L-吡咯烷功能化Zr(IV)金属有机骨架配合物的合成和催化不对称Aldol反应研究
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摘要
设计合成了L-脯氨甲胺三联苯-4,4’-二甲酸配体(H2L)及其Zr(IV)-金属有机骨架配合物Zr6O4(OH)4(L)6(I),并研究了配合物I催化对硝基苯甲醛和环己酮的不对称羟醛缩合反应,催化反应具有适中的产率(60%)和较低的对映选择性(1.5%),催化产物的dr值为26∶74(anti/syn),以顺式异构体为主.
L-prolinmethylamineterphenyl-4,4'-dicarboxylic acid(H2 L)and its Zr(IV)-MOF complex-Zr6 O4(OH)4(L)6(I)were synthesized.The asymmetric aldol condensation of 4-Nitrobenzaldehyde and Cyclohexanone catalyzed by complex I was also investigated.The catalysis reaction exhibited moderate conversion(60%)and low excess(1.5%).The dr value of catalysis product was 26∶74(anti/syn).The isomer of syn-configuration was preponderated.
L-prolinmethylamineterphenyl-4,4'-dicarboxylic acid(H2 L)and its Zr(IV)-MOF complex-Zr6 O4(OH)4(L)6(I)were synthesized.The asymmetric aldol condensation of 4-Nitrobenzaldehyde and Cyclohexanone catalyzed by complex I was also investigated.The catalysis reaction exhibited moderate conversion(60%)and low excess(1.5%).The dr value of catalysis product was 26∶74(anti/syn).The isomer of syn-configuration was preponderated.
引文
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