血清FABP3水平与冠状动脉病变及阿司匹林抵抗的关系
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摘要
目的:测定冠心病患者血清脂肪酸结合蛋白3(fatty acid binding protein 3,FABP3)水平,探讨FABP3与冠心病患者冠状动脉(冠脉)病变严重程度及阿司匹林抵抗的关系。方法:选取2017-06-2017-12成都军区总医院心内科住院部患者80例,其中冠心病患者43例和对照组患者37例,根据病变支数分为单支病变、多支病变组;根据阿司匹林抵抗标准将冠心病患者分为阿司匹林敏感组和阿司匹林非敏感组。根据采用液相蛋白芯片检测血清FABP3水平,同时检测空腹血糖(FPG)、糖化血红蛋白(HbA1c)、血脂各项指标。结果:冠心病组血清FABP3水平高于对照组,多支病变组较单支病变组FABP3水平升高(P<0.05)。阿司匹林敏感组血清FABP3水平显著高于阿司匹林非敏感组(P<0.01)。结论:血清FABP3水平一定程度上可反映冠脉病变严重程度。冠心病患者阿司匹林抵抗发生与FABP3水平密切相关。
Objective:To assay serum FABP3 level in patients with coronary heart disease(CHD) and explore the relationship between FABP3 and coronary artery disease severity as well as aspirin resistance in patients with coronary heart disease.Method:The 80 patients from department of cardiology,general hospital of chengdu military region from June 2017 to December 2017 were selected.There were 43 cases of coronary heart disease and 37 cases of control group.According to the number of coronary lesions,the groups were divided into single-vessel lesions and multi-vessel lesions.Patients with coronary heart disease were divided into aspirin sensitive group and aspirin non-sensitive group according to aspirin resistance standard.Serum FABP3 level was detected by liquid phase protein chip.FPG,HbA1 c,and index of blood lipid were also detected.Result:Serum FABP3 level of coronary heart disease was higher than that of control?group,and FABP3 level was higher in multi-vessel disease than in single-vessel disease group(P<0.05).The serum FABP3 level of aspirin sensitive group was significantly higher than non-sensitive group(P<0.01).Conclusion:Serum FABP3 level can reflect the severity of coronary artery disease to some extent.There was a close relationship between the incidence of aspirin resistance and FABP3 level in patients with coronary heart disease.
Objective:To assay serum FABP3 level in patients with coronary heart disease(CHD) and explore the relationship between FABP3 and coronary artery disease severity as well as aspirin resistance in patients with coronary heart disease.Method:The 80 patients from department of cardiology,general hospital of chengdu military region from June 2017 to December 2017 were selected.There were 43 cases of coronary heart disease and 37 cases of control group.According to the number of coronary lesions,the groups were divided into single-vessel lesions and multi-vessel lesions.Patients with coronary heart disease were divided into aspirin sensitive group and aspirin non-sensitive group according to aspirin resistance standard.Serum FABP3 level was detected by liquid phase protein chip.FPG,HbA1 c,and index of blood lipid were also detected.Result:Serum FABP3 level of coronary heart disease was higher than that of control?group,and FABP3 level was higher in multi-vessel disease than in single-vessel disease group(P<0.05).The serum FABP3 level of aspirin sensitive group was significantly higher than non-sensitive group(P<0.01).Conclusion:Serum FABP3 level can reflect the severity of coronary artery disease to some extent.There was a close relationship between the incidence of aspirin resistance and FABP3 level in patients with coronary heart disease.
引文
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[14] 杨洋,徐娅,刘杨安,等.FABP3 基因对心肌细胞凋亡的影响[J].中国老年学杂志,2017,37(19):4734-4736.
[15] Undas A,Brummel‐Ziedins K,Mann KG.Why does aspirin decrease the risk of venous thromboembolism? On old and novel antithrombotic effects of acetyl salicylic acid[J].J Thromb Haemos,2014,12(11):1776-1787.
[16] Ulehlova J,Slavik L,Kucerova J,et al.Genetic polymorphisms of platelet receptors in patients with acute myocardial infarction and resistance to antiplatelet therapy[J].Gen Test Mol Biomarkers,2014,18(9):599-604.
[17] Gasparyan AY,Watson T,Lip GYH.The Role of Aspirin in cardiovascular prevention implications of aspirin resistance[J].J Am Coll Cardiol,2008,51(19):1829-1843.
[18] 王志军,张鹏宇,周建芝,等.冠心病合并糖尿病患者联合抗血小板药物抵抗的相关研究[J].临床心血管病杂志,2016,32(10):978-982.
[2] Ye X,He Y,Wang S,et al.Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis[J].Acta Pharmacol Sin,2018,39(7):1155-1163.
[3] 蔡玲,范雪梅,孙健,等.血清 H-FABP 和 cTnT 水平联合测定在急性心肌梗死诊断中的作用[J].临床心血管病杂志,2017,33(7):643-645.
[4] Kasmeridis C,Apostolakis S,Lip GYH.Aspirin and aspirin resistance in coronary artery disease[J].Curr Opin Pharm,2013,13(2):242-250.
[5] Shioda N,Yabuki Y,Kobayashi Y,et al.FABP3 protein promotes α-synuclein oligomerization associated with 1-methyl-1,2,3,6-tetrahydropiridine-induced neurotoxicity[J].J Biol Chem,2014,289(27):18957-18965.
[6] Khuseyinova N,Koenig W.Predicting the risk of cardiovascular disease[J].Mol Diag Ther,2007,11(4):203-217.
[7] 吕晓佟,刘鑫,王雪,等.AMI 患者血清 S100A12 水平与冠状动脉病变严重程度的关系[J].临床心血管病杂志,2018,34(6):588-592.
[8] Gum PA,Kottke-Marchant K,Poggio ED,et al.Profile and prevalence of aspirin resistance in patients with cardiovascular disease[J].Am J Cardiol,2001,88(3):230-235.
[9] 谢明水,刘国政,李玲,等.心肌脂肪酸结合蛋白对急性冠脉综合征冠脉病变程度的评估作用[J].山东医药,2012,52(36):60-61.
[10] Azzazy HME,Pelsers MM,Christenson RH.Unbound free fatty acids and heart-type fatty acid-binding protein:diagnostic assays and clinical applications[J].Clin Chem,2006,52(1):19-29.
[11] 沈亚卉.FABP3 基因表达沉默致心肌细胞凋亡的线粒体机制研究[D].南京医科大学,2012.
[12] Zimmerman AW,Veerkamp JH.New insights into the structure and function of fatty acid-binding proteins[J].Cell Mol Life Sci,2002,59(7):1096-1116.
[13] Li A,Wu L,Wang X,et al.Tissue expression analysis,cloning and characterization of the 5'-regulatory region of the bovine FABP3 gene[J].Mol Biol Rep,2016,43(9):991-998.
[14] 杨洋,徐娅,刘杨安,等.FABP3 基因对心肌细胞凋亡的影响[J].中国老年学杂志,2017,37(19):4734-4736.
[15] Undas A,Brummel‐Ziedins K,Mann KG.Why does aspirin decrease the risk of venous thromboembolism? On old and novel antithrombotic effects of acetyl salicylic acid[J].J Thromb Haemos,2014,12(11):1776-1787.
[16] Ulehlova J,Slavik L,Kucerova J,et al.Genetic polymorphisms of platelet receptors in patients with acute myocardial infarction and resistance to antiplatelet therapy[J].Gen Test Mol Biomarkers,2014,18(9):599-604.
[17] Gasparyan AY,Watson T,Lip GYH.The Role of Aspirin in cardiovascular prevention implications of aspirin resistance[J].J Am Coll Cardiol,2008,51(19):1829-1843.
[18] 王志军,张鹏宇,周建芝,等.冠心病合并糖尿病患者联合抗血小板药物抵抗的相关研究[J].临床心血管病杂志,2016,32(10):978-982.