血尿酸水平在评估急性胃肠炎儿童脱水程度中的应用
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摘要
目的探讨血尿酸水平在评估急性胃肠炎(AGE)儿童脱水程度中的应用效果。方法选取正常儿童和AGE儿童作为对照组和观察组,每组80例,记录两组儿童血尿酸、尿素氮、肌酐、Na+、 pH值和HCO_3~-等检测结果,同时记录AGE儿童住院时每天体质量以及上述指标的变化,分析血尿酸水平与其他指标的相关性。结果 AGE组儿童血尿酸和尿素氮水平显著高于对照组(P<0.05),pH值和血HCO_3~-水平显著低于对照组(P<0.05)。血尿酸水平与体质量改变和尿素氮水平呈正相关(r=0.43、0.28,P均<0.05)。重度脱水组患儿的血尿酸水平显著高于轻、中度脱水组(P<0.01或0.05)。结论血尿酸水平可作为评价AGE脱水程度的客观指标,血尿酸水平越高,提示脱水越严重。
Objective To explore the application effect of uric acid in assessing dehydration degree of children with acute gastroenteritis(AGE).Methods The healthy children and children with AGE in our hospital were selected as the Control Group and the AGE Group,80 cases in each group.The uric acid,urea nitrogen,creatinine,Na+,pH and HCO_3~-of both groups were recorded.In addition,the changes in the daily weight and above indicators in children with AGE while in hospital were recorded,and correlation between uric acid level and other indicators was analyzed.Results The uric acid and urea nitrogen in the AGE Group were significantly higher than those in the Control Group(P<0.05)while the pH and HCO_3~-in the AGE Group were significantly lower than those in the Control Group(P<0.05).Uric acid level was positively correlated with weight change and urea nitrogen level(r=0.43,0.28,P<0.05).Moreover,the uric acid level in the Severe Dehydration Group was significantly higher than that in the Mild Dehydration Group and the moderate Dehydration Group(P<0.01 or 0.05).Conclusion Uric acid level may act as an objective indicator for assessing the AGE dehydration degree.A higher uric acid level indicates more severe dehydration.
Objective To explore the application effect of uric acid in assessing dehydration degree of children with acute gastroenteritis(AGE).Methods The healthy children and children with AGE in our hospital were selected as the Control Group and the AGE Group,80 cases in each group.The uric acid,urea nitrogen,creatinine,Na+,pH and HCO_3~-of both groups were recorded.In addition,the changes in the daily weight and above indicators in children with AGE while in hospital were recorded,and correlation between uric acid level and other indicators was analyzed.Results The uric acid and urea nitrogen in the AGE Group were significantly higher than those in the Control Group(P<0.05)while the pH and HCO_3~-in the AGE Group were significantly lower than those in the Control Group(P<0.05).Uric acid level was positively correlated with weight change and urea nitrogen level(r=0.43,0.28,P<0.05).Moreover,the uric acid level in the Severe Dehydration Group was significantly higher than that in the Mild Dehydration Group and the moderate Dehydration Group(P<0.01 or 0.05).Conclusion Uric acid level may act as an objective indicator for assessing the AGE dehydration degree.A higher uric acid level indicates more severe dehydration.
引文
[1]Lo V A,Dias J A,Berkley J A,et al.Comparison of recommendations in clinical practice guidelines for acute gastroenteritis in children[J].J Pediatr Gastroenterol Nutr,2016,63(2):226-235.
[2]Gorelick M H,Shaw K N,Murphy K O.Validity and reliability of clinical signs in the diagnosis of dehydration in children[J].Pediatrics,1997,99(5):E6.
[3]Friedman J N,Goldman R D,Srivastava R,et al.Development of a clinical dehydration scale for use in children between 1 and 36 months of age[J].J Pediatr,2004,145(2):201-207.
[4]Adler R,Robinson R,Pazdral P,et al.Hyperuricemia in diarrheal dehydration[J].Am J Dis Child,1982,136(3):211-213.
[5]Glade M J.Fluid and electrolytes in pediatrics:a comprehensive handbook[J].Nutrition,2010,26(10):1030.
[6]Farthing M,Salam M A,Lindberg G,et al.Acute diarrhea in adults and children:a global perspective[J].J Clin Gastroenterol,2013,47(1):12-20.
[7]Tomasik E,Ziolkowska E,Kolodziej M,et al.Systematic review with meta-analysis:ondansetron for vomiting in children with acute gastroenteritis[J].Aliment Pharmacol Ther,2016,44(5):438-446.
[8]Florez I D,Al-Khalifah R,Sierra J M,et al.The effectiveness and safety of treatments used for acute diarrhea and acute gastroenteritis in children:protocol for a systematic review and network meta-analysis[J].Syst Rev,2016,5:14.
[9]Toaimah F H,Mohammad H M.Rapid intravenous rehydration therapy in children with acute gastroenteritis:a systematic review[J].Pediatr Emerg Care,2016,32(2):131-135.
[10]陈敏,冯文聪.荧光免疫法、ELISA法与PCR在婴幼儿腹泻常见病毒检测中的价值[J].广东医学院学报,2016,34(6):606-608.
[11]Yilmaz K,Karabocuoglu M,Citak A,et al.Evaluation of laboratory tests in dehydrated children with acute gastroenteritis[J].J Paediatr Child Health,2002,38(3):226-228.
[12]Falszewska A,Dziechciarz P,Szajewska H.Diagnostic accuracy of clinical dehydration scales in children[J].Eur JPediatr,2017,176(8):1021-1026.
[13]Bonadio W A,Hennes H H,Machi J,et al.Efficacy of measuring BUN in assessing children with dehydration due to gastroenteritis[J].Ann Emerg Med,1989,18(7):755-757.
[2]Gorelick M H,Shaw K N,Murphy K O.Validity and reliability of clinical signs in the diagnosis of dehydration in children[J].Pediatrics,1997,99(5):E6.
[3]Friedman J N,Goldman R D,Srivastava R,et al.Development of a clinical dehydration scale for use in children between 1 and 36 months of age[J].J Pediatr,2004,145(2):201-207.
[4]Adler R,Robinson R,Pazdral P,et al.Hyperuricemia in diarrheal dehydration[J].Am J Dis Child,1982,136(3):211-213.
[5]Glade M J.Fluid and electrolytes in pediatrics:a comprehensive handbook[J].Nutrition,2010,26(10):1030.
[6]Farthing M,Salam M A,Lindberg G,et al.Acute diarrhea in adults and children:a global perspective[J].J Clin Gastroenterol,2013,47(1):12-20.
[7]Tomasik E,Ziolkowska E,Kolodziej M,et al.Systematic review with meta-analysis:ondansetron for vomiting in children with acute gastroenteritis[J].Aliment Pharmacol Ther,2016,44(5):438-446.
[8]Florez I D,Al-Khalifah R,Sierra J M,et al.The effectiveness and safety of treatments used for acute diarrhea and acute gastroenteritis in children:protocol for a systematic review and network meta-analysis[J].Syst Rev,2016,5:14.
[9]Toaimah F H,Mohammad H M.Rapid intravenous rehydration therapy in children with acute gastroenteritis:a systematic review[J].Pediatr Emerg Care,2016,32(2):131-135.
[10]陈敏,冯文聪.荧光免疫法、ELISA法与PCR在婴幼儿腹泻常见病毒检测中的价值[J].广东医学院学报,2016,34(6):606-608.
[11]Yilmaz K,Karabocuoglu M,Citak A,et al.Evaluation of laboratory tests in dehydrated children with acute gastroenteritis[J].J Paediatr Child Health,2002,38(3):226-228.
[12]Falszewska A,Dziechciarz P,Szajewska H.Diagnostic accuracy of clinical dehydration scales in children[J].Eur JPediatr,2017,176(8):1021-1026.
[13]Bonadio W A,Hennes H H,Machi J,et al.Efficacy of measuring BUN in assessing children with dehydration due to gastroenteritis[J].Ann Emerg Med,1989,18(7):755-757.