水环境中PPCPs检测技术及风险评价研究进展
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摘要
概述了目前水环境中药物及个人护理品(PPCPs)的检测技术,对比分析了常用的水样前处理方法和仪器分析技术的原理、优缺点,介绍了PPCPs的风险评价体系,总结了人体健康风险和生态风险的评价方法,并综述了不同PPCPs的风险水平。指出多技术联合、精准定量的检测技术和综合风险评价方法是今后环境领域PPCPs研究的重点。
The detection technology of aquatic pharmaceuticals and personal care products( PPCPs) were summarized. The principles,advantages and disadvantages of the sample pretreatment method and instrument analysis technology were analyzed and compared. The risk assessment systems of aquatic PPCPs were introduced and the methods of human health risks and ecological risk assessment were summarized. The risk level of different PPCPs was reviewed. It is pointed out that multi-technique combination,precise quantitative detection technology and comprehensive risk assessment method are the key points of PPCPs research in the future.
The detection technology of aquatic pharmaceuticals and personal care products( PPCPs) were summarized. The principles,advantages and disadvantages of the sample pretreatment method and instrument analysis technology were analyzed and compared. The risk assessment systems of aquatic PPCPs were introduced and the methods of human health risks and ecological risk assessment were summarized. The risk level of different PPCPs was reviewed. It is pointed out that multi-technique combination,precise quantitative detection technology and comprehensive risk assessment method are the key points of PPCPs research in the future.
引文
[1]杨晓凡,陆光华,万杰,等.水环境中药物污染、检测及去除研究进展[J].水资源保护,2012,28(2):1-7.(YANG Xiaofan,LU Guanghua,WAN Jie,et al.A review of residue,detection,and removal of pharmaceuticals in aquatic environment[J].Water Resources Protection,2012,28(2):1-7.(in Chinese))
[2]郑少奎,李晓锋.城市污水处理厂出水中的药品和个人护理品[J].环境科学,2013,34(8):3317-3327.(ZHENG Shaokui,LI Xiaofeng.Pharmaceuticals and personal care products(PPCPs)in the effluent of sewage treatment plants[J].Environmental Science,2013,34(8):3317-3327.(in Chinese))
[3]陈月,王风贺,陆建刚,等.长江流域药品和个人护理用品污染状况的研究进展[J].工业水处理,2016,36(7):11-15.(CHEN Yue,WANG Fenghe,LU Jiangang,et al.Research progress in pharmaceutical and personal care products(PPCPs)in the Yangtze River Valley,China[J].Industrial Water Treatment,2016,36(7):11-15.(in Chinese))
[4]张芹,张圣虎,汪贞,等.骆马湖表层水体中32种PPCPs类物质的污染水平、分布特征及风险评估[J].环境科学,2017,38(1):163-170.(ZHANG Qin,ZHANG Shenghu,WANG Zhen,et al.Pollution level,distribution characteristics and risk assessment of 32 PPCPs in surface water of Luomahu Lake[J].Environmental Science,2017,38(1):163-170.(in Chinese))
[5]YAO L,WANG Y,TONG L,et al.Occurrence and risk assessment of antibiotics in surface water and groundwater from different depths of aquifers:a case study at Jianghan Plain,central China[J].Ecotoxicology and Environmental Safety,2017,135:236-242.
[6]LOOS R,CARVALHO R,ANTóNIO D C,et al.EU-wide monitoring survey on emerging polar organic contaminants in wastewater treatment plant effluents[J].Water Research,2013,47(17):6475-6487.
[7]PRABHASANKAR V P,JOSHUA D I,BALAKRISHNA K,et al.Removal rates of antibiotics in four sewage treatment plants in South India[J].Environmental Science and Pollution Research,2016,23(9):8679-8685.
[8]潘潇,强志民,王为东.巢湖东半湖饮用水源区沉积物药品和个人护理品(PPCPs)分布与生态风险[J].环境化学,2016,35(11):2234-2244.(PAN Xiao,QIANG Zhimin,WANG Weidong.Distribution and ecological risk of sedimentary PPCPs in the eastern drinking water source area of Chaohu Lake[J].Environmental Chemistry,2016,35(11):2234-2244.(in Chinese))
[9]金磊,姜蕾,韩琪,等.华东地区某水源水中13种磺胺类抗生素的分布特征及人体健康风险评价[J].环境科学,2016,37(7):2515-2521.(JIN Lei,JIANG Lei,HAN Qi,et al.Distribution characteristics and health risk assessment of thirteen sulfonamides antibiotics in a drinking water source in east China[J].Environmental Science,2016,37(7):2515-2521.(in Chinese))
[10]PAPAGEORGIOU M,KOSMA C,LAMBROPOULOU D.Seasonal occurrence,removal,mass loading and environmental risk assessment of 55 pharmaceuticals and personal care products in a municipal wastewater treatment plant in Central Greece[J].Science of the Total Environment,2016,543:547-569.
[11]CUNHA V,BURKHARDT-MEDICKE K,WELLNER P,et al.Effects of pharmaceuticals and personal care products(PPCPs)on multixenobiotic resistance(MXR)related efflux transporter activity in zebrafish(Danio rerio)embryos[J].Ecotoxicology and Environmental Safety,2017,136:14-23.
[12]YAN Z,LU G,YE Q,et al.Long-term effects of antibiotics,norfloxacin,and sulfamethoxazole,in a partial life-cycle study with zebrafish(Danio rerio):effects on growth,development,and reproduction[J].Environmental Science and Pollution Research,2016,23(18):18222-18228.
[13]LIU J,LU G,WANG Y,et al.Bioconcentration,metabolism,and biomarker responses in freshwater fish Carassius auratus exposed to roxithromycin[J].Chemosphere,2014,99(3):102-108.
[14]ARPIN-PONT L,BUENO M J M,GOMEZ E,et al.Occurrence of PPCPs in the marine environment:a review[J].Environmental Science and Pollution Research,2016,23(6):4978-4991.
[15]MARUBE L C,CALDAS S S,SOARES K L,et al.Dispersive liquid-liquid microextraction with solidification of floating organic droplets for simultaneous extraction of pesticides,pharmaceuticals and personal care products[J].Microchimica Acta,2015,182(9/10):1765-1774.
[16]CALDAS S S,ROMBALDI C,DE OLIVEIRA ARIAS J L,et al.Multi-residue method for determination of 58pesticides,pharmaceuticals and personal care products in water using solvent demulsification dispersive liquid–liquid microextraction combined with liquid chromatography-tandem mass spectrometry[J].Talanta,2016,146(2):676-688.
[17]曹江平,邸宏伟,周继梅,等.分散液液微萃取技术的研究进展[J].分析测试学报,2016,35(7):913-921.(CAO Jiangping,DAI Hongwei,ZHOU Jimei,et al.A review on dispersive liquid-liquid microextraction method[J].Journal of Instrumental Analysis,2016,35(7):913-921.(in Chinese))
[18]KOSMA C I,LAMBROPOULOU D A,ALBANIS T A.Investigation of PPCPs in wastewater treatment plants in Greece:occurrence,removal and environmental risk assessment[J].Science of the Total Environment,2014,466/467:421-438.
[19]BASAGLIA G,PIETROGRANDE M C.Optimization of a SPME/GC/MS method for the simultaneous determination of pharmaceuticals and personal care products in waters[J].Chromatographia,2012,75(7/8):361-370.
[20]张军,王晶晶,彭华,等.SPME-HPLC法测定废水中硝基苯酚类化合物[J].环境监测管理与技术,2015,27(1):35-38.(ZHANG Jun,WANG Jingjing,PENG Hua,et al.Determination of nitrophenols in waste water by solid phase microextraction and high performance liquid chromatography[J].The Administration and Technique of Environmental Monitoring,2015,27(1):35-38.(in Chinese))
[21]OCHIAI N,IEDA T,SASAMOTO K,et al.Stir bar sorptive extraction and comprehensive two-dimensional gas chromatography coupled to high-resolution time-of-flight mass spectrometry for ultra-trace analysis of organochlorine pesticides in river water[J].Journal of Chromatography A,2011,1218(39):6851-6860.
[22]UBUKATA M,JOBST K J,REINER E J,et al.Nontargeted analysis of electronics waste by comprehensive two-dimensional gas chromatography combined with highresolution mass spectrometry:Using accurate mass information and mass defect analysis to explore the data[J].Journal of Chromatography A,2015,1395:152-159.
[23]夏丹,高丽荣,郑明辉.全二维气相色谱分析持久性有机污染物的应用进展[J].色谱,2017,35(1):91-98.(XIA Dan,GAO Lirong,ZHENG Minghui.Recent developments in comprehensive two-dimensional gas chromatography for the anlaysis of persistent organic pollutants[J].Chinese Journal of Chromatography,2017,35(1):91-98.(in Chinese))
[24]文一,姚瑞华,孙宏亮,等.高效液相色谱法测定地下水中洛克沙胂[J].环境监测管理与技术,2016,28(1):58-59.(WEN Yi,YAO Ruihua,SUN Hongliang,et al.Determination of roxarsone in groundwater with high performance liquid chromatography[J].The Administration and Technique of Environmental Monitoring,2016,28(1):58-59.(in Chinese))
[25]CHEN F,GONG Z,KELLY B C.Rapid analysis of pharmaceuticals and personal care products in fish plasma micro-aliquots using liquid chromatography tandem mass spectrometry[J].Journal of Chromatography A,2015,1383:104-111.
[26]张祥民.色谱-质谱技术在生物分析研究中的最新进展[J].色谱,2017,35(1):138-140.(ZHENG Xiangmin.Recent advances in chromatography-mass spectrometry in bioanalytical research[J].Chinese Journal of Chromatography,2017,35(1):138-140.(in Chinese))
[27]周弛,王斐,张会强,等.HPLC和HPLC-MS/MS测定地表水中酚类化合物[J].环境监测管理与技术,2016,28(4):46-49.(ZHOU Chi,WANG Fei,ZHANG Huiqiang,et al.Determination of phenols in surface water by high performance liquidchromatography-diode array detection and high performance liquidchromatography-tandem mass spectrometry[J].The Administration and Technique of Environmental Monitoring,2016,28(4):46-49.(in Chinese))
[28]LING J,YU Y,ZHU J,et al.A highly sensitive HPLC–MS/MS method for quantification of 20(S)-protopanaxadiol in human plasma and its application in phase IIa clinical trial of a novel antidepressant agent[J].Journal of Chromatography B:Analyt Technol Biomed Life Sci,2016,1031:214-220.
[29]HAI-XIA L I U,YAO-XIA Y,MA M G,et al.Selfassembled gold nanoparticles coating for solid-phase microextraction of ultraviolet filters in environmental water[J].Chinese Journal of Analytical Chemistry,2015,43(2):207-211.
[30]TOGUNDE O P,CUDJOE E,OAKES K D,et al.Determination of selected pharmaceutical residues in wastewater using an automated open bed solid phase microextraction system[J].Journal of Chromatography A,2012,1262:34-42.
[31]BARBOSA M O,RIBEIRO A R,PEREIRA M F R,et al.Eco-friendly LC–MS/MS method for analysis of multiclass micropollutants in tap,fountain,and well water from northern Portugal[J].Analytical and Bioanalytical Chemistry,2016,408(29):8355-8367.
[32]BAZREGAR M,RAJABI M,YAMINI Y,et al.Tandem air-agitated liquid–liquid microextraction as an efficient method for determination of acidic drugs in complicated matrices[J].Analytica Chimica Acta,2016,1429:14-21.
[33]顾海东,尹燕敏,秦宏兵.超高效液相色谱三重四级杆质谱联用法测定水中喹诺酮类抗生素[J].环境监测管理与技术,2013,25(3):34-37.(GU Haidong,YIN Yanmin,QIN Hongbing.Determination of quinolone in water samples by solid phase extraction-ultra performance liquid chromatographelectrospray tandem mass spectrometry[J].The Administration and Technique of Environmental Monitoring,2013,25(3):34-37.(in Chinese))
[34]谢正鑫,陆光华,孙丽莎,等.水环境中药物及个人护理品(PPCPs)的生物降解研究进展[J].水资源保护,2013,29(4):5-11.(XIE Zhengxin,LU Guanghua,SUN Lisha,et al.A review of biodegradation of pharmaceuticals and personal care products(PPCPs)in aqueous environment[J].Water Resources Protection,2013,29(4):5-11.(in Chinese))
[35]EPA(US Environmental Protection Agency).Framework for ecological risk assessment.EPA630-R-92-001[R].Office of Research and Development,Washington D C,USA,1992.
[36]CHEN Y,VYMAZAL J,B?倲EZINOVáT,et al.Occurrence,removal and environmental risk assessment of pharmaceuticals and personal care products in rural wastewater treatment wetlands[J].Science of the Total Environment,2016,566/567:1660-1669.
[37]李勇,蒋婷婷,景龙飞,等.舟山岛水库有机农药和抗生素残留特征及潜在风险评估[J].水资源保护,2014,30(3):31-37.(LI Yong,JIANG Tingting,JING Longfei,et al.Characteristics of residual organic pesticides and antibiotics in reservoirs of Zhoushan Islands and potential risk evaluation[J].Water Resources Protection,2014,30(3):31-37.(in Chinese))
[38]ARCHER E,PETRIE B,KASPRZYK-HORDERN B,et al.The fate of pharmaceuticals and personal care products(PPCPs),endocrine disrupting contaminants(EDCs),metabolites and illicit drugs in a WWTW and environmental waters[J].Chemosphere,2017,174:437-446.
[39]PROSSER R S,SIBLEY P K.Human health risk assessment of pharmaceuticals and personal care products in plant tissue due to biosolids and manure amendments,and wastewater irrigation[J].Environment International,2015,75(75C):223-233.
[40]HARRISON E M,PATERSON G K,HOLDEN M T,et al.Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mec A homologue mec C[J].Embo Molecular Medicine,2013,5(4):509-515.
[41]汪涛,杨再福,陈勇航,等.地表水中磺胺类抗生素的生态风险评价[J].生态环境学报2016,25(9):1508-1514.(WANG Tao,YANG Zaifu,CHEN Yonghang,et al.Ecological risk assessment for sulfonamides in surface waters[J].Ecology and Environmental Sciences,2016,25(9):1508-1514.(in Chinese))
[42]YAN Z,YANG X,LU G,et al.Potential environmental implications of emerging organic contaminants in Taihu Lake,China:comparison of two ecotoxicological assessment approaches[J].Science of the Total Environment,2014,470/471:171-179.
[43]LIU J,LU G,XIE Z,et al.Occurrence,bioaccumulation and risk assessment of lipophilic pharmaceutically active compounds in the downstream rivers of sewage treatment plants[J].Science of the Total Environment,2015,511:54-62.
[44]HOYETT Z,OWENS M A,CLARK C J,et al.A comparative evaluation of environmental risk assessment strategies for pharmaceuticals and personal care products[J].Ocean&Coastal Management,2016,127:74-80.
[45]GHEORGHE S,PETRE J,LUCACIU I,et al.Risk screening of pharmaceutical compounds in Romanian aquatic environment[J].Environmental Monitoring and Assessment,2016,188(6):1-16.
[46]PAPAGEORGIOU M,KOSMA C,LAMBROPOULOU D.Seasonal occurrence,removal,mass loading and environmental risk assessment of 55 pharmaceuticals and personal care products in a municipal wastewater treatment plant in Central Greece[J].Science of the Total Environment,2016,543(Pt A):547-569.
[47]GUO J,SELBY K,BOXALL A B A.Assessment of the risks of mixtures of major use veterinary antibiotics in european surface waters[J].Environmental Science&Technology,2016,50(15):8282-8289.
[48]DAOUK S,CHèVRE N,VERNAZ N,et al.Dynamics of active pharmaceutical ingredients loads in a Swiss university hospital wastewaters and prediction of the related environmental risk for the aquatic ecosystems[J].Science of the Total Environment,2016,547:244-253.
[49]MINGUEZ L,PEDELUCQ J,FARCY E,et al.Toxicities of48 pharmaceuticals and their freshwater and marine environmental assessment in northwestern France[J].Environmental Science and Pollution Research,2016,23(6):4992-5001.
[50]程斌,王菲凤,张江山.改进决策树模型支持下的饮用水水源地健康风险评价[J].水资源保护,2013,29(1):27-31.(CHENG Bin,WANG Feifeng,ZHANG Jingshan.An improved decision tree model for health risk assessment of drinking water source[J].Water Resources Protection,2013,29(1):27-31.(in Chinese))
[51]罗慧萍,逄勇,罗缙,等.泰州市第三自来水厂饮用水水源地水环境风险评价[J].河海大学学报(自然科学版),2015,43(2):114-120.(LUO Huiping,PANG Yong,LUO Jing,et al.Water environment risk assessment of Taizhou Three Waterworks drinking water source area[J].Journal of Hohai University(Natural Sciences),2015,43(2):114-120.(in Chinese))
[2]郑少奎,李晓锋.城市污水处理厂出水中的药品和个人护理品[J].环境科学,2013,34(8):3317-3327.(ZHENG Shaokui,LI Xiaofeng.Pharmaceuticals and personal care products(PPCPs)in the effluent of sewage treatment plants[J].Environmental Science,2013,34(8):3317-3327.(in Chinese))
[3]陈月,王风贺,陆建刚,等.长江流域药品和个人护理用品污染状况的研究进展[J].工业水处理,2016,36(7):11-15.(CHEN Yue,WANG Fenghe,LU Jiangang,et al.Research progress in pharmaceutical and personal care products(PPCPs)in the Yangtze River Valley,China[J].Industrial Water Treatment,2016,36(7):11-15.(in Chinese))
[4]张芹,张圣虎,汪贞,等.骆马湖表层水体中32种PPCPs类物质的污染水平、分布特征及风险评估[J].环境科学,2017,38(1):163-170.(ZHANG Qin,ZHANG Shenghu,WANG Zhen,et al.Pollution level,distribution characteristics and risk assessment of 32 PPCPs in surface water of Luomahu Lake[J].Environmental Science,2017,38(1):163-170.(in Chinese))
[5]YAO L,WANG Y,TONG L,et al.Occurrence and risk assessment of antibiotics in surface water and groundwater from different depths of aquifers:a case study at Jianghan Plain,central China[J].Ecotoxicology and Environmental Safety,2017,135:236-242.
[6]LOOS R,CARVALHO R,ANTóNIO D C,et al.EU-wide monitoring survey on emerging polar organic contaminants in wastewater treatment plant effluents[J].Water Research,2013,47(17):6475-6487.
[7]PRABHASANKAR V P,JOSHUA D I,BALAKRISHNA K,et al.Removal rates of antibiotics in four sewage treatment plants in South India[J].Environmental Science and Pollution Research,2016,23(9):8679-8685.
[8]潘潇,强志民,王为东.巢湖东半湖饮用水源区沉积物药品和个人护理品(PPCPs)分布与生态风险[J].环境化学,2016,35(11):2234-2244.(PAN Xiao,QIANG Zhimin,WANG Weidong.Distribution and ecological risk of sedimentary PPCPs in the eastern drinking water source area of Chaohu Lake[J].Environmental Chemistry,2016,35(11):2234-2244.(in Chinese))
[9]金磊,姜蕾,韩琪,等.华东地区某水源水中13种磺胺类抗生素的分布特征及人体健康风险评价[J].环境科学,2016,37(7):2515-2521.(JIN Lei,JIANG Lei,HAN Qi,et al.Distribution characteristics and health risk assessment of thirteen sulfonamides antibiotics in a drinking water source in east China[J].Environmental Science,2016,37(7):2515-2521.(in Chinese))
[10]PAPAGEORGIOU M,KOSMA C,LAMBROPOULOU D.Seasonal occurrence,removal,mass loading and environmental risk assessment of 55 pharmaceuticals and personal care products in a municipal wastewater treatment plant in Central Greece[J].Science of the Total Environment,2016,543:547-569.
[11]CUNHA V,BURKHARDT-MEDICKE K,WELLNER P,et al.Effects of pharmaceuticals and personal care products(PPCPs)on multixenobiotic resistance(MXR)related efflux transporter activity in zebrafish(Danio rerio)embryos[J].Ecotoxicology and Environmental Safety,2017,136:14-23.
[12]YAN Z,LU G,YE Q,et al.Long-term effects of antibiotics,norfloxacin,and sulfamethoxazole,in a partial life-cycle study with zebrafish(Danio rerio):effects on growth,development,and reproduction[J].Environmental Science and Pollution Research,2016,23(18):18222-18228.
[13]LIU J,LU G,WANG Y,et al.Bioconcentration,metabolism,and biomarker responses in freshwater fish Carassius auratus exposed to roxithromycin[J].Chemosphere,2014,99(3):102-108.
[14]ARPIN-PONT L,BUENO M J M,GOMEZ E,et al.Occurrence of PPCPs in the marine environment:a review[J].Environmental Science and Pollution Research,2016,23(6):4978-4991.
[15]MARUBE L C,CALDAS S S,SOARES K L,et al.Dispersive liquid-liquid microextraction with solidification of floating organic droplets for simultaneous extraction of pesticides,pharmaceuticals and personal care products[J].Microchimica Acta,2015,182(9/10):1765-1774.
[16]CALDAS S S,ROMBALDI C,DE OLIVEIRA ARIAS J L,et al.Multi-residue method for determination of 58pesticides,pharmaceuticals and personal care products in water using solvent demulsification dispersive liquid–liquid microextraction combined with liquid chromatography-tandem mass spectrometry[J].Talanta,2016,146(2):676-688.
[17]曹江平,邸宏伟,周继梅,等.分散液液微萃取技术的研究进展[J].分析测试学报,2016,35(7):913-921.(CAO Jiangping,DAI Hongwei,ZHOU Jimei,et al.A review on dispersive liquid-liquid microextraction method[J].Journal of Instrumental Analysis,2016,35(7):913-921.(in Chinese))
[18]KOSMA C I,LAMBROPOULOU D A,ALBANIS T A.Investigation of PPCPs in wastewater treatment plants in Greece:occurrence,removal and environmental risk assessment[J].Science of the Total Environment,2014,466/467:421-438.
[19]BASAGLIA G,PIETROGRANDE M C.Optimization of a SPME/GC/MS method for the simultaneous determination of pharmaceuticals and personal care products in waters[J].Chromatographia,2012,75(7/8):361-370.
[20]张军,王晶晶,彭华,等.SPME-HPLC法测定废水中硝基苯酚类化合物[J].环境监测管理与技术,2015,27(1):35-38.(ZHANG Jun,WANG Jingjing,PENG Hua,et al.Determination of nitrophenols in waste water by solid phase microextraction and high performance liquid chromatography[J].The Administration and Technique of Environmental Monitoring,2015,27(1):35-38.(in Chinese))
[21]OCHIAI N,IEDA T,SASAMOTO K,et al.Stir bar sorptive extraction and comprehensive two-dimensional gas chromatography coupled to high-resolution time-of-flight mass spectrometry for ultra-trace analysis of organochlorine pesticides in river water[J].Journal of Chromatography A,2011,1218(39):6851-6860.
[22]UBUKATA M,JOBST K J,REINER E J,et al.Nontargeted analysis of electronics waste by comprehensive two-dimensional gas chromatography combined with highresolution mass spectrometry:Using accurate mass information and mass defect analysis to explore the data[J].Journal of Chromatography A,2015,1395:152-159.
[23]夏丹,高丽荣,郑明辉.全二维气相色谱分析持久性有机污染物的应用进展[J].色谱,2017,35(1):91-98.(XIA Dan,GAO Lirong,ZHENG Minghui.Recent developments in comprehensive two-dimensional gas chromatography for the anlaysis of persistent organic pollutants[J].Chinese Journal of Chromatography,2017,35(1):91-98.(in Chinese))
[24]文一,姚瑞华,孙宏亮,等.高效液相色谱法测定地下水中洛克沙胂[J].环境监测管理与技术,2016,28(1):58-59.(WEN Yi,YAO Ruihua,SUN Hongliang,et al.Determination of roxarsone in groundwater with high performance liquid chromatography[J].The Administration and Technique of Environmental Monitoring,2016,28(1):58-59.(in Chinese))
[25]CHEN F,GONG Z,KELLY B C.Rapid analysis of pharmaceuticals and personal care products in fish plasma micro-aliquots using liquid chromatography tandem mass spectrometry[J].Journal of Chromatography A,2015,1383:104-111.
[26]张祥民.色谱-质谱技术在生物分析研究中的最新进展[J].色谱,2017,35(1):138-140.(ZHENG Xiangmin.Recent advances in chromatography-mass spectrometry in bioanalytical research[J].Chinese Journal of Chromatography,2017,35(1):138-140.(in Chinese))
[27]周弛,王斐,张会强,等.HPLC和HPLC-MS/MS测定地表水中酚类化合物[J].环境监测管理与技术,2016,28(4):46-49.(ZHOU Chi,WANG Fei,ZHANG Huiqiang,et al.Determination of phenols in surface water by high performance liquidchromatography-diode array detection and high performance liquidchromatography-tandem mass spectrometry[J].The Administration and Technique of Environmental Monitoring,2016,28(4):46-49.(in Chinese))
[28]LING J,YU Y,ZHU J,et al.A highly sensitive HPLC–MS/MS method for quantification of 20(S)-protopanaxadiol in human plasma and its application in phase IIa clinical trial of a novel antidepressant agent[J].Journal of Chromatography B:Analyt Technol Biomed Life Sci,2016,1031:214-220.
[29]HAI-XIA L I U,YAO-XIA Y,MA M G,et al.Selfassembled gold nanoparticles coating for solid-phase microextraction of ultraviolet filters in environmental water[J].Chinese Journal of Analytical Chemistry,2015,43(2):207-211.
[30]TOGUNDE O P,CUDJOE E,OAKES K D,et al.Determination of selected pharmaceutical residues in wastewater using an automated open bed solid phase microextraction system[J].Journal of Chromatography A,2012,1262:34-42.
[31]BARBOSA M O,RIBEIRO A R,PEREIRA M F R,et al.Eco-friendly LC–MS/MS method for analysis of multiclass micropollutants in tap,fountain,and well water from northern Portugal[J].Analytical and Bioanalytical Chemistry,2016,408(29):8355-8367.
[32]BAZREGAR M,RAJABI M,YAMINI Y,et al.Tandem air-agitated liquid–liquid microextraction as an efficient method for determination of acidic drugs in complicated matrices[J].Analytica Chimica Acta,2016,1429:14-21.
[33]顾海东,尹燕敏,秦宏兵.超高效液相色谱三重四级杆质谱联用法测定水中喹诺酮类抗生素[J].环境监测管理与技术,2013,25(3):34-37.(GU Haidong,YIN Yanmin,QIN Hongbing.Determination of quinolone in water samples by solid phase extraction-ultra performance liquid chromatographelectrospray tandem mass spectrometry[J].The Administration and Technique of Environmental Monitoring,2013,25(3):34-37.(in Chinese))
[34]谢正鑫,陆光华,孙丽莎,等.水环境中药物及个人护理品(PPCPs)的生物降解研究进展[J].水资源保护,2013,29(4):5-11.(XIE Zhengxin,LU Guanghua,SUN Lisha,et al.A review of biodegradation of pharmaceuticals and personal care products(PPCPs)in aqueous environment[J].Water Resources Protection,2013,29(4):5-11.(in Chinese))
[35]EPA(US Environmental Protection Agency).Framework for ecological risk assessment.EPA630-R-92-001[R].Office of Research and Development,Washington D C,USA,1992.
[36]CHEN Y,VYMAZAL J,B?倲EZINOVáT,et al.Occurrence,removal and environmental risk assessment of pharmaceuticals and personal care products in rural wastewater treatment wetlands[J].Science of the Total Environment,2016,566/567:1660-1669.
[37]李勇,蒋婷婷,景龙飞,等.舟山岛水库有机农药和抗生素残留特征及潜在风险评估[J].水资源保护,2014,30(3):31-37.(LI Yong,JIANG Tingting,JING Longfei,et al.Characteristics of residual organic pesticides and antibiotics in reservoirs of Zhoushan Islands and potential risk evaluation[J].Water Resources Protection,2014,30(3):31-37.(in Chinese))
[38]ARCHER E,PETRIE B,KASPRZYK-HORDERN B,et al.The fate of pharmaceuticals and personal care products(PPCPs),endocrine disrupting contaminants(EDCs),metabolites and illicit drugs in a WWTW and environmental waters[J].Chemosphere,2017,174:437-446.
[39]PROSSER R S,SIBLEY P K.Human health risk assessment of pharmaceuticals and personal care products in plant tissue due to biosolids and manure amendments,and wastewater irrigation[J].Environment International,2015,75(75C):223-233.
[40]HARRISON E M,PATERSON G K,HOLDEN M T,et al.Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mec A homologue mec C[J].Embo Molecular Medicine,2013,5(4):509-515.
[41]汪涛,杨再福,陈勇航,等.地表水中磺胺类抗生素的生态风险评价[J].生态环境学报2016,25(9):1508-1514.(WANG Tao,YANG Zaifu,CHEN Yonghang,et al.Ecological risk assessment for sulfonamides in surface waters[J].Ecology and Environmental Sciences,2016,25(9):1508-1514.(in Chinese))
[42]YAN Z,YANG X,LU G,et al.Potential environmental implications of emerging organic contaminants in Taihu Lake,China:comparison of two ecotoxicological assessment approaches[J].Science of the Total Environment,2014,470/471:171-179.
[43]LIU J,LU G,XIE Z,et al.Occurrence,bioaccumulation and risk assessment of lipophilic pharmaceutically active compounds in the downstream rivers of sewage treatment plants[J].Science of the Total Environment,2015,511:54-62.
[44]HOYETT Z,OWENS M A,CLARK C J,et al.A comparative evaluation of environmental risk assessment strategies for pharmaceuticals and personal care products[J].Ocean&Coastal Management,2016,127:74-80.
[45]GHEORGHE S,PETRE J,LUCACIU I,et al.Risk screening of pharmaceutical compounds in Romanian aquatic environment[J].Environmental Monitoring and Assessment,2016,188(6):1-16.
[46]PAPAGEORGIOU M,KOSMA C,LAMBROPOULOU D.Seasonal occurrence,removal,mass loading and environmental risk assessment of 55 pharmaceuticals and personal care products in a municipal wastewater treatment plant in Central Greece[J].Science of the Total Environment,2016,543(Pt A):547-569.
[47]GUO J,SELBY K,BOXALL A B A.Assessment of the risks of mixtures of major use veterinary antibiotics in european surface waters[J].Environmental Science&Technology,2016,50(15):8282-8289.
[48]DAOUK S,CHèVRE N,VERNAZ N,et al.Dynamics of active pharmaceutical ingredients loads in a Swiss university hospital wastewaters and prediction of the related environmental risk for the aquatic ecosystems[J].Science of the Total Environment,2016,547:244-253.
[49]MINGUEZ L,PEDELUCQ J,FARCY E,et al.Toxicities of48 pharmaceuticals and their freshwater and marine environmental assessment in northwestern France[J].Environmental Science and Pollution Research,2016,23(6):4992-5001.
[50]程斌,王菲凤,张江山.改进决策树模型支持下的饮用水水源地健康风险评价[J].水资源保护,2013,29(1):27-31.(CHENG Bin,WANG Feifeng,ZHANG Jingshan.An improved decision tree model for health risk assessment of drinking water source[J].Water Resources Protection,2013,29(1):27-31.(in Chinese))
[51]罗慧萍,逄勇,罗缙,等.泰州市第三自来水厂饮用水水源地水环境风险评价[J].河海大学学报(自然科学版),2015,43(2):114-120.(LUO Huiping,PANG Yong,LUO Jing,et al.Water environment risk assessment of Taizhou Three Waterworks drinking water source area[J].Journal of Hohai University(Natural Sciences),2015,43(2):114-120.(in Chinese))