神经节苷脂联合鼠神经生长因子治疗新生儿缺血缺氧性脑病的疗效观察
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摘要
目的观察神经节苷脂联合鼠神经生长因子对新生儿缺血缺氧性脑病(HIE)的治疗效果。方法 140例新生儿缺血缺氧性脑病患儿,随机分为治疗组和对照组,每组70例。两组患儿均采用常规治疗,治疗组患儿在常规治疗基础上采用神经节苷脂联合鼠神经生长因子治疗。观察比较两组患儿的临床疗效。结果治疗组患儿中预后良好65例,预后不良5例;对照组患儿中预后良好36例,预后不良34例;治疗组患儿的预后良好率92.86%显著高于对照组的51.43%,差异具有统计学意义(P<0.05)。结论神经节苷脂联合鼠神经生长因子治疗新生儿缺血缺氧性脑病效果显著。
Objective To observe the treatment effect of ganglioside combined with mouse nerve growth factor on the treatment of neonatal hypoxic ischemic encephalopathy(HIE). Methods A total of 140 children with neonatal hypoxic ischemic encephalopathy were randomly divided into treatment group and control group, with 70 cases in each group. Both groups received conventional therapy, and the treatment group was treated with ganglioside combined with mouse nerve growth factor on the basis of conventional therapy. The clinical efficacy in two groups was observed and compared. Results The treatment group had 65 cases with good prognosis and 5 cases with poor prognosis, and the control group had 36 cases with good prognosis and 34 cases with poor prognosis. The treatment group had significantly higher good prognosis rate as 92.86% than 51.43% in the control group, and the difference was statistically significant(P<0.05). Conclusion Ganglioside combined with mouse nerve growth factor shows remarkable effect on the treatment of neonatal hypoxic ischemic encephalopathy.
Objective To observe the treatment effect of ganglioside combined with mouse nerve growth factor on the treatment of neonatal hypoxic ischemic encephalopathy(HIE). Methods A total of 140 children with neonatal hypoxic ischemic encephalopathy were randomly divided into treatment group and control group, with 70 cases in each group. Both groups received conventional therapy, and the treatment group was treated with ganglioside combined with mouse nerve growth factor on the basis of conventional therapy. The clinical efficacy in two groups was observed and compared. Results The treatment group had 65 cases with good prognosis and 5 cases with poor prognosis, and the control group had 36 cases with good prognosis and 34 cases with poor prognosis. The treatment group had significantly higher good prognosis rate as 92.86% than 51.43% in the control group, and the difference was statistically significant(P<0.05). Conclusion Ganglioside combined with mouse nerve growth factor shows remarkable effect on the treatment of neonatal hypoxic ischemic encephalopathy.
引文
[1]薛辛东.儿科学.第2版.北京:人民卫生出版社,2010:113-116.
[2]中华医学会儿科学会新生儿学组.新生儿缺血缺氧性脑病诊断依据和临床分度.中华儿科杂志,1997,15(2):99-100.
[3]薛辛东,杜立中.儿科学.北京:人民卫生出版社,2005:120-122.
[4]董静玲,朱素梅.脑活素治疗新生儿缺血缺氧性脑病疗效观察.实用医技杂志,2008,15(19):2506-2507.
[5]王燕,王文君.脑活素治疗新生儿缺血缺氧性脑病临床疗效观察.陕西医学杂志,2007,36(8):1060-1062.
[6]陈英娇,袁强辉,裴传玉.单唾液酸四己糖神经节苷脂在急性颅脑损伤患儿中应用的效果分析.中国现代药物应用,2017,11(13):125-126.
[7]杨玉玲,木冬妹,高岭燕,等.鼠神经生长因子联合神经节苷酯对婴儿脑损伤后神经功能修复影响的临床研究.中国临床药理学杂志,2016,32(14):1265-1267.
[8]周蕾,蔡勇,梁少珍,等.神经节苷脂联合鼠神经生长因子对早产儿脑损伤后血清神经损伤标志物的影响.中国临床药理学杂志,2018,34(5):557-261.
[9]李俊,李骋,王尚忠,等.神经节苷脂联合鼠神经生长因子治疗新生儿缺血缺氧性脑病70例疗效观察.海南医学,2015(2):260-262.
[10]张海霞,郭晓燕.鼠神经生长因子联合神经节苷脂治疗新生儿缺血缺氧性脑病患儿的疗效观察.国际医药卫生导报,2017,23(10):1561.
[11]黄坤美,黄永辉,连文喜,等.鼠神经生长因子治疗中重度新生儿缺血缺氧性脑病的临床研究.临床医学工程,2013,20(3):338-339.
[12]逯艳梅,曹甦.新生儿缺血缺氧性脑病51例临床观察.大家健康(学术版),2015,9(18):16-17.
[2]中华医学会儿科学会新生儿学组.新生儿缺血缺氧性脑病诊断依据和临床分度.中华儿科杂志,1997,15(2):99-100.
[3]薛辛东,杜立中.儿科学.北京:人民卫生出版社,2005:120-122.
[4]董静玲,朱素梅.脑活素治疗新生儿缺血缺氧性脑病疗效观察.实用医技杂志,2008,15(19):2506-2507.
[5]王燕,王文君.脑活素治疗新生儿缺血缺氧性脑病临床疗效观察.陕西医学杂志,2007,36(8):1060-1062.
[6]陈英娇,袁强辉,裴传玉.单唾液酸四己糖神经节苷脂在急性颅脑损伤患儿中应用的效果分析.中国现代药物应用,2017,11(13):125-126.
[7]杨玉玲,木冬妹,高岭燕,等.鼠神经生长因子联合神经节苷酯对婴儿脑损伤后神经功能修复影响的临床研究.中国临床药理学杂志,2016,32(14):1265-1267.
[8]周蕾,蔡勇,梁少珍,等.神经节苷脂联合鼠神经生长因子对早产儿脑损伤后血清神经损伤标志物的影响.中国临床药理学杂志,2018,34(5):557-261.
[9]李俊,李骋,王尚忠,等.神经节苷脂联合鼠神经生长因子治疗新生儿缺血缺氧性脑病70例疗效观察.海南医学,2015(2):260-262.
[10]张海霞,郭晓燕.鼠神经生长因子联合神经节苷脂治疗新生儿缺血缺氧性脑病患儿的疗效观察.国际医药卫生导报,2017,23(10):1561.
[11]黄坤美,黄永辉,连文喜,等.鼠神经生长因子治疗中重度新生儿缺血缺氧性脑病的临床研究.临床医学工程,2013,20(3):338-339.
[12]逯艳梅,曹甦.新生儿缺血缺氧性脑病51例临床观察.大家健康(学术版),2015,9(18):16-17.