茶叶降血糖活性及对糖尿病的功效与机理
摘要
糖尿病是现代人群面临的主要病症之一,中国糖尿病患者人数已达1.14亿人之多。茶叶作为广受关注的健康饮料,具有抗氧化、降血糖、抗癌等多种功效。流行病学调查显示,坚持饮茶,例如绿茶、乌龙茶、红茶、黑茶等,有可能降低患糖尿病的风险,因此可作为推荐的日常健康生活方式。茶叶富含茶多糖、茶多酚、儿茶素、茶色素等活性成分,能够抑制α-糖苷酶活性,保护胰脏、肝、肾等器官,改善胰岛素抵抗,从而延缓糖类吸收、降低血糖水平、缓解糖尿病病情等。现代科学研究中,已经发现茶叶功能成分的多种降血糖作用机制。
引文
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[22]倪德江,谢笔钧,宋春和.不同茶类多糖对实验型糖尿病小鼠治疗作用的比较研究[J].茶叶科学,2002,22(2):160-163.
[23]俞东宁,陈萍,王爽,等.龙井茶多糖对ALX糖尿病模型小鼠氧化应激的影响[J].中国食品学报,2016,16(4):30-34.
[24]王林戈.绿茶茶多糖与茶多酚对胰岛细胞的协同保护作用研究[D].青岛:中国海洋大学,2011.
[25]Zhou X,Wang D,Sun P,et al.Effects of soluble tea polysaccharides on hyperglycemia in alloxan-diabetic mice[J].J Agri Food Chem,2007,55(14):5523-5528.
[26]Xu P,Chen H,Wang Y,et al.Oral administration of puerh tea polysaccharides lowers blood glucose levels and enhances antioxidant status in alloxan-induced diabetic mice[J].J Food Sci,2012,77(11):246-252.
[27]曹忠良,彭雨轩.天尖茶对糖尿病小鼠的降血糖作用研究[J].湖南城市学院学报(自然科学版),2017,26(2):76-78.
[28]林裕华,陈进川,黄博威,等.茶多酚在糖尿病糖脂代谢中的作用机制[J].福建中医药,2017,48(5):37-38.
[29]高媛圆,毛立民,徐平,等.茶多酚防治2型糖尿病的分子机理研究进展[J].茶叶科学,2015,35(3):239-247.
[30]李星亚,汪东风,王林戈,等.茶多糖和茶多酚对糖尿病的协同防治作用[J].食品研究与开发,2013,34(11):72-76.
[31]Kamiyama O,Sanae F,Ikeda K,et al.In vitro inhibition ofα-glucosidases and glycogen phosphorylase by catechin gallates in green tea[J].Food Chemistry,2010,122(4):1061-1066.
[32]Abe K,Okada N,Tanabe H,et al.Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats[J].Biomedical Research,2009,30(1):25-29.
[33]Sabu M C,Smitha K,Kuttan R.Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes[J].Journal of Ethnopharmacology,2002,83(1/2):109-116.
[34]Nagao T,Meguro S,Hase T,et al.A catechin-rich beverage improves obesity and blood glucose control in patients with type 2 diabetes[J].Obesity,2009,17(2):310-317.
[35]Qin B,Polansky M M,Harry D,et al.Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats[J].Mol Nutri Food Res,2010,54(s1):s14-s23.
[36]Cai E P,Lin J K.Epigallocatechin gallate(EGCG)and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic beta cells[J].J Agri Food Chem,2009,57(20):9817-9827.
[37]Song E K,Hur H,Han M K.Epigallocatechin gallate prevents autoimmune diabetes induced by multiple low doses of streptozotocin in mice[J].Archi Pharma Res,2003,26(7):559-563.
[38]Lin C L,Lin J K.Epigallocatechin gallate(EGCG)attenuates high glucose-induced insulin signaling blockade in human hepG2 hepatoma cells[J].Mol Nutri Food Res,2008,52(8):930-939.
[39]Anderson R A,Polansky M M.Tea enhances insulin activity[J].J Aagri Food Chem,2002,50(24):7182-7186.
[40]Matsui T,Tanaka T,Tamura S,et al.alpha-Glucosidase inhibitory profile of catechins and theaflavins[J].J Agri Food Chem,2007,55(1):99-105.
[41]陈云.茶色素对糖尿病并发症的防治[J].长春中医药大学学报,2015,31(6):1206-1207.
[42]徐湘婷,王鹏,罗绍忠,等.普洱熟茶茶褐素对2型糖尿病小鼠降糖作用研究[J].中国民族民间医药,2015,24(20):9-10.
[2]丁仁凤,何普明.茶叶与糖尿病关系的研究概况[J].茶叶,2004(4):207-209.
[3]Yang C S,Wang H,Sheridan Z P.Studies on prevention of obesity,metabolic syndrome,diabetes,cardiovascular diseases and cancer by tea[J].J Food Drug Anal,2018,26(1):1-13.
[4]Brownlee M.Biochemistry and molecular cell biology of diabetic complications[J].Nature,2001,414(6865):813-820.
[5]Park J H,Bae J H,Im S S.Green tea and type 2 diabetes[J].Integrative Medicine Research,2014,3(1):4-10.
[6]Huxley R,Lee C M Y,Barzi F,et al.Coffee,decaffeinated coffee,and tea consumption in relation to incident type 2 diabetes mellitus:a systematic review with meta-analysis[J].Archi Intern Med,2009,169(22):2053-2063.
[7]潘雪君,张明,文素利.中医药茶对老年2型糖尿病患者的保健效果[J].西部中医药,2017,30(1):99-102.
[8]Tsuneki H,Ishizuka M,Terasawa M,et al.ect of green tea on blood glucose levels and serum proteomic patterns indiabetic(db/db)mice and on glucose metabolism in healthy humans[J].BMC pharmacology,2004,4:18.
[9]Islam M S,Choi H.Green tea,anti-diabetic or diabetogenic:a dose response study[J].BioFactors,2007,29(1):45-53.
[10]Wu L Y,Juan C C,Ho L T,et al.Effect of green tea supplementation on insulin sensitivity in Sprague-Dawley rats[J].J Agri Food Chem,2004,52(3):643-648.
[11]郑霞,胡申江,张瑛,等.茶多酚对正常大鼠及糖尿病大鼠右室乳头肌收缩功能的影响[J].中国病理生理杂志,2005,21(10):1930-1933.
[12]Nishiumi S,Bessyo H,Kubo M,et al.Green and black tea suppress hyperglycemia and insulin resistance by retaining the expression of glucose transporter 4 in muscle of high-fat diet-fed C57BL/6J mice[J].J Agri Food Chem,2010,58(24):12916-12923.
[13]Gomes A,Vedasiromoni J,Das M,et al.Anti-hyperglycemic effect of black tea(Camellia sinensis)in rat[J].J Ethnopharmac,1995,45(3):223-226.
[14]Manikandan R,Sundaram R,Thiagarajan R,et al.Effect of black tea on histological and immunohistochemical changes in pancreatic tissues of normal and streptozotocin-induced diabetic mice(Mus musculus)[J].Micro Res Techn,2009,72(10):723-726.
[15]Thiagarajan G,Chandani S,Sundari C S,et al.Antioxidant properties of green and black tea,and their potential ability to retard the progression of eye lens cataract[J].Exper Eye Res,2001,73(3):393-401.
[16]黄颂.茯茶对Ⅱ型糖尿病小鼠糖脂代谢的干预作用及机制研究[D].长沙:湖南农业大学,2016.
[17]Hosoda K,Wang M F,Liao M L,et al.Antihyperglycemic effect of Oolong tea in type 2 diabetes[J].Diabetes Care,2003,26(6):1714-1718.
[18]安品弟,蒋慧颖,马玉仙,等.武夷岩茶复方颗粒剂对糖尿病大鼠的降血糖作用[J].河南科技大学学报(医学版),2017,35(1):14-17.
[19]Islam M S.Effects of the aqueous extract of white tea(Camellia sinensis)in a streptozotocin-induced diabetes model of rats[J].Phytomedicine:International Journal of Phytotherapy and Phytopharmacology,2011,19(1):25-31.
[20]Fang C Y,Wang X J,Huang Y W,et al.Caffeine is responsible for the bloodglucose-lowering effects of green tea and Puer tea extractsin BALB/c mice[J].Chinese J Natural Medicines,2015,13(8):595-601.
[21]清水岑夫.ぉ茶の血糖降下作用について[J].茶(日),1987(3):24-27.
[22]倪德江,谢笔钧,宋春和.不同茶类多糖对实验型糖尿病小鼠治疗作用的比较研究[J].茶叶科学,2002,22(2):160-163.
[23]俞东宁,陈萍,王爽,等.龙井茶多糖对ALX糖尿病模型小鼠氧化应激的影响[J].中国食品学报,2016,16(4):30-34.
[24]王林戈.绿茶茶多糖与茶多酚对胰岛细胞的协同保护作用研究[D].青岛:中国海洋大学,2011.
[25]Zhou X,Wang D,Sun P,et al.Effects of soluble tea polysaccharides on hyperglycemia in alloxan-diabetic mice[J].J Agri Food Chem,2007,55(14):5523-5528.
[26]Xu P,Chen H,Wang Y,et al.Oral administration of puerh tea polysaccharides lowers blood glucose levels and enhances antioxidant status in alloxan-induced diabetic mice[J].J Food Sci,2012,77(11):246-252.
[27]曹忠良,彭雨轩.天尖茶对糖尿病小鼠的降血糖作用研究[J].湖南城市学院学报(自然科学版),2017,26(2):76-78.
[28]林裕华,陈进川,黄博威,等.茶多酚在糖尿病糖脂代谢中的作用机制[J].福建中医药,2017,48(5):37-38.
[29]高媛圆,毛立民,徐平,等.茶多酚防治2型糖尿病的分子机理研究进展[J].茶叶科学,2015,35(3):239-247.
[30]李星亚,汪东风,王林戈,等.茶多糖和茶多酚对糖尿病的协同防治作用[J].食品研究与开发,2013,34(11):72-76.
[31]Kamiyama O,Sanae F,Ikeda K,et al.In vitro inhibition ofα-glucosidases and glycogen phosphorylase by catechin gallates in green tea[J].Food Chemistry,2010,122(4):1061-1066.
[32]Abe K,Okada N,Tanabe H,et al.Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats[J].Biomedical Research,2009,30(1):25-29.
[33]Sabu M C,Smitha K,Kuttan R.Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes[J].Journal of Ethnopharmacology,2002,83(1/2):109-116.
[34]Nagao T,Meguro S,Hase T,et al.A catechin-rich beverage improves obesity and blood glucose control in patients with type 2 diabetes[J].Obesity,2009,17(2):310-317.
[35]Qin B,Polansky M M,Harry D,et al.Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats[J].Mol Nutri Food Res,2010,54(s1):s14-s23.
[36]Cai E P,Lin J K.Epigallocatechin gallate(EGCG)and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic beta cells[J].J Agri Food Chem,2009,57(20):9817-9827.
[37]Song E K,Hur H,Han M K.Epigallocatechin gallate prevents autoimmune diabetes induced by multiple low doses of streptozotocin in mice[J].Archi Pharma Res,2003,26(7):559-563.
[38]Lin C L,Lin J K.Epigallocatechin gallate(EGCG)attenuates high glucose-induced insulin signaling blockade in human hepG2 hepatoma cells[J].Mol Nutri Food Res,2008,52(8):930-939.
[39]Anderson R A,Polansky M M.Tea enhances insulin activity[J].J Aagri Food Chem,2002,50(24):7182-7186.
[40]Matsui T,Tanaka T,Tamura S,et al.alpha-Glucosidase inhibitory profile of catechins and theaflavins[J].J Agri Food Chem,2007,55(1):99-105.
[41]陈云.茶色素对糖尿病并发症的防治[J].长春中医药大学学报,2015,31(6):1206-1207.
[42]徐湘婷,王鹏,罗绍忠,等.普洱熟茶茶褐素对2型糖尿病小鼠降糖作用研究[J].中国民族民间医药,2015,24(20):9-10.