中年高血压病人胰岛素抵抗与认知功能障碍的相关性研究
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摘要
目的:探讨中年高血压病人胰岛素抵抗与认知功能障碍之间的相关性。方法:选取中年高血压病人96例作为研究对象,根据简明精神状态检查量表评分结果将病人分为认知功能障碍组40例和认知功能正常组56例,收集病人的一般资料,比较2组病人血压和相关生化指标,分析中年高血压病人认知功能障碍的影响因素。结果:2组病人的文化程度、胰岛素抵抗指数、舒张压差异均有统计学意义(P<0.05)。多因素logistic回归分析结果表明,文化程度、胰岛素抵抗指数是中年高血压病人认知功能障碍的独立影响因素(P<0.01和P<0.05)。结论:胰岛素抵抗是中年高血压病人认知功能障碍的独立危险因素,临床中需对此加以重视。
Objective:To explore the relationship between insulin resistance and cognition impairment in middle-aged hypertensive patients.Methods:Ninety-six middle-aged hypertensive patients were divided into the cognition impairment group(40 cases) and normal cognitive function group(56 cases) according to the score of mini-mental state examination scale.The general data of two groups were collected,the blood pressure and biochemical indicators between two groups were compared,and the influencing factors of cognition impairment were analyzed in middle-aged hypertensive patients.Results:The differences of the cultural level,insulin resistance index and diastolic blood pressure between two groups were statistically significant(P<0.05).The results of multiple factors regression analysis showed that the cultural level and insulin resistance index were the independent influencing factors of cognition impairment in middle-aged hypertensive patients(P<0.01 and P<0.05).Conclusions:The insulin resistance is the independent risk factor of cognition impairment in middle-aged hypertensive patients,which should be paid attention to.
Objective:To explore the relationship between insulin resistance and cognition impairment in middle-aged hypertensive patients.Methods:Ninety-six middle-aged hypertensive patients were divided into the cognition impairment group(40 cases) and normal cognitive function group(56 cases) according to the score of mini-mental state examination scale.The general data of two groups were collected,the blood pressure and biochemical indicators between two groups were compared,and the influencing factors of cognition impairment were analyzed in middle-aged hypertensive patients.Results:The differences of the cultural level,insulin resistance index and diastolic blood pressure between two groups were statistically significant(P<0.05).The results of multiple factors regression analysis showed that the cultural level and insulin resistance index were the independent influencing factors of cognition impairment in middle-aged hypertensive patients(P<0.01 and P<0.05).Conclusions:The insulin resistance is the independent risk factor of cognition impairment in middle-aged hypertensive patients,which should be paid attention to.
引文
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[18] 曾晓龙,钟朝晖,唐晓君,等.血浆同型半胱氨酸与轻度认知功能障碍关联性的Meta分析[J].重庆医科大学学报,2014,38(2):207.
[19] 刘云涛,简磊,李建伟,等.糖代谢及胰岛素抵抗改善对2型糖尿病病人血清nesfatin-1水平的影响[J].重庆医学,2014,43(13):1624.
[20] 韩进,虞立,范红晶,等.丹红注射液活性成分与阿尔茨海默病脑内胰岛素抵抗的相关性[J].中华中医药学刊,2016,34(11):2590.
[2] 李青,刘文莉,帖丽丽,等.老年高血压病人血清抵抗素及脂联素水平的相关性研究[J].实用老年医学,2016,36(11):907.
[3] 赖纪英,曾召平,胡阳,等.慢性心力衰竭病人胰岛素抵抗与认知功能障碍相关性的研究进展[J].中国心血管杂志,2015,20(2):156.
[4] CHO AH,KILLEYA-JONES LA,O′DANIEL JM,et al.Effect of genetic testing for risk of type 2 diabetes mellitus on health behaviors and outcomes:study rationale,development and design[J].BMC Health Serv Res,2012,15(12):16.
[5] 王萌,纪汶君,陈莉娜.糖尿病性认知功能障碍研究进展[J].基础医学与临床,2015,35(2):240.
[6] 彭清,王小洁,卢建刚,等.高血压病人认知功能损害与血清瘦素水平及胰岛素抵抗的关系[J].临床心血管病杂志,2012,33(8):576.
[7] 韩亭亭,胡耀敏,刘伟.胰岛素抵抗和认知功能障碍[J].国际内分泌代谢杂志,2011,31(1):31.
[8] SATO M,ISHIBASHI S,HIGASHIMOTO M,et al.Early changes induced by environmental stresses in insulin sensitivity-related genes[J].Eur J Pharmacol,2011,668(3):472.
[9] ADAMS SH.Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state[J].Adv Nutr,2011,2(6):445.
[10] 马丽娜,李耘.胰岛素抵抗与认知功能障碍关系的研究进展[J].疑难病杂志,2014,44(10):1085.
[11] 魏以新,危月球,洪元红,等.高血压病人抑郁和认知功能损害相关研究[J].心脑血管病防治,2008,8(3):187.
[12] 毕云伟,严治涛,李南方,等.高血压合并阻塞性睡眠呼吸暂停低通气综合征与胰岛素相关性研究[J].中华内科杂志,2011,50(9):734.
[13] 吕爱红,朱帅科,张晓曼.胰岛素抵抗对大鼠脑海马区Aβ蛋白表达的影响及认知行为学的改变[J].中国实用神经疾病杂志,2011,14(21):40.
[14] 赵言玮,曲毅,赵洁慧,等.老年高血压病病人认知功能障碍程度与磁共振弥散加权成像表观弥散系数的关系[J].中国临床神经科学,2011,19(3):285.
[15] 陈谊,HANON OLIVIER.老年人高血压与认知功能障碍的关系[J].中国行为医学科学,2005,14(2):173.
[16] 马艳玲,范兰媛.城市和农村高血压病人对高血压危害的认知情况[J].中国老年学杂志,2011,31(20):4022.
[17] HELAL O,DEFOORT C,ROBERT S,et al.Increased levels of microparticles originating from endothelial cells,platelets and erythrocytes in subjects with metabolic syndrome:relationship with oxidative stress[J].Nutr Metab Cardiovasc Dis,2011,21(9):665.
[18] 曾晓龙,钟朝晖,唐晓君,等.血浆同型半胱氨酸与轻度认知功能障碍关联性的Meta分析[J].重庆医科大学学报,2014,38(2):207.
[19] 刘云涛,简磊,李建伟,等.糖代谢及胰岛素抵抗改善对2型糖尿病病人血清nesfatin-1水平的影响[J].重庆医学,2014,43(13):1624.
[20] 韩进,虞立,范红晶,等.丹红注射液活性成分与阿尔茨海默病脑内胰岛素抵抗的相关性[J].中华中医药学刊,2016,34(11):2590.