思连康联合蒙脱石散治疗小儿急性肠炎的疗效和对血清IgG、IgA、IgM水平的影响
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摘要
目的:探讨思连康联合蒙脱石散治疗小儿急性肠炎的临床疗效和对血清Ig G、Ig A、Ig M水平的影响。方法:选择我院2016年8至2017年8月收治的86例小儿急性肠炎患儿,根据随机数字表法将其随机分为观察组及对照组,两组患儿均给予常规治疗,对照组患儿在常规治疗基础上给予蒙脱石散治疗,观察组在对照组基础上给予思连康治疗。观察和比较两组患儿治疗后的疗效、呕吐缓解时间、发热消退时间、大便恢复正常时间、腹痛缓解时间、粪便常规恢复正常的时间及两组治疗前后的血清Ig G、Ig A、Ig M水平的变化情况。结果:治疗后,观察组和对照组的总有效率分别为95.2%(40/42)、79.5%(35/44),观察组总有效率显著明显高于对照组(P<0.05);观察组患儿的呕吐缓解时间、发热消退时间、大便恢复正常时间、腹痛缓解时间及粪便常规恢复正常的时间均明显短于对照组(P<0.05)。治疗后,两组患儿的血清Ig G、Ig A、Ig M水平均较治疗前明显升高,且观察组治疗后血清Ig G、Ig A、Ig M水平均明显高于对照组(P<0.05)。结论:与单用蒙脱石散治疗相比,思连康联合蒙脱石散治疗小儿急性肠炎可有效提高治疗效果,缩短患儿临床症状改善时间,提高患儿免疫力。
Objective: To investigate the clinical efficacy of Si Liankang combined with montmorillonite in the treatment of children with pediatric acute enteritis and its effect on the serum Ig G, Ig A and Ig M levels. Methods: 86 cases with pediatric acute enteritis from August 2016 to August 2017 in our hospital were selected and divided into the observation group and control group according to random number table method, both groups were given conventional treatment, the control group was given montmorillonite on the basis of conventional treatment, the observation group was given Si Liankang on the basis of control group. The curative effect, remission time of vomiting, remission time of fever, recovery time of stool, abdominal pain relief time, routine recovery time of stool were observed and compared between the two groups. And the changes of serum Ig G, Ig A and Ig M levels before and after treatment were observed and compared between the two groups. Results: After treatment, the total effective rate of observation group and the control group were95.2%(40/42) and 79.5%(35/44), respectively, which was significantly higher in the observation group than that of the control group(P<0.05). The remission time of vomiting, fever subsidence time, fecal recovery time, abdominal pain relief time and fecal routine recovery time of observation group were significantly shorter than those of the control group(P<0.05). After treatment, the levels of serum Ig G, Ig A and Ig M in both groups were significantly higher than those before treatment, and the levels of serum Ig G, Ig A and Ig M in the observation group were significantly higher than those in the control group(P<0.05). Conclusion: Compared with montmorillonite alone,Siliankang combined with montmorillonite can effectively improve the therapeutic effect, shorten the improvement time of clinical symptoms and improve the immunity of children with acute enteritis.
Objective: To investigate the clinical efficacy of Si Liankang combined with montmorillonite in the treatment of children with pediatric acute enteritis and its effect on the serum Ig G, Ig A and Ig M levels. Methods: 86 cases with pediatric acute enteritis from August 2016 to August 2017 in our hospital were selected and divided into the observation group and control group according to random number table method, both groups were given conventional treatment, the control group was given montmorillonite on the basis of conventional treatment, the observation group was given Si Liankang on the basis of control group. The curative effect, remission time of vomiting, remission time of fever, recovery time of stool, abdominal pain relief time, routine recovery time of stool were observed and compared between the two groups. And the changes of serum Ig G, Ig A and Ig M levels before and after treatment were observed and compared between the two groups. Results: After treatment, the total effective rate of observation group and the control group were95.2%(40/42) and 79.5%(35/44), respectively, which was significantly higher in the observation group than that of the control group(P<0.05). The remission time of vomiting, fever subsidence time, fecal recovery time, abdominal pain relief time and fecal routine recovery time of observation group were significantly shorter than those of the control group(P<0.05). After treatment, the levels of serum Ig G, Ig A and Ig M in both groups were significantly higher than those before treatment, and the levels of serum Ig G, Ig A and Ig M in the observation group were significantly higher than those in the control group(P<0.05). Conclusion: Compared with montmorillonite alone,Siliankang combined with montmorillonite can effectively improve the therapeutic effect, shorten the improvement time of clinical symptoms and improve the immunity of children with acute enteritis.
引文
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[24]Sultan M A,Hassan Z.Assessment of severity of acute gastroenteritis in the paediatric Pakistani population by Modified Vesikari Score[J].Journal of the Pakistan Medical Association,2018,68(2):159-164
[25]Piralla A,Lunghi G,Ardissino G,et al.FilmArrayTMGI panel performance for the diagnosis of acute gastroenteritis or hemorragic diarrhea[J].Bmc Microbiology,2017,17(1):111
[26]Parker T C,Mohammed A,Leong T,et al.Rotavirus vaccination rate disparities seen among infants with acute gastroenteritis in Georgia[J].Ethnicity&Health,2017,22(6):1
[27]Lusignan S D,Konstantara E,Joy M,et al.Incidence of household transmission of acute gastroenteritis(AGE)in a primary care sentinel network(1992-2017):cross-sectional and retrospective cohort study protocol[J].Bmj Open,2018,8(8):e022524
[28]Koklu H,Buyukeren B,Inkaya A C,et al.An Unexpected Cause of Acute Enteritis in a Patient with Pure Red Cell Aplasia Parvovirus B19-Associated Acute Enteritis[J].American Journal of Gastroenterology,2018,113(4):630
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[30]Verstraeten T,Cattaert T,Ferreira G.Gender Inequality In Acute Gastro-Enteritis Rates In England[J].Value in Health,2017,20(9):A781
[2]Ntk P,Thongprachum A,Baba T,et al.A 3-Month-Old Child with Acute Gastroenteritis with Enterovirus D68 Detected from Stool Specimen[J].Clinical Laboratory,2017,63(7):1269
[3]Zhuo R,Parsons B D,Lee B E,et al.Identification of Enteric Viruses in Oral Swabs from Children with Acute Gastroenteritis[J].Journal of Molecular Diagnostics,2018,20(1):56-62
[4]Takeuchi M,Yasunaga H,Matsui H,et al.Pediatric urolithiasis associated with acute gastroenteritis:an inpatient database study in Japan[J].European Journal of Pediatrics,2017,176(4):1-7
[5]Geurts D,Moll H,Oostenbrink R.Do we need repeated weight measurements to assess dehydration in children with acute gastroenteritis at the emergency department?[J].European Journal of Pediatrics,2018,177(2):1-2
[6]Gasparinho C,Piedade J,Mirante M C,et al.Characterization of rotavirus infection in children with acute gastroenteritis in Bengo province,Northwestern Angola,prior to vaccine introduction[J].Plos One,2017,12(4):e0176046
[7]Geurts D,Vos-Kerkhof E D,Polinder S,et al.Implementation of clinical decision support in young children with acute gastroenteritis:a randomized controlled trial at the emergency department[J].European Journal of Pediatrics,2017,176(2):173-181
[8]Neres S T,D觔b N,Souza F F,et al.Sapovirus in Fecal and Nasopharyngeal Swab Samples of Children with Symptoms of Acute Gastroenteritis[J].Pediatric Infectious Disease Journal,2017,37(4):1
[9]Iro M A,Sell T,Brown N,et al.Rapid intravenous rehydration of children with acute gastroenteritis and dehydration:a systematic review and meta-analysis[J].Bmc Pediatrics,2018,18(1):44
[10]Imdad A,Foster M A,Iqbal J,et al.Diarrheagenic Escherichia Coli and Acute Gastroenteritis in Children in Davidson County,Tennessee,United States:A Case-Control Study[J].Pediatric Infectious Disease Journal,2018,37(6):1
[11]Kumthip K,Khamrin P,Maneekarn N.Detection of poliovirus infection in children with acute gastroenteritis in Chiang Mai,Thailand[J].Journal of Medical Virology,2017,89(5):775-781
[12]Canziani B C,Uestuener P,Fossali E F,et al.Clinical Practice:Nausea and vomiting in acute gastroenteritis:physiopathology and management[J].European Journal of Pediatrics,2018,177(1):1-5
[13]AlcaláA C,Pérez K,Blanco R,et al.Molecular detection of human enteric viruses circulating among children with acute gastroenteritis in Valencia,Venezuela,before rotavirus vaccine implementation[J].Gut Pathogens,2018,10(1):6
[14]Sakon N,Miyamoto R,Komano J.An infant with acute gastroenteritis caused by a secondary infection with a Rotarix-derived strain[J].European Journal of Pediatrics,2017,176(9):1275-1278
[15]Kaneko M,Takanashi S,Thongprachum A,et al.Identification of vaccine-derived rotavirus strains in children with acute gastroenteritis in Japan,2012-2015[J].Plos One,2017,12(9):e0184067
[16]Felixvalenzuela L,Cooleygarcía D P,Canorangel M A,et al.Predominance of G9P[4]Rotavirus from Children with Acute Gastroenteritis in Northwestern Mexico[J].Intervirology,2017,59(4):228-233
[17]Costa L,Siqueira J,Portal T M,et al.Detection and genotyping of human adenovirus and sapovirus in children with acute gastroenteritis in Belém,Pará,between 1990 and 1992:first detection of GI.7 and GV.2 sapoviruses in Brazil[J].Revista Da Sociedade Brasileira De Medicina Tropical,2017,50(5):621
[18]Kim A,Chang J Y,Shin S,et al.Epidemiology and Factors Related to Clinical Severity of Acute Gastroenteritis in Hospitalized Children after the Introduction of Rotavirus Vaccination[J].Journal of Korean Medical Science,2017,32(3):465
[19]Ko覥odziej M,Bebenek D,Konarska Z,et al.Gelatine tannate in the management of acute gastroenteritis in children:a randomised controlled trial[J].Bmj Open,2018,8(5):e020205
[20]Hendrix N,Barzeev N,Atherly D,et al.The economic impact of childhood acute gastroenteritis on Malawian families and the healthcare system[J].Bmj Open,2017,7(9):e017347
[21]Yoshikawa T,Matsuki T,Sato K,et al.Impact of rotavirus vaccination on the burden of acute gastroenteritis in Nagoya city,Japan[J].Vaccine,2017,36(4):527-534
[22]Saudy N,Elshabrawy W O,Megahed A,et al.Genotyping and Clinicoepidemiological Characterization of Rotavirus Acute Gastroenteritis in Egyptian Children[J].Polish Journal of Microbiology,2017,65(4):433-442
[23]Yin H C,Zhao L L,Li S Q,et al.Autophagy activated by duck enteritis virus infection positively affects its replication[J].Journal of General Virology,2017,98(3):486-495
[24]Sultan M A,Hassan Z.Assessment of severity of acute gastroenteritis in the paediatric Pakistani population by Modified Vesikari Score[J].Journal of the Pakistan Medical Association,2018,68(2):159-164
[25]Piralla A,Lunghi G,Ardissino G,et al.FilmArrayTMGI panel performance for the diagnosis of acute gastroenteritis or hemorragic diarrhea[J].Bmc Microbiology,2017,17(1):111
[26]Parker T C,Mohammed A,Leong T,et al.Rotavirus vaccination rate disparities seen among infants with acute gastroenteritis in Georgia[J].Ethnicity&Health,2017,22(6):1
[27]Lusignan S D,Konstantara E,Joy M,et al.Incidence of household transmission of acute gastroenteritis(AGE)in a primary care sentinel network(1992-2017):cross-sectional and retrospective cohort study protocol[J].Bmj Open,2018,8(8):e022524
[28]Koklu H,Buyukeren B,Inkaya A C,et al.An Unexpected Cause of Acute Enteritis in a Patient with Pure Red Cell Aplasia Parvovirus B19-Associated Acute Enteritis[J].American Journal of Gastroenterology,2018,113(4):630
[29]Bernardes C,Quaresma F,Capela T,et al.Severe Cytomegalovirus ileitis preceded by acute bacterial enteritis in an immunocompetent patient[J].Acta gastro-enterologica Belgica,2018,81(1):109
[30]Verstraeten T,Cattaert T,Ferreira G.Gender Inequality In Acute Gastro-Enteritis Rates In England[J].Value in Health,2017,20(9):A781