获得性局限性皮肤松弛症一例
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摘要
患者,女,24岁。面颈部皮肤逐渐松弛2年。皮肤科查体:面颈部、双上眼睑皮肤松弛下垂,呈早老外观。疲劳试验(-)。皮损组织病理学检查示真皮层弹性纤维减少,形态异常,呈扭曲状。诊断:获得性局限性皮肤松弛症。
A 24-year-old woman presented with redundant skin on her face and neck for 2 years. Physical examination revealed that the loose of skin is noticeable on her face, neck and upper eyelids, resulting in a prematurely aged appearance. Fatigue test was negative. The histopathology showed the reduction in elastic fibers and the abnormally distorted shapes of elastic fibers. The diagnosis of acquired localized cutis laxa was made.
A 24-year-old woman presented with redundant skin on her face and neck for 2 years. Physical examination revealed that the loose of skin is noticeable on her face, neck and upper eyelids, resulting in a prematurely aged appearance. Fatigue test was negative. The histopathology showed the reduction in elastic fibers and the abnormally distorted shapes of elastic fibers. The diagnosis of acquired localized cutis laxa was made.
引文
[1] Kumar P, Savant SS, Das A. Generalized acquired cutis laxa type 1: a case report and brief review of literature[J]. Dermatol Online J, 2016,22(3).pii:13030/qt8rb7f7wl.
[2] Bums T, Breathnaeh S, Cox N, et al. Rook’s Textbook of Dermatology, Eighth Edition[M].2010:14-45,16.
[3] 俞晓林,王睿,郭华,等.获得性全身性弹性组织离解症(国内首例)[J]. 中国皮肤性病学杂志, 2005,19(8):471-473.
[4] 陈新鹏,陈雅硕,叶志中.获得性皮肤松弛症一例[J]. 中华风湿病学杂志,2017,12:844-845.
[5] Dagenais SL, Adam AN, Innis JW, et al. A novel frameshift mutation in exon 23 of ATP7A (MNK) results in occipital horn syndrome and not in Menkes disease[J]. Am J Hum Genet,2001,69(2):420-427.
[6] Rodriguez-Revenga L, Iranzo P, Badenas C, et al. A novel elastin gene mutation resulting in an autosomal dominant form of cutis laxa[J]. Arch Dermatol, 2004,140(9):1135-1139.
[7] Fisher BK, Page E, Hanna W. Acral localized acquired cutis laxa[J]. J Am Acad Dermatol,1989,21(1):33-40.
[8] Lewis PG, Hood AF, Barnett NK, et al. Postinflammatory elastolysis and cutis laxa. A case report[J]. J Am Acad Dermatol,1990,22(1):40-48.
[9] Martin L, Requena L, Yus ES, et al. Acrolocalized acquired cutis laxa[J]. Br J Dermatol,1996,134(5):973-976.
[10] Berk DR, Bentley DD, Bayliss SJ, et al. Cutis laxa: a review[J]. J Am Acad Dermatol,2012,66(5):841-842.
[11] Gkogkolou P, Hildebrandt K, Broekaert S, et al. Cutis laxa acquisita: novel insights into impaired elastic fibre regeneration[J]. Br J Dermatol,2017,176(3):832-835.
[12] 赵辨.中国临床皮肤病学[M].2版.南京:江苏科学技术出版社,2017:1218-1221.
[13] Riveros CJ, Gavilan MF, Franca LF, et al. Acquired localized cutis laxa confined to the face: case report and review of the literature[J]. Int J Dermatol,2004,43(12):931-935.
[14] Paladini D, Di Spiezio SA, Mandato VD, et al. Association of cutis laxa and genital prolapse: a case report[J]. Int Urogynecol J Pelvic Floor Dysfunct,2007,18(11):1367-1370.
[15] Peters T, Barnabe C, Hanna W, et al. Acral localized acquired cutis laxa: report of a case associated with inflammatory arthritis[J]. J Am Acad Dermatol,2015,72(1):e38-e40.
[16] Hoang MV, Dang PV, Bui DV, et al. Acquired cutis laxa associated with cutaneous mastocytosis[J]. Dermatol Online J,2015,21(7):1-5.
[17] Sharma PK, Meena N, Bhardwaj M, et al. Developmental retardation in postinflammatory elastolysis and cutis laxa[J]. Indian J Dermatol Venereol Leprol,2016,82(2):195-197.
[18] 朱学骏,涂平,陈喜雪,等.皮肤病的组织病理诊断[M].3版.北京大学医学出版社,2016:304-305.
[19] 李无言,周璐,王太玲,等.除皱术对先天性皮肤松弛症的效果观察[J].中国美容整形外科杂志,2017,28(1):26-30.
[2] Bums T, Breathnaeh S, Cox N, et al. Rook’s Textbook of Dermatology, Eighth Edition[M].2010:14-45,16.
[3] 俞晓林,王睿,郭华,等.获得性全身性弹性组织离解症(国内首例)[J]. 中国皮肤性病学杂志, 2005,19(8):471-473.
[4] 陈新鹏,陈雅硕,叶志中.获得性皮肤松弛症一例[J]. 中华风湿病学杂志,2017,12:844-845.
[5] Dagenais SL, Adam AN, Innis JW, et al. A novel frameshift mutation in exon 23 of ATP7A (MNK) results in occipital horn syndrome and not in Menkes disease[J]. Am J Hum Genet,2001,69(2):420-427.
[6] Rodriguez-Revenga L, Iranzo P, Badenas C, et al. A novel elastin gene mutation resulting in an autosomal dominant form of cutis laxa[J]. Arch Dermatol, 2004,140(9):1135-1139.
[7] Fisher BK, Page E, Hanna W. Acral localized acquired cutis laxa[J]. J Am Acad Dermatol,1989,21(1):33-40.
[8] Lewis PG, Hood AF, Barnett NK, et al. Postinflammatory elastolysis and cutis laxa. A case report[J]. J Am Acad Dermatol,1990,22(1):40-48.
[9] Martin L, Requena L, Yus ES, et al. Acrolocalized acquired cutis laxa[J]. Br J Dermatol,1996,134(5):973-976.
[10] Berk DR, Bentley DD, Bayliss SJ, et al. Cutis laxa: a review[J]. J Am Acad Dermatol,2012,66(5):841-842.
[11] Gkogkolou P, Hildebrandt K, Broekaert S, et al. Cutis laxa acquisita: novel insights into impaired elastic fibre regeneration[J]. Br J Dermatol,2017,176(3):832-835.
[12] 赵辨.中国临床皮肤病学[M].2版.南京:江苏科学技术出版社,2017:1218-1221.
[13] Riveros CJ, Gavilan MF, Franca LF, et al. Acquired localized cutis laxa confined to the face: case report and review of the literature[J]. Int J Dermatol,2004,43(12):931-935.
[14] Paladini D, Di Spiezio SA, Mandato VD, et al. Association of cutis laxa and genital prolapse: a case report[J]. Int Urogynecol J Pelvic Floor Dysfunct,2007,18(11):1367-1370.
[15] Peters T, Barnabe C, Hanna W, et al. Acral localized acquired cutis laxa: report of a case associated with inflammatory arthritis[J]. J Am Acad Dermatol,2015,72(1):e38-e40.
[16] Hoang MV, Dang PV, Bui DV, et al. Acquired cutis laxa associated with cutaneous mastocytosis[J]. Dermatol Online J,2015,21(7):1-5.
[17] Sharma PK, Meena N, Bhardwaj M, et al. Developmental retardation in postinflammatory elastolysis and cutis laxa[J]. Indian J Dermatol Venereol Leprol,2016,82(2):195-197.
[18] 朱学骏,涂平,陈喜雪,等.皮肤病的组织病理诊断[M].3版.北京大学医学出版社,2016:304-305.
[19] 李无言,周璐,王太玲,等.除皱术对先天性皮肤松弛症的效果观察[J].中国美容整形外科杂志,2017,28(1):26-30.