中药联合他巴唑治疗甲状腺功能亢进临床疗效观察及对甲状腺激素水平的影响
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摘要
目的:探讨甲状腺功能亢进患者应用中药联合他巴唑治疗临床疗效及对甲状腺激素水平的影响,为临床诊断治疗提供一定参考价值。方法:本组114例甲状腺功能亢进患者根据随机数字表法随机分为对照组和观察组各57例。对照组采用他巴唑治疗,观察组在对照组基础上结合中药方剂治疗。结果:观察组治疗后总有效率(94.74%)显著高于对照组(78.95%),且有统计学差异(P<0.05);观察组治疗后心率显著低于治疗前,而体质量显著高于治疗前,且有统计学差异(P<0.05);观察组治疗后T3、T4、FT3、FT4均显著高于对照组治疗后,而TSH显著高于对照组治疗后,且有统计学差异(P<0.05);两组患者不良反应比较无统计学差异(P>0.05);观察组复发率显著低于对照组,且有统计学差异(P<0.05)。结论:甲状腺功能亢进患者应用中药联合他巴唑治疗临床疗效显著,可明显降低甲状腺激素水平,具有重要临床意义。
Objective: To investigate the application of traditional Chinese medicine in patients with hyperthyroidism combined methimazole treatment efficacy and effects on thyroid hormone levels,provide a reference value for clinical diagnosis and treatment. Methods: 114 cases of hyperthyroidism group were randomly divided into two groups according to the random number table( n = 57) and observation group( n = 57). Control group with methimazole treatment,observation group therapy combined with traditional Chinese medicine prescriptions on the basis of the control group. Results: The total observed after treatment efficiency( 94. 74%) was significantly higher( 78. 95%),and there is statistically significant( P < 0. 05); heart rate were observed after treatment group was significantly lower than before treatment,and body weight were significantly higher than before treatment and statistically significant( P < 0. 05); observation group after treatment T3,T4,FT3,FT4 were significantly higher after treatment,while TSH was significantly higher after treatment,and there is significant difference( P < 0. 05); adverse reactions in patients with no significant difference between the two groups( P > 0. 05); observation group,the recurrence rate was significantly lower than the control group,and there are significant differences( P < 0. 05). Conclusion: Patients with hyperthyroidism application of traditional Chinese medicine combined with methimazole significant clinical effect,can significantly reduce thyroid hormone levels,has important clinical significance.
Objective: To investigate the application of traditional Chinese medicine in patients with hyperthyroidism combined methimazole treatment efficacy and effects on thyroid hormone levels,provide a reference value for clinical diagnosis and treatment. Methods: 114 cases of hyperthyroidism group were randomly divided into two groups according to the random number table( n = 57) and observation group( n = 57). Control group with methimazole treatment,observation group therapy combined with traditional Chinese medicine prescriptions on the basis of the control group. Results: The total observed after treatment efficiency( 94. 74%) was significantly higher( 78. 95%),and there is statistically significant( P < 0. 05); heart rate were observed after treatment group was significantly lower than before treatment,and body weight were significantly higher than before treatment and statistically significant( P < 0. 05); observation group after treatment T3,T4,FT3,FT4 were significantly higher after treatment,while TSH was significantly higher after treatment,and there is significant difference( P < 0. 05); adverse reactions in patients with no significant difference between the two groups( P > 0. 05); observation group,the recurrence rate was significantly lower than the control group,and there are significant differences( P < 0. 05). Conclusion: Patients with hyperthyroidism application of traditional Chinese medicine combined with methimazole significant clinical effect,can significantly reduce thyroid hormone levels,has important clinical significance.
引文
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[12]赵震亚.当归六黄汤加他巴唑治疗甲状腺功能亢进症的临床疗效观察[J].河北联合大学学报:医学版,2013,15(1):66-67.
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[14]金美娟,王健,李进,等.中西医结合治疗甲状腺功能亢进症疗效观察[J].浙江中医杂志,2011,46(9):659-660.
[15]凌菁.清肝降火法合他巴唑治疗甲状腺功能亢进症20例[J].湖南中医杂志,2013,9(7):54-55.
[2]徐光.稳心颗粒在治疗甲亢引起心率失常方面的探讨[J].中华中医药学刊,2013,31(2):432-434.
[3]Effraimidis G,Strieder T G A,Tijssen J G P,et al.Natural history of the transition from euthyroidism to overt autoimmune hypo-or hyperthyroidism:a prospective study[J].European Journal of Endocrinology,2011,164(1):107-113.
[4]张煜,王宇坤,邱华,等.康甲颗粒治疗甲状腺功能亢进症合并肝损害的临床研究[J].南京中医药大学学报,2011,27(3):232-234.
[5]丁继存.黄芪平甲方联合他巴唑治疗老年性甲状腺功能亢进症42例[J].中医学报,2010,25(2):290-291.
[6]朱子情,陈霞波.中西医结合疗法治疗甲状腺功能亢进症的临床疗效及安全观察[J].中医药学报,2011,39(2):123-125.
[7]张晋红,符文明.中西医结合治疗甲状腺功能亢进症近期疗效及远期复发率观察[J].中华中医药学刊,2013,31(12):2825-2827.
[8]陈灏珠,林果为.实用内科学[M].13版.北京:人民卫生出版社,2012:1261-1264.
[9]郑筱英.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002:243-253.
[10]Sundaresh V,Brito J P,Wang Z,et al.Comparative effectiveness of therapies for Graves'hyperthyroidism:a systematic review and network meta-analysis[J].The Journal of Clinical Endocrinology&Metabolism,2013,98(9):3671-3677.
[11]刘瑜.藿朴夏苓汤联合西药治疗甲状腺功能亢进症42例[J].陕西中医,2012,33(6):706-708.
[12]赵震亚.当归六黄汤加他巴唑治疗甲状腺功能亢进症的临床疗效观察[J].河北联合大学学报:医学版,2013,15(1):66-67.
[13]易吉秀,吴平.1311治疗甲状腺功能亢进症600例的疗效观察[J].中国药房,2011,22(24):2287-2288.
[14]金美娟,王健,李进,等.中西医结合治疗甲状腺功能亢进症疗效观察[J].浙江中医杂志,2011,46(9):659-660.
[15]凌菁.清肝降火法合他巴唑治疗甲状腺功能亢进症20例[J].湖南中医杂志,2013,9(7):54-55.