疏肝和胃方配合西药治疗胃食管反流病临床观察
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摘要
目的:观察疏肝和胃方配合西药治疗胃食管反流病的临床疗效。方法:将符合纳入标准的胃食管反流患者63例按就诊先后顺序分为两组,其中对照组31例,治疗组32例。对照组给予雷贝拉唑肠溶胶囊20 mg,晨起空腹口服;治疗组在对照组治疗基础上加服疏肝和胃方颗粒制剂。两组疗程均为8周,并在治疗结束后随访4周,观察并比较两组症状缓解程度及停药后症状维持缓解时间。结果:治疗后两组反酸、烧心等症状均改善,食管黏膜恢复速度均提高,且治疗组在缓解主要临床症状、加速食管膜愈及维持症状缓解时间方面明显优于对照组,差异有统计学意义(P﹤0.05)。结论:疏肝和胃方联合雷贝拉唑钠肠溶胶囊治疗胃食管反流病临床疗效确切。
Objective:To observe the clinical effect and and advantages of Shugan Hewei recipe on gastroesophageal reflux disease. Methods:63 cases of patients who meeting the inclusion criteria of gastroesophageal reflux disease were divided into two group according to the visiting order, 31 cases in the control group and 32 cases in the treatment group. The control group was treated with 20 mg Raberazole enteric-coated capsules, fasting orally in the morning;while the treatment group was treated plus with Shugan Hewei recipe granule preparation on the basis of control group. Both groups were treated for 8 weeks. After the end of treatment, the patients were followed up for 4 weeks. Degree of symptom relief and relief time of symptom maintaining after stopping the drugs were observed and compared in two groups. Results:After treatment in both groups, sour regurgitation and heartburn etc. symptoms were improved, the recovering speed of esophageal mucosa was enhanced, and the treatment group was significantly better than the control group in relieving main clinical symptoms, speeding up esophageal mucosa healing and in relief time of symptom maintaining. The difference was statistically significant(P﹤0.05).Conclusion:The clinical effect of Shugan Hewei recipe combined with Raberazole enteric-coated capsules on gastroesophageal reflux disease is definite.
Objective:To observe the clinical effect and and advantages of Shugan Hewei recipe on gastroesophageal reflux disease. Methods:63 cases of patients who meeting the inclusion criteria of gastroesophageal reflux disease were divided into two group according to the visiting order, 31 cases in the control group and 32 cases in the treatment group. The control group was treated with 20 mg Raberazole enteric-coated capsules, fasting orally in the morning;while the treatment group was treated plus with Shugan Hewei recipe granule preparation on the basis of control group. Both groups were treated for 8 weeks. After the end of treatment, the patients were followed up for 4 weeks. Degree of symptom relief and relief time of symptom maintaining after stopping the drugs were observed and compared in two groups. Results:After treatment in both groups, sour regurgitation and heartburn etc. symptoms were improved, the recovering speed of esophageal mucosa was enhanced, and the treatment group was significantly better than the control group in relieving main clinical symptoms, speeding up esophageal mucosa healing and in relief time of symptom maintaining. The difference was statistically significant(P﹤0.05).Conclusion:The clinical effect of Shugan Hewei recipe combined with Raberazole enteric-coated capsules on gastroesophageal reflux disease is definite.
引文
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[12]狄艳琴,关晓清.中药黄芩药理的临床作用分析[J].世界最新医学信息文摘,2017,17(A3):238,240.
[13]张明发,沈雅琴.半夏提取物对呼吸和消化系统药理作用的研究进展[J].抗感染药学,2017,14(8):1 457-1 462.
[14]范丽丽,程江南,张涛,等.旋覆花属植物化学成分及药理活性研究进展[J].中医药导报,2017,23(13):40-43.
[15]范薏淇,赵嫣虹.海螵蛸的研究进展[J].中国民族民间医药,2016,25(4):47-48.
[16]徐雯,吴艳清,丁浩然,等.广藿香的药理作用及机制研究进展[J].上海中医药杂志,2017,51(10):103-106.
[17]贾佼佼,李艳,苗明三.紫苏的化学、药理及应用[J].中医学报,2016,31(9):1 354-1 356.
[2]李颖,李长锋,闫振坤,等.胃食管反流病问卷对胃食管反流病的诊断价值[J].中华消化内镜杂志,2014,31(6):347-349.
[3]王琨,段丽萍.长期使用质子泵抑制剂可能导致的副作用分析[J].胃肠病学和肝病学杂志,2010,19(8):766-769.
[4]林三仁,许国铭,胡品津,等.中国胃食管反流病共识意见(2006,三亚)[J].胃肠病学,2007,12(4):233-236.
[5]KAHRILAS PJ,JONSSON A,DENISON H,et al.Concomitant symptoms itemized in the Reflux Disease Questionnaire are associated with attenuated heartburn response to acid suppression[J].Am J Gastroenterol,2012,107(9):1 354-1 360.
[6]李军祥,陈誩,李岩.胃食管反流病中西医结合诊疗共识意见(2017年)[J].中国中西医结合消化杂志,2018,26(3):221-226,232.
[7]王栋,常虹.《四圣心源》脾升胃降学说探微[J].浙江中医药大学学报,2015,39(1):24-25.
[8]王淑君,钱家鸣.关注质子泵抑制剂长期治疗的不良反应[J].药物不良反应杂志,2015,17(1):1-2.
[9]孙晓卉,张量.柴胡药理作用的研究进展[J].中国医药导报,2017,14(10):52-55.
[10]曲中原,冯晓敏,邹翔,等.枳实研究进展[J].食品与药品,2017,19(6):455-459.
[11]张淑洁,钟凌云.厚朴化学成分及其现代药理研究进展[J].中药材,2013,36(5):838-843.
[12]狄艳琴,关晓清.中药黄芩药理的临床作用分析[J].世界最新医学信息文摘,2017,17(A3):238,240.
[13]张明发,沈雅琴.半夏提取物对呼吸和消化系统药理作用的研究进展[J].抗感染药学,2017,14(8):1 457-1 462.
[14]范丽丽,程江南,张涛,等.旋覆花属植物化学成分及药理活性研究进展[J].中医药导报,2017,23(13):40-43.
[15]范薏淇,赵嫣虹.海螵蛸的研究进展[J].中国民族民间医药,2016,25(4):47-48.
[16]徐雯,吴艳清,丁浩然,等.广藿香的药理作用及机制研究进展[J].上海中医药杂志,2017,51(10):103-106.
[17]贾佼佼,李艳,苗明三.紫苏的化学、药理及应用[J].中医学报,2016,31(9):1 354-1 356.