Graves病固定剂量与个体化剂量~(131)I治疗的临床研究
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摘要
目的:研究比较固定剂量与个体化剂量131I治疗Graves病的临床效果,以及并发生症的发生情况。方法:选取笔者所在医院2014年3月-2015年3月收治的Graves患者300例,随机分为对照组与研究组,其中对照组采用固定剂量131I进行治疗,研究组采用个体化剂量131I进行治疗,随访6个月,比较两组患者的临床疗效以及并发症发生率。结果:治疗后对照组总有效率80.67%,研究组79.33%,两组比较差异无统计学意义(P>0.05)。对照组甲减发生率48.67%,研究组发生率33.33%,两组比较差异有统计学意义(P<0.05)。结论:Graves病采用固定化剂量和个体化剂量131I临床疗效均显著,个体化剂量甲减发生率低,安全性更高,值得临床广泛推广应用。
Objective:To study the clinical effect of 131 I treatment for Graves disease of fixed dose and individual dose,and the incidence condition of complications.Method:From March 2014 to March 2015,300 cases with Graves in our hospital were selected,and they were divided them into the control group and the research group.The control group was treated with the fixed dose 131 I treatment,while the study group was treated with individual dose 131 I treatment.And then they were followed up for 6 months,the clinical efficacy and complications incidence rate of the two groups were compared.Result:After treatment,the total effective rate of the control group was 80.67%,while the research group was 79.33%,and the difference between the two groups showed no statistically significant(P>0.05).However,the incidence of hypothyroidism in the control group was 48.67%,while the research group was 33.33%,and the difference between the two groups was statistically significant(P<0.05).Conclusion:The clinical efficacy of the fixed dose and individual dose 131 I treatment for Graves disease are very significant,but the individual dose treatment has a low incidence rate of hypothyroidism.Benefit from the higher security,the individual dose 131 I treatment is worthy of clinical popularization and application.
Objective:To study the clinical effect of 131 I treatment for Graves disease of fixed dose and individual dose,and the incidence condition of complications.Method:From March 2014 to March 2015,300 cases with Graves in our hospital were selected,and they were divided them into the control group and the research group.The control group was treated with the fixed dose 131 I treatment,while the study group was treated with individual dose 131 I treatment.And then they were followed up for 6 months,the clinical efficacy and complications incidence rate of the two groups were compared.Result:After treatment,the total effective rate of the control group was 80.67%,while the research group was 79.33%,and the difference between the two groups showed no statistically significant(P>0.05).However,the incidence of hypothyroidism in the control group was 48.67%,while the research group was 33.33%,and the difference between the two groups was statistically significant(P<0.05).Conclusion:The clinical efficacy of the fixed dose and individual dose 131 I treatment for Graves disease are very significant,but the individual dose treatment has a low incidence rate of hypothyroidism.Benefit from the higher security,the individual dose 131 I treatment is worthy of clinical popularization and application.
引文
[1]周朋,邱娟,王朋,等.167例精细个体化131I治疗中老年Graves甲亢疗效观察[J].标记免疫分析与临床,2015,22(2):125-128.
[2]许强.小剂量131碘在治疗甲状腺功能亢进中的疗效观察[J].检验医学与临床,2014,11(21):3055-3056.
[3]慕晓梅.131碘剂量规范化治疗甲亢的临床效果分析[J].中国卫生标准管理,2015,6(25):107-108.
[4]吴平,李华,易吉秀,等.2种剂量131碘治疗Graves病的前瞻性随机对照研究[J].第三军医大学学报,2012,34(16):1677-1679.
[5]傅宏亮,杜学亮,李佳宁,等.计算剂量方案行格雷夫斯病甲状腺功能亢进放射性碘治疗的疗效分析[J].上海交通大学学报,2014,34(7):1039-1042.
[6]李爱珍.抗甲状腺药物对131I治疗甲亢疗效的影响[J].中国医学创新,2013,10(3):28-29.
[2]许强.小剂量131碘在治疗甲状腺功能亢进中的疗效观察[J].检验医学与临床,2014,11(21):3055-3056.
[3]慕晓梅.131碘剂量规范化治疗甲亢的临床效果分析[J].中国卫生标准管理,2015,6(25):107-108.
[4]吴平,李华,易吉秀,等.2种剂量131碘治疗Graves病的前瞻性随机对照研究[J].第三军医大学学报,2012,34(16):1677-1679.
[5]傅宏亮,杜学亮,李佳宁,等.计算剂量方案行格雷夫斯病甲状腺功能亢进放射性碘治疗的疗效分析[J].上海交通大学学报,2014,34(7):1039-1042.
[6]李爱珍.抗甲状腺药物对131I治疗甲亢疗效的影响[J].中国医学创新,2013,10(3):28-29.