新晰,刘涛,等.单宁酸对家兔肠道形态和内源酶活性的影响[J].饲料工业,2015,36(9):14-16.
[8]卢俊姣,翟少伟.饲料中添加葡多酚对吉富罗非鱼生长性能、肠道消化酶活性、血脂水平和肝胰脏抗氧化能力的影响[J].动物营养学报,2014,26(4):1095-1102.
[9]解玲娜,茅婷婷,刘畅,等.葡萄籽原花青素对断奶仔猪消化道酶活、内脏相对重量及血细胞参数的影响[J].北京农学院学报,2012,27(4):13-15.
[10]于美慧.不同聚合度的葡萄籽原花青素对营养素吸收及消化酶活性的影响[D].沈阳:沈阳农业大学,2016.
[11]刘婷,李宗军,廖勇,等.乳酸菌和茶多酚对肉鸡消化酶活性的影响[J].中国畜牧杂志,2014,50(3):78-82.
[12]李华丽.乳酸菌与茶多酚对肉鸡生理生化性能及免疫机能的研究[D].长沙:湖南农业大学,2015.
[13]Al-Mamary M,Al-Habori M,Al-Aghbari A,et al.In vivo effects of dietary sorghum tannins on rabbit digestive enzymes and mineral absorption[J].Nutrition Research,2001,21(10):1393-1401.
[14]Griffiths D W,Moseley G.The effect of diets containing field beans of high or low polyphenolic content on the activity of digestive enzymes in the intestines of rats[J].Journal of the Science of Food&Agriculture,1980,31(3):255-259.
[15]王昕.几种食源性多酚对消化道主要酶活性影响的研究[D].重庆:西南大学,2008.
[16]李雅梅,方烁,肖俊松,等.原花青素对营养肥胖模型大鼠肠道消化酶活性的影响[J].食品工业科技,2016,37(10):364-372.
[17]黄群,陈林杰,李彦坡,等.冠突散囊菌黑茶发酵液对消化酶活性影响的研究[J].微生物通报,2007,34(5):917-920.
[18]黄光中,胡辉,肖克宇,等.葡萄籽与青蒿提取物对黄鳝肠道消化酶活性及血液生化指标的影响[J].南方水产科学,2013,9(2):70-75.
[19]刘华伟.栗树单宁的抗氧化能力及其对肉兔生产性能的影响研究[D].北京:中国农业科学院,2010.
[20]李茜,侯海锋.水解单宁酸对肉鸡肠道形态和内源酶活性的影响[J].今日畜牧兽医,2016(4):45-48.
[21]Abeywickrama K R W,Ratnasooriya W D,Amarakoon A M T.Oral hypoglycaemic,antihyperglycaemic and antidiabetic activities of Sri Lankan Broken Orange Pekoe Fannings(BOPF)grade black tea(Camellia sinensis L.)in rats[J].Journal of Ethnopharmacology,2011,135:278-286.
[22]Links M R,Taylor J,Kruger M C,et al.Sorghum condensed tannins encapsulated in kafirin microparticles as a nutraceutical for inhibition of amylases during digestion to attenuate hyperglycaemia[J].Journal of Functional Foods,2015,12:55-63.
[23]Ademiluyi A O,Oboh G,Boligon A A,et al.Effect of fermented soybean condiment supplemented diet onα-amylase andα-glucosidase activities in Streptozotocin-induced diabetic rats[J].Journal of Functional Foods,2014,9(1):1-9.
[24]扶雄,张伟,朱思明,等.香椿叶多酚的提取分离及其体外对糖尿病关键酶活性的抑制作用[J].现代食品科技,2014(7):10-15.
[25]Ighodaro O M,Akinloye O A,Ugbaja R N,et al.FT-IR analysis of Sapium ellipticum,(Hochst)pax ethanol leaf extract and its inhibitory effects on pancreaticα-amylase and intestinalα-glucosidase activities in vitro[J].Egyptian Journal of Basic&Applied Sciences,2016,3(4):343-349.
[26]Pasukamonset P,Kwon O,Adisakwattana S.Alginate-based encapsulation of polyphenols from Clitoria ternatea,petal flower extract enhances stability and biological activity under simulated gastrointestinal conditions[J].Food Hydrocolloids,2016,61:772-779.
[27]张丽娜.水翁花对胰脂肪酶和α-淀粉酶抑制活性及作用机制初步探讨[D].上海:华东理工大学,2012.
[28]田强,吴子健,黄道荣,等.葡萄籽中胰脂肪酶抑制物提取工艺[J].食品研究与开发,2010,31(4):41-44.
[29]Uchiyama S,Taniguchi Y,Saka A,et al.Prevention of dietinduced obesity by dietary black tea polyphenols extract in vitro and in vivo[J].Nutrition,2011,27(3):287-292.
[30]Sergent T,Vanderstraeten J,Winand J,et al.Phenolic compounds and plant extracts as potential natural anti-obesity substances[J].Food Chemistry,2012,135(1):68-73.
[31]Day A J,Canada F J,Diaz J C,et al.Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase[J].FEBS Letters,2000,468(2/3):166-170.
[32]Kemperman R A,Bolca S,Roger L C,et al.Novel approaches for analysing gut microbes and dietary polyphenols:challenges and opportunities[J].Microbiology,2010,156(11):3224-3231.
[33]Gradisar H,Pristovsek P,Plaper A,et al.Green tea catechins inhibit bacterial DNA gyrase by interaction with its ATP binding site[J].Journal of Medicinal Chemistry,2007,50(2):264-271.
[34]Plaper A,Golob M,Hafner I,et al.Characterization of quercetin binding site on DNA gyrase[J].Biochemical&Biophysical Research Communications,2003,306(2):530-536.
[35]Gon9alves R,Mateus N,De F V.Inhibition ofα-amylase activity by condensed tannins[J].Food Chemistry,2011,125(2):665-672.
[36]Wu X L,Wang W P,Zhu T,et al.Phenylpropanoid glycoside inhibition of pepsin,trypsin and chymotrypsin enzyme activity in Kudingcha leaves from Ligustrum purpurascens[J].Food Research International,2013,54(2):1376-1382.
[37]肖俊松,单静敏,曹雁平,等.多酚通过肠道菌群调节能量代谢研究进展[J].食品科学,2012,33(3):300-303.
[38]Gon9alves R,Soares S,Mateus N,et al.Inhibition of trypsin by condensed tannins and wine[J].Journal of Agricultural&Food Chemistry,2007,55(18):7596-7601.
[39]Grussu D,Stewart D,Mc Dougall G J.Berry polyphenols inhibitα-amylase in vitro:identifying active components in rowanberry and raspberry[J].Journal of Agricultural&Food Chemistry,2011,59:2324-2331.
[40]He Q,Lv Y,Yao K.Effects of tea polyphenols on the activities ofα-amylase,pepsin,trypsin and lipase[J].Food Chemistry,2007,101(3):1178-1182.
[41]Rasmussen S E,Frederiksen H,Struntze K K,et al.Dietary proanthocyanidins:occurrence,dietary intake,bioavailability,and protection against cardiovascular disease[J].Molecular Nutrition&Food Research,2005,49(2):159-174.
[2]Sengottuvelan M,Nalini N.Dietary supplementation of resveratrol suppresses colonic tumour incidence in 1,2-dimethylhydrazine-treated rats by modulating biotransforming enzymes and aberrant crypt foci development[J].British Journal of Nutrition,2006,96(1):145-153.
[3]Tokunaga S,White I R,Frost C,et al.Green tea consumption and serum lipids and lipoproteins in a population of healthy workers in Japan[J].Annals of Epidemiology,2002,12(3):157-165.
[4]Ramos S.Cancer chemoprevention and chemotherapy:dietary polyphenols and signalling pathways[J].Molecular Nutrition&Food Research,2008,52(5):507-526.
[5]巩一丁,肖新云,唐标,等.长期食用黄豆对小鼠肠道酶活性的影响研究[J].湖南中医杂志,2016,32(11):173-175.
[6]胡忠泽,杨久峰,谭志静,等.姜黄素对草鱼生长和肠道酶活力的影响[J].粮食与饲料工业,2003(11):29-30.
[7]陈赛娟,谷新晰,刘涛,等.单宁酸对家兔肠道形态和内源酶活性的影响[J].饲料工业,2015,36(9):14-16.
[8]卢俊姣,翟少伟.饲料中添加葡多酚对吉富罗非鱼生长性能、肠道消化酶活性、血脂水平和肝胰脏抗氧化能力的影响[J].动物营养学报,2014,26(4):1095-1102.
[9]解玲娜,茅婷婷,刘畅,等.葡萄籽原花青素对断奶仔猪消化道酶活、内脏相对重量及血细胞参数的影响[J].北京农学院学报,2012,27(4):13-15.
[10]于美慧.不同聚合度的葡萄籽原花青素对营养素吸收及消化酶活性的影响[D].沈阳:沈阳农业大学,2016.
[11]刘婷,李宗军,廖勇,等.乳酸菌和茶多酚对肉鸡消化酶活性的影响[J].中国畜牧杂志,2014,50(3):78-82.
[12]李华丽.乳酸菌与茶多酚对肉鸡生理生化性能及免疫机能的研究[D].长沙:湖南农业大学,2015.
[13]Al-Mamary M,Al-Habori M,Al-Aghbari A,et al.In vivo effects of dietary sorghum tannins on rabbit digestive enzymes and mineral absorption[J].Nutrition Research,2001,21(10):1393-1401.
[14]Griffiths D W,Moseley G.The effect of diets containing field beans of high or low polyphenolic content on the activity of digestive enzymes in the intestines of rats[J].Journal of the Science of Food&Agriculture,1980,31(3):255-259.
[15]王昕.几种食源性多酚对消化道主要酶活性影响的研究[D].重庆:西南大学,2008.
[16]李雅梅,方烁,肖俊松,等.原花青素对营养肥胖模型大鼠肠道消化酶活性的影响[J].食品工业科技,2016,37(10):364-372.
[17]黄群,陈林杰,李彦坡,等.冠突散囊菌黑茶发酵液对消化酶活性影响的研究[J].微生物通报,2007,34(5):917-920.
[18]黄光中,胡辉,肖克宇,等.葡萄籽与青蒿提取物对黄鳝肠道消化酶活性及血液生化指标的影响[J].南方水产科学,2013,9(2):70-75.
[19]刘华伟.栗树单宁的抗氧化能力及其对肉兔生产性能的影响研究[D].北京:中国农业科学院,2010.
[20]李茜,侯海锋.水解单宁酸对肉鸡肠道形态和内源酶活性的影响[J].今日畜牧兽医,2016(4):45-48.
[21]Abeywickrama K R W,Ratnasooriya W D,Amarakoon A M T.Oral hypoglycaemic,antihyperglycaemic and antidiabetic activities of Sri Lankan Broken Orange Pekoe Fannings(BOPF)grade black tea(Camellia sinensis L.)in rats[J].Journal of Ethnopharmacology,2011,135:278-286.
[22]Links M R,Taylor J,Kruger M C,et al.Sorghum condensed tannins encapsulated in kafirin microparticles as a nutraceutical for inhibition of amylases during digestion to attenuate hyperglycaemia[J].Journal of Functional Foods,2015,12:55-63.
[23]Ademiluyi A O,Oboh G,Boligon A A,et al.Effect of fermented soybean condiment supplemented diet onα-amylase andα-glucosidase activities in Streptozotocin-induced diabetic rats[J].Journal of Functional Foods,2014,9(1):1-9.
[24]扶雄,张伟,朱思明,等.香椿叶多酚的提取分离及其体外对糖尿病关键酶活性的抑制作用[J].现代食品科技,2014(7):10-15.
[25]Ighodaro O M,Akinloye O A,Ugbaja R N,et al.FT-IR analysis of Sapium ellipticum,(Hochst)pax ethanol leaf extract and its inhibitory effects on pancreaticα-amylase and intestinalα-glucosidase activities in vitro[J].Egyptian Journal of Basic&Applied Sciences,2016,3(4):343-349.
[26]Pasukamonset P,Kwon O,Adisakwattana S.Alginate-based encapsulation of polyphenols from Clitoria ternatea,petal flower extract enhances stability and biological activity under simulated gastrointestinal conditions[J].Food Hydrocolloids,2016,61:772-779.
[27]张丽娜.水翁花对胰脂肪酶和α-淀粉酶抑制活性及作用机制初步探讨[D].上海:华东理工大学,2012.
[28]田强,吴子健,黄道荣,等.葡萄籽中胰脂肪酶抑制物提取工艺[J].食品研究与开发,2010,31(4):41-44.
[29]Uchiyama S,Taniguchi Y,Saka A,et al.Prevention of dietinduced obesity by dietary black tea polyphenols extract in vitro and in vivo[J].Nutrition,2011,27(3):287-292.
[30]Sergent T,Vanderstraeten J,Winand J,et al.Phenolic compounds and plant extracts as potential natural anti-obesity substances[J].Food Chemistry,2012,135(1):68-73.
[31]Day A J,Canada F J,Diaz J C,et al.Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase[J].FEBS Letters,2000,468(2/3):166-170.
[32]Kemperman R A,Bolca S,Roger L C,et al.Novel approaches for analysing gut microbes and dietary polyphenols:challenges and opportunities[J].Microbiology,2010,156(11):3224-3231.
[33]Gradisar H,Pristovsek P,Plaper A,et al.Green tea catechins inhibit bacterial DNA gyrase by interaction with its ATP binding site[J].Journal of Medicinal Chemistry,2007,50(2):264-271.
[34]Plaper A,Golob M,Hafner I,et al.Characterization of quercetin binding site on DNA gyrase[J].Biochemical&Biophysical Research Communications,2003,306(2):530-536.
[35]Gon9alves R,Mateus N,De F V.Inhibition ofα-amylase activity by condensed tannins[J].Food Chemistry,2011,125(2):665-672.
[36]Wu X L,Wang W P,Zhu T,et al.Phenylpropanoid glycoside inhibition of pepsin,trypsin and chymotrypsin enzyme activity in Kudingcha leaves from Ligustrum purpurascens[J].Food Research International,2013,54(2):1376-1382.
[37]肖俊松,单静敏,曹雁平,等.多酚通过肠道菌群调节能量代谢研究进展[J].食品科学,2012,33(3):300-303.
[38]Gon9alves R,Soares S,Mateus N,et al.Inhibition of trypsin by condensed tannins and wine[J].Journal of Agricultural&Food Chemistry,2007,55(18):7596-7601.
[39]Grussu D,Stewart D,Mc Dougall G J.Berry polyphenols inhibitα-amylase in vitro:identifying active components in rowanberry and raspberry[J].Journal of Agricultural&Food Chemistry,2011,59:2324-2331.
[40]He Q,Lv Y,Yao K.Effects of tea polyphenols on the activities ofα-amylase,pepsin,trypsin and lipase[J].Food Chemistry,2007,101(3):1178-1182.
[41]Rasmussen S E,Frederiksen H,Struntze K K,et al.Dietary proanthocyanidins:occurrence,dietary intake,bioavailability,and protection against cardiovascular disease[J].Molecular Nutrition&Food Research,2005,49(2):159-174.