丙泊酚与气体麻醉对老年患者术后认知功能障碍的影响
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摘要
目的观察丙泊酚与气体麻醉用于老年患者术后对其认知功能障碍的影响。方法选取2017年5月至2018年5月本院收治的96例老年手术患者作为对象,分为观察组和对照组,每组48例。对照组行气体麻醉,观察组行丙泊酚麻醉,对比两组患者术后认知能力。结果两组患者术后4 h均出现认知功能障碍,MMSE评分差异无统计学意义(P> 0.05);术后8 h,观察组患者认知功能障碍有所缓解,其MMSE评分优于对照组(P <0.05);术后120 h,两组患者知功能障碍基本消失,MMSE评分接近(P> 0.05)。结论丙泊酚以及气体麻醉对老年患者术后认知水平均有不利影响,丙泊酚所致认知功能障碍消除时间较短。
Objective To compare the effect of propofol and gas anesthesia on postoperative cognitive dysfunction in elderly patients with. Methods From May 2017 to May 2018,96 elderly surgical patients were divided into observation group and control group,48 cases in each group. The control group received gas anesthesia,and the observation group received propofol anesthesia. The postoperative cognitive ability of the two groups was compared. Results Cognitive dysfunction occurred in both groups 4 h after operation,and there was no significant difference in MMSE score between the two groups(P>0.05),8 h after operation,cognitive dysfunction in the observation group was alleviated,and the MMSE score was better than that in the control group,the difference was statistically significant(P<0.05),120 h after operation,the difference of cognitive dysfunction in the two groups disappeared(P>0.05). Conclusion Both propofol and gas anesthesia have adverse effects on postoperative cognitive level in elderly patients,and the elimination time of propofol-induced cognitive impairment is shorter.
Objective To compare the effect of propofol and gas anesthesia on postoperative cognitive dysfunction in elderly patients with. Methods From May 2017 to May 2018,96 elderly surgical patients were divided into observation group and control group,48 cases in each group. The control group received gas anesthesia,and the observation group received propofol anesthesia. The postoperative cognitive ability of the two groups was compared. Results Cognitive dysfunction occurred in both groups 4 h after operation,and there was no significant difference in MMSE score between the two groups(P>0.05),8 h after operation,cognitive dysfunction in the observation group was alleviated,and the MMSE score was better than that in the control group,the difference was statistically significant(P<0.05),120 h after operation,the difference of cognitive dysfunction in the two groups disappeared(P>0.05). Conclusion Both propofol and gas anesthesia have adverse effects on postoperative cognitive level in elderly patients,and the elimination time of propofol-induced cognitive impairment is shorter.
引文
[1]张毅,陈伟,陈鹏,等.不同麻醉方式对老年患者术中及术后MAP、SPO_2、HR的影响及术后认知功能分析[J].解放军预防医学杂志,2018,36(5):672-675.
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[5]孙娜,金立民,李佳美,等.盐酸羟考酮注射液复合丙泊酚麻醉用于老年患者内镜下逆行胰胆管造影术疗效和安全性[J].中国老年学杂志,2015,35(18):5225-5227.
[6]梁东科,张炳东,梁蓓薇,等.硫酸镁联合复方利多卡因乳膏对丙泊酚麻醉下瑞芬太尼抑制双腔支气管插管反应的半数有效量[J].临床麻醉学杂志,2015,31(1):36-38.
[7]周柃汐,刘庆,彭劲松,等.不同浓度七氟醚复合丙泊酚麻醉对肝脏部分切除术患者术后苏醒质量的影响[J].临床麻醉学杂志,2014,30(6):550-553.
[8]刘景景,李玉兰,杨峰,等.L-655,708对丙泊酚麻醉大鼠海马磷酸化Tau蛋白表达及认知功能的影响[J].临床麻醉学杂志,2014,30(5):494-498.
[2]吉鸿斌.对比分析全身麻醉、硬膜外麻醉两种手术麻醉方式对老年骨科患者术后短期认知功能的影响[J].中国医药指南,2018,16(13):187-188.
[3]兰华.不同麻醉方式对老年骨科患者术后认知功能的影响情况探究[J].临床医药文献电子杂志,2018,5(21):76.
[4]葛明月,王胜,代志刚,等.丙泊酚麻醉对颅脑损伤手术患者脑保护作用的系统评价[J].中国现代医学杂志,2015,25(34):44-50.
[5]孙娜,金立民,李佳美,等.盐酸羟考酮注射液复合丙泊酚麻醉用于老年患者内镜下逆行胰胆管造影术疗效和安全性[J].中国老年学杂志,2015,35(18):5225-5227.
[6]梁东科,张炳东,梁蓓薇,等.硫酸镁联合复方利多卡因乳膏对丙泊酚麻醉下瑞芬太尼抑制双腔支气管插管反应的半数有效量[J].临床麻醉学杂志,2015,31(1):36-38.
[7]周柃汐,刘庆,彭劲松,等.不同浓度七氟醚复合丙泊酚麻醉对肝脏部分切除术患者术后苏醒质量的影响[J].临床麻醉学杂志,2014,30(6):550-553.
[8]刘景景,李玉兰,杨峰,等.L-655,708对丙泊酚麻醉大鼠海马磷酸化Tau蛋白表达及认知功能的影响[J].临床麻醉学杂志,2014,30(5):494-498.