中药注射剂辅助放化疗治疗对肿瘤患者生活质量影响的初步观察
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摘要
目的:探讨中药注射剂辅助放化疗治疗对肿瘤患者生活质量的影响。方法:76例肿瘤患者随机分为观察组以及对照组,每组38例。对照组根据肿瘤类型给予相应放化疗治疗措施,观察组在对照组基础上加用艾迪注射液或参芪扶正注射液静脉滴注。连续观察6周。治疗前后采用Karnofsky功能状态(KPS)评分、简体中文版生活质量评估表(QLQ-C30)评价两组患者生活质量。结果:观察组治疗后KPS评分较治疗前显著升高,而QLQ-C30评分则较前降低(P<0.05),且均优于对照组治疗后的评分(P<0.05)。结论:中药注射剂辅助放化疗治疗较单纯放化疗治疗肿瘤患者生活质量更获益。
Objective: To explore the influence of traditional Chinese medicine injection adjuvant chemoradiotherapy on the quality of life of cancer patients. Methods: Totally 76 cases of cancer patients were selection from PLA 307 hospital and randomly divided into the observation group and the control group with 38 ones in each group. The control group was given chemoradiation,and the observation group was given Aidi injection or Shenqi Fuzheng injection intravenously additionally. The treatment course was 4 weeks. Before and after the treatment,cartesian score( KPS),simplified Chinese quality of life assessment( QLQ C30) were used to evaluate the quality of life. Results: After the treatment,the KPS was higher than that before the treatment,while QLQ C30 score decreased and was better than that in the control group( P<0. 05). Conclusion: The traditional Chinese medicine injection adjuvant chemoradiotherapy is more beneficial to the quality of life of cancer patients than chemoradiortherapy only.
Objective: To explore the influence of traditional Chinese medicine injection adjuvant chemoradiotherapy on the quality of life of cancer patients. Methods: Totally 76 cases of cancer patients were selection from PLA 307 hospital and randomly divided into the observation group and the control group with 38 ones in each group. The control group was given chemoradiation,and the observation group was given Aidi injection or Shenqi Fuzheng injection intravenously additionally. The treatment course was 4 weeks. Before and after the treatment,cartesian score( KPS),simplified Chinese quality of life assessment( QLQ C30) were used to evaluate the quality of life. Results: After the treatment,the KPS was higher than that before the treatment,while QLQ C30 score decreased and was better than that in the control group( P<0. 05). Conclusion: The traditional Chinese medicine injection adjuvant chemoradiotherapy is more beneficial to the quality of life of cancer patients than chemoradiortherapy only.
引文
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3 王奇璐.肿瘤内科治疗的疗效评定[M]//周际昌.实用肿瘤内科学.北京:人民卫生出版社,1999:34-35
4 Aronson NK,Ahmedzai S,Bergman B,et al.The European Organization for Research and Treatment of Cancer QLQ-C30:a quality of life instrument for use in international clinical trials in oncology[J].J Natl Cancer Inst,1993,85(5):365-376
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7 朱亚兰,郭佳奕,包美蓉.参麦注射液辅助化疗治疗恶性肿瘤疗效的Meta分析[J].中国药房,2015.12:1654-1657
8 周维顺,刘振东,吴林生.肝癌中西医结合诊治原则[J].中国肿瘤,2003,12(9):512
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11 李娟,王娟,朱娅,等.艾迪注射液联合化疗方案治疗晚期非小细胞肺癌的临床观察[J].海南医学,2014,25(23):3444-3447
12 冷冬月.艾迪注射液联合TP方案治疗晚期卵巢上皮性癌术后的临床观察[D].武汉:湖北中医药大学硕士学位论文,2013
13 程斌,王增,周俐斐,娄广媛,杨国浓,翁琳.艾迪注射液联合GP化疗方案治疗晚期非小细胞肺癌临床疗效观察[J].中华中医药学刊,2014,32(7):1666-1668
14 梁爱华.近年来国内抗癌中草药药理研究[J].中草药研究,1991,5(1):55
15 张晓君,祝晨,胡黎,等.党参多糖对小鼠免疫和造血功能的影响[J].中药新药与临床药理,2003,14(3):174
2 张健.生活质量研究与恶性肿瘤的中医疗效评价[J].北京中医药大学学报,2000,23(2):67-69
3 王奇璐.肿瘤内科治疗的疗效评定[M]//周际昌.实用肿瘤内科学.北京:人民卫生出版社,1999:34-35
4 Aronson NK,Ahmedzai S,Bergman B,et al.The European Organization for Research and Treatment of Cancer QLQ-C30:a quality of life instrument for use in international clinical trials in oncology[J].J Natl Cancer Inst,1993,85(5):365-376
5 Aronson NK,Cull A,Kaasa S,et al.The EORTC modular approach to quality of life assessment in oncology[J].Int Ment Health,1994,23(4):75-96
6 Olschewski M,Schulgen G,Schumacher M,et al.Quality of life assessment in clinical cancer reaseach[J].Br J Cancer,1994,70:1-5
7 朱亚兰,郭佳奕,包美蓉.参麦注射液辅助化疗治疗恶性肿瘤疗效的Meta分析[J].中国药房,2015.12:1654-1657
8 周维顺,刘振东,吴林生.肝癌中西医结合诊治原则[J].中国肿瘤,2003,12(9):512
9 凌止鸿.艾迪注射液联合化疗治疗中晚期非小细胞肺癌的疗效观察[J].深圳中西医结合杂志,2014,24(3):24-25
10 朱广媛,李东华,张树范,等.艾迪注射液的临床研究进展[J].中医药学报,2010,38(1):123-127
11 李娟,王娟,朱娅,等.艾迪注射液联合化疗方案治疗晚期非小细胞肺癌的临床观察[J].海南医学,2014,25(23):3444-3447
12 冷冬月.艾迪注射液联合TP方案治疗晚期卵巢上皮性癌术后的临床观察[D].武汉:湖北中医药大学硕士学位论文,2013
13 程斌,王增,周俐斐,娄广媛,杨国浓,翁琳.艾迪注射液联合GP化疗方案治疗晚期非小细胞肺癌临床疗效观察[J].中华中医药学刊,2014,32(7):1666-1668
14 梁爱华.近年来国内抗癌中草药药理研究[J].中草药研究,1991,5(1):55
15 张晓君,祝晨,胡黎,等.党参多糖对小鼠免疫和造血功能的影响[J].中药新药与临床药理,2003,14(3):174