肺结核患者血栓前四项的变化与意义
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摘要
目的探讨肺结核患者血栓前四项检测的结果变化及临床意义。方法对43例肺结核患者和40例同期健康体检者利用化学发光酶免疫法分别检测血浆凝血酶-抗凝血酶复合物(TAT)、血栓调节蛋白(TM)、组织型纤溶酶原激活物-纤溶酶原激活抑制复合物(t-PAIC)以及纤溶酶-抗纤溶酶复合物(PIC)的含量。结果肺结核患者TAT水平为(7.75±3.05)ng/mL,明显高于对照组的(2.36±0.85)ng/mL,差异具有统计学意义(P <0.05);而TM、t-PAIC、PIC水平与对照组相比差异无统计学意义(P> 0.05)。结论肺结核患者血栓前四项尤其是TAT水平明显增高,在临床诊治过程中应对此加以重视。
Objective To investigate the changes and clinical significance of the results of four items pre-thrombotic tests in patients with pulmonary tuberculosis. Methods 43 patients with pulmonary tuberculosis and 40 healthy subjects were tested for content of plasma thrombin-antithrombin complex(TAT), thrombomodulin(TM), tissue plasminogen activatorplasminogen activator inhibitory complex and plasmin-antiplasmin complex(PIC) by chemiluminescent enzyme immunoassay. Results The level of TAT in tuberculosis patients was(7.75±3.05) ng/mL, which was significantly higher than(2.36±0.85) ng/mL in the control group, and the difference was statistically significant(P < 0.05). The levels of TM, t-PAIC and PIC in tuberculosis patients were not significantly different from those in the control group(P > 0.05). Conclusion The pre-thrombotic four items, especially the TAT level, are significantly increased in patients with pulmonary tuberculosis, which should be paid attention to during clinical diagnosis and treatment.
Objective To investigate the changes and clinical significance of the results of four items pre-thrombotic tests in patients with pulmonary tuberculosis. Methods 43 patients with pulmonary tuberculosis and 40 healthy subjects were tested for content of plasma thrombin-antithrombin complex(TAT), thrombomodulin(TM), tissue plasminogen activatorplasminogen activator inhibitory complex and plasmin-antiplasmin complex(PIC) by chemiluminescent enzyme immunoassay. Results The level of TAT in tuberculosis patients was(7.75±3.05) ng/mL, which was significantly higher than(2.36±0.85) ng/mL in the control group, and the difference was statistically significant(P < 0.05). The levels of TM, t-PAIC and PIC in tuberculosis patients were not significantly different from those in the control group(P > 0.05). Conclusion The pre-thrombotic four items, especially the TAT level, are significantly increased in patients with pulmonary tuberculosis, which should be paid attention to during clinical diagnosis and treatment.
引文
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[11]吕永楠,任玮,陈晶晶,等.急性心肌梗死患者血栓标志物水平变化及意义[J].微循环学杂志,2017,3(3):43-46.
[12]沈薇,周景艺,顾怡.血栓相关凝血标志物在诊断深静脉血栓患者中的应用[J].血栓与止血学,2018,24(6):905-908.
[2]李加涛,李文胜,陈燕琴,等.急诊收治的初治肺结核患者死亡危险因素分析[J].临床肺科杂志,2018,23(11):1971-1973.
[3]梁大斌,黄敏莹,林定文,等. 2005-2015年广西肺结核患者死亡流行病学特征及疾病负担分析[J].中国卫生统计,2017,34(5):772-775.
[4]江丽君,陈锦荣.结核杆菌T细胞表位识别的免疫学足迹[J].微生物学免疫学进展,2013,41(4):78-80.
[5]孟英,刘宁,薛冰蓉,等.应用凝血标志物诊断创伤骨科术后静脉血栓形成的病例对照研究[J].中华检验医学杂志,2016,3(910):751-755.
[6]张蕾,谭榜云,孙志鹏,等.应用凝血标志物诊断肺癌患者血栓前状态的病例对照[J].兰州大学学报(医学版),2018,44(2):54-58.
[7]陈文欣,李强,薛赢俊,等.恶性肿瘤患者凝血-纤溶系统标志物检测及其临床意义[J].检验医学,2018,33(8):722-726.
[8]邱珊,李娜,颜晓霞,等.结核病患者凝血功能的变化及意义[J].兰州大学学报(医学版),2009,35(1):98-101.
[9]魏方,易树君. 208例肺结核患者凝血功能变化的临床意义[J].国际检验医学杂志,2012,33(10):1200-1203.
[10]马维兰,韩芳,牛敏.肺结核患者免疫细胞、炎症因子及凝血功能的变化及意义[J].海南医学院学报,2017,23(1):85-88.
[11]吕永楠,任玮,陈晶晶,等.急性心肌梗死患者血栓标志物水平变化及意义[J].微循环学杂志,2017,3(3):43-46.
[12]沈薇,周景艺,顾怡.血栓相关凝血标志物在诊断深静脉血栓患者中的应用[J].血栓与止血学,2018,24(6):905-908.