sICAM-1和血小板PAC-1在慢性心力衰竭患者中的表达及与心功能的相关性
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摘要
目的分析可溶性细胞黏附分子-1(sICAM-1)和血小板膜暴露纤维蛋白原受体(PAC-1)在慢性心力衰竭(CHF)患者中的表达及与心功能的相关性。方法选取2016年7月—2017年7月收治的CHF患者92例,根据纽约心脏病协会(NYHA)心功能分级分为心功能Ⅱ级组32例、Ⅲ级组34例和Ⅳ级组26例,另选取同期健康体检者41例作为健康对照组,比较4组sICAM-1、血小板PAC-1和脑钠肽(BNP)表达水平,分析NYHA心功能分级与sICAM-1、血小板PAC-1及BNP表达水平的相关性。结果不同心功能分级CHF患者sICAM-1、血小板PAC-1和BNP水平高于健康对照组,且随着心功能分级的增高,sICAM-1和BNP水平呈不断上升趋势(P<0.05),而不同心功能分级患者间血小板PAC-1比较差异无统计学意义(P>0.05)。sICAM-1、血小板PAC-1和BNP水平与NYHA心功能分级呈正相关(P<0.01)。结论 CHF患者sICAM-1、血小板PAC-1和BNP水平较高,与NYHA心功能分级呈正相关。
Objective To analyze expressions of soluble cell adhesion molecule-1(sICAM-1) and PAC-1 in patients with chronic heart failure(CHF) and their correlations with cardiac function. Methods A total of 92 CHF patients admitted during July 2016 and July 2017 were divided into grade Ⅱ cardiac function group(n=32), grade Ⅲ cardiac function group(n=34) and grade Ⅳ cardiac function group(n=26) according to cardiac functional grading of New York Heart Association(NYHA), and other 41 healthy people taking medical examinations were selected as control group. Among 4 groups, expressions of sICAM-1, PAC-1 and brain natriuretic peptide(BNP) were compared, and correlations between NYHA cardiac functional grading with expressions of sICAM-1, PAC-1 and BNP were analyzed. Results Levels of sICAM-1, PAC-1 and BNP in different grades of cardiac function groups were significantly higher than those in control group, and levels of sICAM-1 and BNP were increased continuously with increasing grade of cardiac function(P<0.05). There were no significant differences in PAC-1 levels among different grades of cardiac function groups(P>0.05). Levels of sICAM-1, PAC-1 and BNP were positively correlated with NYHA cardiac functional grading(P<0.01). Conclusion Levels of sICAM-1, PAC-1 and BNP in CHF patients are higher than those in normal people, and the levels are positively correlated with NYHA cardiac functional grading.
Objective To analyze expressions of soluble cell adhesion molecule-1(sICAM-1) and PAC-1 in patients with chronic heart failure(CHF) and their correlations with cardiac function. Methods A total of 92 CHF patients admitted during July 2016 and July 2017 were divided into grade Ⅱ cardiac function group(n=32), grade Ⅲ cardiac function group(n=34) and grade Ⅳ cardiac function group(n=26) according to cardiac functional grading of New York Heart Association(NYHA), and other 41 healthy people taking medical examinations were selected as control group. Among 4 groups, expressions of sICAM-1, PAC-1 and brain natriuretic peptide(BNP) were compared, and correlations between NYHA cardiac functional grading with expressions of sICAM-1, PAC-1 and BNP were analyzed. Results Levels of sICAM-1, PAC-1 and BNP in different grades of cardiac function groups were significantly higher than those in control group, and levels of sICAM-1 and BNP were increased continuously with increasing grade of cardiac function(P<0.05). There were no significant differences in PAC-1 levels among different grades of cardiac function groups(P>0.05). Levels of sICAM-1, PAC-1 and BNP were positively correlated with NYHA cardiac functional grading(P<0.01). Conclusion Levels of sICAM-1, PAC-1 and BNP in CHF patients are higher than those in normal people, and the levels are positively correlated with NYHA cardiac functional grading.
引文
[1] 黄太宏,薛正青.白细胞膜黏附分子和sICAM-1在慢性充血性心力衰竭患者中的诊断价值[J].检验医学与临床,2017,14(19):2932-2933.
[2] 吴刚.老年慢性心力衰竭严重程度与血小板参数之间的关系[J].血栓与止血学,2016,22(1):99-100,103.
[3] 陈秀锋,王新华,胡静,等.血清可溶性血小板内皮细胞黏附分子-1水平与糖尿病肾病的相关性[J].上海医学,2017,40(1):45-47.
[4] 吴琼,王堃,向满林,等.可溶性细胞间粘附分子-1在乳腺癌患者血清中表达的临床意义[J].实用预防医学,2016,23(5):630-633.
[5] 费怀君,胡容.细胞间粘附分子-1在肿瘤研究中的进展[J].药物生物技术,2017,24(3):259-262.
[6] 葛均波,徐永健,梅长林,等.内科学[M].北京:人民卫生出版社,2013:21-27.
[7] McMurray J J,Adamopoulos S,Anker S D,et al.ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012:The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology.Developed in collaboration with the Heart Failure Association (HFA) of the ESC[J].Eur J Heart Fail,2012,14(8):803-869.
[8] 王齐国,龙训辉,徐测梁.慢性心力衰竭患者血小板PAC-1与NT-proBNP的相关性分析[J].中西医结合心脑血管病杂志,2015,13(14):1650-1652.
[9] 郭新颖,郭彩霞,杜凤和,等.心力衰竭患者血浆可溶性晚期糖基化终末产物受体(sRAGE)变化与心功能的关系[J].首都医科大学学报,2014,35(6):805-808.
[10] 段发兰,李亚新,杨飞翔,等.益心舒胶囊对急性脑梗死患者PAC-1和IL-18表达的影响[J].实用药物与临床,2016,19(3):307-310.
[11] 莫绍琴,王晓容,张箭.临床护理路径对老年慢性心力衰竭患者自我管理的影响[J].保健医学研究与实践,2017,14(4):82-84.
[12] 张艳,杨波,张炳山,等.DKK3基因在心力衰竭家兔心脏中的表达改变研究[J].医学分子生物学杂志,2016,13(5):254-257.
[13] 李明霞,赵轶峰,王俊芳,等.丹红注射液治疗糖尿病肾病的临床效果及对血小板CD62p、PAC-1表达的影响[J].中国医药导报,2016,13(19):92-95.
[14] 闫孝永.血浆肌钙蛋白Ⅰ和NT-proBNP含量对儿童肺炎合并心力衰竭的诊断价值[J].江苏大学学报:医学版,2017,27(4):312-315.
[15] 陈有维,唐娟,何乐愚,等.血清PCT与sICAM-1和sVCAM-1在慢性肾炎患者细菌感染中的应用[J].中华医院感染学杂志,2017,27(19):4359-4362.
[16] 李伟华,曹莉芳,姜威峰,等.应用cTnT和NT-proBNP水平综合评价左西孟旦治疗老年慢性心力衰竭的疗效[J].空军医学杂志,2016,32(2):102-105.
[17] 刘晶.协同护理模式对慢性心力衰竭患者自我护理能力及生活质量的影响[J].保健医学研究与实践,2018,15(1):88-90.
[18] 张艳,杨波,包明威,等.Nek6在心力衰竭家兔心脏中的表达增加[J].医学分子生物学杂志,2016,13(6):317-321.
[19] 赵丽,冯严敏.无创正压呼吸在急诊心力衰竭中的治疗价值[J].空军医学杂志,2017,33(6):401-404.
[20] 闫孝永.血浆肌钙蛋白Ⅰ和NT-proBNP含量对儿童肺炎合并心力衰竭的诊断价值[J].江苏大学学报:医学版,2017,27(4):312-315.
[2] 吴刚.老年慢性心力衰竭严重程度与血小板参数之间的关系[J].血栓与止血学,2016,22(1):99-100,103.
[3] 陈秀锋,王新华,胡静,等.血清可溶性血小板内皮细胞黏附分子-1水平与糖尿病肾病的相关性[J].上海医学,2017,40(1):45-47.
[4] 吴琼,王堃,向满林,等.可溶性细胞间粘附分子-1在乳腺癌患者血清中表达的临床意义[J].实用预防医学,2016,23(5):630-633.
[5] 费怀君,胡容.细胞间粘附分子-1在肿瘤研究中的进展[J].药物生物技术,2017,24(3):259-262.
[6] 葛均波,徐永健,梅长林,等.内科学[M].北京:人民卫生出版社,2013:21-27.
[7] McMurray J J,Adamopoulos S,Anker S D,et al.ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012:The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology.Developed in collaboration with the Heart Failure Association (HFA) of the ESC[J].Eur J Heart Fail,2012,14(8):803-869.
[8] 王齐国,龙训辉,徐测梁.慢性心力衰竭患者血小板PAC-1与NT-proBNP的相关性分析[J].中西医结合心脑血管病杂志,2015,13(14):1650-1652.
[9] 郭新颖,郭彩霞,杜凤和,等.心力衰竭患者血浆可溶性晚期糖基化终末产物受体(sRAGE)变化与心功能的关系[J].首都医科大学学报,2014,35(6):805-808.
[10] 段发兰,李亚新,杨飞翔,等.益心舒胶囊对急性脑梗死患者PAC-1和IL-18表达的影响[J].实用药物与临床,2016,19(3):307-310.
[11] 莫绍琴,王晓容,张箭.临床护理路径对老年慢性心力衰竭患者自我管理的影响[J].保健医学研究与实践,2017,14(4):82-84.
[12] 张艳,杨波,张炳山,等.DKK3基因在心力衰竭家兔心脏中的表达改变研究[J].医学分子生物学杂志,2016,13(5):254-257.
[13] 李明霞,赵轶峰,王俊芳,等.丹红注射液治疗糖尿病肾病的临床效果及对血小板CD62p、PAC-1表达的影响[J].中国医药导报,2016,13(19):92-95.
[14] 闫孝永.血浆肌钙蛋白Ⅰ和NT-proBNP含量对儿童肺炎合并心力衰竭的诊断价值[J].江苏大学学报:医学版,2017,27(4):312-315.
[15] 陈有维,唐娟,何乐愚,等.血清PCT与sICAM-1和sVCAM-1在慢性肾炎患者细菌感染中的应用[J].中华医院感染学杂志,2017,27(19):4359-4362.
[16] 李伟华,曹莉芳,姜威峰,等.应用cTnT和NT-proBNP水平综合评价左西孟旦治疗老年慢性心力衰竭的疗效[J].空军医学杂志,2016,32(2):102-105.
[17] 刘晶.协同护理模式对慢性心力衰竭患者自我护理能力及生活质量的影响[J].保健医学研究与实践,2018,15(1):88-90.
[18] 张艳,杨波,包明威,等.Nek6在心力衰竭家兔心脏中的表达增加[J].医学分子生物学杂志,2016,13(6):317-321.
[19] 赵丽,冯严敏.无创正压呼吸在急诊心力衰竭中的治疗价值[J].空军医学杂志,2017,33(6):401-404.
[20] 闫孝永.血浆肌钙蛋白Ⅰ和NT-proBNP含量对儿童肺炎合并心力衰竭的诊断价值[J].江苏大学学报:医学版,2017,27(4):312-315.