微波辅助合成5-芳亚甲基-2,3-二苯基噻唑-4-酮类衍生物
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摘要
本文报道了一种通过微波辅助合成5-芳亚甲基-2,3--二苯基噻唑-4-酮类衍生物的新方法。以H2O为溶剂、K2CO3为去氢试剂、四丁基溴化铵为相转移催化剂,2,3-二苯基噻唑-4-酮与取代醛在微波辅助下发生Knoevenagel反应,生成5-芳亚甲基-2,3-二苯基噻唑-4-酮类衍生物,产率最高可达85%。
A new and efficient Knoevenagel reaction via microwave irradiation to form 5-arylidene-2,3-diphenylthiazolidin-4-ones is described. Using K2 CO3 as dehydrogenase reagents,H2 O as solvent,TBAB as the catalyst,a series of 5-arylidene-2,3-diphenyl-thiazolidin-4-ones were successfully obtained in excellent yields from 2,3-diphenylthiazolidin-4-ones.
A new and efficient Knoevenagel reaction via microwave irradiation to form 5-arylidene-2,3-diphenylthiazolidin-4-ones is described. Using K2 CO3 as dehydrogenase reagents,H2 O as solvent,TBAB as the catalyst,a series of 5-arylidene-2,3-diphenyl-thiazolidin-4-ones were successfully obtained in excellent yields from 2,3-diphenylthiazolidin-4-ones.
引文
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[2]R Ottana,R Maccari,M L Barreca et al.Bioorg.Med.Chem.,2005,13:4243~4252.
[3]A K Nag.Orient.J.Chem.,2012,28(1):541~545.
[4]A P Krishchishin,D V Kaminskii,N I Zelisko et al.Zhurnal Organichnoi ta Farmatsevtichnoi Khimii,2013,11(2):57~62.
[5]R Lakhan,R L Singh.J.Agr.Food Chem.,1991,39(3):580~583
[6]O Nuket,A Feray,T Zuhal.J.Heterocycl.Chem.,2003,40(4):721~724.
[7]周重镇,何彦祯,曹敏等.有机化学,2006,26(11):1500~1507.
[8]孙小军,周建峰,朱惠琴.有机化学,2011,31(2):242~245.
[9]Z P Che,N Huang,X Yu et al.Comb.Chem.High T.Scr.,2013,16(5):400~407.