明日叶查尔酮制备方法与抗衰老作用研究进展
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摘要
查尔酮是药食兼用植物明日叶中一类具有多种生物活性及药理活性的特殊黄酮类物质。综述了国内外明日叶中查尔酮类化合物的提取分离方法及抗衰老作用研究进展,介绍了衰老和抗衰老机理模型,以及抗衰老作用的研究方法,为明日叶查尔酮的进一步研究和利用提出了建议。
Recognized as food and medicinal plant traditionally,Angelica keiskei Koidzumi(A. keiskei),of which the main compounds with bioactive and pharmacological effects are chalcones. In this paper,the recent advancements on the extraction,isolation methods and anti-aging effects of chalcones(AC)from A. keiskei were reviewed,and the research priorities and directions were proposed,aiming to provide reference for the exploitation and utilization of AC from A. keiskei.
Recognized as food and medicinal plant traditionally,Angelica keiskei Koidzumi(A. keiskei),of which the main compounds with bioactive and pharmacological effects are chalcones. In this paper,the recent advancements on the extraction,isolation methods and anti-aging effects of chalcones(AC)from A. keiskei were reviewed,and the research priorities and directions were proposed,aiming to provide reference for the exploitation and utilization of AC from A. keiskei.
引文
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[6]李子超,王力平,钟进义,等.明日叶及其活性成分查尔酮研究进展[J].中国食物与营养,2016,22(11):68-72
[7]李刚.神奇植物——明日叶[J].现代营销:创富信息版,2004(12):29
[8]KIL Y S,PHAM S T,SEO E K,et al.Angelica keiskei,an emerging medicinal herb with various bioactive constituents and biological activities[J].Archives of pharmacal research,2017,40(6):655-675
[9]BATTENBERG O,YANG Y,VERHELST S,et al.Target profiling of4-hydroxyderricin in S.aureus reveals seryl-t RNA synthetase binding and inhibition by covalent modification[J].Molecular Biosystems,2013,9(3):343-351
[10]INAMORI Y,BABA K,TSUJIBO H,et al.Antibacterial activity of two chalcones,xanthoangelol and 4-hydroxyderricin,isolated from the root of angelica keiskei Koidzumi[J].Chemical and Pharmaceutical Bulletin(Tokyo),1991,39(6):1604-1605
[11]CHANG H R,LEE H J,RYU J H.Chalcones from Angelica keiskei attenuate the inflammatory responses by suppressing nuclear translocation of NF-κB[J].Journal of Medicinal Food,2014,17(12):1306-1313
[12]PARK J Y,JEONG H J,KIM Y M,et al.Characteristic of alkylated chalcones from Angelica keiskei on influenza virus neuraminidase inhibition[J].Bioorganic&medicinal chemistry letters,2011,21(18):5602-5604
[13]LEE H,CHOI T,KIM H J,et al.Anti-inflammatory activity of Angelica keiskei through suppression of mitogen-activated protein kinases and nuclear factor-κB activation pathways[J].Archives of pharmacal research,2012,35(4):723-732
[14]AKIHISA T,KIKUCHI T,NAGAI H,et al.4-Hydroxyderricin from Angelica keiskei roots induces caspase-dependent apoptotic cell death in HL60 human leukemia cells[J].Journal of Oleo Science,2011,60(2):71-77
[15]JEONG Y J,KANG K J.Effect of Angelica keiskei Extract on Apoptosis of MDA-MB-231 Human Breast Cancer Cells[J].Journal of the Korean Society of Food Science and Nutrition,2011,40(12):1654-1661
[16]OKUYAMA T,TAKATA M,TAKAYASU,et al.Anti-tumor-promotion by principles obtained from Angelica keiskei[J].Planta Medica,1991,57(3):242-246
[17]TATSUJI E,HIROMU O,KINUKO N,et al.Antidiabetic activities of chalcones isolated from a Japanese herb,Angelica keiskei[J].Journal of agricultural and food chemistry,2007,55(15):6013-6017
[18]MATSUURA M,KIMURA Y,NAKATA K,et al.Artery relaxation by chalcones isolated from the roots of Angelica keiskei[J].Planta Medica,2001,67(3):230-235
[19]SON D J,PARK Y O,YU C,et al.Bioassay-guided isolation and identification of anti-platelet-active compounds from the root of Ashitaba(Angelica keiskei Koidz.)[J].Natural Product Research,2014,28(24):2312-2316
[20]NOH H M,AHN E M,YUN J M,et al.Angelica keiskei Koidzumi extracts improve some markers of liver function in habitual alcohol drinkers:a randomized double-blind clinical trial[J].Journal of Medicinal Food,2015,18(2):166-166
[21]MURAKAMI S,KIJIMA H,ISOBE Y,et al.Inhibition of gastric H+,K(+)-ATPase by chalcone derivatives,xanthoangelol and 4-hydroxyderricin,from Angelica keiskei Koidzumi[J].Journal of Pharmacy and Pharmacology,1990,42(10):723-726
[22]PAEK S H,LEE B Y,HAN C S,et al.Whitening Effect of Angelica keiskei Koidzumi Extract by Inhibition of Endothelin-1 Production and Melanogenesis[J].Journal of the Society of Cosmetic Scientists of Korea,2008,34(2):101-107
[23]ARUNG E,FURUTA S,SUGAMOTO K,et al.The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells[J].Natural Product Communications,2012,7(8):1007-1010
[24]KIM S K,KIM J A,BYULNIM A H N,et al.Hair growth stimulator based on ecklonia cava extract,preparation method thereof,and cosmetic composition containing the same:US20130089568[P].2012-10-9
[25]OH SR,KIM S J,KIM D H,et al.Angelica keiskei ameliorates scopolamine-induced memory impairments in mice[J].Biological and Pharmaceutical Bulletin,2013,36(1):82-88
[26]HARMAN D.Aging:A Theory Based on Free Radical and Radiation Chemistry[J].Journal of Gerontology,1956,11(3):298-298
[27]MONRONPOT R R.Toxicological assessment of Ashitaba Chalcone[J].Food and chemical toxicology,2015,77:111-119
[28]金慧鸣,谭兴和,蔡文.茅岩莓黄酮提取分离纯化技术的研究进展[J].食品研究与开发,2015,36(24):178-181
[29]郭晓青,吴金鸿,周焱富,等.明日叶叶水溶性总黄酮提纯工艺[J].食品科学,2012,33(22):27-32
[30]OHNOGI H,KUDO Y,TAHARA K,et al.Six new chalcones from Angelica keiskei inducing adiponectin production in 3T3-L1adipocytes[J].Bioscience,biotechnology,and biochemistry,2012,76(5):961-966
[31]郭晓青,张晓春,陈晓靓,等.明日叶黄酮类化合物清除羟基自由基活性研究[J].广州化学,2013,38(4):7-11
[32]KIM D W,CURTIS-LONG M J,YUK H J,et al.Quantitative analysis of phenolic metabolites from different parts of Angelica keiskei by HPLC-ESI MS/MS and their xanthine oxidase inhibition[J].Food chemistry,2014,153:20-27
[33]何月秋,付涛,李文,等.明日叶总黄酮超声提取工艺优化及其DPPH清除能力[J].中成药,2016,38(12):2703-2706
[34]OGAWA H,NAKASHIMA S,BABA K.Effects of dietary Angelica keiskei on lipid metabolism in stroke-prone spontaneously hypertensive rats[J].Clinical and Experimental Pharmacology and Physiology,2003,30(4):284-288
[35]ZHANG T S,YAMASHITA Y,YASUDA M,et al.Ashitaba(Angelica keiskei)extract prevents adiposity in high-fat diet-fed C57BL/6mice[J].Food and Function,2014,6(1):134-144
[36]TOSHIHIRO A,HARUKUNI T,MOTOHIKO U.Chalcones,coumarins,and flavanones from the exudate of Angelica keiskei and their chemopreventive effects[J].Cancer Letters,2003,201(2):133-137
[37]陈欣华,王曼曼,宁鸿珍,等.明日叶中查尔酮三种提取方法的比较研究[J].食品工业,2014,35(6):91-94
[38]宁鸿珍,陈欣华,王曼曼,等.超声波辅助提取明日叶查尔酮的工艺优化[J].食品研究与开发,2014,35(8):34-37
[39]马密霞,胡文祥.微波萃取技术在中药有效成分提取中的应用[J].中国医药导刊,2010,12(9):1583-1585
[40]邹毓兰,单虎,高桂余,等.明日叶中总黄酮的微波辅助提取工艺和检测方法研究[J].食品工业科技,2012,33(5):201-205
[41]尹慧丹,田大永,方波.微波辅助提取明月草叶查尔酮工艺研究[J].食品工业,2011(11):43-46
[42]王敏,高锦明,王军,等.苦荞茎叶粉中总黄酮酶法提取工艺研究[J].中草药,2006,37(11):1645-1648
[43]何扩,李玉锋,张秀媛,等.超临界流体萃取银杏叶黄酮类物质的研究[J].食品工程,2005(4):2-5
[44]GARCIA-MENDOZAA M D P,ESPINOSA-PARDOA F A,ANDRESS M B et al.Extraction of phenolic compounds and anthocyanins from ju觭ara(Euterpe edulis Mart.)residues using pressurized liquids and supercritical fluids[J].The journal of supercritical fluids,2017,119:9-16
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