蜈蚣藻化学成分研究
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摘要
目的研究蜈蚣藻化学成分。方法用色谱和光谱技术分离并鉴定其化学成分。结果从蜈蚣藻中分离鉴定17个化合物,分别为:1,3-二羟基-2-甲氧基-5-羟甲基苯(1),N-甲基-L-酪氨酸(2),苯乙酰胺(3),黑麦草内酯(4),3-乙酰基苯甲酰胺(5),2-亚乙基-3-甲基琥珀酸(6),4-N甲酰胺基正丁酸(7),降倍半萜S-(+)-去氢催吐萝芙叶醇(8),鸟嘌呤核苷(9),马来酸(10),对羟基苯乙酰胺(11),6-氨基己酸乙酯(12),4-N甲酰胺基正丁酸甲酯(13),N-(2-羟乙基)-正己酰胺(14),麦角甾醇(15),4-氨基丁酸甲酯(16)和2,5-二叔丁基苯酚(17)。结论该17个化合物均为首次从该种蜈蚣藻中分离到。
Objective To study the chemical constituents of Grateloupia filicina.Methods The seventeen compounds were isolated and purified by chromatography methods.Their chemical structures were identified by physico chemical analysis.Results The compounds isolated fromGrateloupia filicina were identified as:3,5-dihydroxy-4-methoxybenzyl alcohol(1),N-methyl-L-tyrosine(2),benzeneacetamide(3),loliolide(4),3-acetyl-benzamide(5),2-ethylidene-3-methyl-butanedioic acid(6),4-[(aminocarbonyl)amino]-butanoic acid(7),3,5,5-trimethyl-4-hydroxy-4-(1-buten-3-one)cyclohex-2-en-1-one(8),guanosine(9),maleic acid(10),4-hydroxy-benzeneacetamid(11),6-aminohexanoic acid ethyl ester(12),butanoic acid,4-[(aminocarbonyl)amino]-methyl ester(13),N-(2-hydroxyethyl)hexanamide(14),ergosterol(15),4-aminobutanoic acid methyl ester(16),2,5-bis(1,1-dimethylethyi)phenol(17).Conclusion The 17 compounds were obtained from the Grateloupia filicinafor the first time.
Objective To study the chemical constituents of Grateloupia filicina.Methods The seventeen compounds were isolated and purified by chromatography methods.Their chemical structures were identified by physico chemical analysis.Results The compounds isolated fromGrateloupia filicina were identified as:3,5-dihydroxy-4-methoxybenzyl alcohol(1),N-methyl-L-tyrosine(2),benzeneacetamide(3),loliolide(4),3-acetyl-benzamide(5),2-ethylidene-3-methyl-butanedioic acid(6),4-[(aminocarbonyl)amino]-butanoic acid(7),3,5,5-trimethyl-4-hydroxy-4-(1-buten-3-one)cyclohex-2-en-1-one(8),guanosine(9),maleic acid(10),4-hydroxy-benzeneacetamid(11),6-aminohexanoic acid ethyl ester(12),butanoic acid,4-[(aminocarbonyl)amino]-methyl ester(13),N-(2-hydroxyethyl)hexanamide(14),ergosterol(15),4-aminobutanoic acid methyl ester(16),2,5-bis(1,1-dimethylethyi)phenol(17).Conclusion The 17 compounds were obtained from the Grateloupia filicinafor the first time.
引文
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[17]赵贵钧,张崇禧,吴志军,等.肿柄菊乙酸乙酯部位的化学成分[J].第二军医大学学报,2010,31(2):189-192.
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[2]马凌波,王素娟,何培民.大型经济红藻蜈蚣藻类的室内人工育苗[J].上海水产大学学报,1995,4(2):93-98.
[3]张婧婧,刘秋凤,吴成业.蜈蚣藻多糖纯化及抗氧化作用的研究[J].福建水产,2013,35(5):362-366.
[4]Xu Y F,Wang B,Su C L.Chemical Constituents from Grateloupia filicina[J].Chin J Nat Med Sep,2010,8(5):326-329.
[5]王征,刘建利.冬虫夏草化学成分研究进展[J].中草药,2009,40(7):1157-1160.
[6]冯卫生,张志广,李孟,等.北葶苈子化学成分研究[J].中国药学杂志,2018,53(1):16-19.
[7]袁兆慧,韩丽君,范晓,等.红藻小珊瑚藻化学成分研究[J].中国中药杂志,2006,31(21):1787-1789.
[8]胡进国.邻乙酰基苯甲酰胺衍生物的合成[J].应用化工,2008,37(12):1468-1471.
[9]许文清,龚小见,周欣,等.马兰化学成分及生物活性研究[J].中国中药杂志,2010,35(23):3172-3174.
[10]丁成荣,李伟华,魏一凡,等.4-(N-乙基-3-甲基苯胺基)丁酸甲酯的合成[J].合成化学,2016,24(6):529-532.
[11]张怡评,韩顺风,方华,等.互花米草化学成分研究[J].中国海洋药物,2016,35(1):55-59.
[12]贾陆,李焕芬,敬林林,等.黄秋葵正丁醇部位化学成分研究[J].中草药,2010,41(11):1771-1773.
[13]尹建元,李桂英,王恩思.马来酸罗格列酮的核磁共振谱分析[J].分析化学,2003,31(10):1178-1182.
[14]李文林,毛士龙,易杨华,等.丰头皮海绵化学成分研究[J].中国海洋药物,2000,19(5):1-4.
[15]聂庆庆,范文来,徐岩,等.洋河系列绵柔型白酒香气成分研究[J].食品工业科技,2012,33(12):68-74.
[16]胡合新,孙斌,王恩泉.己内酰胺成品中挥发性碱杂质的研究[J].石油炼制与化工,2011,42(6):84-87.
[17]赵贵钧,张崇禧,吴志军,等.肿柄菊乙酸乙酯部位的化学成分[J].第二军医大学学报,2010,31(2):189-192.
[18]华会明,李铣,邢素娥,等.柳穿鱼化学成分的研究[J].中国药学杂志,2005,40(9):653-656.