拉克替醇散与聚乙二醇电解质散在肠道准备中的效果比较
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摘要
目的探讨拉克替醇散与聚乙二醇电解质散在肠道准备中的效果。方法选取郑州大学第五附属医院2016年1—12月收治的200例行电子结肠镜检查的患者,按随机数表法分为实验组和对照组,各100例。实验组于结肠镜检查前5 h服用拉克替醇散4盒,对照组服用聚乙二醇电解质散4盒。观察两组患者服药后初次排便时间、服药到排便结束时间、初次排便到排便结束时间、排便次数及肠道BBPS评分;观察服药过程中不良反应发生率。结果实验组初次排便时间、服药到排便结束时间、初次排便到排便结束时间均较对照组长,差异有统计学意义(P<0.05);实验组恶心、呕吐、腹胀等不良反应发生率均低于对照组,差异有统计学意义(P<0.05);两组BBPS评分差异无统计学意义(P>0.05)。结论拉克替醇散与聚乙二醇电解质散肠道清洁效果相当,但拉克替醇散口感更好,肠道准备不适症状较轻,但准备时间稍长,值得临床推广。
Objective To compare the effect of lactitol and polyethylene glycol in the bowel Preparation. Methods A total of 200 patients who underwent electronic colonoscopy were enrolled and divided into experimental and control groups. The patients of experimental group received lactitol in bowel preparation and control group patients were treated with polyethylene glycol. The first defecation time after taking the medicine,the time of taking the medicine to the end of the defecation,the time of the first defecation to the end of the defecation,the number of defecation times,BBPS scores and drug side-effects were observed.Results The first defecation time after taking the medicine,the time of taking the medicine to the end of the defecation and the time of the first defecation to the end of the defecation in the experimental group were significantly longer than those of control group( P < 0. 05). However,the incidence of nausea,vomiting and abdominal distention in the experimental group was lower than that of control group,and the difference was statistically significant( P < 0. 05). There was no statistical difference between two groups in BBPS scores( P > 0. 05). Conclusion The effect of lachtiol and polyethylene glycol in bowel preparation was comparable. Alcohol has better taste,low complication rate and slightly longer preparation time.
Objective To compare the effect of lactitol and polyethylene glycol in the bowel Preparation. Methods A total of 200 patients who underwent electronic colonoscopy were enrolled and divided into experimental and control groups. The patients of experimental group received lactitol in bowel preparation and control group patients were treated with polyethylene glycol. The first defecation time after taking the medicine,the time of taking the medicine to the end of the defecation,the time of the first defecation to the end of the defecation,the number of defecation times,BBPS scores and drug side-effects were observed.Results The first defecation time after taking the medicine,the time of taking the medicine to the end of the defecation and the time of the first defecation to the end of the defecation in the experimental group were significantly longer than those of control group( P < 0. 05). However,the incidence of nausea,vomiting and abdominal distention in the experimental group was lower than that of control group,and the difference was statistically significant( P < 0. 05). There was no statistical difference between two groups in BBPS scores( P > 0. 05). Conclusion The effect of lachtiol and polyethylene glycol in bowel preparation was comparable. Alcohol has better taste,low complication rate and slightly longer preparation time.
引文
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[4]中华医学会消化病学分会,中华医学会肝病学分会.中国肝性脑病诊治共识意见(2013年,重庆)[J].中华消化杂志,2013,33(9):581-592.
[5]Delas N,Giston J,Glikmanas M,et al.Lactitol in the treatment of constipation in the adult[J].Ann Gastroenternl Hepatol,1991,27(5):231-233.
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[7]庄金福,叶建新,黄永健,等.拉克替醇术前清洁肠道的有效性及安全性对照观察[J].陕西医学杂志,2016,45(9):1196-1197.
[2]Miller L E,Tennila J,Ouwehand A C.Efficacy and tolerance of lactitol supplementation for adult constipation:a systematic review and metaanalysis[J].Clin Exp Gastroenterol,2014,7(1):241-248.
[3]Jang J Y,Chun H J.Bowel preparations as quality indicators for colonoscopy[J].World J Gastroenterol,2014,20(11):2746-2750.
[4]中华医学会消化病学分会,中华医学会肝病学分会.中国肝性脑病诊治共识意见(2013年,重庆)[J].中华消化杂志,2013,33(9):581-592.
[5]Delas N,Giston J,Glikmanas M,et al.Lactitol in the treatment of constipation in the adult[J].Ann Gastroenternl Hepatol,1991,27(5):231-233.
[6]信成夫,景文利,于丽,等.乳糖醇的性质及其在食品、保健品中的应用[J].中国食品添加剂,2016,(3):151-155.
[7]庄金福,叶建新,黄永健,等.拉克替醇术前清洁肠道的有效性及安全性对照观察[J].陕西医学杂志,2016,45(9):1196-1197.