手术联合碘131、甲状腺片治疗甲状腺乳头状癌(PTC)的临床效果
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摘要
目的探讨采用手术、碘131以及甲状腺片联合治疗甲状腺乳头状癌的临床疗效。方法选择在2015年3月～2017年3月在本院接受甲状腺乳头状癌治疗的80例患者,按照住院的顺序将其随机分成对照组与治疗组各40例。对照组患者采用常规手术治疗方法,治疗组患者在对照组的基础上在手术后服用碘131以及甲状腺片,在治疗结束后对比两组患者3年、5年、10年的生存率以及手术后的复发率。结果在治疗结束后发现,对照组患者中3例患者失访,治疗组患者中有2例患者失访,两组其余患者3年、5年、10年的生存率方面进行对比发现,治疗组的生存率高于对照组,两组间比较差异显著,具有统计学意义(P <0.05);对比两组复发率,治疗组低于对照组,两组间比较差异显著,具有统计学意义(P <0.05)。结论在对甲状腺乳头状癌患者进行治疗时采用手术、碘131以及甲状腺片联合的方法具有良好的临床效果,延长了患者的生存期,降低复发率,值得临床应用。
Objective To investigate the clinical efficacy of surgery, iodine 131 and thyroid tablets in the treatment of papillary thyroid carcinoma. Methods Eighty patients who underwent thyroid papillary carcinoma treatment from March 2015 to March 2017 were randomly divided into control group and treatment group according to the order of hospitalization. The patients in the control group were treated with conventional surgical treatment. The patients in the treatment group received iodine 131 and thyroid tablets after the operation on the basis of the control group. After the treatment, the survival rate of the two groups was compared at 3 years, 5 years, and 10 years, and the recurrence rate after the operation. Results At the end of treatment, 3 patients in the control group were lost to follow-up. Two of the patients in the treatment group were lost to followup. The survival rates of the remaining 3, 5, and 10 years were compared. The survival rate was higher than that of the control group. The difference between the two groups was statistically significant(P < 0.05). The recurrence rate of the treatment group was lower than that of the control group. The difference between the two groups was statistically significant(P < 0.05).Conclusion The combination of surgery, iodine 131 and thyroid tablets in the treatment of patients with papillary thyroid carcinoma has a good clinical effect, prolonging the survival of patients and reducing the recurrence rate, which is worthy of clinical application.
Objective To investigate the clinical efficacy of surgery, iodine 131 and thyroid tablets in the treatment of papillary thyroid carcinoma. Methods Eighty patients who underwent thyroid papillary carcinoma treatment from March 2015 to March 2017 were randomly divided into control group and treatment group according to the order of hospitalization. The patients in the control group were treated with conventional surgical treatment. The patients in the treatment group received iodine 131 and thyroid tablets after the operation on the basis of the control group. After the treatment, the survival rate of the two groups was compared at 3 years, 5 years, and 10 years, and the recurrence rate after the operation. Results At the end of treatment, 3 patients in the control group were lost to follow-up. Two of the patients in the treatment group were lost to followup. The survival rates of the remaining 3, 5, and 10 years were compared. The survival rate was higher than that of the control group. The difference between the two groups was statistically significant(P < 0.05). The recurrence rate of the treatment group was lower than that of the control group. The difference between the two groups was statistically significant(P < 0.05).Conclusion The combination of surgery, iodine 131 and thyroid tablets in the treatment of patients with papillary thyroid carcinoma has a good clinical effect, prolonging the survival of patients and reducing the recurrence rate, which is worthy of clinical application.
引文
[1]孙敬国.手术联合碘131、甲状腺片治疗甲状腺乳头状癌30例疗效观察[J].山东医药,2010,50(35):90-91.
[2]徐一宁,朱建明,刘岗等.双侧甲状腺乳头状癌的临床诊治分析[J].临床外科杂志,2011,19(7):467-468.
[3]林益凯,盛建明,赵文和等.多灶性甲状腺乳头状癌168例临床研究[J].中华外科杂志,2009,47(6):450-453.
[4]黎亮.甲状腺全切除术,中央区淋巴结清扫术治疗甲状腺乳头状癌中的临床效果[J].中国医药指南,2015,1313:36-37.
[5]王晓明,卢秀波.甲状腺乳头状癌的临床特征及外科治疗效果观察[J].医药论坛杂志,2016,3707:136-137.
[2]徐一宁,朱建明,刘岗等.双侧甲状腺乳头状癌的临床诊治分析[J].临床外科杂志,2011,19(7):467-468.
[3]林益凯,盛建明,赵文和等.多灶性甲状腺乳头状癌168例临床研究[J].中华外科杂志,2009,47(6):450-453.
[4]黎亮.甲状腺全切除术,中央区淋巴结清扫术治疗甲状腺乳头状癌中的临床效果[J].中国医药指南,2015,1313:36-37.
[5]王晓明,卢秀波.甲状腺乳头状癌的临床特征及外科治疗效果观察[J].医药论坛杂志,2016,3707:136-137.