中药治疗剖宫产术后下肢深静脉血栓临床研究
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摘要
目的:观察中药治疗剖宫产术后下肢深静脉血栓(deep vein thrombosis,DVT)的临床疗效。方法:选取2016年11月至2018年12月在本院就诊的剖宫产术后DVT患者98例,按照随机数字表法分为对照组和试验组各49例。两组均采取抗感染、翻身、卧床休息、抬高患肢等基础治疗,对照组给予常规西药治疗,试验组在对照组治疗的基础上给予中药治疗,两组均连续治疗10 d。观察两组患者临床疗效、不良反应、治疗前后疼痛程度、肿胀程度,测定血浆凝血酶原时间(prothrombin time,PT)、纤维蛋白原(fibrinogen,FIB)、血浆黏度(plasma viscosity,PV)等指标。结果:对照组有效率为77. 55%,试验组有效率为95. 92%,两组有效率比较,差异有统计学意义(P <0. 05);治疗后两组DVT患者肿胀及疼痛程度评分均较治疗前降低,差异有统计学意义(P <0. 05),组间比较差异有统计学意义(P <0. 05);治疗后两组FIB、PV降低,PT升高,与治疗前比较差异均有统计学意义(P <0. 05),组间比较差异有统计学意义(P <0. 05);对照组不良反应发生率为14. 28%,试验组不良反应发生率为10. 20%,两组不良反应发生率比较,差异无统计学意义(P> 0. 05)。结论:中药治疗剖宫产术后DVT,有利于缓解患者肿胀、疼痛程度,改善血液流变学指标,安全性较高。
Objective: To observe the clinical curative effect of Chinese herbal medicine treatment on thrombosis after pregnancy operation. Methods: Ninety-eight patients with thrombosis after pregnancy treated in our hospital from November 2016 to December2018 were selected and divided into the control group and the experimental group according to random number table method,with49 cases in each group. The two groups were treated with basic treatment such as anti-infection,turning over,bed rest and raising affected limbs. The control group was additionally treated with conventional Western medicine,while the experimental group was additionally treated with Chinese herbal medicine on the basis of the control group. The two groups were treated continuously for10 days. Then the clinical efficacies,adverse reactions,pain and swelling degrees before and after treatment were observed. The prothrombin time( PT),fibrinogen( FIB) and plasma viscosity( PV) were measured. Results: The effective rate was 77. 55% in the control group and 95. 92% in the experimental group. There was a significant difference between the two groups( P < 0. 05).After the treatment,the swelling and pain scores of DVT patients in the two groups were lower than those before the treatment,the difference was statistically significant( P < 0. 05),and the difference between the two groups was also statistically significant( P < 0. 05). After the treatment,FIB and PV decreased and PT increased in the two groups,and all the differences were statistically significant( P < 0. 05),and there was also significant difference between the two groups( P < 0. 05). The incidence of adverse reactions was 14. 28% in the control group and 10. 20% in the experimental group. There was no significant difference in the incidence of adverse reactions between the two groups( P > 0. 05). Conclusion: Chinese herbal medicine treatment has a remarkable efficacy on thrombosis after pregnancy operation,is conducive to relieving swelling and pain,improving hemorheological indicators,and has high safety.
Objective: To observe the clinical curative effect of Chinese herbal medicine treatment on thrombosis after pregnancy operation. Methods: Ninety-eight patients with thrombosis after pregnancy treated in our hospital from November 2016 to December2018 were selected and divided into the control group and the experimental group according to random number table method,with49 cases in each group. The two groups were treated with basic treatment such as anti-infection,turning over,bed rest and raising affected limbs. The control group was additionally treated with conventional Western medicine,while the experimental group was additionally treated with Chinese herbal medicine on the basis of the control group. The two groups were treated continuously for10 days. Then the clinical efficacies,adverse reactions,pain and swelling degrees before and after treatment were observed. The prothrombin time( PT),fibrinogen( FIB) and plasma viscosity( PV) were measured. Results: The effective rate was 77. 55% in the control group and 95. 92% in the experimental group. There was a significant difference between the two groups( P < 0. 05).After the treatment,the swelling and pain scores of DVT patients in the two groups were lower than those before the treatment,the difference was statistically significant( P < 0. 05),and the difference between the two groups was also statistically significant( P < 0. 05). After the treatment,FIB and PV decreased and PT increased in the two groups,and all the differences were statistically significant( P < 0. 05),and there was also significant difference between the two groups( P < 0. 05). The incidence of adverse reactions was 14. 28% in the control group and 10. 20% in the experimental group. There was no significant difference in the incidence of adverse reactions between the two groups( P > 0. 05). Conclusion: Chinese herbal medicine treatment has a remarkable efficacy on thrombosis after pregnancy operation,is conducive to relieving swelling and pain,improving hemorheological indicators,and has high safety.
引文
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[8]谢辉,向琳,李伟,等.盐酸替罗非班对ST段抬高型急性心肌梗死近期预后及心肌标志物的影响[J].医学综述,2017,23(1):174-178.
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[10]侯永兰.中药联合西医治疗妇科肿瘤术后并发下肢深静脉血栓形成的效果[J].血栓与止血学,2018,24(1):73-74.
[11] CRONJE HT,NIENABER-ROUSSEAU C,ZANDBERG L,et al.Fibrinogen and clot-related phenotypes determined by fibrinogen polymorphisms:Independent and IL-6-interactive associations[J]. PLo S ONE,2017,12(11):687-712.
[12]林勇,柴生颋.益气活血通络汤辅助治疗对人工髋关节置换术后下肢深静脉血栓形成的影响[J].现代中西医结合杂志,2018,27(10):1094-1096.
[2]曾丽玲,邹文霞,周立平,等.专项护理对剖宫产术后临床评分和下肢静脉血栓形成的影响[J].护理研究,2017,31(18):2265-2266.
[3]董涛.疏血通注射液联合中药外敷治疗骨科术后下肢深静脉血栓疗效观察[J].辽宁中医药大学学报,2017,19(3):154-156.
[4]刘雨睿,唐霓,范馨,等.腹腔镜胆囊切除术3个切口疼痛程度及切口镇痛与恶心呕吐发生率的研究[J].中国内镜杂志,2017,23(11):35-40.
[5]尚清,邢小芬,李军霞,等.低分子肝素钙与间歇性气囊加压预防剖宫产术后下肢深静脉血栓的效果对比研究[J].临床和实验医学杂志,2018,17(17):1886-1889.
[6]秦思,蔺红静,张学丽,等.抗凝联合穴位按摩对剖宫产术后下肢深静脉血栓的治疗效果[J].中国计划生育学杂志,2017,25(9):601-604.
[7]蔡文隽,薛冰,丁东新,等.急性脑梗死患者采用奥扎格雷钠联合低分子肝素钙治疗对血栓前状态及预后的影响[J].临床和实验医学杂志,2017,16(20):2036-2040.
[8]谢辉,向琳,李伟,等.盐酸替罗非班对ST段抬高型急性心肌梗死近期预后及心肌标志物的影响[J].医学综述,2017,23(1):174-178.
[9]潘建科,陈海云,刘军,等.中药防治髋部骨折深静脉血栓形成的用药规律研究[J].中医药导报,2017,23(8):58-61.
[10]侯永兰.中药联合西医治疗妇科肿瘤术后并发下肢深静脉血栓形成的效果[J].血栓与止血学,2018,24(1):73-74.
[11] CRONJE HT,NIENABER-ROUSSEAU C,ZANDBERG L,et al.Fibrinogen and clot-related phenotypes determined by fibrinogen polymorphisms:Independent and IL-6-interactive associations[J]. PLo S ONE,2017,12(11):687-712.
[12]林勇,柴生颋.益气活血通络汤辅助治疗对人工髋关节置换术后下肢深静脉血栓形成的影响[J].现代中西医结合杂志,2018,27(10):1094-1096.