摘要
目的:探究婴幼儿反复呼吸道感染在常规治疗治疗上加用匹多莫德辅助治疗对其免疫功能的影响。方法:选择2015年3月至2017年5月期间在郑州大学附属儿童医院治疗的76例反复呼吸道感染患儿作为研究对象,按随机数表法分成2组,各38例。对照组给予常规治疗,观察组在此基础上加用匹多莫德,比较两组临床疗效与治疗后免疫细胞及炎性介质水平。结果:观察组半年内感染次数少于对照组,且平均持续时间与抗生素使用时间均短于对照组,差异有统计学意义(P<0.05);观察组治疗后CD3+、CD4+、CD8+、IgG、IgA、IgM水平均较对照组高,PCT、TNF-α水平均较对照组低,IFN-γ、IL-4水平均较对照组高,差异有统计学意义(P<0.05)。结论:在常规治疗基础上辅助匹多莫德治疗婴幼儿反复呼吸道感染可降低机体炎症反应,提高免疫功能,减少感染次数,提高治疗效果。
Objective: To investigate the effect of the adjunctive therapy of pidomod on the immune function of infants with recurrent respiratory tract infection(RRTI). Methods: 76 children with recurrent respiratory tract infection who were treated in our hospital from March 2015 to May 2017 were randomly divided into two groups, with 38 cases in each group. The control group was treated with routine therapy, and the observation group was treated with pidomod on this basis. The clinical efficacy and the levels of immune cells and inflammatory mediators were compared between the two groups. Results: The frequency of infection in the observation group was less than that in the control group in half a year, and the mean duration and antibiotic use time were shorter than those in the control group(P<0.05). The levels of CD3+、CD4+、CD8+、Ig G、Ig A、Ig M in the observation group were higher than those in the control group(P<0.05), and the levels of TNF-α in the control group were lower than those in the control group(P<0.05). Conclusion: On the basis of routine treatment, the treatment of infantile recurrent respiratory tract infection with pidomod can reduce the inflammatory reaction, improve immune function, reduce the number of infections and improve the therapeutic effect.
引文
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