基于合理用药的中药注射剂不良反应研究
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摘要
中药注射剂的不良反应中涉及到国家批准中药制剂109个品种,其不良反应涵盖了:肝肾功能损害、心功能损害、呼吸系统损害、皮肤损害、过敏性休克、全身性过敏反应、急性血管内溶血、胃肠道反应等。引发中药注射剂不良反应的因素较多,尤其在老年患者和儿童患者中,中药注射剂的不合理用药情况较为突出。需要从合理用药层面加以剖析,精准分析病症适应药物、把控用药方案合理性、避免用药浓度剂量过高,尤其不可变更用药途径,在选择合理的溶媒条件下,增强中医注射剂的临床用药合理性,降低不良反应发生率。
The adverse reactions of Chinese medicine injection involve 109 varieties of Chinese medicine preparations approved by the state. Adverse reactions include: liver and kidney damage,cardiac function damage,respiratory system damage,skin damage,allergic shock,systemic allergic reaction,acute intravascular hemolysis,gastrointestinal reaction,etc. There are many factors causing the adverse reactions of Chinese medicine injection,especially in elderly patients and children patients,the unreasonable use of TCM injection is more prominent. It is necessary to analyze from the perspective of rational drug use,accurately analyze the adaptive drug of symptoms,the rationality of drug control scheme,and the avoidance of excessive concentration and dosage of drug use,especially the unchangeable way of drug use,so as to enhance the rationality of clinical drug use of traditional Chinese medicine injection and reduce the incidence of adverse reactions under the choice of reasonable solvent conditions.
The adverse reactions of Chinese medicine injection involve 109 varieties of Chinese medicine preparations approved by the state. Adverse reactions include: liver and kidney damage,cardiac function damage,respiratory system damage,skin damage,allergic shock,systemic allergic reaction,acute intravascular hemolysis,gastrointestinal reaction,etc. There are many factors causing the adverse reactions of Chinese medicine injection,especially in elderly patients and children patients,the unreasonable use of TCM injection is more prominent. It is necessary to analyze from the perspective of rational drug use,accurately analyze the adaptive drug of symptoms,the rationality of drug control scheme,and the avoidance of excessive concentration and dosage of drug use,especially the unchangeable way of drug use,so as to enhance the rationality of clinical drug use of traditional Chinese medicine injection and reduce the incidence of adverse reactions under the choice of reasonable solvent conditions.
引文
[1]郭欣莹.本院2015~2016年中药注射剂使用评价与分析[J].北方药学,2018,15(8):189.
[2]伍延婷,金星.黄石市中心医院2006-2016年抗肿瘤中药注射剂不良反应回顾性分析[J].中国中医药信息杂志,2018,25(8):126-128.
[3]董丽娥,蒋燕,于波涛.中药注射剂用于胃癌患者的合理性评价研究[J].现代预防医学,2018,45(12):2277-2279.
[4]刘洋,肖隆灏,刘莘然,等.从《药品不良反应信息通报》分析中药注射剂ADR[J].天津中医药大学学报,2018,37(2):92-95.
[5]李明.临床药师干预对活血化瘀类中药注射剂合理使用的影响[J].中国药物经济学,2018,13(3):51-53.
[6]程军,韩一萱,张士洋,等.369例中药注射剂不良反应/不良事件分析[J].药物流行病学杂志,2018,27(2):113-116.
[7]廖小娟,尹桃,李逃明,等.中药注射剂超说明书用药与不良反应的关系探讨[J].药物流行病学杂志,2018,27(2):104-108.
[8]何珊.中药注射剂不良反应的特点与临床合理用药情况分析[J].中国社区医师,2018,34(4):7,9.
[9]李昌,常冰,王广伟,等.药师干预对清开灵注射液合理应用的影响研究[J].世界中医药,2018,13(1):216-219,223.
[2]伍延婷,金星.黄石市中心医院2006-2016年抗肿瘤中药注射剂不良反应回顾性分析[J].中国中医药信息杂志,2018,25(8):126-128.
[3]董丽娥,蒋燕,于波涛.中药注射剂用于胃癌患者的合理性评价研究[J].现代预防医学,2018,45(12):2277-2279.
[4]刘洋,肖隆灏,刘莘然,等.从《药品不良反应信息通报》分析中药注射剂ADR[J].天津中医药大学学报,2018,37(2):92-95.
[5]李明.临床药师干预对活血化瘀类中药注射剂合理使用的影响[J].中国药物经济学,2018,13(3):51-53.
[6]程军,韩一萱,张士洋,等.369例中药注射剂不良反应/不良事件分析[J].药物流行病学杂志,2018,27(2):113-116.
[7]廖小娟,尹桃,李逃明,等.中药注射剂超说明书用药与不良反应的关系探讨[J].药物流行病学杂志,2018,27(2):104-108.
[8]何珊.中药注射剂不良反应的特点与临床合理用药情况分析[J].中国社区医师,2018,34(4):7,9.
[9]李昌,常冰,王广伟,等.药师干预对清开灵注射液合理应用的影响研究[J].世界中医药,2018,13(1):216-219,223.