柔性辟谷技术对肥胖人群代谢指标的改善作用
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摘要
目的:依托医院营养科测评柔性辟谷技术对肥胖与相关慢病的改善效果。方法:按照肥胖与相关慢病遴选标准招募志愿者,在营养科医生的指导下进行连续7d的柔性辟谷干预。在柔性辟谷期间及前后不同时间点,对志愿者理化指标进行检测记录,基于自身对照结果进行统计分析,并记录主观受试反馈。结果:柔性辟谷干预后,电解质及肝肾功能正常,志愿者的体重、血压、空腹血糖、血脂指标均显著下降,表现出趋于改善的效果。结论:柔性辟谷技术减重效果明显,能有效改善肥胖人群的血压、血糖、血脂等指标,且安全性测评结果良好,有望成为肥胖人群改善慢病指征的一种方案,为后续将柔性辟谷技术纳入临床专家共识提供科学依据。
【Objective】 To evaluate the effect of flexible fasting( FF) technology on losing weight and improving chronic diseases based on the department of nutrition in the hospital. 【Method】 We recruited volunteers with the selection criteria of obesity and related chronic diseases. All the volunteers experienced 7 days of FF treatment under guidance of nutritionist. We tested and recorded the physical and chemical indicators of the volunteers during the FF operation. All the results were compared by self-control and conducted statistical analysis. The volunteer's physical indicators had been tracking during the period of FF operation. 【Result】 After the FF treatment,the volunteers' weight,blood pressure,fasting blood glucose,and blood lipids were significantly decreased,and theelectrolytes,liver and kidney functions were normal. The volunteer's physical indicators become better. 【Conclusion】 The FF approach has obvious effect on losing weight and improving physical indicators including blood pressure,blood glucose,blood lipids,and the result of safety assessment are well. Therefore,FF technology might be developed as a manner for improving the chronic diseases indicators in obesity people with the potential to be the clinical expert consensus.
【Objective】 To evaluate the effect of flexible fasting( FF) technology on losing weight and improving chronic diseases based on the department of nutrition in the hospital. 【Method】 We recruited volunteers with the selection criteria of obesity and related chronic diseases. All the volunteers experienced 7 days of FF treatment under guidance of nutritionist. We tested and recorded the physical and chemical indicators of the volunteers during the FF operation. All the results were compared by self-control and conducted statistical analysis. The volunteer's physical indicators had been tracking during the period of FF operation. 【Result】 After the FF treatment,the volunteers' weight,blood pressure,fasting blood glucose,and blood lipids were significantly decreased,and theelectrolytes,liver and kidney functions were normal. The volunteer's physical indicators become better. 【Conclusion】 The FF approach has obvious effect on losing weight and improving physical indicators including blood pressure,blood glucose,blood lipids,and the result of safety assessment are well. Therefore,FF technology might be developed as a manner for improving the chronic diseases indicators in obesity people with the potential to be the clinical expert consensus.
引文
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[23] Bckhed F,et al. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice[J]. Proc Natl Acad Sci U S A,2007,104(3):979-984.
[24] Li J,Zhao F,Wang Y,et al. Gut microbiota dysbiosis contributes to the development of hypertension[J]. Microbiome,2017,5(1):14-32.
[25] Zhu W, Gregory JC, Org E, et al. Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis Risk[J]. Cell,2016,165(1):111-124.
[26] Calcinaro F,Dionisi S,Marinaro M,et al. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse[J]. Diabetologia, 2005, 48(8):1565-1575.
[27]张成岗.当前慢病防控困境迫切呼唤新医学和菌心说[J].科技导报,2015,33(22):106-111.
[28]陈玉娟,李立,张立立,等.单纯节食减肥大学生体成分状况分析[J].体育科技,2015,36(1):79-80.
[29]查锡良.生物化学(第七版)[M].北京:人民卫生出版社,2008.
[2]中华人民共和国卫生部疾病控制司.中国成人超重和肥胖症预防控制指南[M].北京:人民卫生出版社,2006.
[3] Li G,Xie C,Lu S,et al. Intermittent fasting promotes white adipose browning and decreases obesity by shaping the gut microbiota[J]. Cell Metab,2017,26(4):672-685.
[4] Wei M, et al. Fasting-mimicking diet and markers/risk factors for aging,diabetes,cancer,and cardiovascular disease[J]. Sci Transl Med,2017,9(377):aai8700.
[5] Brandhorst S,et al. A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance,and healthspan[J]. Cell Metab,2015,22(1):86-99.
[6] Mattson MP,Allison DB,Fontana L,et al. Meal frequency and timing in health and disease[J]. Proc Natl Acad Sci U S A,2014,111(47):16647-16653.
[7] Mattson MP. Lifelong brain health is a lifelong challenge:from evolutionary principles to empirical evidence[J].Ageing Res Rev,2015(20):37-45.
[8]黄清健,等.灾害救援中柔性辟谷提高救援效率的应急方案[J].灾害医学与救援(电子版),2015,4(2):81-85.
[9]张成岗,巩文静.基于饥饿源于菌群的新发现将引发慢病防控突破性进展[J].科技导报,2017,35(21):43-48.
[10]张成岗.新医学·菌心说·云医院[M].北京:中医古籍出版社,2016.
[11]张成岗,巩文静.柔性辟谷:一种可改善肥胖及相关慢性病的新技术[J].中国民康医学,2018,30(6):100-102.
[12]任青河,等.柔性辟谷技术改善高血压的初步研究[J].中国食物与营养,2017,23(8):70-75.
[13]巩文静,等.柔性辟谷技术在青年人群体重控制中的应用[J].军事医学,2016,40(8):651-656.
[14]巩文静.柔性辟谷技术用于改善体重的临床观察研究[D].中国人民解放军军事医学科学院,2017.
[15]苏玉顺,等.柔性辟谷技术对慢性荨麻疹改善作用的初步研究[J].转化医学电子杂志,2017(12):20-25.
[16]贺媛,赵小兰,曾强.城市成人超重、肥胖、中心性肥胖的流行特征和相关危险因素分析[J].实用预防医学,2015,22(4):390-394.
[17]陈春明,等.中国慢性病控制中膳食关键因素的研究[J].中华流行病学杂志,2006,27(9):739-743.
[18]江国虹,等.膳食、体力活动与慢性病关系的研究[J].中国慢性病预防与控制,2007,15(2):94-96.
[19]吕兰婷,邓思兰.我国慢性病管理现状、问题及发展建议[J].中国卫生政策研究,2016,9(7):1-7.
[20] Fei N,Zhao L. An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice[J].ISME J,2013,7(4):880-884.
[21] Turnbaugh PJ,Ley RE,Mahowald MA,et al. An obesityassociated gut microbiome with increased capacity for energy harvest[J]. Nature,2006,444(7122):1027-1031.
[22] Sweeney TE,Morton JM. The human gut microbiome:a review of the effect of obesity and surgically induced weight loss[J]. JAMA Surg,2013,148(6):563-569.
[23] Bckhed F,et al. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice[J]. Proc Natl Acad Sci U S A,2007,104(3):979-984.
[24] Li J,Zhao F,Wang Y,et al. Gut microbiota dysbiosis contributes to the development of hypertension[J]. Microbiome,2017,5(1):14-32.
[25] Zhu W, Gregory JC, Org E, et al. Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis Risk[J]. Cell,2016,165(1):111-124.
[26] Calcinaro F,Dionisi S,Marinaro M,et al. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse[J]. Diabetologia, 2005, 48(8):1565-1575.
[27]张成岗.当前慢病防控困境迫切呼唤新医学和菌心说[J].科技导报,2015,33(22):106-111.
[28]陈玉娟,李立,张立立,等.单纯节食减肥大学生体成分状况分析[J].体育科技,2015,36(1):79-80.
[29]查锡良.生物化学(第七版)[M].北京:人民卫生出版社,2008.