腹腔镜手术治疗Ⅰ期子宫内膜癌的疗效分析
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摘要
目的:探讨腹腔镜手术治疗Ⅰ期子宫内膜癌患者的临床效果。方法:选取2012年1月-2013年1月本院收治的Ⅰ期子宫内膜癌患者66例。按照入院先后顺序将其分为观察组和对照组,各33例。观察组接受腹腔镜手术治疗,对照组接受开腹手术治疗。比较两组手术持续时间、术中出血量、淋巴结清扫数量、术后下床时间、盆腔引流量、导尿管留置时间、整体住院时间、并发症发生率、复发率及转移率。结果:两组手术持续时间、淋巴结清扫数量比较,差异均无统计学意义(P>0.05);观察组术中出血量、术后下床时间、盆腹腔引流量、导尿管留置时间、整体住院时间均优于对照组,比较差异均有统计学意义(P<0.05);观察组并发症发生率为9.09%,低于对照组的33.33%(P<0.05);两组复发率、转移率比较,差异均无统计学意义(P>0.05)。结论:通过为Ⅰ期子宫内膜癌患者提供腹腔镜手术治疗,可有效确保其临床治疗效果,减少并发症的发生率,其临床价值值得肯定。
Objective:To investigate the clinical effect of laparoscopic surgery for stage Ⅰ endometrial carcinoma.Method:A total of 66 patients with stage Ⅰ endometrial carcinoma who were treated in our hospital from January 2012 to January 2013 were selected.According to the order of admission,they were divided into observation group and control group,33 cases in each group.The observation group received laparoscopic surgery,while the control group received conventional laparotomy.The duration of operation,intraoperative bleeding,number of lymph node dissection,time of getting out of bed after operation,pelvic drainage,indwelling time of catheter,overall hospitalization time,incidence of complications,recurrence rate and metastasis rate betweenthe two groups were compared.Result:The duration of operation and the number of lymph node dissection in two groups were compared,the differences were not statistically significant(P>0.05).The intraoperative bleeding,time of getting out of bed after operation,pelvic and abdominal drainage,indwelling time of catheter and overall hospitalization time in observation group were better than those of control group,the differences were statistically significant(P<0.05).The incidence of complications was 9.09% in observation group,which was lower than 33.33% in control group(P<0.05).The recurrence rate and metastasis rate in two groups were compared,the differences were not statistically significant(P>0.05).Conclusion:The laparoscopic surgery for stage Ⅰ endometrial cancer patients can effectively ensure the clinical therapeutic effect and reduce the incidence of complications,the clinical value is worthy of affirmation.
Objective:To investigate the clinical effect of laparoscopic surgery for stage Ⅰ endometrial carcinoma.Method:A total of 66 patients with stage Ⅰ endometrial carcinoma who were treated in our hospital from January 2012 to January 2013 were selected.According to the order of admission,they were divided into observation group and control group,33 cases in each group.The observation group received laparoscopic surgery,while the control group received conventional laparotomy.The duration of operation,intraoperative bleeding,number of lymph node dissection,time of getting out of bed after operation,pelvic drainage,indwelling time of catheter,overall hospitalization time,incidence of complications,recurrence rate and metastasis rate betweenthe two groups were compared.Result:The duration of operation and the number of lymph node dissection in two groups were compared,the differences were not statistically significant(P>0.05).The intraoperative bleeding,time of getting out of bed after operation,pelvic and abdominal drainage,indwelling time of catheter and overall hospitalization time in observation group were better than those of control group,the differences were statistically significant(P<0.05).The incidence of complications was 9.09% in observation group,which was lower than 33.33% in control group(P<0.05).The recurrence rate and metastasis rate in two groups were compared,the differences were not statistically significant(P>0.05).Conclusion:The laparoscopic surgery for stage Ⅰ endometrial cancer patients can effectively ensure the clinical therapeutic effect and reduce the incidence of complications,the clinical value is worthy of affirmation.
引文
[1]王晨笛,徐华,王海英,等.腹腔镜手术治疗早期子宫内膜癌的临床体会[J].腹腔镜外科杂志,2011,16(7):544-547.
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[5]陈志华,张梦真,郭瑞霞,等.腹腔镜手术联合化疗治疗子宫内膜癌的近远期效果分析[J].中国当代医药,2016,23(14):50-53.
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[7]陈红,雷婷婷,李玉红.腹腔镜手术治疗早期子宫内膜癌的近期临床效果及对性功能的影响[J].河北医学,2015,21(12):1992-1995.
[8]王秀文.腹腔镜手术治疗早期子宫内膜癌患者效果观察及对胃肠功能的影响[J].国际医药卫生导报,2016,22(14):2069-2071.
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[10]何莎,刘灵霞,王亚宁,等.腹腔镜辅助阴式手术在早期子宫内膜样腺癌中的应用观察[J].中国性科学,2016,25(3):43-46.
[11]赵成志,王光伟,杨清.腹腔镜手术与开腹手术治疗Ⅰ期子宫内膜癌的临床分析[J].中国妇产科临床杂志,2014,15(3):223-226.
[12]Tan W P,Tecle N,Whelan P,et al.Upper Tract Urothelial Carcinoma in the Genetically Predisposed Patient:Role of Urinary Markers in Predicting Recurrence[J].J Endourol Case Rep,2016,2(1):235-237.
[13]Shimada H,Abe S,Kohno T,et al.Loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in human endometrial cancer[J].Sci Rep,2017,(7):37049.
[14]陈勇,任全珍,蔡容霞,等.腹腔镜手术治疗早期子宫内膜癌的临床研究[J].癌症进展,2016,14(9):917-919.
[15]顾光华,马忠平,徐培箴,等.腹腔镜全面分期手术治疗Ⅰ、Ⅱ期子宫内膜癌75例分析[J].江苏医药,2016,42(5):595-597.
[16]贺红英,阳志军,张洁清,等.腹腔镜与开腹手术治疗早期子宫内膜癌近远期疗效的比较[J].中华妇产科杂志,2015,50(12):902-909.
[17]沈萍,黄梅.腹腔镜手术与开腹手术治疗Ⅰ期子宫内膜癌的近期及远期临床疗效观察[J].河北医学,2015,21(9):1423-1426.
[18]李丽,赵丽娟,郭宇玉.腹腔镜手术治疗Ⅰ期子宫内膜癌患者的预后观察[J].实用癌症杂志,2017,32(5):814-816.
[19]Tuomi T,Pasanen A,Leminen A,et al.Prediction of lymphaticdissemination in endometrioid endometrial cancer:Comparison of threerisk-stratification models in a singleinstitution cohort[J].Gynecol Oncol,2017,144(3):510-514.
[20]窦磊,郭科军.腹腔镜手术在早期子宫内膜癌治疗中的疗效观察[J].中国医科大学学报,2016,45(3):241-245.
[2]徐凤华,张丽华.腹腔镜手术与开腹手术治疗早期子宫内膜癌的效果比较[J].中国现代医生,2012,50(17):58-59.
[3]郭芳芳,邢洪存.腹腔镜与开腹手术治疗早期子宫内膜癌的对比分析[J].中国妇幼保健,2013,28(32):5393-5394.
[4]冯文,钱卫卫,谷冀辉,等.腹腔镜手术治疗早期子宫内膜癌30例分析[J].江苏医药,2016,42(20):2232-2234.
[5]陈志华,张梦真,郭瑞霞,等.腹腔镜手术联合化疗治疗子宫内膜癌的近远期效果分析[J].中国当代医药,2016,23(14):50-53.
[6]王明,冯力民.宫腔镜技术在诊治子宫内膜癌及癌前病变中的作用[J/OL].妇产与遗传(电子版),2012,2(2):9-15.
[7]陈红,雷婷婷,李玉红.腹腔镜手术治疗早期子宫内膜癌的近期临床效果及对性功能的影响[J].河北医学,2015,21(12):1992-1995.
[8]王秀文.腹腔镜手术治疗早期子宫内膜癌患者效果观察及对胃肠功能的影响[J].国际医药卫生导报,2016,22(14):2069-2071.
[9]段予新,李玉洁,南燕.腹腔镜手术治疗早期老年子宫内膜癌的远期疗效分析[J].中国内镜杂志,2012,18(7):713-716.
[10]何莎,刘灵霞,王亚宁,等.腹腔镜辅助阴式手术在早期子宫内膜样腺癌中的应用观察[J].中国性科学,2016,25(3):43-46.
[11]赵成志,王光伟,杨清.腹腔镜手术与开腹手术治疗Ⅰ期子宫内膜癌的临床分析[J].中国妇产科临床杂志,2014,15(3):223-226.
[12]Tan W P,Tecle N,Whelan P,et al.Upper Tract Urothelial Carcinoma in the Genetically Predisposed Patient:Role of Urinary Markers in Predicting Recurrence[J].J Endourol Case Rep,2016,2(1):235-237.
[13]Shimada H,Abe S,Kohno T,et al.Loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in human endometrial cancer[J].Sci Rep,2017,(7):37049.
[14]陈勇,任全珍,蔡容霞,等.腹腔镜手术治疗早期子宫内膜癌的临床研究[J].癌症进展,2016,14(9):917-919.
[15]顾光华,马忠平,徐培箴,等.腹腔镜全面分期手术治疗Ⅰ、Ⅱ期子宫内膜癌75例分析[J].江苏医药,2016,42(5):595-597.
[16]贺红英,阳志军,张洁清,等.腹腔镜与开腹手术治疗早期子宫内膜癌近远期疗效的比较[J].中华妇产科杂志,2015,50(12):902-909.
[17]沈萍,黄梅.腹腔镜手术与开腹手术治疗Ⅰ期子宫内膜癌的近期及远期临床疗效观察[J].河北医学,2015,21(9):1423-1426.
[18]李丽,赵丽娟,郭宇玉.腹腔镜手术治疗Ⅰ期子宫内膜癌患者的预后观察[J].实用癌症杂志,2017,32(5):814-816.
[19]Tuomi T,Pasanen A,Leminen A,et al.Prediction of lymphaticdissemination in endometrioid endometrial cancer:Comparison of threerisk-stratification models in a singleinstitution cohort[J].Gynecol Oncol,2017,144(3):510-514.
[20]窦磊,郭科军.腹腔镜手术在早期子宫内膜癌治疗中的疗效观察[J].中国医科大学学报,2016,45(3):241-245.