复发性阿弗他溃疡相关危险因素的病例对照研究
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摘要
目的 :通过病例对照研究,调查复发性阿弗他溃疡(recurrent aphthous ulcer, RAU)发生的可能危险因素。方法 :对113例RAU患者、102例非RAU患者进行问卷调查,包括系统疾病、吸烟、饮酒、居住地改变、饮食、心理因素等58项内容,采用SPSS23.0软件包对各个相关因素进行Logistic回归分析,筛选出RAU的致病高危因素,并进行趋势分析。结果:单因素分析显示,居住地改变、亲属患病、胃肠道症状(疾病)、月经相关、软垢、结石和焦虑等是RAU患病的关联因素。多因素非条件Logistic回归显示,亲属易患病、大量口腔结石是RAU患病的危险因素。趋势χ2分析发现,蔬菜的种类、软垢的量与RAU存在等级效应关系,蔬菜的摄入种类越少,口腔内软垢、结石的量越多,RAU的患病危险性越高(P<0.05)。结论:RAU的发生是消化系统、遗传系统、免疫系统、口腔微环境"多联因素"综合作用的结果。
PURPOSE: To evaluate the risk factors for the occurrence of recurrent aphthous ulcer(RAU) in Fuzhou city by case-control study. METHODS: A questionnaire survey of 113 patients with RAU and 102 non-RAU patients in the same hospital was made, including 58 items. Chi-square test and conditional logistic regression were used for monovariate and multivariate analysis respectively with SPSS23.0 software package. RESULTS: One-way Chi-square test showed that immigrants, genetic factors, gastrointestinal disorders, menstrual period, oral health status, anxiety were related factors for patients suffering from RAU. Conditional logistic regression analysis indicated that genetic factors as well as more dental calculus in the oral cavity were RAU risk factors. Tendency Chi-square test revealed that there was a negative correlation between the occurrence of RAU and vegetable intake, and a positive correlation with the amount of dental calculus and soft scale in the oral cavity. CONCLUSIONS: The occurrence of RAU is the result of combination of "multiple factors" in the digestive system, genetic system, immune system and oral microenvironment.
PURPOSE: To evaluate the risk factors for the occurrence of recurrent aphthous ulcer(RAU) in Fuzhou city by case-control study. METHODS: A questionnaire survey of 113 patients with RAU and 102 non-RAU patients in the same hospital was made, including 58 items. Chi-square test and conditional logistic regression were used for monovariate and multivariate analysis respectively with SPSS23.0 software package. RESULTS: One-way Chi-square test showed that immigrants, genetic factors, gastrointestinal disorders, menstrual period, oral health status, anxiety were related factors for patients suffering from RAU. Conditional logistic regression analysis indicated that genetic factors as well as more dental calculus in the oral cavity were RAU risk factors. Tendency Chi-square test revealed that there was a negative correlation between the occurrence of RAU and vegetable intake, and a positive correlation with the amount of dental calculus and soft scale in the oral cavity. CONCLUSIONS: The occurrence of RAU is the result of combination of "multiple factors" in the digestive system, genetic system, immune system and oral microenvironment.
引文
[1] Akintoye SO, Greenberg MS. Recurrent aphthous stomatitis[J].Dent Clin North Am, 2005, 49(1):31-47.
[2]赖荫光.对失眠的定义、诊断及药物治疗的探讨[J].中国民康医学, 2008, 20(15):1785-1786.
[3]卞金有.预防口腔医学[M].第6版.北京:人民卫生出版社,2007:55.
[4]中国营养学会.中国居民膳食指南(2007)[M].拉萨:西藏人民出版社, 2008:9193.
[5]陈谦明,周曾同.口腔黏膜病学[M].第3版.北京:人民卫生出版社, 2008:58.
[6] Sridhar T, Elumalai M, Karthika B. Recurrent aphthousstomatitis:a review[J]. Biomed Pharmacol J, 2013, 6(1):17-22.
[7] Kignel S, de Almeida Pina F, AndréEA, et al. Occurrence ofHelicobacter pylori in dental plaque and saliva of dyspepticpatients[J]. Oral Dis, 2005, 11(1):17-21.
[8]龙宝军,陈柯,吴补领,等.复发性口腔溃疡患者口腔幽门螺杆菌的检测[J].南方医科大学学报, 2007, 27(4):477-478.
[9]张慧,陈柯.应用PCR-SSCP技术检测消化道疾病伴发复发性口腔溃疡患者口腔和胃内幽门螺杆菌的实验研究[J].牙体牙髓牙周病学杂志, 2005, 15(5):274-278.
[10] Soto Araya M, Rojas Alcayaga G, et al. Association betweenpsychological disorders and the presence of oral lichen planus,burning mouth syndrome and recurrent aphthous stomatitis[J].Med Oral, 2004, 9(1):1-7.
[11] Lewkowicz N, Kur B, Kurnatowska A, et al. Expression of Th1/Th2/Th3/Th17-related genes in recurrent aphthous ulcers[J].Arch Immunol Et Ther Exp(Warsz), 2011, 59(5):399-406.
[12] Ozdemir M, Acar H, Deniz F, et al. HLA-B 51 in patients withrecurrent aphthous stomatitis[J]. Acta Derm Venereol, 2009, 89(2):202-300.
[13] J agtap K, Baad RK. Estimation of salivary nitric oxide in recurrentaphthous ulcer and oral lichen planus patients with its clinicalsignificance[J]. J Contemp Den Pract, 2012, 13(5):623-626.
[14]蓝余炼,唐亮,崔日林.铁代谢在复发性口腔溃疡患者中的变化及其与细胞免疫功能的关系[J].上海口腔医学, 2017, 26(3):302-304.
[15] Landesberg R, Falon M, Insel R. Alterations of T helper/inducerand Tsuppressor/inducer cells in patients with recurrent aphthousulcers[J]. Oral Surg Oral Med Oral Pathol, 1990,69(2):205-208.
[16] Lehner T. Pathology of recurrent oral ulceration and oralulceration in Behcet's syndrome:light, electron and fluorescencemicroscopy[J]. J Pathol, 1969, 97(3):481-494.
[17]邹俐琳,王文梅,刘雅菁,等.顽固性复发性阿弗他溃疡患者外周血Th17细胞与免疫球蛋白及补体水平的变化[J].上海口腔医学, 2017, 26(5):521-525.
[18]吴敏,刘寿桃,陈少武,等.与经期相关的复发性口腔溃疡患者黄体期性激素水平的研究[J].实用口腔医学杂志, 2010, 26(3):360-362.
[19]何剑玲,夏娟,陈怡.复发性阿弗他溃疡患者的牙周状况分析[J].基层医学论坛, 2010, 14(7):203-205.
[20] Marehini L, Campos MS, Silva AM, et al. Bacterial diversity inaphthous ulcers[J]. Oral Mierobiol Immunol, 2007, 22(4):225-231.
[2]赖荫光.对失眠的定义、诊断及药物治疗的探讨[J].中国民康医学, 2008, 20(15):1785-1786.
[3]卞金有.预防口腔医学[M].第6版.北京:人民卫生出版社,2007:55.
[4]中国营养学会.中国居民膳食指南(2007)[M].拉萨:西藏人民出版社, 2008:9193.
[5]陈谦明,周曾同.口腔黏膜病学[M].第3版.北京:人民卫生出版社, 2008:58.
[6] Sridhar T, Elumalai M, Karthika B. Recurrent aphthousstomatitis:a review[J]. Biomed Pharmacol J, 2013, 6(1):17-22.
[7] Kignel S, de Almeida Pina F, AndréEA, et al. Occurrence ofHelicobacter pylori in dental plaque and saliva of dyspepticpatients[J]. Oral Dis, 2005, 11(1):17-21.
[8]龙宝军,陈柯,吴补领,等.复发性口腔溃疡患者口腔幽门螺杆菌的检测[J].南方医科大学学报, 2007, 27(4):477-478.
[9]张慧,陈柯.应用PCR-SSCP技术检测消化道疾病伴发复发性口腔溃疡患者口腔和胃内幽门螺杆菌的实验研究[J].牙体牙髓牙周病学杂志, 2005, 15(5):274-278.
[10] Soto Araya M, Rojas Alcayaga G, et al. Association betweenpsychological disorders and the presence of oral lichen planus,burning mouth syndrome and recurrent aphthous stomatitis[J].Med Oral, 2004, 9(1):1-7.
[11] Lewkowicz N, Kur B, Kurnatowska A, et al. Expression of Th1/Th2/Th3/Th17-related genes in recurrent aphthous ulcers[J].Arch Immunol Et Ther Exp(Warsz), 2011, 59(5):399-406.
[12] Ozdemir M, Acar H, Deniz F, et al. HLA-B 51 in patients withrecurrent aphthous stomatitis[J]. Acta Derm Venereol, 2009, 89(2):202-300.
[13] J agtap K, Baad RK. Estimation of salivary nitric oxide in recurrentaphthous ulcer and oral lichen planus patients with its clinicalsignificance[J]. J Contemp Den Pract, 2012, 13(5):623-626.
[14]蓝余炼,唐亮,崔日林.铁代谢在复发性口腔溃疡患者中的变化及其与细胞免疫功能的关系[J].上海口腔医学, 2017, 26(3):302-304.
[15] Landesberg R, Falon M, Insel R. Alterations of T helper/inducerand Tsuppressor/inducer cells in patients with recurrent aphthousulcers[J]. Oral Surg Oral Med Oral Pathol, 1990,69(2):205-208.
[16] Lehner T. Pathology of recurrent oral ulceration and oralulceration in Behcet's syndrome:light, electron and fluorescencemicroscopy[J]. J Pathol, 1969, 97(3):481-494.
[17]邹俐琳,王文梅,刘雅菁,等.顽固性复发性阿弗他溃疡患者外周血Th17细胞与免疫球蛋白及补体水平的变化[J].上海口腔医学, 2017, 26(5):521-525.
[18]吴敏,刘寿桃,陈少武,等.与经期相关的复发性口腔溃疡患者黄体期性激素水平的研究[J].实用口腔医学杂志, 2010, 26(3):360-362.
[19]何剑玲,夏娟,陈怡.复发性阿弗他溃疡患者的牙周状况分析[J].基层医学论坛, 2010, 14(7):203-205.
[20] Marehini L, Campos MS, Silva AM, et al. Bacterial diversity inaphthous ulcers[J]. Oral Mierobiol Immunol, 2007, 22(4):225-231.