婴儿喂养方式与儿童哮喘相关性的前瞻性研究
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摘要
目的通过婴儿喂养方式与儿童哮喘相关性的前瞻性研究,探讨母乳喂养是否能够减少儿童哮喘的发生率。方法收集我市城镇及农村年龄为6个月内的婴儿3 005例(列入统计者1 442例),将列入统计者根据喂养方式的不同分为纯母乳组和纯人工组,对两组进行随访,比较两组儿童支气管哮喘发生率。结果纯母乳组有92例诊断为支气管哮喘,哮喘发生率为11.5%;纯人工组有148例诊断为支气管哮喘,哮喘发生率为23.1%。纯母乳组的哮喘发生率明显低于纯人工组,两组哮喘发生率比较差异有统计学意义(P<0.05)。结论婴儿母乳喂养6个月能够减少儿童哮喘的发生率。
Objective To investigate whether breastfeeding can reduce the incidence of child asthma through analyzing the correlation between the infant feeding method and the child asthma.Methods 3 005 infants(1 442 infants were included in statistics) aged less than 6 months old in the urban and rural areas of Jieyang City were collected,of which the included infants were divided into the pure breastfeeding group and the pure artificial group according to the feeding method.The two groups were followed up and the incidence of child bronchial asthma was compared between the two groups.Results In the pure breastfeeding group,92 infants were diagnosed with bronchial asthma,with the asthma incidence rate of 11.5%. In the pure artificial group,148 infants were diagnosed with bronchial asthma,with the asthma incidence rate of 23.1%. The asthma incidence rate of the pure breastfeeding group was significantly lower than that of the pure artificial group,with statistically significant difference between the two groups(P<0.05).Conclusion Six months of breastfeeding can reduce the incidence of child asthma.
Objective To investigate whether breastfeeding can reduce the incidence of child asthma through analyzing the correlation between the infant feeding method and the child asthma.Methods 3 005 infants(1 442 infants were included in statistics) aged less than 6 months old in the urban and rural areas of Jieyang City were collected,of which the included infants were divided into the pure breastfeeding group and the pure artificial group according to the feeding method.The two groups were followed up and the incidence of child bronchial asthma was compared between the two groups.Results In the pure breastfeeding group,92 infants were diagnosed with bronchial asthma,with the asthma incidence rate of 11.5%. In the pure artificial group,148 infants were diagnosed with bronchial asthma,with the asthma incidence rate of 23.1%. The asthma incidence rate of the pure breastfeeding group was significantly lower than that of the pure artificial group,with statistically significant difference between the two groups(P<0.05).Conclusion Six months of breastfeeding can reduce the incidence of child asthma.
引文
[1]中华医学会儿科学分会呼吸学组.儿童支气管哮喘诊断与防治指南[J].中华儿科杂志,2008,46(10):745-753.
[2]Burgess SW,Dakin CJ,O'Callaghan MJ,et al.Breastfeeding does not increase the risk of asthma at 14 years[J].Pediatrics,2006,117(4):787-792.
[3]Sears MR,Greene JM,Willan AR,et al.Long-term relation betweenbreastfeeding and development of atopy and asthma in children andasthma in children and young adults:a longitudinal study[J].Lancet,2002,360(9337):901-907.
[4]Wright AL,Holberg CJ,Taussig LM,et al.Factors influencingthe rela-tion of infant feeding to asthma and recurrent wheeze in childhood[J].Thorax,2001,56(3):192-197.
[5]钱继红,陈同辛,敖黎明,等.过敏高风险婴儿罹患过敏性疾病的多因素分析及干预[J].上海医学,2008,3(1):77-81.
[6]王红玉,陈育智,马煜,等.中国儿童哮喘患病率的地区差异与生活方式的不同有关[J].中华儿科杂志,2006,10(1):34-38.
[7]王从军,徐佳伟,吴小艳.婴儿喂养方式对婴幼儿患支气管哮喘的影响[J].中国妇幼保健,2008,23:2528-2529.
[8]Oddy WH,Deklerk NH,Sly PD,et al.The effects of respiratory in-fec-tions,atopy,and breastfeeding on childhood asthma[J].Eur Respir J,2002,19(5):899-905.
[9]吴剑.儿童支气管哮喘相关危险因素分析[J].右江民族医学院学报,2010,32(6):904-905.
[10]Gonzalez J,Fernandez M,Garcia Fragoso L.Exclusive breastfeeding re-duces asthma in a group of children from the Caguas municipality ofPuerto Rico[J].Bol Asoc Med P R,2010,102(1):10-12.
[11]李斐,黎海芪.卵清蛋白致敏小鼠肠道黏膜sIgA抗体反应的实验研究[J].中华儿科杂志,2006,44(4):294.
[2]Burgess SW,Dakin CJ,O'Callaghan MJ,et al.Breastfeeding does not increase the risk of asthma at 14 years[J].Pediatrics,2006,117(4):787-792.
[3]Sears MR,Greene JM,Willan AR,et al.Long-term relation betweenbreastfeeding and development of atopy and asthma in children andasthma in children and young adults:a longitudinal study[J].Lancet,2002,360(9337):901-907.
[4]Wright AL,Holberg CJ,Taussig LM,et al.Factors influencingthe rela-tion of infant feeding to asthma and recurrent wheeze in childhood[J].Thorax,2001,56(3):192-197.
[5]钱继红,陈同辛,敖黎明,等.过敏高风险婴儿罹患过敏性疾病的多因素分析及干预[J].上海医学,2008,3(1):77-81.
[6]王红玉,陈育智,马煜,等.中国儿童哮喘患病率的地区差异与生活方式的不同有关[J].中华儿科杂志,2006,10(1):34-38.
[7]王从军,徐佳伟,吴小艳.婴儿喂养方式对婴幼儿患支气管哮喘的影响[J].中国妇幼保健,2008,23:2528-2529.
[8]Oddy WH,Deklerk NH,Sly PD,et al.The effects of respiratory in-fec-tions,atopy,and breastfeeding on childhood asthma[J].Eur Respir J,2002,19(5):899-905.
[9]吴剑.儿童支气管哮喘相关危险因素分析[J].右江民族医学院学报,2010,32(6):904-905.
[10]Gonzalez J,Fernandez M,Garcia Fragoso L.Exclusive breastfeeding re-duces asthma in a group of children from the Caguas municipality ofPuerto Rico[J].Bol Asoc Med P R,2010,102(1):10-12.
[11]李斐,黎海芪.卵清蛋白致敏小鼠肠道黏膜sIgA抗体反应的实验研究[J].中华儿科杂志,2006,44(4):294.