当归补血汤在血液疾病中作用机制的研究进展
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摘要
当归补血汤作为一首补气生血之名方,现代药理研究已经对其进行了多方面的探索,包括促进骨组织修复,改善循环、保护肾组织、抗纤维化、调节免疫、促进造血等作用。但该方在血液疾病中起效的作用机制笔者尚未见系统的总结分析。文章通过查阅当归补血汤在血液疾病及与血液疾病存在相同病理机制疾病的研究文献,从当归补血汤的经典配伍、调节免疫系统,维持机体免疫耐受、促进骨髓造血系统重建、对传导通路的调节等方面对该方在血液疾病中发挥效用的作用机制作一综述,以期为该方在临床的应用提供理论基础及科学依据。
Danggui Buxue Decoction is a famous Chinese medicinal prescription with the effect of benefiting qi and nourishing blood. Modern pharmacological research has been carried out in many aspects, including promoting bone repair, improving circulation, protecting kidney tissue, anti-fibrosis, regulating immunity, promoting hematopoiesis, and so on. However, the mechanism of this prescription in the blood system diseases has not been systematically analyzed. In this paper, by summarizing literatures about Danggui Buxue Decoction in blood diseases and diseases with similar mechanism as blood diseases, a review of the mechanism of Danggui Buxue Decoction in blood disease has been made from the aspects of the classical compatibility, the regulation of the immune system, the maintenance of the immune tolerance of the body, the promotion of the reconstruction of the hematopoietic system of the bone marrow, the regulation of the conduction pathway and so on, hoping to provide theoretical basis and scientific basis for its clinical application.
Danggui Buxue Decoction is a famous Chinese medicinal prescription with the effect of benefiting qi and nourishing blood. Modern pharmacological research has been carried out in many aspects, including promoting bone repair, improving circulation, protecting kidney tissue, anti-fibrosis, regulating immunity, promoting hematopoiesis, and so on. However, the mechanism of this prescription in the blood system diseases has not been systematically analyzed. In this paper, by summarizing literatures about Danggui Buxue Decoction in blood diseases and diseases with similar mechanism as blood diseases, a review of the mechanism of Danggui Buxue Decoction in blood disease has been made from the aspects of the classical compatibility, the regulation of the immune system, the maintenance of the immune tolerance of the body, the promotion of the reconstruction of the hematopoietic system of the bone marrow, the regulation of the conduction pathway and so on, hoping to provide theoretical basis and scientific basis for its clinical application.
引文
[1]吴素芬,余日跃,周俊,等.析因设计与中医补气生血方剂最佳药效配伍的研究.中国实验方剂学杂志,2011,17(8):153-156
[2]陆泳萍.加味当归补血汤联合维铁缓释片治疗缺铁性贫血43例临床观察.中医药导报,2016,22(2):67-69
[3]廖大忠,李静,鲁光洪,等.加味当归补血汤治疗肿瘤相关性贫血72例临床观察.四川中医,2016,34(1):81-83
[4]窦昊颖,张盼盼,高晓宁,等.当归补血汤加味治疗白细胞减少症疗效的Meta分析.辽宁中医杂志,2016,43(9):1807-1811
[5]曲文闻,胡晓梅.邓成珊治疗特发性血小板减少性紫癜经验.上海中医药杂志,2012,46(5):24-25
[6]黎承平,杨弘,李维佳,等.当归补血汤辅助治疗慢性再生障碍性贫血疗效观察.中国中医急症,2008,17(11):1525-1536
[7]陈苹.当归补血汤治疗24例白血病临床观察.中国实用医药,2016,11(18):209-210
[8]王文萍,王华伟,曹琦琛,等.当归补血汤不同配伍比例时阿魏酸含量的比较研究.实用药物与临床,2008,11(6):381-382
[9]魏春华.当归补血汤中当归与黄芪不同比例搭配对其化学成分的影响.四川中医,2015,33(6):51-53
[10]谢瑞芳,林评兰,王瑛,等.不同配伍比例当归补血汤化学成分及促血管新生作用比较.中国中医药信息杂志,2016,23(6):83-87
[11]田昌平,陈召洋,赵瑞,等.当归补血汤不同配伍比例对血虚证小鼠脏器系数的影响.山东中医杂志,2014,33(10):839-840
[12]王文萍,曹琦琛,王华伟,等.当归补血汤不同配伍的药动学研究.中国临床药理学与治疗学,2009,14(6):659-663
[13]Zheng K Y,Choi R C,Guo A J,et al.The membrane permeability of Astragali Radix-derived formononetin and calycosin is increased by Angelicae Sinensis Radix in Caco-2 cells:A synergistic action of an ancient herbal decoction Danggui Buxue Tang.J Pharm Biomed Anal,2012,70:671-679
[14]付勤,王莉.当归补血汤对化疗小鼠红细胞黏附功能及IL-2免疫调节作用的影响.中国实用医药,2008,3(11):70-71
[15]徐厚谦,高军太,曲争艳,等.当归补血汤对心衰大鼠心功能、血浆TNF-α及IL-6的影响.甘肃中医学院学报,2010,27(4):1-4
[16]孙璐,黄水清,马文静,等.当归补血汤对RAW264.7细胞的TNF-α、ICAM-1表达的作用.北京中医药大学学报,2010,33(1):33-35
[17]刘涛,黄瑞峰,王毅.当归补血汤对脓毒症小鼠脾脏Treg细胞比例、Foxp3 m RNA表达的影响.山东医药,2014,54(30):26-28
[18]冯璟,于远望.当归补血汤对辐射损伤小鼠免疫功能的影响.中医药导报,2016,22(13):17-20
[19]黄丽萍,陈耀辉,吴素芬,等.当归补血汤含药血清对血虚小鼠骨髓造血功能的影响.中药药理与临床,2014,30(2):18-20
[20]杨岚,张力华,周毅.当归补血汤对骨髓抑制小鼠骨髓细胞增殖的影响.中国组织工程研究与临床康复,2007,11(3):538-539
[21]王晓玲,赵舒武,王媛媛,等.当归补血汤对骨髓辐射损伤过程中NF-κB及bax、bcl-2表达的影响.中国老年学杂志,2015,35(11):2887-2890
[22]徐瑞荣,崔兴,王琰,等.当归补血汤促进小鼠骨髓移植后造血组织重建的研究.中国实验方剂学杂志,2008,14(10):39-41
[23]Yang X,Huang C G,Du S Y,et al.Effect of Danggui Buxue Tang on immune-mediated aplastic anemia bone marrow proliferation mice.Phytomedicine,2014,21(5):640-646
[24]薄华本,陈启助,沈晗,等.当归补血汤调控骨髓造血机理及对造血微环境的影响.中国新药与临床杂志,2013,32(10):824-828
[25]Yang M,Chan G C,Deng R,et al.An herbal decoction of Radix astragali and Radix angelicae sinensis promotes hematopoiesis and thrombopoiesis.J Ethnopharmacol,2009,124(1):87-97
[26]王晓玲,汪涛,王学谦,等.当归补血汤对体外造血微环境中小鼠肌卫星细胞增殖及c-kit表达的影响.中国老年学杂志,2012,32(10):2071-2074
[27]王立妍,陈玉芳,王丹,等.当归补血汤促进异体移植的肌卫星细胞存活.中国组织化学与细胞化学杂志,2016,25(5):422-425
[28]严苏纯,祝彼得,韩英光,等.当归补血汤不同剂型及配伍对骨髓抑制小鼠造血调控的实验研究.中国药学杂志,2008,43(18):1386-1390
[29]王晓玲,汪涛,汪雅妮,等.当归补血汤载药血清对骨髓基质细胞增殖及细胞因子表达的影响.辽宁中医杂志,2011,38(2):363-365
[30]唐干益,詹晓敏,李敏,等.当归补血汤对小鼠骨髓间充质干细胞增殖的影响及作用机制.广东药学院学报,2014,30(5):612-615
[31]刘娟,初杰.不同提取方法的当归补血汤对化疗贫血模型的药效学研究.辽宁中医药大学学报,2011,13(8):113-115
[32]王晓玲,卢斌,赵舒武,等.当归补血汤对亚致死剂量γ射线照射小鼠骨髓Notch信号通路作用的研究.时珍国医国药,2015,26(8):1861-1863
[33]窦昊颖,张盼盼,梁芳芳,等.Notch2、Notch3、Jagged2和Hes3在当归补血汤协同肌源性干细胞移植鼠骨髓中的表达和作用.时珍国医国药,2016,27(12):3059-3061
[34]秦臻,黄水清.当归补血汤含药血清对内皮祖细胞功能及其PI3K/Akt通路影响的研究.中国药理学通报,2013,29(9):1320-1323
[35]刘福和,倪文娟,王国康,等.当归补血汤对大鼠肾缺血-再灌注损伤后TLR4/NF-κB信号通路的影响.中国药业,2016,25(21):7-10
[2]陆泳萍.加味当归补血汤联合维铁缓释片治疗缺铁性贫血43例临床观察.中医药导报,2016,22(2):67-69
[3]廖大忠,李静,鲁光洪,等.加味当归补血汤治疗肿瘤相关性贫血72例临床观察.四川中医,2016,34(1):81-83
[4]窦昊颖,张盼盼,高晓宁,等.当归补血汤加味治疗白细胞减少症疗效的Meta分析.辽宁中医杂志,2016,43(9):1807-1811
[5]曲文闻,胡晓梅.邓成珊治疗特发性血小板减少性紫癜经验.上海中医药杂志,2012,46(5):24-25
[6]黎承平,杨弘,李维佳,等.当归补血汤辅助治疗慢性再生障碍性贫血疗效观察.中国中医急症,2008,17(11):1525-1536
[7]陈苹.当归补血汤治疗24例白血病临床观察.中国实用医药,2016,11(18):209-210
[8]王文萍,王华伟,曹琦琛,等.当归补血汤不同配伍比例时阿魏酸含量的比较研究.实用药物与临床,2008,11(6):381-382
[9]魏春华.当归补血汤中当归与黄芪不同比例搭配对其化学成分的影响.四川中医,2015,33(6):51-53
[10]谢瑞芳,林评兰,王瑛,等.不同配伍比例当归补血汤化学成分及促血管新生作用比较.中国中医药信息杂志,2016,23(6):83-87
[11]田昌平,陈召洋,赵瑞,等.当归补血汤不同配伍比例对血虚证小鼠脏器系数的影响.山东中医杂志,2014,33(10):839-840
[12]王文萍,曹琦琛,王华伟,等.当归补血汤不同配伍的药动学研究.中国临床药理学与治疗学,2009,14(6):659-663
[13]Zheng K Y,Choi R C,Guo A J,et al.The membrane permeability of Astragali Radix-derived formononetin and calycosin is increased by Angelicae Sinensis Radix in Caco-2 cells:A synergistic action of an ancient herbal decoction Danggui Buxue Tang.J Pharm Biomed Anal,2012,70:671-679
[14]付勤,王莉.当归补血汤对化疗小鼠红细胞黏附功能及IL-2免疫调节作用的影响.中国实用医药,2008,3(11):70-71
[15]徐厚谦,高军太,曲争艳,等.当归补血汤对心衰大鼠心功能、血浆TNF-α及IL-6的影响.甘肃中医学院学报,2010,27(4):1-4
[16]孙璐,黄水清,马文静,等.当归补血汤对RAW264.7细胞的TNF-α、ICAM-1表达的作用.北京中医药大学学报,2010,33(1):33-35
[17]刘涛,黄瑞峰,王毅.当归补血汤对脓毒症小鼠脾脏Treg细胞比例、Foxp3 m RNA表达的影响.山东医药,2014,54(30):26-28
[18]冯璟,于远望.当归补血汤对辐射损伤小鼠免疫功能的影响.中医药导报,2016,22(13):17-20
[19]黄丽萍,陈耀辉,吴素芬,等.当归补血汤含药血清对血虚小鼠骨髓造血功能的影响.中药药理与临床,2014,30(2):18-20
[20]杨岚,张力华,周毅.当归补血汤对骨髓抑制小鼠骨髓细胞增殖的影响.中国组织工程研究与临床康复,2007,11(3):538-539
[21]王晓玲,赵舒武,王媛媛,等.当归补血汤对骨髓辐射损伤过程中NF-κB及bax、bcl-2表达的影响.中国老年学杂志,2015,35(11):2887-2890
[22]徐瑞荣,崔兴,王琰,等.当归补血汤促进小鼠骨髓移植后造血组织重建的研究.中国实验方剂学杂志,2008,14(10):39-41
[23]Yang X,Huang C G,Du S Y,et al.Effect of Danggui Buxue Tang on immune-mediated aplastic anemia bone marrow proliferation mice.Phytomedicine,2014,21(5):640-646
[24]薄华本,陈启助,沈晗,等.当归补血汤调控骨髓造血机理及对造血微环境的影响.中国新药与临床杂志,2013,32(10):824-828
[25]Yang M,Chan G C,Deng R,et al.An herbal decoction of Radix astragali and Radix angelicae sinensis promotes hematopoiesis and thrombopoiesis.J Ethnopharmacol,2009,124(1):87-97
[26]王晓玲,汪涛,王学谦,等.当归补血汤对体外造血微环境中小鼠肌卫星细胞增殖及c-kit表达的影响.中国老年学杂志,2012,32(10):2071-2074
[27]王立妍,陈玉芳,王丹,等.当归补血汤促进异体移植的肌卫星细胞存活.中国组织化学与细胞化学杂志,2016,25(5):422-425
[28]严苏纯,祝彼得,韩英光,等.当归补血汤不同剂型及配伍对骨髓抑制小鼠造血调控的实验研究.中国药学杂志,2008,43(18):1386-1390
[29]王晓玲,汪涛,汪雅妮,等.当归补血汤载药血清对骨髓基质细胞增殖及细胞因子表达的影响.辽宁中医杂志,2011,38(2):363-365
[30]唐干益,詹晓敏,李敏,等.当归补血汤对小鼠骨髓间充质干细胞增殖的影响及作用机制.广东药学院学报,2014,30(5):612-615
[31]刘娟,初杰.不同提取方法的当归补血汤对化疗贫血模型的药效学研究.辽宁中医药大学学报,2011,13(8):113-115
[32]王晓玲,卢斌,赵舒武,等.当归补血汤对亚致死剂量γ射线照射小鼠骨髓Notch信号通路作用的研究.时珍国医国药,2015,26(8):1861-1863
[33]窦昊颖,张盼盼,梁芳芳,等.Notch2、Notch3、Jagged2和Hes3在当归补血汤协同肌源性干细胞移植鼠骨髓中的表达和作用.时珍国医国药,2016,27(12):3059-3061
[34]秦臻,黄水清.当归补血汤含药血清对内皮祖细胞功能及其PI3K/Akt通路影响的研究.中国药理学通报,2013,29(9):1320-1323
[35]刘福和,倪文娟,王国康,等.当归补血汤对大鼠肾缺血-再灌注损伤后TLR4/NF-κB信号通路的影响.中国药业,2016,25(21):7-10