2型糖尿病同型半胱氨酸水平与血压昼夜节律的相关性研究
摘要
目的探讨非高血压2型糖尿病(T2DM)患者血清同型半胱氨酸(Hcy)水平与血压昼夜节律的关系。方法选取80例非高血压T2DM患者(观察组)与35例健康志愿者(对照组),比较Hcy水平及动态血压水平;观察组内以糖化血红蛋白(HbA1c)及血压模式分别分组比较临床、生化及动态血压水平。结果观察组与对照组非杓型模式比例分别为72.50%、25.71%,Hcy水平分别为(12.80±6.40)、(10.40±4.50)μmol/L,两组比较均差异有统计学意义(P<0.05)。观察组中血糖控制满意组与控制差组的Hcy水平分别为(11.10±5.40)、(14.90±7.30)μmol/L,杓型模式与非杓型模式Hcy水平分别为(9.70±5.30)、(13.40±8.00)μmol/L,组间比较差异有统计学意义(P<0.05)。结论 T2DM患者Hcy水平与血压昼夜节律异常之间存在相关性。
引文
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[12]杨英,杨俊.同型半胱氨酸与心血管疾病关系的研究进展[J].临床心血管病杂志,2017,33(2):106-109.
[13]甄卓丽,陈晓铭,周飞,等.2型糖尿病肾病患者血清同型半胱氨酸水平的变化及意义[J].广东医学,2015,36(16):2556-2557.
[14]NDREPEPA G,KASTRATI A,BRAUN S,et al.Circulating homocysteine levels in patients with type 2diabetes mellitus[J].Nutr Metab Cardiovasc Dis,2008,18(1):66-73.
[15]GU W,LU J,YANG G,et al.Plasma homocysteine thiolactone associated with risk of macrovasculopathy in Chinese patients with type 2diabetes mellitus[J].Adv Ther,2008,25(9):914-924.
[16]SONKAR S K,SONKAR G K,SONI D,et al.Plasma homocysteine level and its clinical correlation with type 2diabetes mellitus and its complications[J].Int J Diabetes Dev Ctries,2014,34(1):3-6.
[17]NABIPOUR I,EBRAHIMI A,JAFARI S M,et al.The metabolic syndrome is not associated with homocysteinemia:the Persian Gulf Healthy Heart Study[J].J Endocrinol Invest,2009,32(5):406-410.
[18]康健,赵兴山,丁幼楠.高同型半胱氨酸血症对高血压患者血压变异性的影响[J].广东医学,2014,35(17):2738-2740.
[19]单海燕,李效娟,李婉.老年非杓型高血压患者血压昼夜节律变化与尿微量白蛋白,同型半胱氨酸的相关性[J].山东医药,2013,53(11):22-24.
[20]陈利强,彭林平,骆秀婷,等.新诊断糖尿病胰岛素强化治疗前,后同型半胱氨酸水平的研究[J].重庆医学,2015,44(8):1052-1053.
[2]MONTUSCHI A,IAZZOLINO B,CALVO A,et al.Cognitive correlates in amyotrophic lateral sclerosis:apopulationbased study in Italy[J].J Neurol Neurosurg Psychiatry,2015,86(2):168-173.
[3]中华医学会内分泌学分会.中国成人2型糖尿病患者动脉粥样硬化性脑心血管疾病分级预防指南[J].中国循环杂志,2016,31(z2):72-76.
[4]FOX C S,GOLDEN S H,ANDERSON C,et al.Update on prevention of cardiovascular disease in adults with type 2diabetes mellitus in light of recent evidence:a scientific statement from the American heart association and the American diabetes association[J].Circulation,2015,132(8):691-718.
[5]ZHOU L,DENG Y,GONG J,et al.Epicardial adipose tissue volume a diagnostic study for Independent predicting disorder of circadian rhythm of blood pressure in patients with essential hypertension[J].Cell Mol Biol(Noisy-le-grand),2016,62(6):1-7.
[6]KALAYCIOGLU E,GKDENIZ T,AYKAN A,et al.The relationship between dipper/nondipper pattern and cardioankle vascular index in hypertensive diabetic patients[J].Blood Press Monit,2013,18(4):188-194.
[7]BAUDUCEAU B,MAYAUDON H,DUPUY O,et al.The impact of dipper and non-dipper characteristics in the fluctuation of arterial blood pressure.A study of a population of 484diabetic patients[J].Arch Mal Coeur Vaiss,2000,93(8):969-973.
[8]LI Y,YIN H J.Study on the relationship between plasma homocysteine,high-sensitivity rotic plaque[J].Med Inf,2014,27(8):197-198.
[9]MOAT S J,BONHAM J R,POWERS H J.Role of aminothiols as a component of the plasma antioxidant system and relevance to homocysteine-mediated vascular disease[J].Clin Sci(Lond),2001,100(1):73-79.
[10]KIM B J,KIM B S,KANG J H.Plasma homocysteine and coronary artery calcification in Korean men[J].Eur J Prev Cardiol,2015,22(4):478-485.
[11]MCDONALD I,CONNOLLY M,TOBIN AM.A review of psoriasis,a known risk factor for cardiovascular disease and its impact on folate and homocysteine metabolism[J].J Nutr Metab,2012(2012):965385.
[12]杨英,杨俊.同型半胱氨酸与心血管疾病关系的研究进展[J].临床心血管病杂志,2017,33(2):106-109.
[13]甄卓丽,陈晓铭,周飞,等.2型糖尿病肾病患者血清同型半胱氨酸水平的变化及意义[J].广东医学,2015,36(16):2556-2557.
[14]NDREPEPA G,KASTRATI A,BRAUN S,et al.Circulating homocysteine levels in patients with type 2diabetes mellitus[J].Nutr Metab Cardiovasc Dis,2008,18(1):66-73.
[15]GU W,LU J,YANG G,et al.Plasma homocysteine thiolactone associated with risk of macrovasculopathy in Chinese patients with type 2diabetes mellitus[J].Adv Ther,2008,25(9):914-924.
[16]SONKAR S K,SONKAR G K,SONI D,et al.Plasma homocysteine level and its clinical correlation with type 2diabetes mellitus and its complications[J].Int J Diabetes Dev Ctries,2014,34(1):3-6.
[17]NABIPOUR I,EBRAHIMI A,JAFARI S M,et al.The metabolic syndrome is not associated with homocysteinemia:the Persian Gulf Healthy Heart Study[J].J Endocrinol Invest,2009,32(5):406-410.
[18]康健,赵兴山,丁幼楠.高同型半胱氨酸血症对高血压患者血压变异性的影响[J].广东医学,2014,35(17):2738-2740.
[19]单海燕,李效娟,李婉.老年非杓型高血压患者血压昼夜节律变化与尿微量白蛋白,同型半胱氨酸的相关性[J].山东医药,2013,53(11):22-24.
[20]陈利强,彭林平,骆秀婷,等.新诊断糖尿病胰岛素强化治疗前,后同型半胱氨酸水平的研究[J].重庆医学,2015,44(8):1052-1053.