血脂康降脂以外的心血管保护作用及机制研究进展
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摘要
心血管疾病是全球"头号杀手",其主要病理基础是动脉粥样硬化。血脂康以特制红曲为原料,对改善动脉粥样硬化具有积极意义。血脂康除能安全、有效降低血脂外,近年来其降脂以外的心血管获益也备受关注。研究表明,血脂康通过调节内皮功能、保护内皮祖细胞、改善氧化应激和减轻炎症反应等多种机制发挥抗动脉粥样硬化作用,本文从以上几方面综述血脂康抗动脉粥样硬化、心血管保护的研究进展。
Cardiovascular disease(CVD) has been one of the leading causes of mortality worldwide,and atherosclerosis(As) is a common pathogenic basis for CVD. Xuezhikang is a purified extract of fermented red yeast rice with benefits to improvement of As. Apart from being a safe and effective lipid-lowering drug,Xuezhikang has drawn growing awareness due to its cardiovascular protection beyond lipid modulation. Studies have shown that Xuezhikang exerts its anti-atherosclerotic function via mechanisms as the following: regulation of endothelial function,protection for endothelial progentitor cells,alleviation of oxidative stress and attenuation of inflammation.This article reviews the research progress of Xuezhikang on cardiovascular protection against atherosclerosis from the above aspects.
Cardiovascular disease(CVD) has been one of the leading causes of mortality worldwide,and atherosclerosis(As) is a common pathogenic basis for CVD. Xuezhikang is a purified extract of fermented red yeast rice with benefits to improvement of As. Apart from being a safe and effective lipid-lowering drug,Xuezhikang has drawn growing awareness due to its cardiovascular protection beyond lipid modulation. Studies have shown that Xuezhikang exerts its anti-atherosclerotic function via mechanisms as the following: regulation of endothelial function,protection for endothelial progentitor cells,alleviation of oxidative stress and attenuation of inflammation.This article reviews the research progress of Xuezhikang on cardiovascular protection against atherosclerosis from the above aspects.
引文
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[14]BALAKUMAR P,KATHURIA S,TANEJA G,et al.Is targeting e NOS a key mechanistic insight of cardiovascular defensive potentials of statins?[J].J Mol Cell Cardiol,2012,52(1):83-92.
[15]CHEN Z,DS OS,ZIMNICKA AM,et al.Reciprocal regulation of e NOS and caveolin-1 functions in endothelial cells[J].Mol Biol Cell,2018,29(10):1190-1202.
[16]BIANCONI V,MANNARINO MR,SAHEBKAR A,et al.Cholesterol-lowering nutraceuticals affecting vascular function and cardiovascular disease risk[J].Curr Cardiol Rep,2018,20(7):53.
[17]KONG XQ,WANG MZ,WANG LX,et al.Effects of xuezhikang on proliferation and adhesion capacity of cultured endothelial progenitor cells:An in vitro study[J].Curr Ther Res Clin Exp,2008,69(3):252-259.
[18]LIU JT,CHEN HY,CHEN WC,et al.Red yeast rice protects circulating bone marrow-derived proangiogenic cells against highglucose-induced senescence and oxidative stress:the role of heme oxygenase-1[J].Oxid Med Cell Longev,2017,2017:3831750.
[19]薛铸,郑士富,朱秉匡.血脂康对中老年早期糖尿病肾病患者血脂的影响及肾脏保护的作用[J].中国老年学杂志,2018,38(12):2852-2854.
[20]STUPIN A,COSIC A,NOVAK S,et al.Reduced dietary selenium impairs vascular function by increasing oxidative stress in sprague-dawley rat aortas[J].Int J Environ Res Public Health,2017,14(6):piiE 591.
[21]王俊,张珍,邵加庆,等.血脂康对db/db糖尿病小鼠胰岛分泌功能和氧化应激影响的研究[J].中国糖尿病杂志,2015(2):169-173.
[22]LIN CH,LIN TH,PAN TM.Alleviation of metabolic syndrome by monascin and ankaflavin:the perspective of Monascus functional foods[J].Food Funct,2017,8(6):2102-2109.
[23]BARTEKOVA M,RADOSINSKA J,JELEMENSKY M,et al.Role of cytokines and inflammation in heart function during health and disease[J].Heart Fail Rev,2018,23(5):733-758.
[24]袁千,王凌.中国药典2015年版收载治疗高血压的中成药用药特点研究[J].中国现代应用药学,2017,34(4):530-532.
[2]陈伟伟,高润霖,刘力生,等.《中国心血管病报告2017》概要[J].中国循环杂志,2018,33(1):1-8.
[3]中国老年学和老年医学学会心脑血管病专业委员会,血脂康(胶囊)临床应用中国专家共识组.血脂康(胶囊)临床应用中国专家共识(2017修订版)[J].中华内科杂志,2018,57(2):97-100.
[4]陈盼盼,江龙,王伟,等.血脂康对血清胆固醇代谢标志物的影响及其降脂机制初步探究[J].中国医药,2017,12(1):28-32.
[5]王丽娟,陈四喜,杨雁冰,等.HPLC法测定血脂康胶囊中Monacolin类成分的含量[J].中国疗养医学,2015,24(5):479-481.
[6]SHEN L,SUN Z,CHU S,et al.Xuezhikang,an extract from red yeast rice,attenuates vulnerable plaque progression by suppressing endoplasmic reticulum stress-mediated apoptosis and inflammation[J].PLoS One,2017,12(11):e0188841.
[7]FENG D,GE C,TAN ZY,et al.Isoflavones enhance pharmacokinetic exposure of active lovastatin acid via the upregulation of carboxylesterase in high-fat diet mice after oral administration of Xuezhikang capsules[J].Acta Pharmacol Sin,2018,39(11):1804-1805.
[8]FENG Y,XU H,CHEN K.Natural polypill Xuezhikang:its clinical benefit and potential multicomponent synergistic mechanisms of action in cardiovascular disease and other chronic conditions[J].J Altern Complement Med,2012,18(4):318-328.
[9]胡敏,郭树仁,孙晓波.血脂康心血管保护作用临床研究进展[J].中国药物与临床,2017,17(1):66-69.
[10]XIONG X,WANG P,LI X,et al.The effects of red yeast rice dietary supplement on blood pressure,lipid profile,and C-reactive protein in hypertension:A systematic review[J].Crit Rev Food Sci Nutr,2017,57(9):1831-1851.
[11]PENG W,LAUCHE R,FERGUSON C,et al.Efficacy of Chinese herbal medicine for stroke modifiable risk factors:a systematic review[J].Chin Med,2017,12:25.
[12]ZHENG J,XIAO T,YE P,et al.Xuezhikang reduced arterial stiffness in patients with essential hypertension:a preliminary study[J].Braz J Med Biol Res,2017,50(10):e6363.
[13]王炎焱,赵征,黄烽,等.红曲抗炎作用的实验研究[J].中国新药杂志,2006,15(2):96-98.
[14]BALAKUMAR P,KATHURIA S,TANEJA G,et al.Is targeting e NOS a key mechanistic insight of cardiovascular defensive potentials of statins?[J].J Mol Cell Cardiol,2012,52(1):83-92.
[15]CHEN Z,DS OS,ZIMNICKA AM,et al.Reciprocal regulation of e NOS and caveolin-1 functions in endothelial cells[J].Mol Biol Cell,2018,29(10):1190-1202.
[16]BIANCONI V,MANNARINO MR,SAHEBKAR A,et al.Cholesterol-lowering nutraceuticals affecting vascular function and cardiovascular disease risk[J].Curr Cardiol Rep,2018,20(7):53.
[17]KONG XQ,WANG MZ,WANG LX,et al.Effects of xuezhikang on proliferation and adhesion capacity of cultured endothelial progenitor cells:An in vitro study[J].Curr Ther Res Clin Exp,2008,69(3):252-259.
[18]LIU JT,CHEN HY,CHEN WC,et al.Red yeast rice protects circulating bone marrow-derived proangiogenic cells against highglucose-induced senescence and oxidative stress:the role of heme oxygenase-1[J].Oxid Med Cell Longev,2017,2017:3831750.
[19]薛铸,郑士富,朱秉匡.血脂康对中老年早期糖尿病肾病患者血脂的影响及肾脏保护的作用[J].中国老年学杂志,2018,38(12):2852-2854.
[20]STUPIN A,COSIC A,NOVAK S,et al.Reduced dietary selenium impairs vascular function by increasing oxidative stress in sprague-dawley rat aortas[J].Int J Environ Res Public Health,2017,14(6):piiE 591.
[21]王俊,张珍,邵加庆,等.血脂康对db/db糖尿病小鼠胰岛分泌功能和氧化应激影响的研究[J].中国糖尿病杂志,2015(2):169-173.
[22]LIN CH,LIN TH,PAN TM.Alleviation of metabolic syndrome by monascin and ankaflavin:the perspective of Monascus functional foods[J].Food Funct,2017,8(6):2102-2109.
[23]BARTEKOVA M,RADOSINSKA J,JELEMENSKY M,et al.Role of cytokines and inflammation in heart function during health and disease[J].Heart Fail Rev,2018,23(5):733-758.
[24]袁千,王凌.中国药典2015年版收载治疗高血压的中成药用药特点研究[J].中国现代应用药学,2017,34(4):530-532.