原发性肝癌中医证型与血清肿瘤标志物关系分析
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摘要
目的探讨原发性肝癌中医证型同血清肿瘤标志物的相关性。方法选择2016年11月—2018年9月收治的208例原发性肝癌患者作为试验对象;依据中医辨证分型完成分组,分别设为A组(肝气郁结型46例)、B组(瘀血阻络型52例)、C组(肝郁脾虚瘀血阻络型58例)以及D组(脾气虚证52例),对每组患者血清肿瘤标志物水平进行测定,并且探讨与中医证型的相关性。结果与A组以及B组原发性肝癌患者AFU水平以及AFP水平对比,C组以及D组患者呈现出显著提升(P <0. 05);与C组以及D组原发性肝癌患者异常凝血酶原(DCP)水平对比,A组以及B组患者呈现出显著提升(P <0. 05);与A组以及C组原发性肝癌患者γ-GT2水平对比,B组以及D组呈现出显著提升(P <0. 05);对于A组患者,DCP水平占有较高比例;对于B组患者,γ-GT2水平以及DCP水平占有较高比例;对于C组患者,AFU水平、AFP水平以及γ-GT2水平占有较高比例;对于D组患者,AFU水平、AFP水平占有较高比例。结论对于原发性肝癌患者而言,临床对其完成中医辨证分型后实施血清肿瘤标志物水平测定发现,二者之间存在相关性。对于肝气郁结型患者,DCP水平与其表现出较高相关性,对患者实施AFP+γ-GT2水平联合检测,对于肝郁脾虚瘀血阻络证可以有效明确诊断。
To investigate the correlation between TCM syndromes and serum tumor markers in patients with primary liver cancer. Methods A total of 208 patients with primary liver cancer admitted to our hospital from November 2016 to September 2018 were selected as subjects.According to TCM syndrome differentiation,they were grouped into group A( 46 cases of liver qi stagnation type) and group B( 52 cases of blood stasis type),group C( 58 cases of liver stagnation and spleen deficiency and blood stasis type) and group D( 52 cases of spleen qi deficiency syndrome). The serum tumor marker levels of each group were measured,and the correlation of TCM syndromes was discussed.Results Compared with AFU and AFP levels in patients with primary liver cancer,group A,group C and group D showed significant improvement( P < 0. 05). Compared with group C and group D,primary liver cancer patients with DCP levels,patients in group A and group B showed significant improvement( P < 0. 05). Compared with group γ-GT2 in group A and group D,group B and group C showed significant improvement( P < 0. 05). Group A patients with primary liver cancer accounted for a high proportion of DCP; for group B,γ-GT2 level and DCP level accounted for a higher proportion; for group C patients,AFU level,AFP level and γ-GT2 level A higher proportion; for patients in group D,AFU levels,AFP levels accounted for a higher proportion. Conclusion For patients with primary liver cancer,it is found that there is a correlation between serum and tumor markers after the completion of TCM syndrome differentiation. For patients with liver qi stagnation,the level of DCP is highly correlated with the level of AFP + γ-GT2,which can be effectively determined for liver stagnation and spleen deficiency.
To investigate the correlation between TCM syndromes and serum tumor markers in patients with primary liver cancer. Methods A total of 208 patients with primary liver cancer admitted to our hospital from November 2016 to September 2018 were selected as subjects.According to TCM syndrome differentiation,they were grouped into group A( 46 cases of liver qi stagnation type) and group B( 52 cases of blood stasis type),group C( 58 cases of liver stagnation and spleen deficiency and blood stasis type) and group D( 52 cases of spleen qi deficiency syndrome). The serum tumor marker levels of each group were measured,and the correlation of TCM syndromes was discussed.Results Compared with AFU and AFP levels in patients with primary liver cancer,group A,group C and group D showed significant improvement( P < 0. 05). Compared with group C and group D,primary liver cancer patients with DCP levels,patients in group A and group B showed significant improvement( P < 0. 05). Compared with group γ-GT2 in group A and group D,group B and group C showed significant improvement( P < 0. 05). Group A patients with primary liver cancer accounted for a high proportion of DCP; for group B,γ-GT2 level and DCP level accounted for a higher proportion; for group C patients,AFU level,AFP level and γ-GT2 level A higher proportion; for patients in group D,AFU levels,AFP levels accounted for a higher proportion. Conclusion For patients with primary liver cancer,it is found that there is a correlation between serum and tumor markers after the completion of TCM syndrome differentiation. For patients with liver qi stagnation,the level of DCP is highly correlated with the level of AFP + γ-GT2,which can be effectively determined for liver stagnation and spleen deficiency.
引文
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[2]林恒红,陈闯,徐望,等.原发性肝癌不同中医证型与客观指标关系的研究进展[J].内蒙古中医药,2015,34(12):93-94.
[3]欧杰,陈闯,胡利荣,等. 175例原发性肝癌患者甲胎蛋白与中医证型的相关性研究[J].中医药导报,2015,21(23):29-31.
[4]欧杰,陈闯,诸佳瑜,等. 175例原发性肝癌中医证型与Child-Pugh分级相关性的研究[J].四川中医,2017,35(1):54-57.
[5]欧杰,陈闯,胡利荣,等. 175例原发性肝癌中医证型分布规律及其与GPC-3的相关性研究[J].中国中医基础医学杂志,2016,22(9):1199-1200,1225.