通痹舒心颗粒对急性冠脉综合征伴焦虑抑郁患者生活质量的影响
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摘要
目的观察通痹舒心颗粒对急性冠脉综合征(ACS)伴焦虑抑郁患者生活质量的影响。方法采用随机数字表法将90例患者分为治疗组和对照组各45例。对照组予基础治疗并进行情志干预,治疗组在对照组治疗基础上加服通痹舒心颗粒。分别于治疗前及治疗第4、12周采用汉密顿焦虑量表(HAMA)和抑郁量表(HAMD)进行评分,在治疗前及治疗第12周进行西雅图心绞痛量表(SAQ)评分,比较2组变化情况。结果 2组患者治疗第4周时HAMD、HAMA评分与本组治疗前比较均降低,差异有统计学意义(P<0.05),组间比较差异也有统计学意义(P<0.05)。治疗第12周时,对照组HAMD、HAMA评分较第4周时略有降低(P>0.05),治疗组较治疗前及治疗第4周时明显下降(P<0.05),组间比较差异有统计学意义(P<0.05)。2组患者治疗第12周时SAQ评分所有维度较治疗前均提高(P<0.05),治疗组评分较对照组提高更明显,其中躯体活动受限程度、心绞痛稳定状态和心绞痛发作情况评分与对照组比较差异有统计学意义(P<0.05)。结论通痹舒心颗粒治疗ACS伴焦虑抑郁患者有明显疗效。
Objective To observe the effects of Tongbi Shuxin Granule on life quality of acute coronary syndrome(ACS) patients with anxiety and depression. Methods Ninety patients were randomly divided into the treatment group and control group through random number table method, 45 cases for each group. The control group was given fundamental treatment and emotional intervention, while the treatment group was given Tongbi Shuxin Granule additionally. On admission and 4th and 12 th weeks, the scores of HAMA and HAMD were evaluated. On admission and 12 th week, SAQ score was observed. Results In the 4th week, scores of HAMD and HAMA of two groups decreased compared with those on admission(P <0.05), with statistical significance(P <0.05). In the 12 th week, scores of HAMD and HAMA of the control group were lower than those of 4th week, without statistical significance(P >0.05);the treatment group decreased significantly compared with on admission and 4th week(P <0.05), without statistical significance between the two groups(P <0.05). In the 12 th week, all dimensions of SAQ score in the two groups increased compared with those on admission(P <0.05);the treatment group was much higher than the control group, especially the scores of physical limitation, angina stability and angina frequency(P <0.05). Conclusion Tongbi Shuxin Granule has the exact treatment effects on ACS patients with anxiety and depression.
Objective To observe the effects of Tongbi Shuxin Granule on life quality of acute coronary syndrome(ACS) patients with anxiety and depression. Methods Ninety patients were randomly divided into the treatment group and control group through random number table method, 45 cases for each group. The control group was given fundamental treatment and emotional intervention, while the treatment group was given Tongbi Shuxin Granule additionally. On admission and 4th and 12 th weeks, the scores of HAMA and HAMD were evaluated. On admission and 12 th week, SAQ score was observed. Results In the 4th week, scores of HAMD and HAMA of two groups decreased compared with those on admission(P <0.05), with statistical significance(P <0.05). In the 12 th week, scores of HAMD and HAMA of the control group were lower than those of 4th week, without statistical significance(P >0.05);the treatment group decreased significantly compared with on admission and 4th week(P <0.05), without statistical significance between the two groups(P <0.05). In the 12 th week, all dimensions of SAQ score in the two groups increased compared with those on admission(P <0.05);the treatment group was much higher than the control group, especially the scores of physical limitation, angina stability and angina frequency(P <0.05). Conclusion Tongbi Shuxin Granule has the exact treatment effects on ACS patients with anxiety and depression.
引文
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[8]Garratt AM,Hutchinson A,Russell I.The UK version of the seattle angina questionnaire(SAQ-UK):reliability,validity and responsiveness[J].J Clin Epidemiol,2001,54(9):907-915.
[9]Neil N,Ramsey SD,Cohen DJ,et al.Resource utilization,cost,and health status impacts of coronary stent versus“optiaml”percutaneous coronary angioplasty:results from the OPUS-I trail[J].Journal of Interventional Cardiology,2002,15(4):249-255.
[10]李静,常改.西雅图量表测量冠心病患者生活质量的评价[J].中国公共卫生,2004,20(5):594.
[2]丁荣晶.双心医学研究进展[J].四川精神卫生,2014,27(3):193-197.
[3]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.非ST段抬高急性冠脉综合征诊断和治疗指南[J].中华心血管病杂志,2012,40(5):353-367.
[4]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:68-76.
[5]张明园.精神科评定量表手册(第3版)[M].长沙:湖南科学技术出版社,2003:121-126,133-137.
[6]Martin CR,Thompson DR,Chan DS.An examination of the psychometric properties of the Hospital Anxiety and Depression Scale in Chinese patients with acute coronary syndrome[J].Psychiatry Res,2004,129:279-288.
[7]Grace SL,Abbey SE,Kapral MK,et al.Effect of depression on five-year mortality after an acuter coronary syndome[J].Am J Cardiol,2005,96:1179-1185.
[8]Garratt AM,Hutchinson A,Russell I.The UK version of the seattle angina questionnaire(SAQ-UK):reliability,validity and responsiveness[J].J Clin Epidemiol,2001,54(9):907-915.
[9]Neil N,Ramsey SD,Cohen DJ,et al.Resource utilization,cost,and health status impacts of coronary stent versus“optiaml”percutaneous coronary angioplasty:results from the OPUS-I trail[J].Journal of Interventional Cardiology,2002,15(4):249-255.
[10]李静,常改.西雅图量表测量冠心病患者生活质量的评价[J].中国公共卫生,2004,20(5):594.