新当归补血颗粒对冠心病心衰病人6min步行试验及NT-proBNP的影响
摘要
目的观察新当归补血颗粒对气虚血瘀,水饮内停型冠心病心衰病人6 min步行试验及N端B型脑利钠肽前体(NTpro BNP)的影响,评价新当归补血颗粒的疗效及安全性。方法选取符合纳入标准的冠心病心衰病人120例,按随机数字表分成两组,每组60例,对照组给予培哚普利、酒石酸美托洛尔,逐渐增加至目标剂量或最大剂量,培哚普利目标剂量为4 mg~8 mg,每日1次,酒石酸美托洛尔目标剂量为150 mg~200 mg分2次服用。治疗组在对照组治疗基础上加用新当归补血颗粒1包,每日2次,饭后30 min口服。观察两组治疗前后NT-pro BNP、6 min步行试验变化,比较两组临床疗效。结果治疗组总有效率为91.67%,高于对照组的59.53%,差异有统计学意义(P<0.05)。两组治疗后NT-pro BNP较治疗前明显降低,差异有统计学意义(P<0.05),但治疗组降低更明显,差异有统计学意义(P<0.05)。治疗组治疗后6 min步行距离较治疗前明显增加,差异有统计学意义(P<0.05),组间治疗后比较差异有统计学意义(P<0.05)。结论新当归补血颗粒能增加气虚血瘀型冠心病心衰病人6 min步行距离,降低NT-pro BNP值。
引文
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