乳腺癌实验动物模型的研究进展
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摘要
乳腺癌是女性最常见的自发性恶性肿瘤,给女性健康造成了严重威胁。而对乳腺癌的相关研究及治疗方法的探索上,在一定程度上需要依赖于乳腺癌实验动物模型得以实现。理想的乳腺癌实验动物模型应与人类乳腺癌在肿瘤分子特性及生物学行为等方面存在共性,以便于研究各种乳腺癌的发病机制及治疗新药的开发。本文对5种乳腺癌实验动物模型的研究进展进行了综述,以期为人乳腺癌的诊断和治疗提供依据。
Breast cancer is the most common spontaneous malignancy in women,causing a serious threat to women's health. Experimental animal models have been important research tools in bringing insights into the related mechanisms of breast cancer,as well as in delivering improved therapies for the disease. To reveal the pathogenesis of various breast cancers and facilitate the development of new drugs,ideal animal models of breast cancer should share some common tumor molecular characteristics and biological behavior with that of human breast cancer. In this review,five types of experimental animal breast cancer models were included,which may provide a basis for research on diagnosis and treatment of human breast cancer.
Breast cancer is the most common spontaneous malignancy in women,causing a serious threat to women's health. Experimental animal models have been important research tools in bringing insights into the related mechanisms of breast cancer,as well as in delivering improved therapies for the disease. To reveal the pathogenesis of various breast cancers and facilitate the development of new drugs,ideal animal models of breast cancer should share some common tumor molecular characteristics and biological behavior with that of human breast cancer. In this review,five types of experimental animal breast cancer models were included,which may provide a basis for research on diagnosis and treatment of human breast cancer.
引文
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[24]曹让娟,翟艳华,卿旭,等.乳腺癌细胞MDA-MB-231肺转移模型的建立及其评价[J].吉林大学学报:医学版,2011,37(3):403-406.
[25]杜娟.FOXC1抑制乳腺癌体内肺转移及CARM1通过位点特异性甲基化HP1γ抑制肿瘤细胞的衰老和SAHF[D].东北师范大学,2012.
[26]龚宏霞,林洪生,张英,等.小鼠乳腺癌4T1-luc细胞实验性肺转移模型的建立及其评价[J].现代肿瘤医学,2015,23(6):735-737.
[27]Price JE.Metastasis from human breast cancer cell lines[J].Breast Cancer Res Treat,1996,39(1):93-102.
[28]Goddard ET,Fischer J,Schedin P.A portal vein injection model to study liver metastasis of breast cancer[J].J Vis Exp,2016,(118):54903..
[29]胡孝渠,宋尔卫,陈积圣,等.原位小鼠乳腺癌肝转移模型[J].广东医学,2006,27(4):454-455.
[30]Thibaudeau L,Quent VM,Holzapfel BM,et al.Mimicking breast cancer-induced bone metastasis in vivo:current transplantation models and advanced humanized strategies[J].Cancer Metastasis Rev,2014,33(2-3):721-735.
[31]Sloan EK,Pouliot N,Stanley KL,et al.Tumor-specific expression ofαvβ3 integrin promotes spontaneous metastasis of breast cancer to bone[J].Breast Cancer Res,2006,8(2):R20.
[32]Zibly Z,Schlaff CD,Gordon I,et al.A novel rodent model of spinal metastasis and spinal cord compression[J].BMC Neurosci,2012,13:137.
[33]Ghajar CM,Peinado H,Mori H,et al.The perivascular niche regulates breast tumour dormancy[J].Natcell Biol,2013,15(7):807-817.
[34]DeRose YS,Wang G,Lin YC,et al.Tumor grafts derived from women with breast cancer authentically reflect tumor pathology,growth,metastasis and disease outcomes[J].Nat Med,2011,17(11):1514-1520.
[35]Garcia T,Jackson A,Bachelier R,et al.A convenient clinically relevant model of human breast cancer bone metastasis[J].Clin Exp Metast,2008,25(1):33-42.
[36]Ono K,Akatsu T,Murakami T,et al.Involvement of cyclo-oxygenase-2 in osteoclast formation and bone destruction in bone metastasis of mammary carcinoma cell lines[J].J Bone Miner Res,2002,17(5):774-781.
[37]Kim IS,Baek SH.Mouse models for breast cancer metastasis[J].Biochem Biophys Res Commun,2010,394(3):443-447.
[38]Denzel MS,Hebbard LW,Shostak G,et al.Adiponectin deficiency limits tumor vascularization in the MMTV-Py V-m T mouse model of mammary cancer[J].Clin Cancer Res,2009,15(10):3256-3264.
[39]孙强,王晓辉,闫志峰,等.MMTV-Wnt-1转基因小鼠作为高发乳腺癌动物模型的观察[J].中国实验动物学报,2002,10(3):151-154.
[2]American Cancer Society.Cancer Facts&Figures 2015[M].Atlanta,GA:American Cancer Society,2015.
[3]Sun B,Zhang S,Zhang D,et al.Identification of metastasis-related proteins and their clinical relevance to triple-negative human breast cancer[J].Clin Cancer Res,2008,14(21):7050-7059.
[4]Fabris VT.From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer[J].Cancer Genet,2014,207(6):233-246.
[5]Simian M,Manzur T,Rodriguez V,et al.A spontaneous estrogen dependent,tamoxifen sensitive mouse mammary tumor:a new model system to study hormone-responsiveness in immune competent mice[J].Breast Cancer Res Treat.2009,113(1):1-8.
[6]邹移海.实验动物学[M].北京,科学出版社,2012.
[7]Mollard S,Mousseau Y,Baaj Y,et al.How can grafted breast cancer models be optimized?[J].Cancer Biol Ther,2011,12(10):855-864.
[8]Currier N,Solomon SE,Demicco EG,et al.Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors[J].Toxicol Pathol,2005,33:726-737.
[9]Lanari C,Molinolo AA,Pasqualini CD.Induction of mammary adenocarcinomas by medroxyprogesterone acetate in BALB/c female mice[J].Cancer Lett,1986,33(2):215-223.
[10]盛佳钰,陈红风.顺铂诱导三阴性乳腺癌4T1耐药小鼠模型的建立[J].中国实验动物学报,2015,23(5):466-473.
[11]Krishnan AV,Swami S,Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer:Importance of mammary CYP27B1 for treatment and prevention[J].J Steroid Biochem Mol Biol,2013,136:289-295.
[12]Lacroix M,Leclercq G.Relevance of breast cancer cell lines as models for breast tumours:an update[J].Breast Cancer Res Treat,2004,83(4):249-289.
[13]Pearson HB,Pouliot N.Modeling metastasis in vivo-Madame Curie Bioscience Database-NCBI Bookshelf[M].Landes Bioscience,2000.
[14]Rashid OM,Takabe K.Animal models for exploring the pharmacokinetics of breast cancer therapies[J].Expert Opin Drug Metab Toxicol,2015,11(2):221-230.
[15]Ottewell PD,Coleman RE,Holen I.From genetic abnormality to metastases:murine models of breast cancer and their use in the development of anticancer therapies[J].Breast Cancer Res Treat,2006,96(2):101-113.
[16]Rosland GV,Svendsen A,Torsvik A,et al.Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation[J].Cancer Res,2009,69(13):5331-5339.
[17]Clarke R.The role of preclinical animal models in breast cancer drug development[J].Breast Cancer Res,2009,11(Suppl3):S22.
[18]Ji XW,Ji SM,Li RT,et al.Pharmacokinetic-pharmacodynamic modeling of the antitumor effect of TM208 and EGFR-TKI resistance in human breast cancer xenograft mice[J].Acta Pharmacol Sin,2016,37(6):825-833.
[19]Yen TH,Lee GD,Chai JW,et al.Characterization of a murine xenograft model for contrast agent development in breast lesion malignancy assessment[J].J Biomed Sci,2016,23(1):46.
[20]Xin Z,Wang Q,Yang S,et al.Quercetin inhibits angiogenesis by targeting calcineurin in the xenograft model of human breast cancer[J].Eur J Pharmacol,2016,781:60-68.
[21]Frese KK,Tuveson DA.Maximizing mouse cancer models[J].Nat Rev Cancer,2007,7(9):645-658.
[22]Sharpless NE,Depinho RA.The mighty mouse:genetically engineered mouse models in cancer drug development[J].Nat Rev Drug Discov,2006,5(9):741-54.
[23]Vargo-Gogola T,Rosen JM.Modelling breast cancer:one size does not fit all[J].Nat Rev Cancer,2007,7(9):659-672.
[24]曹让娟,翟艳华,卿旭,等.乳腺癌细胞MDA-MB-231肺转移模型的建立及其评价[J].吉林大学学报:医学版,2011,37(3):403-406.
[25]杜娟.FOXC1抑制乳腺癌体内肺转移及CARM1通过位点特异性甲基化HP1γ抑制肿瘤细胞的衰老和SAHF[D].东北师范大学,2012.
[26]龚宏霞,林洪生,张英,等.小鼠乳腺癌4T1-luc细胞实验性肺转移模型的建立及其评价[J].现代肿瘤医学,2015,23(6):735-737.
[27]Price JE.Metastasis from human breast cancer cell lines[J].Breast Cancer Res Treat,1996,39(1):93-102.
[28]Goddard ET,Fischer J,Schedin P.A portal vein injection model to study liver metastasis of breast cancer[J].J Vis Exp,2016,(118):54903..
[29]胡孝渠,宋尔卫,陈积圣,等.原位小鼠乳腺癌肝转移模型[J].广东医学,2006,27(4):454-455.
[30]Thibaudeau L,Quent VM,Holzapfel BM,et al.Mimicking breast cancer-induced bone metastasis in vivo:current transplantation models and advanced humanized strategies[J].Cancer Metastasis Rev,2014,33(2-3):721-735.
[31]Sloan EK,Pouliot N,Stanley KL,et al.Tumor-specific expression ofαvβ3 integrin promotes spontaneous metastasis of breast cancer to bone[J].Breast Cancer Res,2006,8(2):R20.
[32]Zibly Z,Schlaff CD,Gordon I,et al.A novel rodent model of spinal metastasis and spinal cord compression[J].BMC Neurosci,2012,13:137.
[33]Ghajar CM,Peinado H,Mori H,et al.The perivascular niche regulates breast tumour dormancy[J].Natcell Biol,2013,15(7):807-817.
[34]DeRose YS,Wang G,Lin YC,et al.Tumor grafts derived from women with breast cancer authentically reflect tumor pathology,growth,metastasis and disease outcomes[J].Nat Med,2011,17(11):1514-1520.
[35]Garcia T,Jackson A,Bachelier R,et al.A convenient clinically relevant model of human breast cancer bone metastasis[J].Clin Exp Metast,2008,25(1):33-42.
[36]Ono K,Akatsu T,Murakami T,et al.Involvement of cyclo-oxygenase-2 in osteoclast formation and bone destruction in bone metastasis of mammary carcinoma cell lines[J].J Bone Miner Res,2002,17(5):774-781.
[37]Kim IS,Baek SH.Mouse models for breast cancer metastasis[J].Biochem Biophys Res Commun,2010,394(3):443-447.
[38]Denzel MS,Hebbard LW,Shostak G,et al.Adiponectin deficiency limits tumor vascularization in the MMTV-Py V-m T mouse model of mammary cancer[J].Clin Cancer Res,2009,15(10):3256-3264.
[39]孙强,王晓辉,闫志峰,等.MMTV-Wnt-1转基因小鼠作为高发乳腺癌动物模型的观察[J].中国实验动物学报,2002,10(3):151-154.