自拟滋补肝肾组方对肝肾阴虚型更年期综合征患者血清卵泡刺激素与儿茶酚胺水平的影响
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摘要
目的探讨自拟滋补肝肾组方对肝肾阴虚型更年期综合征患者血清卵泡刺激素(FSH)与儿茶酚胺的影响,为临床治疗提供依据。方法选取2014年1月-2016年1月于围场满族蒙古族自治县中医院妇产科接受中医治疗的80例肝肾阴虚型更年期患者为观察组,同期入院接受西医治疗的60例肝肾阴虚型更年期患者为对照组。观察组患者给予自拟滋补肝肾组方治疗,对照组患者给予尼尔雌醇治疗。比较两组患者的疗效,治疗前后血清FSH、雌二醇(E_2)水平,子宫内膜厚度,血清肾上腺素(E)、去甲肾上腺素(NE)及多巴胺(DA)水平,血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)和高密度脂蛋白胆固醇(HDL-C)水平,不良反应发生率。结果观察组治疗总有效率为93.75%,显著高于对照组(81.67%)(P<0.05)。治疗前,两组患者血清FSH、E_2、E、NE、DA、TG、TC、LDL-C、HDL-C水平及子宫内膜厚度比较,差异均无统计学意义(均P>0.05)。治疗后,两组患者血清FSH、E_2水平比较,差异均有统计学意义(均P<0.05);两组患者子宫内膜厚度比较,差异无统计学意义(P>0.05)。在两组患者中,治疗前后血清FSH、E_2水平比较,差异均有统计学意义(均P<0.05);对照组治疗前后子宫内膜厚度比较,差异有统计学意义(P<0.05);观察组治疗前后子宫内膜厚度比较,差异无统计学意义(P>0.05)。治疗后,两组患者血清E、NE及DA水平比较,差异均有统计学意义(均P<0.05)。在两组患者中,治疗前后血清E、NE及DA水平比较,差异均有统计学意义(均P<0.05)。治疗后,两组患者血清TG、TC、LDL-C、HDL-C水平比较,差异均有统计学意义(均P<0.05)。在两组患者中,治疗前后血清TG、TC、LDL-C、HDL-C水平比较,差异均有统计学意义(均P<0.05)。两组患者不良反应发生率比较,差异均无统计学意义(均P>0.05)。结论自拟滋补肝肾组方治疗肝肾阴虚型更年期综合征患者具有良好疗效,能够显著降低患者血清FSH与儿茶酚胺水平,值得临床推广应用。
Objective To explore the effect of self-prescription for nourishing liver-kidney on serum follicle-stimulating hormone( FSH)and catecholamine levels in patients with climacteric syndrome of Yin-deficiency of liver and kidney,and provide a basis for clinical treatment.Methods From January 2014 to January 2016,80 patients with climacteric syndrome of Yin-deficiency of liver and kidney treated with traditional Chinese medicine therapy in Department of Gynecology and Obstetrics in the hospital were selected as observation group,60 patients with climacteric syndrome of Yin-deficiency of liver and kidney treated with western medicine therapy in Department of Gynecology and Obstetrics in the hospital were selected as control group. The patients in observation group were treated with self-prescription for nourishing liver-kidney,while the patients in control group were treated with nilestriol. The curative effects,endometrial thickness,serum levels of FSH,estradiol( E_2),epinephrine( E),noradrenaline( NE),and dopamine( DA),total cholesterol( TC),triglyceride( TG),low-density lipoprotein cholesterin( LDL-C),and high-density lipoprotein cholesterol( HDL-C),the incidence rates of adverse reactions in the two groups were compared. Results The total effective rate in observation group was 93. 75%,which was statistically significantly higher than that in control group( 81. 67%)( P= 0. 000). Before treatment,there was no statistically significant difference in levels of serum FSH、E_2、E、NE、DA、TG、TC、LDL-C、HDL-C and endometrial thickness between the two groups( all P>0. 05). After treatment,there were statistically significant differences in levels of serum FSH and E_2 between the two groups( P< 0. 05); there was no statistically significant difference in endometrial thickness between the two groups( P>0. 05). In the two groups,there were statistically significant differences in levels of serum FSH and E_2 between before and after treatment( all P<0. 05). In control group,there was statistically significant difference in endometrial thickness between before and after treatment( P<0. 05). In observation group,there was no statistically significant difference in endometrial thickness between before and after treatment( P>0. 05). After treatment,there were statistically significant differences in levels of serum E,NE,and DA between the two groups( all P<0. 05). In the two groups,there were statistically significant differences in levels of serum E,NE,and DA between before and after treatment( all P< 0. 05). After treatment,there were statistically significant differences in levels of serum TG,TC,LDL-C,and HDL-C between the two groups( all P<0. 05). In the two groups,there were statistically significant differences in levels of serum TG,TC,LDL-C,and HDL-C between before and after treatment( all P<0. 05). There was no statistically significant difference in the incidence rate of adverse reactions between the two groups( P>0. 05). Conclusion The curative effect of self-prescription for nourishing liver-kidney in treatment of patients with climacteric syndrome of Yin-deficiency of liver and kidney is good,the prescription can significantly reduce the levels of serum FSH and catecholamine,which is worthy of clinical application and promotion.
Objective To explore the effect of self-prescription for nourishing liver-kidney on serum follicle-stimulating hormone( FSH)and catecholamine levels in patients with climacteric syndrome of Yin-deficiency of liver and kidney,and provide a basis for clinical treatment.Methods From January 2014 to January 2016,80 patients with climacteric syndrome of Yin-deficiency of liver and kidney treated with traditional Chinese medicine therapy in Department of Gynecology and Obstetrics in the hospital were selected as observation group,60 patients with climacteric syndrome of Yin-deficiency of liver and kidney treated with western medicine therapy in Department of Gynecology and Obstetrics in the hospital were selected as control group. The patients in observation group were treated with self-prescription for nourishing liver-kidney,while the patients in control group were treated with nilestriol. The curative effects,endometrial thickness,serum levels of FSH,estradiol( E_2),epinephrine( E),noradrenaline( NE),and dopamine( DA),total cholesterol( TC),triglyceride( TG),low-density lipoprotein cholesterin( LDL-C),and high-density lipoprotein cholesterol( HDL-C),the incidence rates of adverse reactions in the two groups were compared. Results The total effective rate in observation group was 93. 75%,which was statistically significantly higher than that in control group( 81. 67%)( P= 0. 000). Before treatment,there was no statistically significant difference in levels of serum FSH、E_2、E、NE、DA、TG、TC、LDL-C、HDL-C and endometrial thickness between the two groups( all P>0. 05). After treatment,there were statistically significant differences in levels of serum FSH and E_2 between the two groups( P< 0. 05); there was no statistically significant difference in endometrial thickness between the two groups( P>0. 05). In the two groups,there were statistically significant differences in levels of serum FSH and E_2 between before and after treatment( all P<0. 05). In control group,there was statistically significant difference in endometrial thickness between before and after treatment( P<0. 05). In observation group,there was no statistically significant difference in endometrial thickness between before and after treatment( P>0. 05). After treatment,there were statistically significant differences in levels of serum E,NE,and DA between the two groups( all P<0. 05). In the two groups,there were statistically significant differences in levels of serum E,NE,and DA between before and after treatment( all P< 0. 05). After treatment,there were statistically significant differences in levels of serum TG,TC,LDL-C,and HDL-C between the two groups( all P<0. 05). In the two groups,there were statistically significant differences in levels of serum TG,TC,LDL-C,and HDL-C between before and after treatment( all P<0. 05). There was no statistically significant difference in the incidence rate of adverse reactions between the two groups( P>0. 05). Conclusion The curative effect of self-prescription for nourishing liver-kidney in treatment of patients with climacteric syndrome of Yin-deficiency of liver and kidney is good,the prescription can significantly reduce the levels of serum FSH and catecholamine,which is worthy of clinical application and promotion.
引文
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[13]黄爱华.补肾调脾方对更年期综合征妇女糖脂代谢及内分泌水平的影响[J].中国老年学杂志,2015,35(14):3872-3874.
[2]Wee JH,Jung HJ,Jung KO,et al.Pomegranate extract improves menopausal syndrome in ovariectomized rats[J].J Korean Soc Food Sci Nutr,2015,44(4):506-515.
[3]GüdücüN,ⅰsci H,Grmüs U,et al.Serum visfatin levels do not increase in post-menopausal women with metabolic syndrome[J].J Endocrinol Invest,2013,36(3):157-161.
[4]李琦,周佩云,李浩,等.更年期综合征中医肾虚证患者实验室指标判别分析[J].中国中西医结合杂志,2013,33(8):1064-1068.
[5]阮彩莲.中药辨证治疗更年期综合征效果分析[J].中国老年学杂志,2015,35(4):1093-1094.
[6]Jia M,Kluwe L,Liu HC,et al.Efficacy and side-effects of a semiindividualized Chinese herb mixture"Tiáo Gēng Tāng"for menopausal syndrome in China[J].In Vivo,2015,29(1):109-115.
[7]张园园.百合知母汤加味治疗肝肾阴虚型更年期综合征疗效观察[J].中医临床研究,2015,7(33):15-16.
[8]贾维宁,陈体辉.从“肝肾瘀”论治卵巢早衰体会[J].实用中医药杂志,2015,31(10):967-968.
[9]王天鹭,徐丽梅.养肝滋阴法治疗更年期综合征[J].中医临床研究,2015,7(8):57,59.
[10]李步满,卢世秀.中医药治疗更年期综合征的思路与方法[J].西部中医药,2013,26(11):44-46.
[11]Chedraui P,Pérez-López FR,Hidalgo L,et al.Evaluation of the presence and severity of menopausal symptoms among postmenopausal women screened for the metabolic syndrome[J].Gynecol Endocrinol,2014,30(12):918-924.
[12]杨爱玲.更年期妇女临床症状与促卵泡刺激素及雌二醇水平的相关性研究[J].中国临床实用医学,2015,6(5):50-51.
[13]黄爱华.补肾调脾方对更年期综合征妇女糖脂代谢及内分泌水平的影响[J].中国老年学杂志,2015,35(14):3872-3874.