三种高分子材料对甘草次酸脂化乳物理稳定性的影响
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摘要
目的:考察不同稳定材料对提高甘草次酸脂化乳物理稳定性的影响。方法:采用离心分光光度法分别测定不同稳定材料黄原胶、羟丙基甲基纤维素(HPMC K100M)、聚乙烯醇(PVA)加入后甘草次酸脂化乳稳定系数大小,与未添加稳定材料的空白制剂稳定系数进行比较,分别评价各种稳定材料对脂化乳稳定性提高的影响,并初步确定加入浓度,筛选简单、有效地提升稳定性新材料。结果:初步筛选出0.0 5%黄原胶、0.0 2%的HPMC K1 0 0 M、0.0 3%的PVA 1 8-8 8一定程度上均可提升甘草次酸脂化乳物理稳定性,且工艺稳定。结论:三种稳定材料均可一定程度上提升甘草次酸脂化乳制剂物理稳定性,尤以0.0 5%的黄原胶效果为佳。
Objective: To investigate the effects of different stable materials on the stability of glycyrrhetinic acid liposome emulsion. Methods: Centrifugal spectrophotometry method was adopted to determine the stability parameter of glycyrrhetinic acid liposome emulsion after using Xanthan,HPMC K100 M and PVA 18-88 as stable materials respectively,compared with stability coefficient of blank preparation,the effect after using three kinds of materials on stability of glycyrrhetinic acid liposome emulsion was evaluate. The added concentration was initially determined. Results: Three kinds of materials can reduce the stability parameter to a certain extent,effectively improve the stability of preparation. 0. 05% Xanthan,0. 02%HPMC K100 M and 0. 03% PVA 18-88 were the suitable concentration for stability improvement. Conclusion: Three kinds of materials can play a certain role in improvement of the stability of glycyrrhetinic acid liposome emulsion,of which 0. 05% Xanthan was better in experimental results and preparation state than others.
Objective: To investigate the effects of different stable materials on the stability of glycyrrhetinic acid liposome emulsion. Methods: Centrifugal spectrophotometry method was adopted to determine the stability parameter of glycyrrhetinic acid liposome emulsion after using Xanthan,HPMC K100 M and PVA 18-88 as stable materials respectively,compared with stability coefficient of blank preparation,the effect after using three kinds of materials on stability of glycyrrhetinic acid liposome emulsion was evaluate. The added concentration was initially determined. Results: Three kinds of materials can reduce the stability parameter to a certain extent,effectively improve the stability of preparation. 0. 05% Xanthan,0. 02%HPMC K100 M and 0. 03% PVA 18-88 were the suitable concentration for stability improvement. Conclusion: Three kinds of materials can play a certain role in improvement of the stability of glycyrrhetinic acid liposome emulsion,of which 0. 05% Xanthan was better in experimental results and preparation state than others.
引文
[1]陈芳宁,张秀荣,王秀丽,等.丹酚酸B脂化乳的制备及其稳定性研究[J].现代药物与临床,2017,32(2):179-182.
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[16]穆筱梅,钟振声,陈焕钦.聚乙烯醇脂质体的制备及性能研究[J].精细化工,2003,20(6):323-325.
[17]陈亭亭,陆伟根,王莉莉,等.助乳化剂对多囊脂质体影响的初步考察[J].中国医药工业杂志,2009,40(10):758-760.
[2]李士远.抗癌先导物T-OA脂质体及甘草次酸脂质体的肠淋巴转运研究[D].北京:北京中医药大学,2017.
[3]麻建国,Dickinson E,Povey M J W.黄原胶对O/W乳状液稳定性的影响[J].食品与发酵工业,1998,24(1):26-33.
[4]汪震,丁玉峰,黄旭彤,等.药用活性炭灌肠剂的制备[J].医药导报,2010,29(11):1472-1474.
[5]高媛媛.大蒜素脂质体的制备及其稳定性研究[D].武汉:武汉工业学院,2011.
[6]马萍,辛艳茹,杨京燕,等.离心分光光度法测定乳剂的稳定性[J].药学实践杂志,2001,19(1):23-23.
[7]Iijima M,Shinozaki M,Hatakeyama T,et al.AFM studies on gelation mechanism of xanthan gum hydrogels[J].Carbohydrate Polymers,2007,68(4):701-707.
[8]赵容钟,周雪松,曾建新.黄原胶与几种胶复配对花生乳稳定性的影响[J].现代食品科技,2007,23(11):58-60.
[9]赵谋明,孔静,刘丽娅,等.黄原胶/CMC复合稳定剂对酪蛋白乳液稳定性的影响[J].吉林大学学报(工),2012,42(5):1343-1348.
[10]Gao P,Morozowich W.Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs[J].Expert Opinion on Drug Delivery,2006,3(1):97-110.
[11]彭璇,陈萍萍,包强,等.水飞蓟宾过饱和自乳化给药系统的制备及性质研究[C]//中国药学大会暨中国药师周.2009:40-44.
[12]宋恬,何再安,刘焱文.消旋卡多曲干混悬液的制备与稳定性考察[J].医药导报,2007,26(1):57-59.
[13]刘杰,杨盛林,陈建英.阿昔洛韦眼用混悬液的助悬剂筛选[J].食品与药品,2008,10(11):21-23.
[14]Lyoo W S,Seo I S,Ji B C,et al.Role of the stereosequences of poly(vinyl alcohol)in the rheological properties of syndiotacticity-rich poly(vinyl alcohol)/water solutions[J].Journal of Applied Polymer Science,2003,88(7):1858-1863.
[15]Song X,Zhao Y,Wu W,et al.PLGA nanoparticles simultaneously loaded with vincristine sulfate and verapamil hydrochloride:systematic study of particle size and drug entrapment efficiency.[J].International Journal of Pharmaceutics,2008,350(1-2):320-329.
[16]穆筱梅,钟振声,陈焕钦.聚乙烯醇脂质体的制备及性能研究[J].精细化工,2003,20(6):323-325.
[17]陈亭亭,陆伟根,王莉莉,等.助乳化剂对多囊脂质体影响的初步考察[J].中国医药工业杂志,2009,40(10):758-760.