青少年肌阵挛癫痫15例临床特点分析
摘要
目的:探讨青少年肌阵挛癫痫(JME)的临床特点。方法:总结15例JME患者的临床表现、脑电图特点及药物治疗预后。结果:15例均有肌阵挛发作(MS);合并失神发作(AS)3例;合并全面强直阵挛发作(GTCS)12例;三种发作类型均有2例;单独以肌阵挛为表现不伴有其他发作类型2例。脑电图特征是发作间期双侧导联的3～6 Hz棘慢波或多棘慢波,以前头部为主。应用丙戊酸钠、左乙拉西坦、拉莫三嗪治疗,发作完全控制10例,发作明显减少5例。结论:JME是一种较常见的特发性全面性癫痫综合征,详细询问病史结合规范的脑电图检查可尽早明确诊断。选择合适的抗癫痫药物治疗预后较好。
引文
[1] Senf P, Schmitz B, Holtkamp M, et al. Prognosis of Juvenile myoclonic epilepsy 45 Years After Onset:Seizure Outcome and Predictors[J]. Neurology, 2013, 81:2128-2133.
[2] Engel J. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy:report of the ILAE Task Force on Classification and Terminology[J]. Epilepsia, 2001, 4:796-803.
[3] Delgado-Escueta AV, Koeleman BP, Bailey JN, et al. The quest for juvenile myoclonic epilepsy genes[J]. Epilepsy Behav, 2013, 28:S52-S57.
[4] Oflazolu B, Yal?in D,?ztürk F, et al. Clinical and EEG Findings In Juvenile myoclonic epilepsy[J]. Neurol Sci[Turk]. 2007, 24:109-114.
[5] Thomas P, Genton P, Gelisse P, et al. Juvenile myoclonic epilepsy. In:Epileptic syndromes in infancy, childhood and adolescence[M]. London:John Libbey&Co Ltd, 2002:335-355.
[6] Martínez-Juárez IR, Alonso ME, Medina MT, et al. Juvenile myoclonic epilepsy subsyndromes:family studies and longterm follow-up[J]. Brain, 2006, 129:1269-1280.
[7] Wirrell EC, Camfield PR, Camfield PR, et al. Long-term prognosis of typical childhood absence epilepsy:remission or progression to juvenile myoclonic epilepsy[J]. Neurology, 1996, 47:912-918.
[8] Grunewald RA, Chroni E, Panayiotopoulos CP. Delayed diagnosis of juvenile myoclonic epilepsy[J]. J Neurol Neurosurg Psychiatry, 1992, 55:497-499.
[9] Panayiotopoulos CP. Treatment of typical absences and related epileptic syndromes[J]. Paediatr Drugs, 2001, 3:379-403.
[10] Calleja S, Salas-Puig, Ribacoba R, et al. Evolution of juvenile myoclonic epilepsy treated from the outset with sodium valproate[J].Seizure, 2001, 10:424-427.
[11]中国抗癫痫协会.临床诊疗指南-癫痫病分册2015修订版[M].北京:人民卫生出版社, 2015.
[12] Sharpe DV, Patel AD, Abou-Khalil B, et al. Levetiracetam monotherapy in juvenile myoclonic epilepsy[J]. Seizure, 2008, 17:64-68.
[13] Murthy JM, Rao CM, Meena AK. Clinical observations of juvenile myoclonic epilepsy in 131 patients:a study in South India[J]. Seizure,1998, 7:43-47.
[2] Engel J. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy:report of the ILAE Task Force on Classification and Terminology[J]. Epilepsia, 2001, 4:796-803.
[3] Delgado-Escueta AV, Koeleman BP, Bailey JN, et al. The quest for juvenile myoclonic epilepsy genes[J]. Epilepsy Behav, 2013, 28:S52-S57.
[4] Oflazolu B, Yal?in D,?ztürk F, et al. Clinical and EEG Findings In Juvenile myoclonic epilepsy[J]. Neurol Sci[Turk]. 2007, 24:109-114.
[5] Thomas P, Genton P, Gelisse P, et al. Juvenile myoclonic epilepsy. In:Epileptic syndromes in infancy, childhood and adolescence[M]. London:John Libbey&Co Ltd, 2002:335-355.
[6] Martínez-Juárez IR, Alonso ME, Medina MT, et al. Juvenile myoclonic epilepsy subsyndromes:family studies and longterm follow-up[J]. Brain, 2006, 129:1269-1280.
[7] Wirrell EC, Camfield PR, Camfield PR, et al. Long-term prognosis of typical childhood absence epilepsy:remission or progression to juvenile myoclonic epilepsy[J]. Neurology, 1996, 47:912-918.
[8] Grunewald RA, Chroni E, Panayiotopoulos CP. Delayed diagnosis of juvenile myoclonic epilepsy[J]. J Neurol Neurosurg Psychiatry, 1992, 55:497-499.
[9] Panayiotopoulos CP. Treatment of typical absences and related epileptic syndromes[J]. Paediatr Drugs, 2001, 3:379-403.
[10] Calleja S, Salas-Puig, Ribacoba R, et al. Evolution of juvenile myoclonic epilepsy treated from the outset with sodium valproate[J].Seizure, 2001, 10:424-427.
[11]中国抗癫痫协会.临床诊疗指南-癫痫病分册2015修订版[M].北京:人民卫生出版社, 2015.
[12] Sharpe DV, Patel AD, Abou-Khalil B, et al. Levetiracetam monotherapy in juvenile myoclonic epilepsy[J]. Seizure, 2008, 17:64-68.
[13] Murthy JM, Rao CM, Meena AK. Clinical observations of juvenile myoclonic epilepsy in 131 patients:a study in South India[J]. Seizure,1998, 7:43-47.