生长抑素联合乌司他丁治疗结肠癌术后炎性肠梗阻的疗效观察
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摘要
目的观察生长抑素联合乌司他丁治疗结肠癌术后炎性肠梗阻的疗效。方法将78例结肠癌术后炎性肠梗阻患者随机分为对照组38例及观察组40例。对照组患者在常规治疗基础上给予生长抑素治疗,观察组患者在对照组基础上加用乌司他丁治疗。比较两组患者治疗有效率及治疗前后血清肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、白细胞介素8(IL-8)的表达水平。结果观察组治疗有效率高于对照组(P <0. 05)。两组患者治疗前血清IL-6、IL-8及TNF-α表达水平比较,差异均无统计学意义(均P> 0. 05);治疗7 d后,两组患者血清IL-6、IL-8及TNF-α表达水平均低于治疗前,且观察组低于对照组(均P <0. 05)。结论与单用生长抑素相比,生长抑素联合乌司他丁应用于结肠癌术后炎性肠梗阻患者能更好地降低血清炎症因子水平,提高治疗有效率。
Objective To observe the efficacy of somatostatin combined with ulinastatin for postoperative inflammatory ileus in colon cancer patients. Methods Seventy-eight colon cancer patients with postoperative inflammatory ileus were randomly divided into control group(38 cases) and observation group(40 cases). Patients in the control group were given somatostatin on the basis of conventional treatment,while patients in the observation group were given ulinastatin on the basis of the therapy performed in the control group. The effective rates of treatment of the two groups were compared,and the expression levels of serum tumor necrosis factor α(TNF-α),interleukin6(IL-6) and interleukin 8(IL-8) before and after treatment were compared between the two groups as well. Results The effective rate of treatment in the observation group was higher than that in the control group(P < 0. 05). There was no statistically significant difference in the expression level of serum IL-6,IL-8 or TNF-α between the two groups before treatment(all P > 0. 05); after 7 days of treatment,the expression levels of serum IL-6,IL-8 and TNF-α in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group(all P < 0. 05). Conclusion Compared with somatostatin alone,somatostatin combined with ulinastatin can better reduce the levels of serum inflammatory factors and improve the effective rate of treatment for colon cancer patients with postoperative inflammatory ileus.
Objective To observe the efficacy of somatostatin combined with ulinastatin for postoperative inflammatory ileus in colon cancer patients. Methods Seventy-eight colon cancer patients with postoperative inflammatory ileus were randomly divided into control group(38 cases) and observation group(40 cases). Patients in the control group were given somatostatin on the basis of conventional treatment,while patients in the observation group were given ulinastatin on the basis of the therapy performed in the control group. The effective rates of treatment of the two groups were compared,and the expression levels of serum tumor necrosis factor α(TNF-α),interleukin6(IL-6) and interleukin 8(IL-8) before and after treatment were compared between the two groups as well. Results The effective rate of treatment in the observation group was higher than that in the control group(P < 0. 05). There was no statistically significant difference in the expression level of serum IL-6,IL-8 or TNF-α between the two groups before treatment(all P > 0. 05); after 7 days of treatment,the expression levels of serum IL-6,IL-8 and TNF-α in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group(all P < 0. 05). Conclusion Compared with somatostatin alone,somatostatin combined with ulinastatin can better reduce the levels of serum inflammatory factors and improve the effective rate of treatment for colon cancer patients with postoperative inflammatory ileus.
引文
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[8]范莺莺,华青云,余萍.乌司他丁治疗炎性肠梗阻的临床疗效观察及对血浆IL-6,IL-8和TNF-α的调控作用[J].放射免疫学杂志,2013,26(4):540-542.
[9]贾力,马官华. UAP患者血清IL-6,TNF-α,血浆BNP测定的临床应用[J].放射免疫学杂志,2012,25(1):19-20.
[10]朱维铭.再谈胃肠道术后早期炎性肠梗阻[J].中国实用外科杂志,2013,33(4):270-271.
[11]潘红芳.乌司他丁联合奥曲肽对急性轻症胰腺炎患者四种血清IL水平的影响[J].山东医药,2011,51(23):85-86.
[12]张建新,郭平选.乌司他丁对急腹症患者围术期肿瘤坏死因子及白介素的影响[J].山东医药,2008,48(10):77-78.
[2]朱维铭,李宁.术后早期炎性肠梗阻的诊治[J].中国实用外科杂志,2000,20(8):456-458.
[3] Barmparas G,Branco BC,Schnüriger B,et al. The incidence and risk factors of post-laparotomy adhesive small bowel obstruction[J]. J Gastrointest Surg,2010,14(10):1 619-1 628.
[4] Chu DI,Gainsbury ML,Howard LA,et al. Early versus late adhesiolysis for adhesive-related intestinal obstruction:a nationwide analysis of inpatient outcomes[J]. J Gastrointest Surg,2013,17(2):288-297.
[5] Saklani AP,Naguib N,Shah PR,et al. Adhesive intestinal obstruction in laparoscopic vs open colorectal resection[J].Colorectal Dis,2013,15(1):80-84.
[6] Gao C,Li R,Wang S. Ulinastatin protects pulmonary tissues from lipopolysaccharide-induced injury as an immunomodulator[J]. J Trauma Acute Care Sur,2012,72(1):169-176.
[7]黎介寿.认识术后早期炎性肠梗阻的特性[J].中国实用外科杂志,1998,18(7):387-388.
[8]范莺莺,华青云,余萍.乌司他丁治疗炎性肠梗阻的临床疗效观察及对血浆IL-6,IL-8和TNF-α的调控作用[J].放射免疫学杂志,2013,26(4):540-542.
[9]贾力,马官华. UAP患者血清IL-6,TNF-α,血浆BNP测定的临床应用[J].放射免疫学杂志,2012,25(1):19-20.
[10]朱维铭.再谈胃肠道术后早期炎性肠梗阻[J].中国实用外科杂志,2013,33(4):270-271.
[11]潘红芳.乌司他丁联合奥曲肽对急性轻症胰腺炎患者四种血清IL水平的影响[J].山东医药,2011,51(23):85-86.
[12]张建新,郭平选.乌司他丁对急腹症患者围术期肿瘤坏死因子及白介素的影响[J].山东医药,2008,48(10):77-78.