坤宝制剂治疗更年期综合征的循证药学评价研究
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摘要
目的评价坤宝制剂治疗更年期综合征的有效性和安全性。方法计算机检索Pub Med数据库、Embase数据库、中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊全文数据库、万方数据库,纳入坤宝制剂与雌激素对于更年期综合征的随机对照试验、系统评价和Meta分析,对纳入资料进行方法学质量评价和Meta分析;结果坤宝制剂与雌激素对于更年期综合征治疗共纳入4个随机对照试验,2组治疗更年期综合征总有效率差异有统计学意义[OR=2.33,95%CI (1.47,3.69),P<0.001],显效或治愈率差异有统计学意义[OR=1.94,95%CI(1.37,2.75),P<0.001],对体内卵泡刺激素(P<0.001)、黄体生成素(P<0.05)、雌二醇(P>0.05)等激素水平影响不同。结论坤宝制剂治疗更年期综合征的有效性和安全性均优于雌激素。
Objective To evaluate the therapeutic effect and safety of Kunbao preparations for menopausal syndrome. Methods The PubMed database, Embase database, CBM database, CJF database, CSTJ Database, and Wanfang database were searched.Randomized controlled trials( RCT), systematic reviews( SR) and meta-analysis of treating female menopausal syndrome by Kunbao preparations and oestrogen were included. Methodological quality assessment and meta-analysis were carried out. Results Four RCTs comparing Kunbao preparations and oestrogen for treatment of female menopausal syndrome were included into the analysis. The total efficiencies of the two drugs had statistical significance [ OR =2.33, 95% CI( 1.47, 3.69), P <0.001]. The obvious effective rates were statistically different [OR=1.94, 95% CI(1.37, 2.75), P<0.001]. There was different effects between Kunbao preparations and oestrogen for hormone levels, FSH [SMD=-0.49, 95% CI(-0.77,-0.34), P<0.001], LH [SMD=-0.21,95% CI(-0.37,-0.05), P<0.05], E2[SMD=-1.59, 95% CI(-3.55, 0.37), P>0.05]. Conclusion The therapeutic effect and safety of Kunbao preparations for treating menopausal is better than oestrogen.
Objective To evaluate the therapeutic effect and safety of Kunbao preparations for menopausal syndrome. Methods The PubMed database, Embase database, CBM database, CJF database, CSTJ Database, and Wanfang database were searched.Randomized controlled trials( RCT), systematic reviews( SR) and meta-analysis of treating female menopausal syndrome by Kunbao preparations and oestrogen were included. Methodological quality assessment and meta-analysis were carried out. Results Four RCTs comparing Kunbao preparations and oestrogen for treatment of female menopausal syndrome were included into the analysis. The total efficiencies of the two drugs had statistical significance [ OR =2.33, 95% CI( 1.47, 3.69), P <0.001]. The obvious effective rates were statistically different [OR=1.94, 95% CI(1.37, 2.75), P<0.001]. There was different effects between Kunbao preparations and oestrogen for hormone levels, FSH [SMD=-0.49, 95% CI(-0.77,-0.34), P<0.001], LH [SMD=-0.21,95% CI(-0.37,-0.05), P<0.05], E2[SMD=-1.59, 95% CI(-3.55, 0.37), P>0.05]. Conclusion The therapeutic effect and safety of Kunbao preparations for treating menopausal is better than oestrogen.
引文
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[9]李晔,周明芳,王君伟.坤宝丸治疗围绝经期综合征的临床研究[J].时珍国医国药,2013,24(8):1957-1958.
[10]杨玉环.坤宝丸治疗更年期综合征的临床观察[J].实用妇科内分泌电子杂志,2015,2(11):97-98.
[11]郭睿,刘砚韬.坤宝丸治疗更年期综合征32例疗效及安全性分析[J].中国药业,2015,24(24):223-224.
[12]徐琦.坤宝丸治疗更年期综合征28例[J].中国临床医生,2013,41(3):72-73.
[13]郭力文.坤宝丸为主治疗更年期综合征60例[J].实用中医药杂志,2010,26(4):234-235.
[14]闫桦.坤宝丸治疗女性更年期综合征36例[J].中国民间疗法,2006,14(10):38-39.
[15]魏桂梅,张兰芳.坤宝丸治疗妇女更年期综合征42例临床追踪观察[J].中医临床研究,2015,7(26):97,99.
[16]何彬.坤宝丸治疗妇女围绝经期综合征108例效果观察[J].社区医学杂志,2010,8(14):55.
[2]于舒雁,刘会丽,苗明三.更年期综合征的分子机制及中医药治疗更年期综合征的特点[J].中医学报,2012,3(3):338-339.
[3]任婕,王天芳,李力,等.更年期综合征绝经前与绝经后临床常见中医症状及体征的分布特点[J].中华中医药杂志,2010,25(8):1202-1204.
[4]孙艳,张百梅,左卓,等.补肾健脾方缓解女性更年期综合征的实验研究[J].中医药信息,2014,31(3):70-72.
[5]代利民.替勃龙治疗绝经后更年期综合征临床效果观察[J].临床和实验医学杂志,2007,6(3):45-46.
[6]杨新,康佳丽,聂妙玲,等.HRT对更年期综合症治疗的研究[J].临床医药实践,2009,18(2):100-101.
[7]罗娟,于铁.坤泰胶囊治疗女性肝肾阴虚型更年期综合征临床观察[J].临床医药文献杂志,2016,3(24):4893-4896.
[8]刘琪.坤宝丸与西药治疗更年期综合征临床疗效对比分析[J].中医药学报,2014,42(5):143-145.
[9]李晔,周明芳,王君伟.坤宝丸治疗围绝经期综合征的临床研究[J].时珍国医国药,2013,24(8):1957-1958.
[10]杨玉环.坤宝丸治疗更年期综合征的临床观察[J].实用妇科内分泌电子杂志,2015,2(11):97-98.
[11]郭睿,刘砚韬.坤宝丸治疗更年期综合征32例疗效及安全性分析[J].中国药业,2015,24(24):223-224.
[12]徐琦.坤宝丸治疗更年期综合征28例[J].中国临床医生,2013,41(3):72-73.
[13]郭力文.坤宝丸为主治疗更年期综合征60例[J].实用中医药杂志,2010,26(4):234-235.
[14]闫桦.坤宝丸治疗女性更年期综合征36例[J].中国民间疗法,2006,14(10):38-39.
[15]魏桂梅,张兰芳.坤宝丸治疗妇女更年期综合征42例临床追踪观察[J].中医临床研究,2015,7(26):97,99.
[16]何彬.坤宝丸治疗妇女围绝经期综合征108例效果观察[J].社区医学杂志,2010,8(14):55.