扭曲的时钟——生物节律与神经退行性疾病
摘要
您注意到了吗?随着年龄增长,许多老年人的生物节律会发生紊乱,白天瞌睡晚上醒,或者本来白天好好的,却在日落时分犯起糊涂来。此外,老年人也易患阿尔兹海默病、帕金森病等神经退行性疾病,这些问题出现的背后有什么内在的联系?
Many patients of neurodegenerative diseases were also suffered from circadian-related problems, but the underlying molecular mechanisms are largely unknown. Recently, researchers found that the neurodegenerative diseases-associated gene could directly regulate the expression of core circadian genes, and thus influences the circadian-related behaviors.
Many patients of neurodegenerative diseases were also suffered from circadian-related problems, but the underlying molecular mechanisms are largely unknown. Recently, researchers found that the neurodegenerative diseases-associated gene could directly regulate the expression of core circadian genes, and thus influences the circadian-related behaviors.
引文
[1] Jiang X, Zhang T, Wang H, et al. Neurodegeneration-associated FUS is a novel regulator of circadian gene expression. Translational Neurodegeneration, 2018, 7:24-34.
[2] Dormann D, Haass C. TDP-43 and FUS:a nuclear affair. Trends Neurosci, 2011, 34(7):339-48.
[3] Zhang T, Jiang X, Xu M, et al. Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats. Neurobiology of Aging, 2018, 72:159-70.
[2] Dormann D, Haass C. TDP-43 and FUS:a nuclear affair. Trends Neurosci, 2011, 34(7):339-48.
[3] Zhang T, Jiang X, Xu M, et al. Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats. Neurobiology of Aging, 2018, 72:159-70.