大蒜素抗肿瘤作用及其机制的研究进展
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摘要
大蒜素是从新鲜大蒜中提取的挥发性油状物,为多种烯丙基有机硫化合物复合体,是大蒜中主要的有效生物学活性成分。具有多种生物学功能,降血脂、抗菌消炎、提高免疫力,预防心血管疾病等生理学作用。与传统药物相比大蒜素具有在人和动物体内残留量低,不易造成环境污染,来源广泛的优点,近期研究证实大蒜素还具有抗癌作用,对多种肿瘤细胞如肝癌、胃癌、结肠癌、肺癌等具有明显的抑制作用。本文就大蒜素的抗肿瘤作用及其机制的研究进展做一综述。
Allicin as a volatile oil content extracted from freshly garlic which is a complx includes a variety of allyl organosulfur components. One of the most biologically active ingredient of garlic. Allicin contents abundant of biological functions, lipid-lowering, anti-bacterial, alleviates inflammation, immune-enhancing, to prevent heart vascular disease and other physiological function.Compared with traditional chemical theropy, allicin is low residues in human and animals, non environmental pollution and has a broad resource. Recent study verify that allicin is able to obviously inhibite cancer cell proliferation, such as liver cancer, gastric cancer, colon carcinoma, lung cancer.Author briefly summarized recent research progress in the anti-tumor effect and mechanism of allicin.
Allicin as a volatile oil content extracted from freshly garlic which is a complx includes a variety of allyl organosulfur components. One of the most biologically active ingredient of garlic. Allicin contents abundant of biological functions, lipid-lowering, anti-bacterial, alleviates inflammation, immune-enhancing, to prevent heart vascular disease and other physiological function.Compared with traditional chemical theropy, allicin is low residues in human and animals, non environmental pollution and has a broad resource. Recent study verify that allicin is able to obviously inhibite cancer cell proliferation, such as liver cancer, gastric cancer, colon carcinoma, lung cancer.Author briefly summarized recent research progress in the anti-tumor effect and mechanism of allicin.
引文
[1]蒋淑婉,李云,陈鹤.大蒜素的抗肿瘤作用及其机制研究进展[J].医学综述,2013,19(8):1420-1422.
[2]Chu Q,Ling MT,Feng H,et al.A novel anticancer effect of garlic derivatives:inhibition of cancer cell invasion through restoration of E-cadherin expression[J].Carcinogenesis,2006,27(11):2180-2189.
[3]尹春晖,霍诗然.大蒜素抗癌作用及其机制研究进展[J].食品科学,2009,30(7):270-272.
[4]Oommen S,Anto RJ,Srinivas G,et al.Allicin(from garlic)induces caspase-mediated apoptosis in cancer cells[J].Eur J Pharmacol,2004,485(1-3):97-103.
[5]夏磊,周玲,崔淑香,等.大蒜素诱导胃肿瘤细胞凋亡机制的探讨[J].中华肿瘤防治杂志,2010,17(16):1266-1269.
[6]黄从兵,唐再军,谢远杰,等.大蒜素对膀胱癌细胞增殖和B细胞淋巴瘤-2表达的影响[J].实用临床医药杂志,2015,19(3):23-26.
[7]Zhang ZM,Zhong N,Gao HQ,et al.Inducing apoptosis and upregulation of Bax and Fas ligand expression by allicin in hepatocellular carcinoma in Balb/c nude mice[J].Chin Med J(Engl),2006,119(5):422-425.
[8]Xu L,Yu J,Zhai D,et al.Role of JNK Activation and Mitochondrial Bax Translocation in Allicin-Induced Apoptosis in Human Ovarian Cancer SKOV3 Cells[J].Evid Based Complement Alternat Med,2014,2014:378684.
[9]张丹.大蒜素对人胃癌SGC-7901细胞的抑制作用及相关机制的初步探讨[D].安徽医科大学,2013,60.
[10]张永奎,李建民,王东隶,等.大蒜素对体外人骨肉瘤细胞周期和细胞凋亡的影响[J].肿瘤,2013,33(3):214-222.
[11]邢永达,袁媛,李建鹏,等,大蒜素对人胃癌细胞系MGC-803增殖的影响及其作用机制[J].山东医药,2010,50(1):4-6.
[12]廖洋,陈建斌,汤为学,等.P38MAPK信号转导通路在大蒜素诱导THP-1细胞凋亡中的作用[J].中国中药杂志,2009,34(11):1439-1443.
[13]侯旭奔,方浩,杜金童,等.细胞周期蛋白依赖性激酶抑制剂的临床研究进展[J].中国新药杂志,2011,20(14):1280-1286.
[14]李永生,王允金,穆细院.大蒜素联合长春新碱对膀胱癌BIU-87细胞增殖和凋亡的影响[J].广西医科大学学报,2013,30(1):69-73.
[15]兰泓,吕有勇.大蒜素对人胃癌细胞BGC823 cyclin D1和p27~(Kip1)表达的影响[J].癌症,2003,22(12):1268-1271.
[16]Prager-Khoutorsky M,Goncharov I,Rabinkov A,et al.Allicin inhibits cell polarization,migration and division via its direct effect on microtubules[J].Cell Motil Cytoskeleton,2007,64(5):321-337.
[17]侯嘉杰,孙倍成.STAT3:慢性炎症介导肿瘤发生和进展的关键节点[J].生物化学与生物物理进展,2014,41(1):69-78.
[18]王一,黎燕,沈倍奋,等.炎症:肿瘤的推进器[J].国际药学研究杂志,2014,41(1):63-67.
[19]黄波.肿瘤微环境中免疫与炎症的调节[J].中国肿瘤生物治疗杂志,2012,19(2):111-115.
[20]Li C,Lun W,Zhao X,et al.Allicin alleviates inflammation of trinitrobenzenesulfonic acid-induced rats and suppresses P38 and JNK pathways in Caco-2 cells[J].Mediators Inflamm,2015,2015:434692.
[21]Pandurangan AK,Ismail S,Saadatdoust Z,et al.Allicin Alleviates Dextran Sodium Sulfate-(DSS-)Induced Ulcerative Colitis in BALB/c Mice[J].Oxid Med Cell Longev,2015,2015:605208.
[22]梁笑倾,谭布珍.大蒜素对提高肿瘤细胞免疫功能的研究进展[J].南昌大学学报(医学版),2010,50(5):109-111.
[23]区俊文.抗氧化剂在肿瘤防治中的作用[J].肿瘤代谢与营养电子杂志,2014,1(1):60-64.
[24]王珊,王辉,陈小燕.硫氧还蛋白-过氧化物氧还蛋白与过氧化氢构成环路参与肿瘤的发生与发展[J].中国生物化学与分子生物学报,2015,31(4):360-366.
[25]Ili DP,Stojanovi S,Najman S,et al.Biological evaluation of synthesized allicin and its transformation products obtained by microwaves in methanol:antioxidant activity and effect on cell growth[J].Biotechnol Biotechnol Equip,2015,29(1):189-194.
[26]李季.DATS逆转人类骨肉瘤多药耐药株耐药及对类肿瘤干细胞作用的初步研究[D].山东大学,2009.
[27]Li J,Liu W,Zhao K,et al.Diallyl trisulfide reverses drug resistance and lowers the ratio of CD133+cells in conjunction with methotrexate in a human osteosarcoma drug-resistant cell subline[J].Mol Med Rep,2009,2(2):245-252.
[28]Gao XY,Geng XJ,Zhai WL,et al.Effect of combined treatment with cyclophosphamidum and allicin on neuroblastoma-bearing mice[J].Asian Pac J Trop Med,2015,8(2):137-141.
[29]Wang CJ,Wang C,Han J,et al.,Effect of combined treatment with recombinant interleukin-2 and allicin on pancreatic cancer[J].Mol Biol Rep,2013,40(12):6579-6785.
[30]谢军,朱德力,曾纪晓.大蒜素联合环磷酰胺对体外人神经母细胞瘤细胞增殖的影响[J].实用医学杂志,2014,30(11):1716-1718.
[2]Chu Q,Ling MT,Feng H,et al.A novel anticancer effect of garlic derivatives:inhibition of cancer cell invasion through restoration of E-cadherin expression[J].Carcinogenesis,2006,27(11):2180-2189.
[3]尹春晖,霍诗然.大蒜素抗癌作用及其机制研究进展[J].食品科学,2009,30(7):270-272.
[4]Oommen S,Anto RJ,Srinivas G,et al.Allicin(from garlic)induces caspase-mediated apoptosis in cancer cells[J].Eur J Pharmacol,2004,485(1-3):97-103.
[5]夏磊,周玲,崔淑香,等.大蒜素诱导胃肿瘤细胞凋亡机制的探讨[J].中华肿瘤防治杂志,2010,17(16):1266-1269.
[6]黄从兵,唐再军,谢远杰,等.大蒜素对膀胱癌细胞增殖和B细胞淋巴瘤-2表达的影响[J].实用临床医药杂志,2015,19(3):23-26.
[7]Zhang ZM,Zhong N,Gao HQ,et al.Inducing apoptosis and upregulation of Bax and Fas ligand expression by allicin in hepatocellular carcinoma in Balb/c nude mice[J].Chin Med J(Engl),2006,119(5):422-425.
[8]Xu L,Yu J,Zhai D,et al.Role of JNK Activation and Mitochondrial Bax Translocation in Allicin-Induced Apoptosis in Human Ovarian Cancer SKOV3 Cells[J].Evid Based Complement Alternat Med,2014,2014:378684.
[9]张丹.大蒜素对人胃癌SGC-7901细胞的抑制作用及相关机制的初步探讨[D].安徽医科大学,2013,60.
[10]张永奎,李建民,王东隶,等.大蒜素对体外人骨肉瘤细胞周期和细胞凋亡的影响[J].肿瘤,2013,33(3):214-222.
[11]邢永达,袁媛,李建鹏,等,大蒜素对人胃癌细胞系MGC-803增殖的影响及其作用机制[J].山东医药,2010,50(1):4-6.
[12]廖洋,陈建斌,汤为学,等.P38MAPK信号转导通路在大蒜素诱导THP-1细胞凋亡中的作用[J].中国中药杂志,2009,34(11):1439-1443.
[13]侯旭奔,方浩,杜金童,等.细胞周期蛋白依赖性激酶抑制剂的临床研究进展[J].中国新药杂志,2011,20(14):1280-1286.
[14]李永生,王允金,穆细院.大蒜素联合长春新碱对膀胱癌BIU-87细胞增殖和凋亡的影响[J].广西医科大学学报,2013,30(1):69-73.
[15]兰泓,吕有勇.大蒜素对人胃癌细胞BGC823 cyclin D1和p27~(Kip1)表达的影响[J].癌症,2003,22(12):1268-1271.
[16]Prager-Khoutorsky M,Goncharov I,Rabinkov A,et al.Allicin inhibits cell polarization,migration and division via its direct effect on microtubules[J].Cell Motil Cytoskeleton,2007,64(5):321-337.
[17]侯嘉杰,孙倍成.STAT3:慢性炎症介导肿瘤发生和进展的关键节点[J].生物化学与生物物理进展,2014,41(1):69-78.
[18]王一,黎燕,沈倍奋,等.炎症:肿瘤的推进器[J].国际药学研究杂志,2014,41(1):63-67.
[19]黄波.肿瘤微环境中免疫与炎症的调节[J].中国肿瘤生物治疗杂志,2012,19(2):111-115.
[20]Li C,Lun W,Zhao X,et al.Allicin alleviates inflammation of trinitrobenzenesulfonic acid-induced rats and suppresses P38 and JNK pathways in Caco-2 cells[J].Mediators Inflamm,2015,2015:434692.
[21]Pandurangan AK,Ismail S,Saadatdoust Z,et al.Allicin Alleviates Dextran Sodium Sulfate-(DSS-)Induced Ulcerative Colitis in BALB/c Mice[J].Oxid Med Cell Longev,2015,2015:605208.
[22]梁笑倾,谭布珍.大蒜素对提高肿瘤细胞免疫功能的研究进展[J].南昌大学学报(医学版),2010,50(5):109-111.
[23]区俊文.抗氧化剂在肿瘤防治中的作用[J].肿瘤代谢与营养电子杂志,2014,1(1):60-64.
[24]王珊,王辉,陈小燕.硫氧还蛋白-过氧化物氧还蛋白与过氧化氢构成环路参与肿瘤的发生与发展[J].中国生物化学与分子生物学报,2015,31(4):360-366.
[25]Ili DP,Stojanovi S,Najman S,et al.Biological evaluation of synthesized allicin and its transformation products obtained by microwaves in methanol:antioxidant activity and effect on cell growth[J].Biotechnol Biotechnol Equip,2015,29(1):189-194.
[26]李季.DATS逆转人类骨肉瘤多药耐药株耐药及对类肿瘤干细胞作用的初步研究[D].山东大学,2009.
[27]Li J,Liu W,Zhao K,et al.Diallyl trisulfide reverses drug resistance and lowers the ratio of CD133+cells in conjunction with methotrexate in a human osteosarcoma drug-resistant cell subline[J].Mol Med Rep,2009,2(2):245-252.
[28]Gao XY,Geng XJ,Zhai WL,et al.Effect of combined treatment with cyclophosphamidum and allicin on neuroblastoma-bearing mice[J].Asian Pac J Trop Med,2015,8(2):137-141.
[29]Wang CJ,Wang C,Han J,et al.,Effect of combined treatment with recombinant interleukin-2 and allicin on pancreatic cancer[J].Mol Biol Rep,2013,40(12):6579-6785.
[30]谢军,朱德力,曾纪晓.大蒜素联合环磷酰胺对体外人神经母细胞瘤细胞增殖的影响[J].实用医学杂志,2014,30(11):1716-1718.