孕期被动吸烟动物模型的制备方法概述
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摘要
香烟烟雾中含有大量的有害化合物,长期处于被动吸烟的环境中不仅可致亲代多器官系统发生病变,亦可引起子代神经系统发育迟缓和认知障碍。孕期被动吸烟的危害越来越受到关注,但目前国内外被动吸烟动物模型的构建方法多种多样,尚无通用的造模方法。本文结合相关文献对孕期被动吸烟模型制备的种类和方法进行综述,为进一步做好被动吸烟的相关研究提供参考。
Cigarette smoke contains a large number of harmful compounds. In a passive smoking environment for a long time,it can not only cause pathological changes in the multiple organs system,but also cause neurodevelopmental retardation and cognitive impairment in the offspring. The danger of passive smoking during pregnancy is becoming more and more concerned.At present,there are many ways to build passive smoking animal models at home and abroad,and there is no general modeling method. Combined with the relevant literature,this paper reviews the types and methods of passive smoking models during pregnancy to provide reference for further research on passive smoking.
Cigarette smoke contains a large number of harmful compounds. In a passive smoking environment for a long time,it can not only cause pathological changes in the multiple organs system,but also cause neurodevelopmental retardation and cognitive impairment in the offspring. The danger of passive smoking during pregnancy is becoming more and more concerned.At present,there are many ways to build passive smoking animal models at home and abroad,and there is no general modeling method. Combined with the relevant literature,this paper reviews the types and methods of passive smoking models during pregnancy to provide reference for further research on passive smoking.
引文
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[2]徐绍业,林燕萍,梁紫微,等.蚊香熏染对大鼠胚胎发育的影响[J].现代预防医学,2014,41(21):3973-3974,3982.
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[4]张霞燕.孕期被动吸烟对子代大鼠血清白三烯B4水平的影响[J].中国妇幼保健,2014,29(34):5685-5686.
[5]王元耕,刘明慧,李宪东,等.清燥救肺汤对被动吸烟小鼠呼吸系统的保护作用[J].山东中医药大学学报,2015,39(4):365-367.
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[7]Sonnenfeld G,Griffith RB,Hudgens RW.The effect of smoke Generation and manipulation variables on the cytotoxicity of mainstream and sidestream cigarette smoke to monolayer cultures of L-929 cells[J].Archives of Toxicology,1985,58(2):120-122.
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[9]宋旭艳,罗诚浩,魏敏,等.木蝴蝶提取物在卷烟中的应用研究[J].中国烟草学报,2010,16(4):19-23,39.
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[11]李芳兰.被动吸烟对幼鼠学习记忆及小脑皮质神经生长因子含量的影响[J].南京医科大学学报(自然科学版),2010,30(2):188-190.
[12]聂黎虹,胡雅洁,李显科,等.宫内香烟烟雾暴露对新生大鼠延髓3-巯基丙酮酸转硫酶表达的影响[J].四川大学学报(医学版),2013,44(4):526-530.
[13]章诗琪,陈弦,何倩,等.被动吸烟对子鼠海马神经元内钙/钙调蛋白激酶的影响[J].神经解剖学杂志,2009,25(4):465-468.
[14]Neal RE,Jagadapillai R,Chen J,et al.Developmental cigarette smoke exposure II:Hippocampus proteome and metabolome profiles in adult offspring[J].Reproductive Toxicology(Elmsford,N.Y.),2016,65:436-447.
[15]胡灵玉,何德文.被动吸烟对孕鼠及胚胎发育的影响[J].环境与健康杂志,2003,20(6):329-330.
[16]于向民,潘晓亮,闫凤霞,等.被动吸烟对胚胎致畸作用的研究和致畸动物模型的建立[J].中国优生与遗传杂志,2006,14(6):89-90.
[17]伦宗姬,薄其付.吸入性烟雾对大鼠胚胎发育影响的实验研究[J].中国现代药物应用,2011,5(5):29-30.
[18]徐绍业,曹山虎,张大红,等.被动吸烟对大鼠卵泡发育和胚胎发育的影响[J].现代预防医学,2014,41(17):3194-3197,3203.
[19]Hall BJ,Cauley M,Burke DA,et al.Cognitive and behavioral impairments evoked by low-level exposure to tobacco smoke components:comparison with nicotine alone[J].Toxicological Sciences,2016,151(2):236-244.
[20]韩国庆,杨博,张君嗣,等.围产期慢性尼古丁摄入对子代小鼠学习与记忆的影响[J].生物物理学报,2012,28(2):112-118.
[21]冯和玺,关怀,梅俊杰.妊娠期大鼠皮下注射尼古丁对子代发育和行为的影响[J].环境与职业医学,2014,32(9):714.
[22]张玉英,杨玮丽,朱琍燕,等.孕产期母鼠体内给予尼古丁对其子代肾脏RAS发育的影响[J].苏州大学学报(医学版),2010,30(4):677-680.
[2]徐绍业,林燕萍,梁紫微,等.蚊香熏染对大鼠胚胎发育的影响[J].现代预防医学,2014,41(21):3973-3974,3982.
[3]zbeyli D,Berberoglu AC,zen A,et al.Protective effect of alpha-lipoic acid,aerobic or resistance exercise from colitis in second hand smoke exposed young rats[J].Clinical and Experimental Pharmacology&Physiology,2017,44(1):62-70.
[4]张霞燕.孕期被动吸烟对子代大鼠血清白三烯B4水平的影响[J].中国妇幼保健,2014,29(34):5685-5686.
[5]王元耕,刘明慧,李宪东,等.清燥救肺汤对被动吸烟小鼠呼吸系统的保护作用[J].山东中医药大学学报,2015,39(4):365-367.
[6]李阳青.被动吸烟动物COPD模型染毒系统的设计[J].中国医疗器械信息,2016,22(4):23-52.
[7]Sonnenfeld G,Griffith RB,Hudgens RW.The effect of smoke Generation and manipulation variables on the cytotoxicity of mainstream and sidestream cigarette smoke to monolayer cultures of L-929 cells[J].Archives of Toxicology,1985,58(2):120-122.
[8]Santiago HA,Zamarioli A,Sousa Neto MD,et al.Exposure to secondhand smoke impairs fracture healing in rats[J].Clinical Orthopaedics and Related Research,2017,475(3):894-902.
[9]宋旭艳,罗诚浩,魏敏,等.木蝴蝶提取物在卷烟中的应用研究[J].中国烟草学报,2010,16(4):19-23,39.
[10]叶力通,江雪燕,张梦珍,等.孕期吸烟对SD大鼠胚胎心脏发育的影响[J].热带医学杂志,2014,14(5):551-554.
[11]李芳兰.被动吸烟对幼鼠学习记忆及小脑皮质神经生长因子含量的影响[J].南京医科大学学报(自然科学版),2010,30(2):188-190.
[12]聂黎虹,胡雅洁,李显科,等.宫内香烟烟雾暴露对新生大鼠延髓3-巯基丙酮酸转硫酶表达的影响[J].四川大学学报(医学版),2013,44(4):526-530.
[13]章诗琪,陈弦,何倩,等.被动吸烟对子鼠海马神经元内钙/钙调蛋白激酶的影响[J].神经解剖学杂志,2009,25(4):465-468.
[14]Neal RE,Jagadapillai R,Chen J,et al.Developmental cigarette smoke exposure II:Hippocampus proteome and metabolome profiles in adult offspring[J].Reproductive Toxicology(Elmsford,N.Y.),2016,65:436-447.
[15]胡灵玉,何德文.被动吸烟对孕鼠及胚胎发育的影响[J].环境与健康杂志,2003,20(6):329-330.
[16]于向民,潘晓亮,闫凤霞,等.被动吸烟对胚胎致畸作用的研究和致畸动物模型的建立[J].中国优生与遗传杂志,2006,14(6):89-90.
[17]伦宗姬,薄其付.吸入性烟雾对大鼠胚胎发育影响的实验研究[J].中国现代药物应用,2011,5(5):29-30.
[18]徐绍业,曹山虎,张大红,等.被动吸烟对大鼠卵泡发育和胚胎发育的影响[J].现代预防医学,2014,41(17):3194-3197,3203.
[19]Hall BJ,Cauley M,Burke DA,et al.Cognitive and behavioral impairments evoked by low-level exposure to tobacco smoke components:comparison with nicotine alone[J].Toxicological Sciences,2016,151(2):236-244.
[20]韩国庆,杨博,张君嗣,等.围产期慢性尼古丁摄入对子代小鼠学习与记忆的影响[J].生物物理学报,2012,28(2):112-118.
[21]冯和玺,关怀,梅俊杰.妊娠期大鼠皮下注射尼古丁对子代发育和行为的影响[J].环境与职业医学,2014,32(9):714.
[22]张玉英,杨玮丽,朱琍燕,等.孕产期母鼠体内给予尼古丁对其子代肾脏RAS发育的影响[J].苏州大学学报(医学版),2010,30(4):677-680.