滩羊裘皮毛色调控基因的研究进展
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摘要
滩羊是中国裘皮来源的珍稀地方绵羊品种,以所产二毛裘皮而著称,二毛裘皮在国内外毛皮市场上均享有较高的声誉。毛色是宁夏滩羊重要的经济性状,滩羊多为体躯白色,头部有黑褐斑,个别个体黑头或体躯黑杂色,少数纯白。毛色与体内黑色素的数量、种类和分布等情况有关。掌握调控滩羊毛色基因的作用机制,可以有效控制其毛色性状。本文从滩羊的裘皮特性、毛色形成机理、毛色相关基因(MC1R基因、Agouti基因、TYR基因、MITF基因和KIT基因)的功能及选择信号检测等方面进行了综述。
Tan sheep is one of the rare local breeds of sheep for fur use in China. It is famous for its one-month lamb fur,which enjoys a high reputation in the fur market at home and abroad. The fur color is an important economic character of Tan sheep in Ningxia. Mostly Tan sheep has white bodies,and with black and brown spots on their heads. Some have black heads and black mixed bodies. Only a few are pure white. The fur color of Tan sheep is related to the quantity,species and distribution of melanin in vivo. To master the mechanism of regulating the fur color-related genes can ef-fectively control their fur color traits. This paper reviews the fur characteristics,fur color formation mechanism,and functions and selective signal detection of fur color-related genes,such as MC1 R gene,Agouti gene,TYR gene,MITF gene and KIT gene.
Tan sheep is one of the rare local breeds of sheep for fur use in China. It is famous for its one-month lamb fur,which enjoys a high reputation in the fur market at home and abroad. The fur color is an important economic character of Tan sheep in Ningxia. Mostly Tan sheep has white bodies,and with black and brown spots on their heads. Some have black heads and black mixed bodies. Only a few are pure white. The fur color of Tan sheep is related to the quantity,species and distribution of melanin in vivo. To master the mechanism of regulating the fur color-related genes can ef-fectively control their fur color traits. This paper reviews the fur characteristics,fur color formation mechanism,and functions and selective signal detection of fur color-related genes,such as MC1 R gene,Agouti gene,TYR gene,MITF gene and KIT gene.
引文
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[22] Li Y J, Tang J M, Zhang L, et al. Research progress of Agouti gene and its relationship with animal hair color[J]. Acta Ecologae Animalis Domastici, 2015, 36(9):85-89.李英杰,唐家明,张磊,等. Agouti基因及其与动物毛色关系的研究进展[J].家畜生态学报, 2015, 36(9):85-89.
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[24] Fontanesi L, Dall′Olio S, Beretti F, et al. Coat colours in the Massese sheep breed are associated with muta-tions in the agouti signalling protein(ASIP)and melano-cortin 1 receptor(MC1R)genes[J]. Animal,2011, 5(1):8-17.
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[29] Muheyizha R, Sun J, He J M, et al. Phenotype associa-tion of TYR gene and its polymorphism with coat color in Kazakh sheep[J]. Journal of Xinjiang Agricultural University, 2016, 39(4):307-310.木合依扎·热很别克,孙军,何军敏,等. TYR基因多态性与哈萨克羊毛色相关的研究[J].新疆农业大学学报, 2016, 39(4):307-310.
[30] Meng H H. Association between the polymorphisms of TYR, ASIP gene and coat color in sheep[D]. Shihezi:Shihezi University, 2014.孟浩浩. TYR, ASIP基因多态性与绵羊毛色相关的研究[D].石河子:石河子大学, 2014.
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[2] Jia H, Yang L J, Li A H, et al. Study on gene poly-morphism and its relationship with important characters of two-wool fur in KAP1. 1 Ningxia Tanyang sheep[J].Journal of Mudanjiang Medical University, 2013, 34(6):1-5.贾桦,杨丽娟,李爱华,等.宁夏滩羊KAP1. 1基因多态性及其与二毛裘皮重要性状关系的研究[J].牡丹江医学院学报, 2013, 34(6):1-5.
[3] Xue W, Zhang G L, Chai J X. Germplasm and produc-tion performance of different color Tan sheep in Ningxia[J]. Modern Agricultural Science and Technology, 2010(17):318-319.薛伟,张国玲,柴君秀.宁夏不同颜色滩羊的种质及生产性能研究[J].现代农业科技, 2010(17):318-319.
[4] Yang H X. Research on ecosystem and future resources of human beings[M]. Beijing:Science Press, 2001:7-44.阳含熙.生态系统的研究和人类的未来资源[M].北京:科学出版社,2001:7-44.
[5] Zhao J N, Chen X J, Zhang X R, et al. Germplasm characteristics and production performance of Ningxia white Tan sheep and black Tan sheep[J]. Heilongjiang Animal Husbandry and Veterinary Science, 2010(5):58-59.赵金宇,陈学娟,张鑫荣,等.宁夏白滩羊与黑滩羊的种质特性及生产性能的研究[J].黑龙江畜牧兽医,2010(5):58-59.
[6] Bai C N, Gao Y H, Pang Q H. Genes affecting animal hair color[J]. Pigs and Birds, 2008, 28(5):71-73.白春雨,高玉花,庞全海.影响动物毛色的基因[J].猪与禽, 2008, 28(5):71-73.
[7] Ouyang J. Genome wide association analysis revealed that the combined action of main genes and modification genes determines the color of black hair on two local pigs in China[D]. Nanchang:Jiangxi Agricultural Uni-versity, 2012.欧阳婧.全基因组关联分析揭示主效基因及修饰基因共同作用决定中国地方猪两头乌毛色[D].南昌:江西农业大学, 2012.
[8] Han J L, Yue Y J, Guo J, et al. mRNA expression of Agouti and MITF in skin tissues of Tibetan sheep with different colors[J]. Chinese Herbivore Science, 2012(S1):165-169.韩吉龙,岳耀敬,郭健,等. Agouti与MITF在不同颜色被毛藏羊皮肤组织中mRNA表达量研究[J].中国草食动物科学, 2012(S1):165-169.
[9] Parsons Y M, Fleel M R, Cooper D W. Investigation of the gene responsible for recessive pigmentation in Australian Merino sheep[J]. Proc Assoc Advmt Anim Breed Genet, 1997, 12:447-451.
[10] Parsons Y M, Fleet M R, Cooper D W. Isolation of the ovine agouti coding sequence[J]. Pigment Cell Res,1999,12(6):394-397.
[11] Zhu Z, He J, Jia X, et al. MicroRNA-25 functions in regulation of pigmentation by targeting the transcription factor MITF in Alpaca(Lama pacos)skin melanocytes[J]. Domest Anim Endocrinol, 2010, 38(3):200-209.
[12] Stella A, Ajmone-Marsan P, Lazzari B, et al. Identifi-cation of selection signatures in cattle breeds selected for dairy production[J]. Genetics, 2010, 185(4):1451-1461.
[13] Wiener P, Wilkinson S. Deciphering the genetic basis of animal domestication[J]. Proceedings of the Royal Society B:Biological Sciences, 2011, 278(1722):3161-3170.
[14] Kijas J W, Lenstra J A, Hayes B, et al. Genome-wide analysis of the world’s sheep breeds reveals high levels of historic mixture and strong recent selection[J]. PLoS Biol, 2012, 10(2):e1001258.
[15] Fang M Y, Larson G, Ribeiro H S, et al. Contrasting mode of evolution at a coat color locus in wild and do-mestic pigs[J]. PLoS Genet, 2009, 5(1):e1000341.
[16] Li J, Yang H, Li J R, et al. Artificial selection of the melanocortin receptor 1 gene in Chinese domestic pigs during domestication[J]. Heredity(Edinb), 2010, 105(3):274-281.
[17] Abdel-Malek Z, Swope V B, Suzuki I, et al. Mitoge-nie and melano-genic stimulation of normal human mela-nocytes by melanotropic peptides[J]. Proc Natl Acad Sci, 1995, 92(5):1789-1793.
[18] Fu D L. Polymorphism of MC1R and ASIP genes and their correlation with wool color in 10 local sheep breeds in China[D]. Lanzhou:Gansu Agricultural University,2013.付冬丽. 10个中国地方绵羊品种MC1R和ASIP基因多态性及其与毛色关联性分析[D].兰州:甘肃农业大学, 2013.
[19] Xu G L, Liu Z Z, Gong Y F, et al. Research progress of hair color regulation genes in fur animals[J]. Hei-longjiang Animal Husbandry and Veterinary Science,2015(13):52-54.徐桂利,刘铮铸,巩元芳,等.毛皮动物毛色调控基因的研究进展[J].黑龙江畜牧兽医, 2015(13):52-54.
[20] Wang L, Zhang B, Zheng W X, et al. The hair color of animal and melanocortin receptor 1(MC1R)[J]. Grass-Feeding Livestock, 2009(2):10-12.王乐,张斌,郑文新,等.动物毛色与黑色素皮质素受体1(MC1R)基因[J].草食家畜, 2009(2):10-12.
[21] Wang L, Lv X F, Zheng W X, et al. The cause and mechanism of animal coat color formed[J]. Grass-Feed-ing Livestock, 2009(1):20-21.王乐,吕雪峰,郑文新,等.动物毛色形成的原因和机制[J].草食家畜, 2009(1):20-21.
[22] Li Y J, Tang J M, Zhang L, et al. Research progress of Agouti gene and its relationship with animal hair color[J]. Acta Ecologae Animalis Domastici, 2015, 36(9):85-89.李英杰,唐家明,张磊,等. Agouti基因及其与动物毛色关系的研究进展[J].家畜生态学报, 2015, 36(9):85-89.
[23] TangC J. Study on the relationship between goat Agouti gene and color phenotype and its variation in goat popu-lations[D]. Baoding:Hebei Agricultural University,2008.唐春娟.山羊Agouti基因与毛色表型相关分析及其遗传变异的研究[D].保定:河北农业大学, 2008.
[24] Fontanesi L, Dall′Olio S, Beretti F, et al. Coat colours in the Massese sheep breed are associated with muta-tions in the agouti signalling protein(ASIP)and melano-cortin 1 receptor(MC1R)genes[J]. Animal,2011, 5(1):8-17.
[25] Oetting W S. The tyrosinase gene and oculocutaneous albinism type 1(OCA1):a model for understanding the molecular biology of melanin formation[J] Pigment Cell Res, 2000, 13(5):320-325.
[26] Southern E, Mir K, Shchepinov M. Molecular interac-tions on microarrays[J]. Nat Genet, 1999, 21(1 Suppl):5-9.
[27] Guo M, Zhang D S, Li X L. TYR gene and its relation-ship with animal coat color research progress[J]. Hei-longjiang Animal Science and Veterinary Medicine,2017(1):83-85.郭敏,张大山,李祥龙. TYR基因及其与动物毛色关系的研究进展[J].黑龙江畜牧兽医,2017(1):83-85.
[28] Jiang J B, Yu X J, He J P, et al. Expression and local-ization of tyrosinase in alpaca skin tissues with different coat colors[J]. Scientia Agricultura Sinica, 2010, 43(12):2555-2560.姜俊兵,于秀菊,贺俊平,等.酪氨酸酶在不同被毛颜色羊驼皮肤组织中的表达与定位[J].中国农业科学,2010, 43(12):2555-2560.
[29] Muheyizha R, Sun J, He J M, et al. Phenotype associa-tion of TYR gene and its polymorphism with coat color in Kazakh sheep[J]. Journal of Xinjiang Agricultural University, 2016, 39(4):307-310.木合依扎·热很别克,孙军,何军敏,等. TYR基因多态性与哈萨克羊毛色相关的研究[J].新疆农业大学学报, 2016, 39(4):307-310.
[30] Meng H H. Association between the polymorphisms of TYR, ASIP gene and coat color in sheep[D]. Shihezi:Shihezi University, 2014.孟浩浩. TYR, ASIP基因多态性与绵羊毛色相关的研究[D].石河子:石河子大学, 2014.
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